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P09480

- ACHA2_CHICK

UniProt

P09480 - ACHA2_CHICK

Protein

Neuronal acetylcholine receptor subunit alpha-2

Gene

CHRNA2

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

    GO - Molecular functioni

    1. acetylcholine-activated cation-selective channel activity Source: InterPro

    Keywords - Molecular functioni

    Ion channel, Ligand-gated ion channel, Receptor

    Keywords - Biological processi

    Ion transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuronal acetylcholine receptor subunit alpha-2
    Gene namesi
    Name:CHRNA2
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. integral component of membrane Source: UniProtKB-KW
    3. postsynaptic membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Add
    BLAST
    Chaini24 – 528505Neuronal acetylcholine receptor subunit alpha-2PRO_0000000344Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi54 – 541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi158 ↔ 172By similarity
    Disulfide bondi222 ↔ 223Associated with receptor activationBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Interactioni

    Subunit structurei

    Neuronal AChR seems to be composed of two different type of subunits: alpha and non-alpha (also called beta). A functional receptor seems to consist of two alpha-chains and three non-alpha chains.

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000030930.

    Structurei

    3D structure databases

    ProteinModelPortaliP09480.
    SMRiP09480. Positions 240-331.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini24 – 239216ExtracellularAdd
    BLAST
    Topological domaini328 – 501174CytoplasmicAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei240 – 26425HelicalAdd
    BLAST
    Transmembranei272 – 29019HelicalAdd
    BLAST
    Transmembranei306 – 32722HelicalAdd
    BLAST
    Transmembranei502 – 52019HelicalAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi394 – 41017Poly-GluAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG290206.
    HOGENOMiHOG000006756.
    HOVERGENiHBG003756.
    KOiK04804.
    PhylomeDBiP09480.

    Family and domain databases

    Gene3Di1.20.120.370. 2 hits.
    2.70.170.10. 1 hit.
    InterProiIPR027361. Acetylcholine_rcpt_TM.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    IPR002394. Nicotinic_acetylcholine_rcpt.
    [Graphical view]
    PANTHERiPTHR18945. PTHR18945. 1 hit.
    PfamiPF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view]
    PRINTSiPR00254. NICOTINICR.
    PR00252. NRIONCHANNEL.
    SUPFAMiSSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 2 hits.
    TIGRFAMsiTIGR00860. LIC. 1 hit.
    PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P09480-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGWPCRSIIP LLVWCFVTLQ AATREQKQPH GFAEDRLFKH LFTGYNRWSR    50
    PVPNTSDVVI VKFGLSIAQL IDVDEKNQMM TTNVWLKQEW SDYKLRWNPE 100
    DFDNVTSIRV PSEMIWIPDI VLYNNADGEF AVTHMTKAHL FSNGKVKWVP 150
    PAIYKSSCSI DVTYFPFDQQ NCKMKFGSWT YDKAKIDLEN MEHHVDLKDY 200
    WESGEWAIIN AIGRYNSKKY DCCTEIYPDI TFYFVIRRLP LFYTINLIIP 250
    CLLISCLTVL VFYLPSDCGE KITLCISVLL SLTVFLLLIT EIIPSTSLVI 300
    PLIGEYLLFT MIFVTLSIII TVFVLNVHHR SPSTHTMPHW VRSFFLGFIP 350
    RWLFMKRPPL LLPAEGTTGQ YDPPGTRLST SRCWLETDVD DKWEEEEEEE 400
    EEEEEEEEEE KAYPSRVPSG GSQGTQCHYS CERQAGKASG GPAPQVPLKG 450
    EEVGSDQGLT LSPSILRALE GVQYIADHLR AEDADFSVKE DWKYVAMVID 500
    RIFLWMFIIV CLLGTVGLFL PPYLAGMI 528
    Length:528
    Mass (Da):60,675
    Last modified:July 1, 1989 - v1
    Checksum:iE76C6360AF876364
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X07339
    , X07340, X07341, X07342, X07343, X07344 Genomic DNA. Translation: CAB59645.1.
    AJ250360 mRNA. Translation: CAB59625.1.
    PIRiS00377. ACCH2N.
    RefSeqiNP_990146.1. NM_204815.2.
    UniGeneiGga.337.

    Genome annotation databases

    GeneIDi395607.
    KEGGigga:395607.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X07339
    , X07340 , X07341 , X07342 , X07343 , X07344 Genomic DNA. Translation: CAB59645.1 .
    AJ250360 mRNA. Translation: CAB59625.1 .
    PIRi S00377. ACCH2N.
    RefSeqi NP_990146.1. NM_204815.2.
    UniGenei Gga.337.

    3D structure databases

    ProteinModelPortali P09480.
    SMRi P09480. Positions 240-331.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000030930.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 395607.
    KEGGi gga:395607.

    Organism-specific databases

    CTDi 1135.

    Phylogenomic databases

    eggNOGi NOG290206.
    HOGENOMi HOG000006756.
    HOVERGENi HBG003756.
    KOi K04804.
    PhylomeDBi P09480.

    Miscellaneous databases

    NextBioi 20815680.

    Family and domain databases

    Gene3Di 1.20.120.370. 2 hits.
    2.70.170.10. 1 hit.
    InterProi IPR027361. Acetylcholine_rcpt_TM.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    IPR002394. Nicotinic_acetylcholine_rcpt.
    [Graphical view ]
    PANTHERi PTHR18945. PTHR18945. 1 hit.
    Pfami PF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view ]
    PRINTSi PR00254. NICOTINICR.
    PR00252. NRIONCHANNEL.
    SUPFAMi SSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 2 hits.
    TIGRFAMsi TIGR00860. LIC. 1 hit.
    PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genes expressed in the brain define three distinct neuronal nicotinic acetylcholine receptors."
      Nef P., Oneyser C., Alliod C., Couturier S., Ballivet M.
      EMBO J. 7:595-601(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Strain: White leghorn.
      Tissue: Brain.

    Entry informationi

    Entry nameiACHA2_CHICK
    AccessioniPrimary (citable) accession number: P09480
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3