ID   ACHA2_CHICK             Reviewed;         528 AA.
AC   P09480;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   27-MAR-2024, entry version 155.
DE   RecName: Full=Neuronal acetylcholine receptor subunit alpha-2;
DE   Flags: Precursor;
GN   Name=CHRNA2;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC   STRAIN=White leghorn; TISSUE=Brain;
RX   PubMed=3267226; DOI=10.1002/j.1460-2075.1988.tb02852.x;
RA   Nef P., Oneyser C., Alliod C., Couturier S., Ballivet M.;
RT   "Genes expressed in the brain define three distinct neuronal nicotinic
RT   acetylcholine receptors.";
RL   EMBO J. 7:595-601(1988).
CC   -!- FUNCTION: After binding acetylcholine, the AChR responds by an
CC       extensive change in conformation that affects all subunits and leads to
CC       opening of an ion-conducting channel across the plasma membrane.
CC   -!- SUBUNIT: Neuronal AChR seems to be composed of two different type of
CC       subunits: alpha and non-alpha (also called beta). A functional receptor
CC       seems to consist of two alpha-chains and three non-alpha chains.
CC   -!- SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane
CC       protein. Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC       Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-2/CHRNA2 sub-
CC       subfamily. {ECO:0000305}.
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DR   EMBL; X07339; CAB59645.1; -; Genomic_DNA.
DR   EMBL; X07340; CAB59645.1; JOINED; Genomic_DNA.
DR   EMBL; X07341; CAB59645.1; JOINED; Genomic_DNA.
DR   EMBL; X07342; CAB59645.1; JOINED; Genomic_DNA.
DR   EMBL; X07343; CAB59645.1; JOINED; Genomic_DNA.
DR   EMBL; X07344; CAB59645.1; JOINED; Genomic_DNA.
DR   EMBL; AJ250360; CAB59625.1; -; mRNA.
DR   PIR; S00377; ACCH2N.
DR   RefSeq; NP_990146.1; NM_204815.2.
DR   AlphaFoldDB; P09480; -.
DR   SMR; P09480; -.
DR   ComplexPortal; CPX-179; Neuronal nicotinic acetylcholine receptor complex, alpha2-beta2.
DR   ComplexPortal; CPX-184; Neuronal nicotinic acetylcholine receptor complex, alpha2-beta4.
DR   IntAct; P09480; 2.
DR   STRING; 9031.ENSGALP00000026687; -.
DR   GlyCosmos; P09480; 2 sites, No reported glycans.
DR   PaxDb; 9031-ENSGALP00000026687; -.
DR   GeneID; 395607; -.
DR   KEGG; gga:395607; -.
DR   CTD; 1135; -.
DR   VEuPathDB; HostDB:geneid_395607; -.
DR   eggNOG; KOG3645; Eukaryota.
DR   InParanoid; P09480; -.
DR   OMA; SSYHWLE; -.
DR   PhylomeDB; P09480; -.
DR   PRO; PR:P09480; -.
DR   Proteomes; UP000000539; Unassembled WGS sequence.
DR   GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR   GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045202; C:synapse; IBA:GO_Central.
DR   GO; GO:0022848; F:acetylcholine-gated monoatomic cation-selective channel activity; IBA:GO_Central.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0035094; P:response to nicotine; IBA:GO_Central.
DR   GO; GO:0007271; P:synaptic transmission, cholinergic; IBA:GO_Central.
DR   CDD; cd19015; LGIC_ECD_nAChR_A2; 1.
DR   CDD; cd19064; LGIC_TM_nAChR; 1.
DR   Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR   Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 2.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR   InterPro; IPR038050; Neuro_actylchol_rec.
DR   InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR   InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR   InterPro; IPR002394; Nicotinic_acetylcholine_rcpt.
DR   NCBIfam; TIGR00860; LIC; 1.
DR   PANTHER; PTHR18945:SF757; NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-2; 1.
DR   PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR   Pfam; PF02931; Neur_chan_LBD; 1.
DR   Pfam; PF02932; Neur_chan_memb; 1.
DR   PRINTS; PR00254; NICOTINICR.
DR   PRINTS; PR00252; NRIONCHANNEL.
DR   SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR   SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
DR   PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; Glycoprotein; Ion channel; Ion transport;
KW   Ligand-gated ion channel; Membrane; Postsynaptic cell membrane; Receptor;
KW   Reference proteome; Signal; Synapse; Transmembrane; Transmembrane helix;
KW   Transport.
FT   SIGNAL          1..23
FT   CHAIN           24..528
FT                   /note="Neuronal acetylcholine receptor subunit alpha-2"
FT                   /id="PRO_0000000344"
FT   TOPO_DOM        24..239
FT                   /note="Extracellular"
FT   TRANSMEM        240..264
FT                   /note="Helical"
FT   TRANSMEM        272..290
FT                   /note="Helical"
FT   TRANSMEM        306..327
FT                   /note="Helical"
FT   TOPO_DOM        328..501
FT                   /note="Cytoplasmic"
FT   TRANSMEM        502..520
FT                   /note="Helical"
FT   REGION          390..427
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        390..410
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        54
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        104
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        158..172
FT                   /evidence="ECO:0000250"
FT   DISULFID        222..223
FT                   /note="Associated with receptor activation"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   528 AA;  60675 MW;  E76C6360AF876364 CRC64;
     MGWPCRSIIP LLVWCFVTLQ AATREQKQPH GFAEDRLFKH LFTGYNRWSR PVPNTSDVVI
     VKFGLSIAQL IDVDEKNQMM TTNVWLKQEW SDYKLRWNPE DFDNVTSIRV PSEMIWIPDI
     VLYNNADGEF AVTHMTKAHL FSNGKVKWVP PAIYKSSCSI DVTYFPFDQQ NCKMKFGSWT
     YDKAKIDLEN MEHHVDLKDY WESGEWAIIN AIGRYNSKKY DCCTEIYPDI TFYFVIRRLP
     LFYTINLIIP CLLISCLTVL VFYLPSDCGE KITLCISVLL SLTVFLLLIT EIIPSTSLVI
     PLIGEYLLFT MIFVTLSIII TVFVLNVHHR SPSTHTMPHW VRSFFLGFIP RWLFMKRPPL
     LLPAEGTTGQ YDPPGTRLST SRCWLETDVD DKWEEEEEEE EEEEEEEEEE KAYPSRVPSG
     GSQGTQCHYS CERQAGKASG GPAPQVPLKG EEVGSDQGLT LSPSILRALE GVQYIADHLR
     AEDADFSVKE DWKYVAMVID RIFLWMFIIV CLLGTVGLFL PPYLAGMI
//