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P09463 (PYRF_PENCH) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Uridine 5'-monophosphate synthase
Short name=UMP synthase
Gene names
Name:pyrG
OrganismPenicillium chrysogenum (Penicillium notatum)
Taxonomic identifier5076 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaePenicilliumPenicillium chrysogenum complex

Protein attributes

Sequence length278 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Sequence similarities

Belongs to the OMP decarboxylase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 278278Orotidine 5'-phosphate decarboxylase
PRO_0000134669

Regions

Region65 – 673Substrate binding By similarity
Region96 – 10510Substrate binding By similarity

Sites

Active site981Proton donor By similarity
Binding site401Substrate By similarity
Binding site2301Substrate By similarity
Binding site2481Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P09463 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: 3BE30ED800D209F8

FASTA27830,000
        10         20         30         40         50         60 
MSSKSQLTYT ARAQSHPNPL ARKLFQVAEE KKSNVTVSAD VTTTKELLDL ADPSTGLGPY 

        70         80         90        100        110        120 
IAVIKTHIDI LSDFSQETID GLNALAQKHN FLIFEDRKFI DIGNTVQKQY HNGTLRISEW 

       130        140        150        160        170        180 
AHIINCSILP GEGIVEALAQ TAQATDFPYG SERGLLILAE MTSKGSLATG AYTSASVDIA 

       190        200        210        220        230        240 
RKYPSFVLGF VSTRSLGEVE STEAPASEDF VVFTTGVNLS SKGDKLGQQY QTPQSAVGRG 

       250        260        270 
ADFIISGRGI YAAADPVEAA KQYQQQGWEA YLARVGAQ 

« Hide

References

[1]"Nucleotide sequence of the Penicillium chrysogenum pyrG (orotidine-5'-phosphate decarboxylase) gene."
Cantoral J.M., Barredo J.L., Alvarez E., Diez B., Martin J.F.
Nucleic Acids Res. 16:8177-8177(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: AS-P-78.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X08037 Genomic DNA. Translation: CAA30835.1.
PIRDCPLOC. S01287.

3D structure databases

ProteinModelPortalP09463.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_PENCH
AccessionPrimary (citable) accession number: P09463
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 13, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways