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P09480 (ACHA2_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neuronal acetylcholine receptor subunit alpha-2
Gene names
Name:CHRNA2
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length528 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Subunit structure

Neuronal AChR seems to be composed of two different type of subunits: alpha and non-alpha (also called beta). A functional receptor seems to consist of two alpha-chains and three non-alpha chains.

Subcellular location

Cell junctionsynapsepostsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-2/CHRNA2 sub-subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323
Chain24 – 528505Neuronal acetylcholine receptor subunit alpha-2
PRO_0000000344

Regions

Topological domain24 – 239216Extracellular
Transmembrane240 – 26425Helical
Transmembrane272 – 29019Helical
Transmembrane306 – 32722Helical
Topological domain328 – 501174Cytoplasmic
Transmembrane502 – 52019Helical
Compositional bias394 – 41017Poly-Glu

Amino acid modifications

Glycosylation541N-linked (GlcNAc...) Potential
Glycosylation1041N-linked (GlcNAc...) Potential
Disulfide bond158 ↔ 172 By similarity
Disulfide bond222 ↔ 223Associated with receptor activation By similarity

Sequences

Sequence LengthMass (Da)Tools
P09480 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: E76C6360AF876364

FASTA52860,675
        10         20         30         40         50         60 
MGWPCRSIIP LLVWCFVTLQ AATREQKQPH GFAEDRLFKH LFTGYNRWSR PVPNTSDVVI 

        70         80         90        100        110        120 
VKFGLSIAQL IDVDEKNQMM TTNVWLKQEW SDYKLRWNPE DFDNVTSIRV PSEMIWIPDI 

       130        140        150        160        170        180 
VLYNNADGEF AVTHMTKAHL FSNGKVKWVP PAIYKSSCSI DVTYFPFDQQ NCKMKFGSWT 

       190        200        210        220        230        240 
YDKAKIDLEN MEHHVDLKDY WESGEWAIIN AIGRYNSKKY DCCTEIYPDI TFYFVIRRLP 

       250        260        270        280        290        300 
LFYTINLIIP CLLISCLTVL VFYLPSDCGE KITLCISVLL SLTVFLLLIT EIIPSTSLVI 

       310        320        330        340        350        360 
PLIGEYLLFT MIFVTLSIII TVFVLNVHHR SPSTHTMPHW VRSFFLGFIP RWLFMKRPPL 

       370        380        390        400        410        420 
LLPAEGTTGQ YDPPGTRLST SRCWLETDVD DKWEEEEEEE EEEEEEEEEE KAYPSRVPSG 

       430        440        450        460        470        480 
GSQGTQCHYS CERQAGKASG GPAPQVPLKG EEVGSDQGLT LSPSILRALE GVQYIADHLR 

       490        500        510        520 
AEDADFSVKE DWKYVAMVID RIFLWMFIIV CLLGTVGLFL PPYLAGMI 

« Hide

References

[1]"Genes expressed in the brain define three distinct neuronal nicotinic acetylcholine receptors."
Nef P., Oneyser C., Alliod C., Couturier S., Ballivet M.
EMBO J. 7:595-601(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Strain: White leghorn.
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X07339 expand/collapse EMBL AC list , X07340, X07341, X07342, X07343, X07344 Genomic DNA. Translation: CAB59645.1.
AJ250360 mRNA. Translation: CAB59625.1.
PIRACCH2N. S00377.
RefSeqNP_990146.1. NM_204815.2.
UniGeneGga.337.

3D structure databases

ProteinModelPortalP09480.
SMRP09480. Positions 240-331.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000030930.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID395607.
KEGGgga:395607.

Organism-specific databases

CTD1135.

Phylogenomic databases

eggNOGNOG290206.
HOGENOMHOG000006756.
HOVERGENHBG003756.
KOK04804.
PhylomeDBP09480.

Family and domain databases

Gene3D1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERPTHR18945. PTHR18945. 1 hit.
PfamPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 2 hits.
TIGRFAMsTIGR00860. LIC. 1 hit.
PROSITEPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20815680.

Entry information

Entry nameACHA2_CHICK
AccessionPrimary (citable) accession number: P09480
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: April 16, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families