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P09480

- ACHA2_CHICK

UniProt

P09480 - ACHA2_CHICK

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Protein

Neuronal acetylcholine receptor subunit alpha-2

Gene
CHRNA2
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

GO - Molecular functioni

  1. acetylcholine-activated cation-selective channel activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal acetylcholine receptor subunit alpha-2
Gene namesi
Name:CHRNA2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 239216ExtracellularAdd
BLAST
Transmembranei240 – 26425HelicalAdd
BLAST
Transmembranei272 – 29019HelicalAdd
BLAST
Transmembranei306 – 32722HelicalAdd
BLAST
Topological domaini328 – 501174CytoplasmicAdd
BLAST
Transmembranei502 – 52019HelicalAdd
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. postsynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Add
BLAST
Chaini24 – 528505Neuronal acetylcholine receptor subunit alpha-2PRO_0000000344Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi54 – 541N-linked (GlcNAc...) Reviewed prediction
Glycosylationi104 – 1041N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi158 ↔ 172 By similarity
Disulfide bondi222 ↔ 223Associated with receptor activation By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Neuronal AChR seems to be composed of two different type of subunits: alpha and non-alpha (also called beta). A functional receptor seems to consist of two alpha-chains and three non-alpha chains.

Protein-protein interaction databases

STRINGi9031.ENSGALP00000030930.

Structurei

3D structure databases

ProteinModelPortaliP09480.
SMRiP09480. Positions 240-331.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi394 – 41017Poly-GluAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG290206.
HOGENOMiHOG000006756.
HOVERGENiHBG003756.
KOiK04804.
PhylomeDBiP09480.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 2 hits.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09480-1 [UniParc]FASTAAdd to Basket

« Hide

MGWPCRSIIP LLVWCFVTLQ AATREQKQPH GFAEDRLFKH LFTGYNRWSR    50
PVPNTSDVVI VKFGLSIAQL IDVDEKNQMM TTNVWLKQEW SDYKLRWNPE 100
DFDNVTSIRV PSEMIWIPDI VLYNNADGEF AVTHMTKAHL FSNGKVKWVP 150
PAIYKSSCSI DVTYFPFDQQ NCKMKFGSWT YDKAKIDLEN MEHHVDLKDY 200
WESGEWAIIN AIGRYNSKKY DCCTEIYPDI TFYFVIRRLP LFYTINLIIP 250
CLLISCLTVL VFYLPSDCGE KITLCISVLL SLTVFLLLIT EIIPSTSLVI 300
PLIGEYLLFT MIFVTLSIII TVFVLNVHHR SPSTHTMPHW VRSFFLGFIP 350
RWLFMKRPPL LLPAEGTTGQ YDPPGTRLST SRCWLETDVD DKWEEEEEEE 400
EEEEEEEEEE KAYPSRVPSG GSQGTQCHYS CERQAGKASG GPAPQVPLKG 450
EEVGSDQGLT LSPSILRALE GVQYIADHLR AEDADFSVKE DWKYVAMVID 500
RIFLWMFIIV CLLGTVGLFL PPYLAGMI 528
Length:528
Mass (Da):60,675
Last modified:July 1, 1989 - v1
Checksum:iE76C6360AF876364
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X07339
, X07340, X07341, X07342, X07343, X07344 Genomic DNA. Translation: CAB59645.1.
AJ250360 mRNA. Translation: CAB59625.1.
PIRiS00377. ACCH2N.
RefSeqiNP_990146.1. NM_204815.2.
UniGeneiGga.337.

Genome annotation databases

GeneIDi395607.
KEGGigga:395607.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X07339
, X07340 , X07341 , X07342 , X07343 , X07344 Genomic DNA. Translation: CAB59645.1 .
AJ250360 mRNA. Translation: CAB59625.1 .
PIRi S00377. ACCH2N.
RefSeqi NP_990146.1. NM_204815.2.
UniGenei Gga.337.

3D structure databases

ProteinModelPortali P09480.
SMRi P09480. Positions 240-331.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000030930.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 395607.
KEGGi gga:395607.

Organism-specific databases

CTDi 1135.

Phylogenomic databases

eggNOGi NOG290206.
HOGENOMi HOG000006756.
HOVERGENi HBG003756.
KOi K04804.
PhylomeDBi P09480.

Miscellaneous databases

NextBioi 20815680.

Family and domain databases

Gene3Di 1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProi IPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view ]
PANTHERi PTHR18945. PTHR18945. 1 hit.
Pfami PF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view ]
PRINTSi PR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMi SSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 2 hits.
TIGRFAMsi TIGR00860. LIC. 1 hit.
PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genes expressed in the brain define three distinct neuronal nicotinic acetylcholine receptors."
    Nef P., Oneyser C., Alliod C., Couturier S., Ballivet M.
    EMBO J. 7:595-601(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: White leghorn.
    Tissue: Brain.

Entry informationi

Entry nameiACHA2_CHICK
AccessioniPrimary (citable) accession number: P09480
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: April 16, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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