Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ATP synthase subunit 5, mitochondrial

Gene

ATP5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha3beta3 subcomplex and subunit a/ATP6 static relative to the rotary elements.

Miscellaneous

Present with 32400 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

  • ATP synthesis coupled proton transport Source: SGD

Keywordsi

Biological processATP synthesis, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29859-MONOMER

Protein family/group databases

TCDBi3.A.2.1.3 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit 5, mitochondrial
Short name:
ATP synthase chain 5
Alternative name(s):
Oligomycin sensitivity conferral protein
Short name:
OSCP
Gene namesi
Name:ATP5
Synonyms:OSCP
Ordered Locus Names:YDR298C
ORF Names:D9740.11
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR298C
SGDiS000002706 ATP5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 17MitochondrionAdd BLAST17
ChainiPRO_000000265618 – 212ATP synthase subunit 5, mitochondrialAdd BLAST195

Proteomic databases

MaxQBiP09457
PaxDbiP09457
PRIDEiP09457

2D gel databases

UCD-2DPAGEP09457

PTM databases

iPTMnetiP09457

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c.

Protein-protein interaction databases

BioGridi32350, 153 interactors
DIPiDIP-3037N
IntActiP09457, 9 interactors
MINTiP09457
STRINGi4932.YDR298C

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6B8Helectron microscopy3.60O/o18-212[»]
6CP3electron microscopy3.80Y18-212[»]
6CP6electron microscopy3.60Y18-212[»]
ProteinModelPortaliP09457
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase delta chain family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00390000015060
HOGENOMiHOG000075825
InParanoidiP09457
KOiK02137
OMAiMVDNIQD
OrthoDBiEOG092C4VM2

Family and domain databases

Gene3Di1.10.520.20, 1 hit
HAMAPiMF_01416 ATP_synth_delta_bact, 1 hit
InterProiView protein in InterPro
IPR026015 ATP_synth_OSCP/delta_N_sf
IPR020781 ATPase_OSCP/d_CS
IPR000711 ATPase_OSCP/dsu
PANTHERiPTHR11910 PTHR11910, 1 hit
PfamiView protein in Pfam
PF00213 OSCP, 1 hit
PRINTSiPR00125 ATPASEDELTA
SUPFAMiSSF47928 SSF47928, 1 hit
TIGRFAMsiTIGR01145 ATP_synt_delta, 1 hit
PROSITEiView protein in PROSITE
PS00389 ATPASE_DELTA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09457-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFNRVFTRSF ASSLRAAASK AAAPPPVRLF GVEGTYATAL YQAAAKNSSI
60 70 80 90 100
DAAFQSLQKV ESTVKKNPKL GHLLLNPALS LKDRNSVIDA IVETHKNLDG
110 120 130 140 150
YVVNLLKVLS ENNRLGCFEK IASDFGVLND AHNGLLKGTV TSAEPLDPKS
160 170 180 190 200
FKRIEKALSA SKLVGQGKSL KLENVVKPEI KGGLIVELGD KTVDLSISTK
210
IQKLNKVLED SI
Length:212
Mass (Da):22,814
Last modified:July 1, 1989 - v1
Checksum:iBD5F8EF4503E4D66
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12356 Genomic DNA Translation: CAA30917.1
M32487 Genomic DNA Translation: AAA34836.1
U28374 Genomic DNA Translation: AAB64734.1
AY557732 Genomic DNA Translation: AAS56058.1
BK006938 Genomic DNA Translation: DAA12137.1
PIRiS05726 PWBYD
RefSeqiNP_010584.1, NM_001180606.1

Genome annotation databases

EnsemblFungiiYDR298C; YDR298C; YDR298C
GeneIDi851892
KEGGisce:YDR298C

Similar proteinsi

Entry informationi

Entry nameiATPO_YEAST
AccessioniPrimary (citable) accession number: P09457
Secondary accession number(s): D6VSS7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: May 23, 2018
This is version 174 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health