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Protein

Glycodelin

Gene

PAEP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Glycoprotein that regulates critical steps during fertilization and also has immunomonomodulatory effects. Four glycoforms, namely glycodelin-S, -A, -F and -C have been identified in reproductive tissues that differ in glycosylation and biological activity. Glycodelin-A has contraceptive and immunosuppressive activities (PubMed:9918684, PubMed:7531163). Glycodelin-C stimulates binding of spermatozoa to the zona pellucida (PubMed:17192260). Glycodelin-F inhibits spermatozoa-zona pellucida binding and significantly suppresses progesterone-induced acrosome reaction of spermatozoa (PubMed:12672671). Glycodelin-S in seminal plasma maintains the uncapacitated state of human spermatozoa (PubMed:15883155).5 Publications

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: CACAO
  • multicellular organism development Source: ProtInc
  • negative regulation of sperm capacitation Source: UniProtKB
  • positive regulation of granulocyte macrophage colony-stimulating factor production Source: CACAO
  • positive regulation of interleukin-13 secretion Source: CACAO
  • positive regulation of interleukin-6 secretion Source: CACAO
  • regulation of binding of sperm to zona pellucida Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Glycodelin
Short name:
GD
Alternative name(s):
Placental protein 142 Publications
Short name:
PP14
Pregnancy-associated endometrial alpha-2 globulin1 Publication
Short name:
PAEG
Short name:
PEG
Progestagen-associated endometrial protein
Progesterone-associated endometrial protein
Zona-binding inhibitory factor-11 Publication
Short name:
ZIF-11 Publication
Gene namesi
Name:PAEP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000122133.16
HGNCiHGNC:8573 PAEP
MIMi173310 gene
neXtProtiNX_P09466

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5047
OpenTargetsiENSG00000122133
PharmGKBiPA32904

Chemistry databases

DrugBankiDB02405 12-Bromododecanoic Acid
DB04077 Glycerol
DB03796 Palmitic Acid

Polymorphism and mutation databases

BioMutaiPAEP
DMDMi130701

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 183 PublicationsAdd BLAST18
ChainiPRO_000001795319 – 180GlycodelinAdd BLAST162

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
GlycosylationiCAR_00012346N-linked (GlcNAc...) (complex) asparagine1 Publication1
GlycosylationiCAR_00012481N-linked (GlcNAc...) (complex) asparagine1 Publication1
Disulfide bondi84 ↔ 178Combined sources1 Publication
Disulfide bondi124 ↔ 137Combined sources1 Publication

Post-translational modificationi

Four distinct glycoforms A, C, F and S arise from different N-linked oligosaccharide chains at amino acid residues Asn-46 and Asn-81. Glycodelin-A and -F are taken up by the cumulus cells in which partial deglycosylation takes place to produce glycodelin-C.4 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP09466
PeptideAtlasiP09466
PRIDEiP09466
ProteomicsDBi52220
52221 [P09466-2]
52222 [P09466-3]

PTM databases

GlyConnecti177
iPTMnetiP09466
PhosphoSitePlusiP09466
UniCarbKBiP09466

Expressioni

Tissue specificityi

This protein is, the main protein synthesized and secreted in the endometrium from mid-luteal phase of the menstrual cycle and during the first semester of pregnancy (PubMed:3667877). Glycodelin-A is expressed in amniotic fluid, endometrium/decidua and maternal serum (at protein level) (PubMed:3194393). Glycodelin-F is expressed in follicular fluid, luteinized granulosa cells and the oviduct (at protein level) (PubMed:12672671). Glycodelin-S is expressed in seminal plasma and seminal vesicles (at protein level) (PubMed:9239694). Glycodelin-C is detected in cumulus cells (at protein level), but cumulus cells do not synthesize Glycodelin-C but take up and convert glycodelin-A and -F vis glycan remodeling (PubMed:17192260).5 Publications

Gene expression databases

BgeeiENSG00000122133
CleanExiHS_PAEP
ExpressionAtlasiP09466 baseline and differential
GenevisibleiP09466 HS

Organism-specific databases

HPAiCAB016762
HPA020108
HPA029473

Interactioni

Subunit structurei

Homodimer (PubMed:25422905, PubMed:9239694).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GRAMD2BQ96HH95EBI-465167,EBI-2832937

Protein-protein interaction databases

BioGridi111084, 19 interactors
IntActiP09466, 14 interactors
MINTiP09466
STRINGi9606.ENSP00000277508

Structurei

Secondary structure

1180
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi30 – 33Combined sources4
Beta strandi38 – 46Combined sources9
Helixi47 – 49Combined sources3
Beta strandi60 – 66Combined sources7
Beta strandi72 – 79Combined sources8
Beta strandi81 – 93Combined sources13
Beta strandi99 – 104Combined sources6
Beta strandi107 – 115Combined sources9
Beta strandi117 – 127Combined sources11
Beta strandi129 – 132Combined sources4
Beta strandi134 – 144Combined sources11
Helixi148 – 158Combined sources11
Beta strandi159 – 162Combined sources4
Beta strandi167 – 170Combined sources4
Turni173 – 175Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4R0BX-ray2.45A20-180[»]
ProteinModelPortaliP09466
SMRiP09466
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JCG3 Eukaryota
ENOG4111386 LUCA
GeneTreeiENSGT00620000088158
HOGENOMiHOG000113272
HOVERGENiHBG104361
InParanoidiP09466
OMAiSMMCQYL
OrthoDBiEOG091G0M2T
PhylomeDBiP09466
TreeFamiTF342475

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR002447 Blactoglobulin
IPR012674 Calycin
IPR002345 Lipocalin
IPR022272 Lipocalin_CS
IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR11430 PTHR11430, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR01172 BLCTOGLOBULN
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00213 LIPOCALIN, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P09466-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLCLLLTLGV ALVCGVPAMD IPQTKQDLEL PKLAGTWHSM AMATNNISLM
60 70 80 90 100
ATLKAPLRVH ITSLLPTPED NLEIVLHRWE NNSCVEKKVL GEKTENPKKF
110 120 130 140 150
KINYTVANEA TLLDTDYDNF LFLCLQDTTT PIQSMMCQYL ARVLVEDDEI
160 170 180
MQGFIRAFRP LPRHLWYLLD LKQMEEPCRF
Length:180
Mass (Da):20,624
Last modified:March 1, 1992 - v2
Checksum:i0813A74A4231149E
GO
Isoform 2 (identifier: P09466-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     33-54: Missing.

Show »
Length:158
Mass (Da):18,279
Checksum:iFEB77A0B313F33C8
GO
Isoform 3 (identifier: P09466-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     33-126: Missing.

Show »
Length:86
Mass (Da):9,953
Checksum:i01C203BBE8D26652
GO

Sequence cautioni

The sequence AAA60147 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB43305 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35 – 37GTW → VTA AA sequence (PubMed:11278680).Curated3
Sequence conflicti36T → K AA sequence (PubMed:3667877).Curated1
Sequence conflicti95E → G (PubMed:3194393).Curated1
Sequence conflicti152Q → E (PubMed:3194393).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05017828L → V. Corresponds to variant dbSNP:rs34284195Ensembl.1
Natural variantiVAR_034355126Q → K. Corresponds to variant dbSNP:rs3748210Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00314133 – 126Missing in isoform 3. CuratedAdd BLAST94
Alternative sequenceiVSP_00314033 – 54Missing in isoform 2. CuratedAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04129 mRNA Translation: AAA60147.1 Different initiation.
M34046 Genomic DNA Translation: AAA60148.1
M61886 mRNA Translation: AAA35801.1
M61886 mRNA Translation: AAA35802.1
AL050169 mRNA Translation: CAB43305.1 Different initiation.
AL354761 Genomic DNA No translation available.
BC069451 mRNA Translation: AAH69451.1
BC069562 mRNA Translation: AAH69562.1
BC112304 mRNA Translation: AAI12305.1
BC113728 mRNA Translation: AAI13729.1
CCDSiCCDS35173.1 [P09466-1]
PIRiA35570 A39167
RefSeqiNP_001018058.1, NM_001018048.1 [P09466-2]
NP_001018059.1, NM_001018049.2 [P09466-1]
NP_002562.2, NM_002571.3 [P09466-1]
XP_011517051.1, XM_011518749.2 [P09466-1]
XP_011517053.1, XM_011518751.1 [P09466-2]
UniGeneiHs.532325

Genome annotation databases

EnsembliENST00000277508; ENSP00000277508; ENSG00000122133 [P09466-1]
ENST00000371766; ENSP00000360831; ENSG00000122133 [P09466-1]
ENST00000479141; ENSP00000417898; ENSG00000122133 [P09466-1]
GeneIDi5047
KEGGihsa:5047
UCSCiuc004cgd.2 human [P09466-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPAEP_HUMAN
AccessioniPrimary (citable) accession number: P09466
Secondary accession number(s): Q5T6T1, Q9UG92
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: March 1, 1992
Last modified: June 20, 2018
This is version 179 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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