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Protein

Clathrin light chain A

Gene

CLTA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:21297582).2 Publications

GO - Molecular functioni

  • clathrin heavy chain binding Source: FlyBase
  • peptide binding Source: Ensembl
  • structural molecule activity Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000122705-MONOMER.
ReactomeiR-HSA-168275. Entry of Influenza Virion into Host Cell via Endocytosis.
R-HSA-171052. LDL-mediated lipid transport.
R-HSA-177504. Retrograde neurotrophin signalling.
R-HSA-190873. Gap junction degradation.
R-HSA-196025. Formation of annular gap junctions.
R-HSA-2132295. MHC class II antigen presentation.
R-HSA-3928665. EPH-ephrin mediated repulsion of cells.
R-HSA-432720. Lysosome Vesicle Biogenesis.
R-HSA-432722. Golgi Associated Vesicle Biogenesis.
R-HSA-437239. Recycling pathway of L1.
R-HSA-5099900. WNT5A-dependent internalization of FZD4.
R-HSA-5140745. WNT5A-dependent internalization of FZD2, FZD5 and ROR2.
R-HSA-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-HSA-8856828. Clathrin-mediated endocytosis.
R-HSA-8866427. VLDLR internalisation and degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Clathrin light chain A
Short name:
Lca
Gene namesi
Name:CLTA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:2090. CLTA.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Coated pit, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1211.
OpenTargetsiENSG00000122705.
PharmGKBiPA26616.

Polymorphism and mutation databases

BioMutaiCLTA.
DMDMi116501.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002057671 – 248Clathrin light chain AAdd BLAST248

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei105PhosphoserineCombined sources1
Modified residuei206PhosphoserineCombined sources1
Modified residuei223N6-acetyllysineBy similarity1
Modified residuei236PhosphoserineCombined sources1
Modified residuei242N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP09496.
MaxQBiP09496.
PaxDbiP09496.
PeptideAtlasiP09496.
PRIDEiP09496.
TopDownProteomicsiP09496-1. [P09496-1]
P09496-2. [P09496-2]

2D gel databases

OGPiP09496.

PTM databases

iPTMnetiP09496.
PhosphoSitePlusiP09496.
SwissPalmiP09496.

Miscellaneous databases

PMAP-CutDBP09496.

Expressioni

Gene expression databases

BgeeiENSG00000122705.
CleanExiHS_CLTA.
ExpressionAtlasiP09496. baseline and differential.
GenevisibleiP09496. HS.

Organism-specific databases

HPAiCAB002665.
HPA050918.
HPA054667.

Interactioni

Subunit structurei

Clathrin coats are formed from molecules containing 3 heavy chains and 3 light chains. Interacts with CALY; the interaction stimulates clathrin self-assembly and clathrin-mediated endocytosis. Interacts with CKAP5 and TACC3 forming the TACC3/ch-TOG/clathrin complex located at spindle inter-microtubules bridges; the complex implicates clathrin triskelions.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CALYQ9NYX44EBI-1171169,EBI-10904725
TACC3Q9Y6A53EBI-1171169,EBI-2554984

GO - Molecular functioni

  • clathrin heavy chain binding Source: FlyBase

Protein-protein interaction databases

BioGridi107621. 76 interactors.
IntActiP09496. 73 interactors.
MINTiMINT-1326541.
STRINGi9606.ENSP00000242285.

Structurei

3D structure databases

ProteinModelPortaliP09496.
SMRiP09496.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni100 – 162Involved in binding clathrin heavy chainAdd BLAST63

Sequence similaritiesi

Belongs to the clathrin light chain family.Curated

Phylogenomic databases

eggNOGiKOG4031. Eukaryota.
ENOG4111J5K. LUCA.
GeneTreeiENSGT00390000010441.
HOGENOMiHOG000008147.
HOVERGENiHBG003386.
InParanoidiP09496.
KOiK04644.
OMAiDEWYARQ.
OrthoDBiEOG091G0WEF.
PhylomeDBiP09496.
TreeFamiTF313162.

Family and domain databases

InterProiIPR000996. Clathrin_L-chain.
[Graphical view]
PANTHERiPTHR10639. PTHR10639. 2 hits.
PfamiPF01086. Clathrin_lg_ch. 1 hit.
[Graphical view]
PROSITEiPS00224. CLATHRIN_LIGHT_CHN_1. 1 hit.
PS00581. CLATHRIN_LIGHT_CHN_2. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Brain (identifier: P09496-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAELDPFGAP AGAPGGPALG NGVAGAGEED PAAAFLAQQE SEIAGIENDE
60 70 80 90 100
AFAILDGGAP GPQPHGEPPG GPDAVDGVMN GEYYQESNGP TDSYAAISQV
110 120 130 140 150
DRLQSEPESI RKWREEQMER LEALDANSRK QEAEWKEKAI KELEEWYARQ
160 170 180 190 200
DEQLQKTKAN NRVADEAFYK QPFADVIGYV TNINHPCYSL EQAAEEAFVN
210 220 230 240
DIDESSPGTE WERVARLCDF NPKSSKQAKD VSRMRSVLIS LKQAPLVH
Length:248
Mass (Da):27,077
Last modified:July 1, 1989 - v1
Checksum:i8D8A3B49E6353D93
GO
Isoform Non-brain (identifier: P09496-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     163-192: Missing.

Show »
Length:218
Mass (Da):23,662
Checksum:i05C5037569FB6E8D
GO
Isoform 3 (identifier: P09496-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     181-192: Missing.

Show »
Length:236
Mass (Da):25,676
Checksum:iDAD1A01F3FD51284
GO
Isoform 4 (identifier: P09496-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     162-180: RVADEAFYKQPFADVIGYV → S

Note: No experimental confirmation available.
Show »
Length:230
Mass (Da):24,993
Checksum:iB9644FCE2C09A116
GO
Isoform 5 (identifier: P09496-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     73-124: Missing.
     163-192: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:166
Mass (Da):17,687
Checksum:i1F8381B9C1F55136
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti207P → Q in ABB76683 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04716873 – 124Missing in isoform 5. CuratedAdd BLAST52
Alternative sequenceiVSP_043239162 – 180RVADE…VIGYV → S in isoform 4. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_001095163 – 192Missing in isoform Non-brain and isoform 5. 4 PublicationsAdd BLAST30
Alternative sequenceiVSP_024238181 – 192Missing in isoform 3. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20471 mRNA. Translation: AAA51817.1.
M20472 mRNA. Translation: AAA59505.1.
DQ270158 mRNA. Translation: ABB76683.1.
BT007170 mRNA. Translation: AAP35834.1.
AK291078 mRNA. Translation: BAF83767.1.
AK295692 mRNA. Translation: BAG58543.1.
AL158830 Genomic DNA. Translation: CAD13387.1.
AL158830 Genomic DNA. Translation: CAD13388.1.
AL161792 Genomic DNA. No translation available.
CH471071 Genomic DNA. Translation: EAW58312.1.
BC009201 mRNA. Translation: AAH09201.1.
BC019287 mRNA. Translation: AAH19287.1.
CCDSiCCDS43802.1. [P09496-3]
CCDS55306.1. [P09496-4]
CCDS55307.1. [P09496-5]
CCDS6600.1. [P09496-2]
CCDS6601.1. [P09496-1]
PIRiA31775.
RefSeqiNP_001070145.1. NM_001076677.2. [P09496-3]
NP_001171689.1. NM_001184760.1. [P09496-4]
NP_001171691.1. NM_001184762.1. [P09496-5]
NP_001824.1. NM_001833.3. [P09496-2]
NP_009027.1. NM_007096.3. [P09496-1]
UniGeneiHs.522114.

Genome annotation databases

EnsembliENST00000242285; ENSP00000242285; ENSG00000122705. [P09496-1]
ENST00000345519; ENSP00000242284; ENSG00000122705. [P09496-2]
ENST00000396603; ENSP00000379848; ENSG00000122705. [P09496-3]
ENST00000433436; ENSP00000401019; ENSG00000122705. [P09496-1]
ENST00000470744; ENSP00000419746; ENSG00000122705. [P09496-4]
ENST00000538225; ENSP00000442869; ENSG00000122705. [P09496-4]
ENST00000540080; ENSP00000437508; ENSG00000122705. [P09496-5]
GeneIDi1211.
KEGGihsa:1211.
UCSCiuc003zzc.4. human. [P09496-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20471 mRNA. Translation: AAA51817.1.
M20472 mRNA. Translation: AAA59505.1.
DQ270158 mRNA. Translation: ABB76683.1.
BT007170 mRNA. Translation: AAP35834.1.
AK291078 mRNA. Translation: BAF83767.1.
AK295692 mRNA. Translation: BAG58543.1.
AL158830 Genomic DNA. Translation: CAD13387.1.
AL158830 Genomic DNA. Translation: CAD13388.1.
AL161792 Genomic DNA. No translation available.
CH471071 Genomic DNA. Translation: EAW58312.1.
BC009201 mRNA. Translation: AAH09201.1.
BC019287 mRNA. Translation: AAH19287.1.
CCDSiCCDS43802.1. [P09496-3]
CCDS55306.1. [P09496-4]
CCDS55307.1. [P09496-5]
CCDS6600.1. [P09496-2]
CCDS6601.1. [P09496-1]
PIRiA31775.
RefSeqiNP_001070145.1. NM_001076677.2. [P09496-3]
NP_001171689.1. NM_001184760.1. [P09496-4]
NP_001171691.1. NM_001184762.1. [P09496-5]
NP_001824.1. NM_001833.3. [P09496-2]
NP_009027.1. NM_007096.3. [P09496-1]
UniGeneiHs.522114.

3D structure databases

ProteinModelPortaliP09496.
SMRiP09496.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107621. 76 interactors.
IntActiP09496. 73 interactors.
MINTiMINT-1326541.
STRINGi9606.ENSP00000242285.

PTM databases

iPTMnetiP09496.
PhosphoSitePlusiP09496.
SwissPalmiP09496.

Polymorphism and mutation databases

BioMutaiCLTA.
DMDMi116501.

2D gel databases

OGPiP09496.

Proteomic databases

EPDiP09496.
MaxQBiP09496.
PaxDbiP09496.
PeptideAtlasiP09496.
PRIDEiP09496.
TopDownProteomicsiP09496-1. [P09496-1]
P09496-2. [P09496-2]

Protocols and materials databases

DNASUi1211.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000242285; ENSP00000242285; ENSG00000122705. [P09496-1]
ENST00000345519; ENSP00000242284; ENSG00000122705. [P09496-2]
ENST00000396603; ENSP00000379848; ENSG00000122705. [P09496-3]
ENST00000433436; ENSP00000401019; ENSG00000122705. [P09496-1]
ENST00000470744; ENSP00000419746; ENSG00000122705. [P09496-4]
ENST00000538225; ENSP00000442869; ENSG00000122705. [P09496-4]
ENST00000540080; ENSP00000437508; ENSG00000122705. [P09496-5]
GeneIDi1211.
KEGGihsa:1211.
UCSCiuc003zzc.4. human. [P09496-1]

Organism-specific databases

CTDi1211.
DisGeNETi1211.
GeneCardsiCLTA.
HGNCiHGNC:2090. CLTA.
HPAiCAB002665.
HPA050918.
HPA054667.
MIMi118960. gene.
neXtProtiNX_P09496.
OpenTargetsiENSG00000122705.
PharmGKBiPA26616.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4031. Eukaryota.
ENOG4111J5K. LUCA.
GeneTreeiENSGT00390000010441.
HOGENOMiHOG000008147.
HOVERGENiHBG003386.
InParanoidiP09496.
KOiK04644.
OMAiDEWYARQ.
OrthoDBiEOG091G0WEF.
PhylomeDBiP09496.
TreeFamiTF313162.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000122705-MONOMER.
ReactomeiR-HSA-168275. Entry of Influenza Virion into Host Cell via Endocytosis.
R-HSA-171052. LDL-mediated lipid transport.
R-HSA-177504. Retrograde neurotrophin signalling.
R-HSA-190873. Gap junction degradation.
R-HSA-196025. Formation of annular gap junctions.
R-HSA-2132295. MHC class II antigen presentation.
R-HSA-3928665. EPH-ephrin mediated repulsion of cells.
R-HSA-432720. Lysosome Vesicle Biogenesis.
R-HSA-432722. Golgi Associated Vesicle Biogenesis.
R-HSA-437239. Recycling pathway of L1.
R-HSA-5099900. WNT5A-dependent internalization of FZD4.
R-HSA-5140745. WNT5A-dependent internalization of FZD2, FZD5 and ROR2.
R-HSA-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-HSA-8856828. Clathrin-mediated endocytosis.
R-HSA-8866427. VLDLR internalisation and degradation.

Miscellaneous databases

ChiTaRSiCLTA. human.
GenomeRNAii1211.
PMAP-CutDBP09496.
PROiP09496.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000122705.
CleanExiHS_CLTA.
ExpressionAtlasiP09496. baseline and differential.
GenevisibleiP09496. HS.

Family and domain databases

InterProiIPR000996. Clathrin_L-chain.
[Graphical view]
PANTHERiPTHR10639. PTHR10639. 2 hits.
PfamiPF01086. Clathrin_lg_ch. 1 hit.
[Graphical view]
PROSITEiPS00224. CLATHRIN_LIGHT_CHN_1. 1 hit.
PS00581. CLATHRIN_LIGHT_CHN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLCA_HUMAN
AccessioniPrimary (citable) accession number: P09496
Secondary accession number(s): A8K4W3
, B4DIN1, F5H6N3, Q2XPN5, Q53XZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 30, 2016
This is version 165 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.