Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P09480

- ACHA2_CHICK

UniProt

P09480 - ACHA2_CHICK

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Neuronal acetylcholine receptor subunit alpha-2

Gene

CHRNA2

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

GO - Molecular functioni

  1. acetylcholine-activated cation-selective channel activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal acetylcholine receptor subunit alpha-2
Gene namesi
Name:CHRNA2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 239216ExtracellularAdd
BLAST
Transmembranei240 – 26425HelicalAdd
BLAST
Transmembranei272 – 29019HelicalAdd
BLAST
Transmembranei306 – 32722HelicalAdd
BLAST
Topological domaini328 – 501174CytoplasmicAdd
BLAST
Transmembranei502 – 52019HelicalAdd
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. postsynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Add
BLAST
Chaini24 – 528505Neuronal acetylcholine receptor subunit alpha-2PRO_0000000344Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi54 – 541N-linked (GlcNAc...)Sequence Analysis
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi158 ↔ 172By similarity
Disulfide bondi222 ↔ 223Associated with receptor activationBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Neuronal AChR seems to be composed of two different type of subunits: alpha and non-alpha (also called beta). A functional receptor seems to consist of two alpha-chains and three non-alpha chains.

Protein-protein interaction databases

STRINGi9031.ENSGALP00000030930.

Structurei

3D structure databases

ProteinModelPortaliP09480.
SMRiP09480. Positions 240-331.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi394 – 41017Poly-GluAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG290206.
HOGENOMiHOG000006756.
HOVERGENiHBG003756.
InParanoidiP09480.
KOiK04804.
PhylomeDBiP09480.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 2 hits.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09480-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGWPCRSIIP LLVWCFVTLQ AATREQKQPH GFAEDRLFKH LFTGYNRWSR
60 70 80 90 100
PVPNTSDVVI VKFGLSIAQL IDVDEKNQMM TTNVWLKQEW SDYKLRWNPE
110 120 130 140 150
DFDNVTSIRV PSEMIWIPDI VLYNNADGEF AVTHMTKAHL FSNGKVKWVP
160 170 180 190 200
PAIYKSSCSI DVTYFPFDQQ NCKMKFGSWT YDKAKIDLEN MEHHVDLKDY
210 220 230 240 250
WESGEWAIIN AIGRYNSKKY DCCTEIYPDI TFYFVIRRLP LFYTINLIIP
260 270 280 290 300
CLLISCLTVL VFYLPSDCGE KITLCISVLL SLTVFLLLIT EIIPSTSLVI
310 320 330 340 350
PLIGEYLLFT MIFVTLSIII TVFVLNVHHR SPSTHTMPHW VRSFFLGFIP
360 370 380 390 400
RWLFMKRPPL LLPAEGTTGQ YDPPGTRLST SRCWLETDVD DKWEEEEEEE
410 420 430 440 450
EEEEEEEEEE KAYPSRVPSG GSQGTQCHYS CERQAGKASG GPAPQVPLKG
460 470 480 490 500
EEVGSDQGLT LSPSILRALE GVQYIADHLR AEDADFSVKE DWKYVAMVID
510 520
RIFLWMFIIV CLLGTVGLFL PPYLAGMI
Length:528
Mass (Da):60,675
Last modified:July 1, 1989 - v1
Checksum:iE76C6360AF876364
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07339
, X07340, X07341, X07342, X07343, X07344 Genomic DNA. Translation: CAB59645.1.
AJ250360 mRNA. Translation: CAB59625.1.
PIRiS00377. ACCH2N.
RefSeqiNP_990146.1. NM_204815.2.
UniGeneiGga.337.

Genome annotation databases

GeneIDi395607.
KEGGigga:395607.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07339
, X07340 , X07341 , X07342 , X07343 , X07344 Genomic DNA. Translation: CAB59645.1 .
AJ250360 mRNA. Translation: CAB59625.1 .
PIRi S00377. ACCH2N.
RefSeqi NP_990146.1. NM_204815.2.
UniGenei Gga.337.

3D structure databases

ProteinModelPortali P09480.
SMRi P09480. Positions 240-331.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000030930.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 395607.
KEGGi gga:395607.

Organism-specific databases

CTDi 1135.

Phylogenomic databases

eggNOGi NOG290206.
HOGENOMi HOG000006756.
HOVERGENi HBG003756.
InParanoidi P09480.
KOi K04804.
PhylomeDBi P09480.

Miscellaneous databases

NextBioi 20815680.

Family and domain databases

Gene3Di 1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProi IPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view ]
PANTHERi PTHR18945. PTHR18945. 1 hit.
Pfami PF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view ]
PRINTSi PR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMi SSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 2 hits.
TIGRFAMsi TIGR00860. LIC. 1 hit.
PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genes expressed in the brain define three distinct neuronal nicotinic acetylcholine receptors."
    Nef P., Oneyser C., Alliod C., Couturier S., Ballivet M.
    EMBO J. 7:595-601(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: White leghorn.
    Tissue: Brain.

Entry informationi

Entry nameiACHA2_CHICK
AccessioniPrimary (citable) accession number: P09480
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 26, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3