P09455 (RET1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Retinol-binding protein 1

Alternative name(s):
Cellular retinol-binding protein
Short name=CRBP
Cellular retinol-binding protein I
Short name=CRBP-I

Gene names

Name:	RBP1
Synonyms:	CRBP1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	135 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Intracellular transport of retinol.
Subcellular location	Cytoplasm.
Tissue specificity	Detected in nearly all the tissues with higher expression in adult ovary, pancreas, pituitary gland and adrenal gland, and fetal liver. Ref.6
Domain	Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior By similarity.
Sequence similarities	Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cytoplasm
Ligand	Retinol-binding Vitamin A
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	retinal binding Inferred from electronic annotation. Source: UniProtKB-KW retinol binding Inferred from electronic annotation. Source: UniProtKB-KW transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 135	134	Retinol-binding protein 1		PRO_0000067392
Sites
	Binding site	109	1	Retinoic acid By similarity

Sequences

	Sequence		Length	Mass (Da)
	P09455 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: FA47545761AFA3A2	FASTA	135	15,850
	10 20 30 40 50 60 MPVDFTGYWK MLVNENFEEY LRALDVNVAL RKIANLLKPD KEIVQDGDHM IIRTLSTFRN 70 80 90 100 110 120 YIMDFQVGKE FEEDLTGIDD RKCMTTVSWD GDKLQCVQKG EKEGRGWTQW IEGDELHLEM 130 RVEGVVCKQV FKKVQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and sequencing of a full length cDNA corresponding to human cellular retinol-binding protein." Colantuoni V., Cortese R., Nilsson M., Lundvall J., Baavik C.-O., Eriksson U., Peterson P.A., Sundelin J. Biochem. Biophys. Res. Commun. 130:431-439(1985) [PubMed: 2992469] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Human cellular retinol-binding protein gene organization and chromosomal location." Nilsson M.H.L., Spurr N.K., Lundvall J., Rask L., Peterson P.A. Eur. J. Biochem. 173:35-44(1988) [PubMed: 3356192] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Cellular retinoic acid- and cellular retinol-binding proteins: complementary deoxyribonucleic acid cloning, chromosomal assignment, and tissue specific expression." Wei L.-N., Mertz J.R., Goodman D.S., Nguyen-Huu M.C. Mol. Endocrinol. 1:526-534(1987) [PubMed: 2856408] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-121.
[6]	"Identification, retinoid binding and X-ray analysis of a human retinol-binding protein." Folli C., Calderone V., Ottonello S., Bolchi A., Zanotti G., Stoppini M., Berni R. Proc. Natl. Acad. Sci. U.S.A. 98:3710-3715(2001) [PubMed: 11274389] [Abstract] Cited for: TISSUE SPECIFICITY.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M11433 mRNA. Translation: AAA60257.1. X07437, X07438 Genomic DNA. Translation: CAA30318.1. CR541979 mRNA. Translation: CAG46776.1. CR542005 mRNA. Translation: CAG46802.1. BC121052 mRNA. Translation: AAI21053.1. M36809 mRNA. Translation: AAA35714.1.
IPI	IPI00219718.
PIR	RJHUO. S00399.
RefSeq	NP_002890.2. NM_002899.3.
UniGene	Hs.529571.
3D structure databases
ProteinModelPortal	P09455.
SMR	P09455. Positions 1-135.
ModBase	Search...
Protein-protein interaction databases
IntAct	P09455. 1 interaction.
STRING	P09455.
Polymorphism databases
DMDM	132387.
Proteomic databases
PRIDE	P09455.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000232219; ENSP00000232219; ENSG00000114115. ENST00000428090; ENSP00000408010; ENSG00000114115.
GeneID	5947.
KEGG	hsa:5947.
UCSC	uc003eti.1. human.
Organism-specific databases
CTD	5947.
GeneCards	GC03M139236.
H-InvDB	HIX0030850.
HGNC	HGNC:9919. RBP1.
HPA	CAB018603. CAB019276.
MIM	180260. gene.
neXtProt	NX_P09455.
PharmGKB	PA34286.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG15131.
GeneTree	ENSGT00560000076799.
HOGENOM	HBG714759.
HOVERGEN	HBG005633.
InParanoid	P09455.
OrthoDB	EOG4G4GRR.
PhylomeDB	P09455.
Enzyme and pathway databases
Pathway_Interaction_DB	retinoic_acid_pathway. Retinoic acid receptors-mediated signaling.
Gene expression databases
ArrayExpress	P09455.
Bgee	P09455.
CleanEx	HS_RBP1.
Genevestigator	P09455.
GermOnline	ENSG00000114115. Homo sapiens.
Family and domain databases
InterPro	IPR012674. Calycin. IPR011038. Calycin-like. IPR000463. Fatty_acid-bd. IPR000566. Lipocln_cytosolic_FA-bd_dom. [Graphical view]
Gene3D	G3DSA:2.40.128.20. Calycin. 1 hit.
Pfam	PF00061. Lipocalin. 1 hit. [Graphical view]
PRINTS	PR00178. FATTYACIDBP.
SUPFAM	SSF50814. Calycin. 1 hit.
PROSITE	PS00214. FABP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
DrugBank	DB00162. Vitamin A.
NextBio	23170.
SOURCE	Search...

Entry information

Entry name

RET1_HUMAN

Accession

Primary (citable) accession number: P09455
Secondary accession number(s): Q6FGX8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	January 23, 2007
Last modified:	January 25, 2012
This is version 113 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.