Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tropomyosin alpha-1 chain

Gene

TPM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.

GO - Molecular functioni

  • actin binding Source: BHF-UCL
  • cytoskeletal protein binding Source: UniProtKB
  • structural constituent of cytoskeleton Source: BHF-UCL
  • structural constituent of muscle Source: ProtInc

GO - Biological processi

  • cardiac muscle contraction Source: BHF-UCL
  • cellular response to reactive oxygen species Source: BHF-UCL
  • cytoskeleton organization Source: BHF-UCL
  • in utero embryonic development Source: Ensembl
  • movement of cell or subcellular component Source: UniProtKB
  • muscle contraction Source: Reactome
  • muscle filament sliding Source: BHF-UCL
  • negative regulation of cell migration Source: BHF-UCL
  • negative regulation of vascular associated smooth muscle cell migration Source: BHF-UCL
  • negative regulation of vascular smooth muscle cell proliferation Source: BHF-UCL
  • positive regulation of ATPase activity Source: BHF-UCL
  • positive regulation of cell adhesion Source: BHF-UCL
  • positive regulation of heart rate by epinephrine Source: BHF-UCL
  • positive regulation of stress fiber assembly Source: BHF-UCL
  • regulation of cell shape Source: BHF-UCL
  • regulation of heart contraction Source: ProtInc
  • regulation of muscle contraction Source: ProtInc
  • ruffle organization Source: BHF-UCL
  • sarcomere organization Source: BHF-UCL
  • ventricular cardiac muscle tissue morphogenesis Source: BHF-UCL
  • wound healing Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000140416-MONOMER.
ReactomeiR-HSA-390522. Striated Muscle Contraction.
R-HSA-445355. Smooth Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Tropomyosin alpha-1 chain
Alternative name(s):
Alpha-tropomyosin
Tropomyosin-1
Gene namesi
Name:TPM1
Synonyms:C15orf13, TMSA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:12010. TPM1.

Subcellular locationi

GO - Cellular componenti

  • bleb Source: BHF-UCL
  • cytoskeleton Source: UniProtKB
  • cytosol Source: Reactome
  • filamentous actin Source: Ensembl
  • muscle thin filament tropomyosin Source: ProtInc
  • ruffle membrane Source: BHF-UCL
  • sarcomere Source: BHF-UCL
  • stress fiber Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Involvement in diseasei

Cardiomyopathy, familial hypertrophic 3 (CMH3)5 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
See also OMIM:115196
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01313563A → V in CMH3. 1 PublicationCorresponds to variant rs199476306dbSNPEnsembl.1
Natural variantiVAR_007601175D → N in CMH3. 4 PublicationsCorresponds to variant rs28934270dbSNPEnsembl.1
Natural variantiVAR_007602180E → G in CMH3. 1 PublicationCorresponds to variant rs28934269dbSNPEnsembl.1
Natural variantiVAR_029452180E → V in CMH3. 1 PublicationCorresponds to variant rs104894502dbSNPEnsembl.1
Cardiomyopathy, dilated 1Y (CMD1Y)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
See also OMIM:611878
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04398640E → K in CMD1Y. 1 PublicationCorresponds to variant rs104894501dbSNPEnsembl.1
Natural variantiVAR_04398754E → K in CMD1Y. 1 PublicationCorresponds to variant rs104894505dbSNPEnsembl.1
Left ventricular non-compaction 9 (LVNC9)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease due to an arrest of myocardial morphogenesis. It is characterized by a hypertrophic left ventricle with deep trabeculations and with poor systolic function, with or without associated left ventricular dilation. In some cases, it is associated with other congenital heart anomalies.
See also OMIM:611878
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070121192E → K in LVNC9. 1 PublicationCorresponds to variant rs199476315dbSNPEnsembl.1
Natural variantiVAR_070122248K → E in LVNC9. 1 PublicationCorresponds to variant rs199476319dbSNPEnsembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi15K → N: Impairs interaction with LMOD2 and TMOD1. 1 Publication1
Mutagenesisi283S → A: Loss of phosphorylation and decreased formation of actin stress fibers. 1 Publication1
Mutagenesisi283S → E: Increased formation of actin stress fibers. 1 Publication1

Keywords - Diseasei

Cardiomyopathy, Disease mutation

Organism-specific databases

DisGeNETi7168.
MalaCardsiTPM1.
MIMi115196. phenotype.
611878. phenotype.
OpenTargetsiENSG00000140416.
Orphaneti154. Familial isolated dilated cardiomyopathy.
155. Familial isolated hypertrophic cardiomyopathy.
54260. Left ventricular noncompaction.
PharmGKBiPA36690.

Polymorphism and mutation databases

BioMutaiTPM1.
DMDMi136092.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002056201 – 284Tropomyosin alpha-1 chainAdd BLAST284

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine1 Publication1
Modified residuei45PhosphoserineBy similarity1
Modified residuei53PhosphothreonineBy similarity1
Modified residuei61PhosphoserineBy similarity1
Modified residuei79PhosphothreonineBy similarity1
Modified residuei87PhosphoserineBy similarity1
Modified residuei108PhosphothreonineBy similarity1
Modified residuei174PhosphoserineCombined sources1
Modified residuei186PhosphoserineBy similarity1
Modified residuei206PhosphoserineBy similarity1
Modified residuei215PhosphoserineBy similarity1
Modified residuei252PhosphoserineBy similarity1
Modified residuei261PhosphotyrosineBy similarity1
Modified residuei271PhosphoserineBy similarity1
Modified residuei282PhosphothreonineBy similarity1
Modified residuei283Phosphoserine; by DAPK11 Publication1
Isoform 2 (identifier: P09493-2)
Modified residuei31PhosphoserineCombined sources1
Isoform 5 (identifier: P09493-5)
Modified residuei51PhosphoserineCombined sources1
Isoform 3 (identifier: P09493-3)
Modified residuei213N6-acetyllysineCombined sources1
Isoform 4 (identifier: P09493-4)
Modified residuei213N6-acetyllysineCombined sources1
Isoform 8 (identifier: P09493-8)
Modified residuei213N6-acetyllysineCombined sources1
Isoform 10 (identifier: P09493-10)
Modified residuei213N6-acetyllysineCombined sources1

Post-translational modificationi

Phosphorylated at Ser-283 by DAPK1 in response to oxidative stress and this phosphorylation enhances stress fiber formation in endothelial cells.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP09493.
MaxQBiP09493.
PeptideAtlasiP09493.
PRIDEiP09493.

2D gel databases

UCD-2DPAGEP09493.

PTM databases

iPTMnetiP09493.
PhosphoSitePlusiP09493.
SwissPalmiP09493.

Expressioni

Tissue specificityi

Detected in primary breast cancer tissues but undetectable in normal breast tissues in Sudanese patients. Isoform 1 is expressed in adult and fetal skeletal muscle and cardiac tissues, with higher expression levels in the cardiac tissues. Isoform 10 is expressed in adult and fetal cardiac tissues, but not in skeletal muscle.2 Publications

Gene expression databases

BgeeiENSG00000140416.
ExpressionAtlasiP09493. baseline and differential.
GenevisibleiP09493. HS.

Organism-specific databases

HPAiCAB017698.
HPA000261.
HPA047089.
HPA053624.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain. Interacts with HRG (via the HRR domain); the interaction contributes to the antiangiogenic properties of the histidine/proline-rich region (HRR) of HRG (By similarity). Interacts (via N-terminus) with LMOD2 (via N-terminus) and TMOD1 (via N-terminus) (PubMed:26873245).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
C1orf216Q8TAB53EBI-351158,EBI-747505
CAGE1Q8TC203EBI-351158,EBI-10196469
GOLGA2Q083793EBI-10196387,EBI-618309
HEL-S-108V9HW563EBI-10196387,EBI-10330141
KXD1Q9BQD34EBI-351158,EBI-739657
MAD1L1Q9Y6D93EBI-351158,EBI-742610
SYCE1Q8N0S23EBI-351158,EBI-6872807
TFPTG5E9B53EBI-10196387,EBI-10178002
TNNT1P138054EBI-351158,EBI-726527

GO - Molecular functioni

  • actin binding Source: BHF-UCL
  • cytoskeletal protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi113021. 126 interactors.
IntActiP09493. 30 interactors.
MINTiMINT-1458755.

Structurei

3D structure databases

ProteinModelPortaliP09493.
SMRiP09493.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1 – 284By similarityAdd BLAST284

Domaini

The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

Sequence similaritiesi

Belongs to the tropomyosin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00550000074494.
HOGENOMiHOG000231521.
HOVERGENiHBG107404.
InParanoidiP09493.
KOiK10373.
PhylomeDBiP09493.
TreeFamiTF351519.

Family and domain databases

InterProiIPR000533. Tropomyosin.
[Graphical view]
PfamiPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSiPR00194. TROPOMYOSIN.
PROSITEiPS00326. TROPOMYOSIN. 1 hit.
[Graphical view]

Sequences (10)i

Sequence statusi: Complete.

This entry describes 10 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: P09493-1) [UniParc]FASTAAdd to basket
Also known as: Skeletal muscle, TPM1alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDAIKKKMQM LKLDKENALD RAEQAEADKK AAEDRSKQLE DELVSLQKKL
60 70 80 90 100
KGTEDELDKY SEALKDAQEK LELAEKKATD AEADVASLNR RIQLVEEELD
110 120 130 140 150
RAQERLATAL QKLEEAEKAA DESERGMKVI ESRAQKDEEK MEIQEIQLKE
160 170 180 190 200
AKHIAEDADR KYEEVARKLV IIESDLERAE ERAELSEGKC AELEEELKTV
210 220 230 240 250
TNNLKSLEAQ AEKYSQKEDR YEEEIKVLSD KLKEAETRAE FAERSVTKLE
260 270 280
KSIDDLEDEL YAQKLKYKAI SEELDHALND MTSI
Length:284
Mass (Da):32,709
Last modified:November 1, 1990 - v2
Checksum:iF57139E2B0972F4D
GO
Isoform 2 (identifier: P09493-2) [UniParc]FASTAAdd to basket
Also known as: Smooth muscle

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: MDAIKKKMQM...LELAEKKATD → MCRLRIFLRTASSEHLHERKLRET
     189-212: KCAELEEELKTVTNNLKSLEAQAE → QVRQLEEQLRIMDSDLESINAAED
     258-284: DELYAQKLKYKAISEELDHALNDMTSI → EKVAHAKEENLSMHQMLDQTLLELNNM

Note: Incomplete sequence.Combined sources
Show »
Length:228
Mass (Da):26,680
Checksum:iA6770D102A359A7B
GO
Isoform 3 (identifier: P09493-3) [UniParc]FASTAAdd to basket
Also known as: Fibroblast, TM3

The sequence of this isoform differs from the canonical sequence as follows:
     189-212: KCAELEEELKTVTNNLKSLEAQAE → QVRQLEEQLRIMDQTLKALMAAED
     258-284: DELYAQKLKYKAISEELDHALNDMTSI → EKVAHAKEENLSMHQMLDQTLLELNNM

Show »
Length:284
Mass (Da):32,876
Checksum:iFDBEEFE342C4ACE3
GO
Isoform 4 (identifier: P09493-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     189-212: KCAELEEELKTVTNNLKSLEAQAE → QVRQLEEQLRIMDQTLKALMAAED

Show »
Length:284
Mass (Da):32,848
Checksum:iD29DBCA97BC3C6EE
GO
Isoform 5 (identifier: P09493-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: MDAIKKKMQM...LELAEKKATD → MAGSSSLEAV...LDHERKLRET
     259-284: ELYAQKLKYKAISEELDHALNDMTSI → QLYQQLEQNRRLTNELKLALNED

Show »
Length:245
Mass (Da):28,385
Checksum:i1255A14D9F26E29F
GO
Isoform 6 (identifier: P09493-6) [UniParc]FASTAAdd to basket
Also known as: 10, TPM1kappa

The sequence of this isoform differs from the canonical sequence as follows:
     41-80: DELVSLQKKL...LELAEKKATD → EDIAAKEKLL...LLAAEEAAAK

Show »
Length:284
Mass (Da):32,649
Checksum:i1610BB50FB8EB0F5
GO
Isoform 7 (identifier: P09493-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-80: DELVSLQKKL...LELAEKKATD → EDIAAKEKLL...LLAAEEAAAK
     258-284: DELYAQKLKYKAISEELDHALNDMTSI → EKVAHAKEENLSMHQMLDQTLLELNNM

Note: No experimental confirmation available.
Show »
Length:284
Mass (Da):32,678
Checksum:i3933E81AC289DAF8
GO
Isoform 8 (identifier: P09493-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-53: DELVSLQKKLKGT → EDIAAKEKLLRVS
     57-80: LDKYSEALKDAQEKLELAEKKATD → RDRVLEELHKAEDSLLAAEEAAAK
     189-192: KCAE → QVRQ
     196-212: ELKTVTNNLKSLEAQAE → QLRIMDQTLKALMAAED
     258-284: DELYAQKLKYKAISEELDHALNDMTSI → EKVAHAKEENLSMHQMLDQTLLELNNM

Note: Gene prediction based on EST data.Combined sources
Show »
Length:284
Mass (Da):32,817
Checksum:i1EDF6D5109DD335B
GO
Isoform 9 (identifier: P09493-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     258-284: DELYAQKLKYKAISEELDHALNDMTSI → EKVAHAKEENLSMHQMLDQTLLELNNM

Note: Gene prediction based on EST data.
Show »
Length:284
Mass (Da):32,737
Checksum:iDA526AA889904540
GO
Isoform 10 (identifier: P09493-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     189-192: KCAE → QVRQ
     196-212: ELKTVTNNLKSLEAQAE → QLRIMDQTLKALMAAED
     284-284: I → M

Note: No experimental confirmation available.Combined sources
Show »
Length:284
Mass (Da):32,866
Checksum:iD45DBCA97BC3C6EE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti109A → V in CAA30930 (PubMed:3138425).Curated1
Sequence conflicti203N → D in AAT68294 (PubMed:15249230).Curated1
Sequence conflicti203N → D in AAT68295 (PubMed:15249230).Curated1

Mass spectrometryi

Isoform 3 : Molecular mass is 32875.93 Da from positions 1 - 284. Determined by MALDI. 1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04398640E → K in CMD1Y. 1 PublicationCorresponds to variant rs104894501dbSNPEnsembl.1
Natural variantiVAR_04398754E → K in CMD1Y. 1 PublicationCorresponds to variant rs104894505dbSNPEnsembl.1
Natural variantiVAR_01313563A → V in CMH3. 1 PublicationCorresponds to variant rs199476306dbSNPEnsembl.1
Natural variantiVAR_007601175D → N in CMH3. 4 PublicationsCorresponds to variant rs28934270dbSNPEnsembl.1
Natural variantiVAR_007602180E → G in CMH3. 1 PublicationCorresponds to variant rs28934269dbSNPEnsembl.1
Natural variantiVAR_029452180E → V in CMH3. 1 PublicationCorresponds to variant rs104894502dbSNPEnsembl.1
Natural variantiVAR_070121192E → K in LVNC9. 1 PublicationCorresponds to variant rs199476315dbSNPEnsembl.1
Natural variantiVAR_070122248K → E in LVNC9. 1 PublicationCorresponds to variant rs199476319dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0065761 – 80MDAIK…KKATD → MCRLRIFLRTASSEHLHERK LRET in isoform 2. 1 PublicationAdd BLAST80
Alternative sequenceiVSP_0174981 – 80MDAIK…KKATD → MAGSSSLEAVRRKIRSLQEQ ADAAEERAGTLQRELDHERK LRET in isoform 5. 1 PublicationAdd BLAST80
Alternative sequenceiVSP_03606441 – 80DELVS…KKATD → EDIAAKEKLLRVSEDERDRV LEELHKAEDSLLAAEEAAAK in isoform 6 and isoform 7. 2 PublicationsAdd BLAST40
Alternative sequenceiVSP_04729741 – 53DELVS…KLKGT → EDIAAKEKLLRVS in isoform 8. CuratedAdd BLAST13
Alternative sequenceiVSP_04729857 – 80LDKYS…KKATD → RDRVLEELHKAEDSLLAAEE AAAK in isoform 8. CuratedAdd BLAST24
Alternative sequenceiVSP_006578189 – 212KCAEL…EAQAE → QVRQLEEQLRIMDSDLESIN AAED in isoform 2. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_006577189 – 212KCAEL…EAQAE → QVRQLEEQLRIMDQTLKALM AAED in isoform 3 and isoform 4. 3 PublicationsAdd BLAST24
Alternative sequenceiVSP_047299189 – 192KCAE → QVRQ in isoform 8 and isoform 10. Curated4
Alternative sequenceiVSP_047300196 – 212ELKTV…EAQAE → QLRIMDQTLKALMAAED in isoform 8 and isoform 10. CuratedAdd BLAST17
Alternative sequenceiVSP_006579258 – 284DELYA…DMTSI → EKVAHAKEENLSMHQMLDQT LLELNNM in isoform 2, isoform 3, isoform 7, isoform 8 and isoform 9. 4 PublicationsAdd BLAST27
Alternative sequenceiVSP_017499259 – 284ELYAQ…DMTSI → QLYQQLEQNRRLTNELKLAL NED in isoform 5. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_047301284I → M in isoform 10. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19267 mRNA. Translation: AAA36771.1.
M19713 mRNA. Translation: AAA61225.1.
M19714 mRNA. Translation: AAA61226.1.
M19715 mRNA. Translation: AAA61227.1.
AY640414 mRNA. Translation: AAT68294.1.
AY640415 mRNA. Translation: AAT68295.1.
AK299387 mRNA. Translation: BAH13023.1.
AL050179 mRNA. Translation: CAB43309.2.
GU324929 Genomic DNA. Translation: ADL14500.1.
GU324930 Genomic DNA. Translation: ADL14501.1.
GU324933 Genomic DNA. Translation: ADL14504.1.
GU324935 Genomic DNA. Translation: ADL14506.1.
AC079328 Genomic DNA. No translation available.
CH471082 Genomic DNA. Translation: EAW77619.1.
CH471082 Genomic DNA. Translation: EAW77622.1.
CH471082 Genomic DNA. Translation: EAW77623.1.
CH471082 Genomic DNA. Translation: EAW77627.1.
CH471082 Genomic DNA. Translation: EAW77628.1.
BC007433 mRNA. Translation: AAH07433.1.
BC050473 mRNA. Translation: AAH50473.1.
BC053545 mRNA. Translation: AAH53545.1.
X12369 mRNA. Translation: CAA30930.1.
CCDSiCCDS10181.1. [P09493-10]
CCDS32262.1. [P09493-7]
CCDS32263.1. [P09493-3]
CCDS32264.1. [P09493-5]
CCDS45273.1. [P09493-1]
CCDS58368.1. [P09493-8]
CCDS58369.1. [P09493-9]
PIRiA27674.
A27678. A25825.
S05585.
RefSeqiNP_000357.3. NM_000366.5. [P09493-10]
NP_001018004.1. NM_001018004.1. [P09493-9]
NP_001018005.1. NM_001018005.1. [P09493-1]
NP_001018006.1. NM_001018006.1. [P09493-3]
NP_001018007.1. NM_001018007.1. [P09493-7]
NP_001018008.1. NM_001018008.1. [P09493-5]
NP_001018020.1. NM_001018020.1. [P09493-8]
NP_001288173.1. NM_001301244.1. [P09493-6]
NP_001317273.1. NM_001330344.1.
NP_001317275.1. NM_001330346.1.
NP_001317280.1. NM_001330351.1.
UniGeneiHs.133892.
Hs.602995.

Genome annotation databases

EnsembliENST00000267996; ENSP00000267996; ENSG00000140416. [P09493-7]
ENST00000288398; ENSP00000288398; ENSG00000140416. [P09493-10]
ENST00000334895; ENSP00000334624; ENSG00000140416. [P09493-5]
ENST00000358278; ENSP00000351022; ENSG00000140416. [P09493-3]
ENST00000403994; ENSP00000385107; ENSG00000140416. [P09493-1]
ENST00000559397; ENSP00000452879; ENSG00000140416. [P09493-8]
ENST00000559556; ENSP00000453941; ENSG00000140416. [P09493-9]
GeneIDi7168.
KEGGihsa:7168.
UCSCiuc002alg.4. human. [P09493-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19267 mRNA. Translation: AAA36771.1.
M19713 mRNA. Translation: AAA61225.1.
M19714 mRNA. Translation: AAA61226.1.
M19715 mRNA. Translation: AAA61227.1.
AY640414 mRNA. Translation: AAT68294.1.
AY640415 mRNA. Translation: AAT68295.1.
AK299387 mRNA. Translation: BAH13023.1.
AL050179 mRNA. Translation: CAB43309.2.
GU324929 Genomic DNA. Translation: ADL14500.1.
GU324930 Genomic DNA. Translation: ADL14501.1.
GU324933 Genomic DNA. Translation: ADL14504.1.
GU324935 Genomic DNA. Translation: ADL14506.1.
AC079328 Genomic DNA. No translation available.
CH471082 Genomic DNA. Translation: EAW77619.1.
CH471082 Genomic DNA. Translation: EAW77622.1.
CH471082 Genomic DNA. Translation: EAW77623.1.
CH471082 Genomic DNA. Translation: EAW77627.1.
CH471082 Genomic DNA. Translation: EAW77628.1.
BC007433 mRNA. Translation: AAH07433.1.
BC050473 mRNA. Translation: AAH50473.1.
BC053545 mRNA. Translation: AAH53545.1.
X12369 mRNA. Translation: CAA30930.1.
CCDSiCCDS10181.1. [P09493-10]
CCDS32262.1. [P09493-7]
CCDS32263.1. [P09493-3]
CCDS32264.1. [P09493-5]
CCDS45273.1. [P09493-1]
CCDS58368.1. [P09493-8]
CCDS58369.1. [P09493-9]
PIRiA27674.
A27678. A25825.
S05585.
RefSeqiNP_000357.3. NM_000366.5. [P09493-10]
NP_001018004.1. NM_001018004.1. [P09493-9]
NP_001018005.1. NM_001018005.1. [P09493-1]
NP_001018006.1. NM_001018006.1. [P09493-3]
NP_001018007.1. NM_001018007.1. [P09493-7]
NP_001018008.1. NM_001018008.1. [P09493-5]
NP_001018020.1. NM_001018020.1. [P09493-8]
NP_001288173.1. NM_001301244.1. [P09493-6]
NP_001317273.1. NM_001330344.1.
NP_001317275.1. NM_001330346.1.
NP_001317280.1. NM_001330351.1.
UniGeneiHs.133892.
Hs.602995.

3D structure databases

ProteinModelPortaliP09493.
SMRiP09493.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113021. 126 interactors.
IntActiP09493. 30 interactors.
MINTiMINT-1458755.

PTM databases

iPTMnetiP09493.
PhosphoSitePlusiP09493.
SwissPalmiP09493.

Polymorphism and mutation databases

BioMutaiTPM1.
DMDMi136092.

2D gel databases

UCD-2DPAGEP09493.

Proteomic databases

EPDiP09493.
MaxQBiP09493.
PeptideAtlasiP09493.
PRIDEiP09493.

Protocols and materials databases

DNASUi7168.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267996; ENSP00000267996; ENSG00000140416. [P09493-7]
ENST00000288398; ENSP00000288398; ENSG00000140416. [P09493-10]
ENST00000334895; ENSP00000334624; ENSG00000140416. [P09493-5]
ENST00000358278; ENSP00000351022; ENSG00000140416. [P09493-3]
ENST00000403994; ENSP00000385107; ENSG00000140416. [P09493-1]
ENST00000559397; ENSP00000452879; ENSG00000140416. [P09493-8]
ENST00000559556; ENSP00000453941; ENSG00000140416. [P09493-9]
GeneIDi7168.
KEGGihsa:7168.
UCSCiuc002alg.4. human. [P09493-1]

Organism-specific databases

CTDi7168.
DisGeNETi7168.
GeneCardsiTPM1.
GeneReviewsiTPM1.
HGNCiHGNC:12010. TPM1.
HPAiCAB017698.
HPA000261.
HPA047089.
HPA053624.
MalaCardsiTPM1.
MIMi115196. phenotype.
191010. gene.
611878. phenotype.
neXtProtiNX_P09493.
OpenTargetsiENSG00000140416.
Orphaneti154. Familial isolated dilated cardiomyopathy.
155. Familial isolated hypertrophic cardiomyopathy.
54260. Left ventricular noncompaction.
PharmGKBiPA36690.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00550000074494.
HOGENOMiHOG000231521.
HOVERGENiHBG107404.
InParanoidiP09493.
KOiK10373.
PhylomeDBiP09493.
TreeFamiTF351519.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000140416-MONOMER.
ReactomeiR-HSA-390522. Striated Muscle Contraction.
R-HSA-445355. Smooth Muscle Contraction.

Miscellaneous databases

ChiTaRSiTPM1. human.
GeneWikiiTPM1.
GenomeRNAii7168.
PROiP09493.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000140416.
ExpressionAtlasiP09493. baseline and differential.
GenevisibleiP09493. HS.

Family and domain databases

InterProiIPR000533. Tropomyosin.
[Graphical view]
PfamiPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSiPR00194. TROPOMYOSIN.
PROSITEiPS00326. TROPOMYOSIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTPM1_HUMAN
AccessioniPrimary (citable) accession number: P09493
Secondary accession number(s): B7Z5T7
, D9YZV2, D9YZV3, D9YZV8, P09494, P10469, Q6DV89, Q6DV90, Q7Z6L8, Q86W64, Q96IK2, Q9UCI1, Q9UCI2, Q9UCY9, Q9Y427
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1990
Last modified: November 30, 2016
This is version 184 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.