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Protein

ATP synthase subunit 5, mitochondrial

Gene

ATP5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha3beta3 subcomplex and subunit a/ATP6 static relative to the rotary elements.

GO - Molecular functioni

GO - Biological processi

  • ATP synthesis coupled proton transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

ATP synthesis, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29859-MONOMER.

Protein family/group databases

TCDBi3.A.2.1.3. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit 5, mitochondrial
Short name:
ATP synthase chain 5
Alternative name(s):
Oligomycin sensitivity conferral protein
Short name:
OSCP
Gene namesi
Name:ATP5
Synonyms:OSCP
Ordered Locus Names:YDR298C
ORF Names:D9740.11
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR298C.
SGDiS000002706. ATP5.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial proton-transporting ATP synthase, stator stalk Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1717MitochondrionAdd
BLAST
Chaini18 – 212195ATP synthase subunit 5, mitochondrialPRO_0000002656Add
BLAST

Proteomic databases

MaxQBiP09457.

2D gel databases

UCD-2DPAGEP09457.

PTM databases

iPTMnetiP09457.

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c.

Protein-protein interaction databases

BioGridi32350. 108 interactions.
DIPiDIP-3037N.
IntActiP09457. 8 interactions.
MINTiMINT-688192.

Structurei

3D structure databases

ProteinModelPortaliP09457.
SMRiP09457. Positions 25-210.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase delta chain family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00390000015060.
HOGENOMiHOG000075825.
InParanoidiP09457.
KOiK02137.
OMAiHGQNLVK.
OrthoDBiEOG092C4VM2.

Family and domain databases

Gene3Di1.10.520.20. 1 hit.
HAMAPiMF_01416. ATP_synth_delta_bact. 1 hit.
InterProiIPR020781. ATPase_OSCP/d_CS.
IPR026015. ATPase_OSCP/delta_N.
IPR000711. ATPase_OSCP/dsu.
[Graphical view]
PANTHERiPTHR11910. PTHR11910. 1 hit.
PfamiPF00213. OSCP. 1 hit.
[Graphical view]
PRINTSiPR00125. ATPASEDELTA.
SUPFAMiSSF47928. SSF47928. 1 hit.
TIGRFAMsiTIGR01145. ATP_synt_delta. 1 hit.
PROSITEiPS00389. ATPASE_DELTA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09457-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFNRVFTRSF ASSLRAAASK AAAPPPVRLF GVEGTYATAL YQAAAKNSSI
60 70 80 90 100
DAAFQSLQKV ESTVKKNPKL GHLLLNPALS LKDRNSVIDA IVETHKNLDG
110 120 130 140 150
YVVNLLKVLS ENNRLGCFEK IASDFGVLND AHNGLLKGTV TSAEPLDPKS
160 170 180 190 200
FKRIEKALSA SKLVGQGKSL KLENVVKPEI KGGLIVELGD KTVDLSISTK
210
IQKLNKVLED SI
Length:212
Mass (Da):22,814
Last modified:July 1, 1989 - v1
Checksum:iBD5F8EF4503E4D66
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12356 Genomic DNA. Translation: CAA30917.1.
M32487 Genomic DNA. Translation: AAA34836.1.
U28374 Genomic DNA. Translation: AAB64734.1.
AY557732 Genomic DNA. Translation: AAS56058.1.
BK006938 Genomic DNA. Translation: DAA12137.1.
PIRiS05726. PWBYD.
RefSeqiNP_010584.1. NM_001180606.1.

Genome annotation databases

EnsemblFungiiYDR298C; YDR298C; YDR298C.
GeneIDi851892.
KEGGisce:YDR298C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12356 Genomic DNA. Translation: CAA30917.1.
M32487 Genomic DNA. Translation: AAA34836.1.
U28374 Genomic DNA. Translation: AAB64734.1.
AY557732 Genomic DNA. Translation: AAS56058.1.
BK006938 Genomic DNA. Translation: DAA12137.1.
PIRiS05726. PWBYD.
RefSeqiNP_010584.1. NM_001180606.1.

3D structure databases

ProteinModelPortaliP09457.
SMRiP09457. Positions 25-210.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32350. 108 interactions.
DIPiDIP-3037N.
IntActiP09457. 8 interactions.
MINTiMINT-688192.

Protein family/group databases

TCDBi3.A.2.1.3. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

PTM databases

iPTMnetiP09457.

2D gel databases

UCD-2DPAGEP09457.

Proteomic databases

MaxQBiP09457.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR298C; YDR298C; YDR298C.
GeneIDi851892.
KEGGisce:YDR298C.

Organism-specific databases

EuPathDBiFungiDB:YDR298C.
SGDiS000002706. ATP5.

Phylogenomic databases

GeneTreeiENSGT00390000015060.
HOGENOMiHOG000075825.
InParanoidiP09457.
KOiK02137.
OMAiHGQNLVK.
OrthoDBiEOG092C4VM2.

Enzyme and pathway databases

BioCyciYEAST:G3O-29859-MONOMER.

Miscellaneous databases

PROiP09457.

Family and domain databases

Gene3Di1.10.520.20. 1 hit.
HAMAPiMF_01416. ATP_synth_delta_bact. 1 hit.
InterProiIPR020781. ATPase_OSCP/d_CS.
IPR026015. ATPase_OSCP/delta_N.
IPR000711. ATPase_OSCP/dsu.
[Graphical view]
PANTHERiPTHR11910. PTHR11910. 1 hit.
PfamiPF00213. OSCP. 1 hit.
[Graphical view]
PRINTSiPR00125. ATPASEDELTA.
SUPFAMiSSF47928. SSF47928. 1 hit.
TIGRFAMsiTIGR01145. ATP_synt_delta. 1 hit.
PROSITEiPS00389. ATPASE_DELTA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATPO_YEAST
AccessioniPrimary (citable) accession number: P09457
Secondary accession number(s): D6VSS7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: September 7, 2016
This is version 159 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 32400 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.