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P09463

- PYRF_PENCH

UniProt

P09463 - PYRF_PENCH

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Protein
Orotidine 5'-phosphate decarboxylase
Gene
pyrG
Organism
Penicillium chrysogenum (Penicillium notatum)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei40 – 401Substrate By similarity
Active sitei98 – 981Proton donor By similarity
Binding sitei230 – 2301Substrate By similarity
Binding sitei248 – 2481Substrate By similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  2. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Uridine 5'-monophosphate synthase
Short name:
UMP synthase
Gene namesi
Name:pyrG
OrganismiPenicillium chrysogenum (Penicillium notatum)
Taxonomic identifieri5076 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaePenicilliumPenicillium chrysogenum complex

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278Orotidine 5'-phosphate decarboxylase
PRO_0000134669Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP09463.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni65 – 673Substrate binding By similarity
Regioni96 – 10510Substrate binding By similarity

Sequence similaritiesi

Belongs to the OMP decarboxylase family.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P09463-1 [UniParc]FASTAAdd to Basket

« Hide

MSSKSQLTYT ARAQSHPNPL ARKLFQVAEE KKSNVTVSAD VTTTKELLDL    50
ADPSTGLGPY IAVIKTHIDI LSDFSQETID GLNALAQKHN FLIFEDRKFI 100
DIGNTVQKQY HNGTLRISEW AHIINCSILP GEGIVEALAQ TAQATDFPYG 150
SERGLLILAE MTSKGSLATG AYTSASVDIA RKYPSFVLGF VSTRSLGEVE 200
STEAPASEDF VVFTTGVNLS SKGDKLGQQY QTPQSAVGRG ADFIISGRGI 250
YAAADPVEAA KQYQQQGWEA YLARVGAQ 278
Length:278
Mass (Da):30,000
Last modified:July 1, 1989 - v1
Checksum:i3BE30ED800D209F8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X08037 Genomic DNA. Translation: CAA30835.1.
PIRiS01287. DCPLOC.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X08037 Genomic DNA. Translation: CAA30835.1 .
PIRi S01287. DCPLOC.

3D structure databases

ProteinModelPortali P09463.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of the Penicillium chrysogenum pyrG (orotidine-5'-phosphate decarboxylase) gene."
    Cantoral J.M., Barredo J.L., Alvarez E., Diez B., Martin J.F.
    Nucleic Acids Res. 16:8177-8177(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: AS-P-78.

Entry informationi

Entry nameiPYRF_PENCH
AccessioniPrimary (citable) accession number: P09463
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 13, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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