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Protein

Tropomyosin-2

Gene

Tm2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction. May also regulate motor systems required to maintain nuclear integrity and apico-basal polarity during embryogenesis.1 Publication

GO - Molecular functioni

  • actin binding Source: FlyBase

GO - Biological processi

  • heart development Source: FlyBase
  • positive regulation of sarcomere organization Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Enzyme and pathway databases

ReactomeiR-DME-445355. Smooth Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Tropomyosin-2
Alternative name(s):
Tropomyosin I
Gene namesi
Name:Tm2
Synonyms:TmI
ORF Names:CG4843
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0004117. Tm2.

Pathology & Biotechi

Disruption phenotypei

Pre-cellular embryos exhibit abnormal nuclear divisions with frequent loss of chromosome fragments. During cellularization, apico-basal polarity is also disrupted.1 Publication

Protein family/group databases

Allergomei1517. Dro m 7.
4080. Dro m 7.0102.
4174. Dro m 7.0104.
4175. Dro m 7.0105.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002056861 – 284Tropomyosin-2Add BLAST284

Proteomic databases

PaxDbiP09491.
PRIDEiP09491.

Expressioni

Gene expression databases

BgeeiFBgn0004117.
ExpressionAtlasiP09491. baseline.
GenevisibleiP09491. DM.

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

  • actin binding Source: FlyBase

Protein-protein interaction databases

BioGridi66917. 69 interactors.
DIPiDIP-21556N.
IntActiP09491. 2 interactors.
STRINGi7227.FBpp0082535.

Structurei

3D structure databases

ProteinModelPortaliP09491.
SMRiP09491.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1 – 284By similarityAdd BLAST284

Domaini

The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

Sequence similaritiesi

Belongs to the tropomyosin family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG1003. Eukaryota.
ENOG410XR5K. LUCA.
GeneTreeiENSGT00550000074494.
InParanoidiP09491.
KOiK10374.
OMAiLEDEICQ.
OrthoDBiEOG091G0UO7.
PhylomeDBiP09491.

Family and domain databases

InterProiIPR000533. Tropomyosin.
[Graphical view]
PfamiPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSiPR00194. TROPOMYOSIN.
PROSITEiPS00326. TROPOMYOSIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Thoracic (identifier: P09491-1) [UniParc]FASTAAdd to basket
Also known as: 127, C, t

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDAIKKKMQA MKLEKDNAID KADTCENQAK DANSRADKLN EEVRDLEKKF
60 70 80 90 100
VQVEIDLVTA KEQLEKANTE LEEKEKLLTA TESEVATQNR KVQQIEEDLE
110 120 130 140 150
KSEERSTTAQ QKLLEATQSA DENNRMCKVL ENRSQQDEER MDQLTNQLKE
160 170 180 190 200
ARMLAEDADT KSDEVSRKLA FVEDELEVAE DRVRSGESKI MELEEELKVV
210 220 230 240 250
GNSLKSLEVS EEKANQRVEE FKREMKTLSI KLKEAEQRAE HAEKQVKRLQ
260 270 280
KEVDRLEDRL FNEKEKYKAI CDDLDQTFAE LTGY
Length:284
Mass (Da):32,981
Last modified:July 1, 1989 - v1
Checksum:i07AD03FDD304EA5F
GO
Isoform Embryonic (identifier: P09491-2) [UniParc]FASTAAdd to basket
Also known as: 129, A, B, e

The sequence of this isoform differs from the canonical sequence as follows:
     259-284: RLFNEKEKYKAICDDLDQTFAELTGY → ELGINKDRYKSLADEMDSTFAELAGY

Show »
Length:284
Mass (Da):32,807
Checksum:i73C07D18BD7AD709
GO

Sequence cautioni

The sequence ABK30920 differs from that shown. Reason: Frameshift at position 274.Curated
The sequence CAA26142 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11M → V in AAA28970 (PubMed:6202423).Curated1
Sequence conflicti11M → V in AAA28971 (PubMed:6202423).Curated1
Sequence conflicti88Q → L in AAA28970 (PubMed:6202423).Curated1
Sequence conflicti88Q → L in AAA28971 (PubMed:6202423).Curated1
Sequence conflicti95I → T in AAA28970 (PubMed:6202423).Curated1
Sequence conflicti95I → T in AAA28971 (PubMed:6202423).Curated1
Sequence conflicti255R → D in AAA28970 (PubMed:6202423).Curated1
Sequence conflicti255R → D in AAA28971 (PubMed:6202423).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006616259 – 284RLFNE…ELTGY → ELGINKDRYKSLADEMDSTF AELAGY in isoform Embryonic. 2 PublicationsAdd BLAST26

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02622 Genomic DNA. Translation: AAA28970.1.
K02623, K02622 Genomic DNA. Translation: AAA28971.1.
K03277 Genomic DNA. Translation: AAA28973.1.
K03277 Genomic DNA. Translation: AAA28974.1.
AE014297 Genomic DNA. Translation: AAN13652.1.
AE014297 Genomic DNA. Translation: AAN13653.1.
AE014297 Genomic DNA. Translation: AAN13654.2.
AY071087 mRNA. Translation: AAL48709.1.
BT029283 mRNA. Translation: ABK30920.1. Frameshift.
BT044580 mRNA. Translation: ACI16542.1.
X02220 Genomic DNA. Translation: CAA26142.1. Sequence problems.
PIRiA25624.
B25624.
RefSeqiNP_001262592.1. NM_001275663.1. [P09491-2]
NP_001262593.1. NM_001275664.1. [P09491-2]
NP_001287337.1. NM_001300408.1. [P09491-2]
NP_524361.4. NM_079637.5. [P09491-2]
NP_732012.1. NM_169644.2. [P09491-2]
NP_732013.2. NM_169645.4. [P09491-1]
UniGeneiDm.2422.

Genome annotation databases

EnsemblMetazoaiFBtr0083080; FBpp0089270; FBgn0004117. [P09491-1]
GeneIDi41853.
KEGGidme:Dmel_CG4843.
UCSCiCG4843-RB. d. melanogaster.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02622 Genomic DNA. Translation: AAA28970.1.
K02623, K02622 Genomic DNA. Translation: AAA28971.1.
K03277 Genomic DNA. Translation: AAA28973.1.
K03277 Genomic DNA. Translation: AAA28974.1.
AE014297 Genomic DNA. Translation: AAN13652.1.
AE014297 Genomic DNA. Translation: AAN13653.1.
AE014297 Genomic DNA. Translation: AAN13654.2.
AY071087 mRNA. Translation: AAL48709.1.
BT029283 mRNA. Translation: ABK30920.1. Frameshift.
BT044580 mRNA. Translation: ACI16542.1.
X02220 Genomic DNA. Translation: CAA26142.1. Sequence problems.
PIRiA25624.
B25624.
RefSeqiNP_001262592.1. NM_001275663.1. [P09491-2]
NP_001262593.1. NM_001275664.1. [P09491-2]
NP_001287337.1. NM_001300408.1. [P09491-2]
NP_524361.4. NM_079637.5. [P09491-2]
NP_732012.1. NM_169644.2. [P09491-2]
NP_732013.2. NM_169645.4. [P09491-1]
UniGeneiDm.2422.

3D structure databases

ProteinModelPortaliP09491.
SMRiP09491.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi66917. 69 interactors.
DIPiDIP-21556N.
IntActiP09491. 2 interactors.
STRINGi7227.FBpp0082535.

Protein family/group databases

Allergomei1517. Dro m 7.
4080. Dro m 7.0102.
4174. Dro m 7.0104.
4175. Dro m 7.0105.

Proteomic databases

PaxDbiP09491.
PRIDEiP09491.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0083080; FBpp0089270; FBgn0004117. [P09491-1]
GeneIDi41853.
KEGGidme:Dmel_CG4843.
UCSCiCG4843-RB. d. melanogaster.

Organism-specific databases

CTDi41853.
FlyBaseiFBgn0004117. Tm2.

Phylogenomic databases

eggNOGiKOG1003. Eukaryota.
ENOG410XR5K. LUCA.
GeneTreeiENSGT00550000074494.
InParanoidiP09491.
KOiK10374.
OMAiLEDEICQ.
OrthoDBiEOG091G0UO7.
PhylomeDBiP09491.

Enzyme and pathway databases

ReactomeiR-DME-445355. Smooth Muscle Contraction.

Miscellaneous databases

GenomeRNAii41853.
PROiP09491.

Gene expression databases

BgeeiFBgn0004117.
ExpressionAtlasiP09491. baseline.
GenevisibleiP09491. DM.

Family and domain databases

InterProiIPR000533. Tropomyosin.
[Graphical view]
PfamiPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSiPR00194. TROPOMYOSIN.
PROSITEiPS00326. TROPOMYOSIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTPM2_DROME
AccessioniPrimary (citable) accession number: P09491
Secondary accession number(s): A0AVW5
, A4V2Y6, P09490, Q24408, Q24427, Q24428, Q8SZ65, Q9VF95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 30, 2016
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.