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Protein

Transcription factor jun-B

Gene

Junb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3'.

GO - Molecular functioni

GO - Biological processi

  • cellular process Source: MGI
  • cellular response to calcium ion Source: MGI
  • cellular response to hormone stimulus Source: GO_Central
  • decidualization Source: MGI
  • embryonic process involved in female pregnancy Source: MGI
  • in utero embryonic development Source: MGI
  • labyrinthine layer blood vessel development Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: GO_Central
  • osteoblast differentiation Source: MGI
  • osteoblast proliferation Source: MGI
  • osteoclast differentiation Source: MGI
  • positive regulation of cell differentiation Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • regulation of cell cycle Source: MGI
  • regulation of cell death Source: GO_Central
  • regulation of cell proliferation Source: GO_Central
  • regulation of transcription, DNA-templated Source: MGI
  • response to cAMP Source: GO_Central
  • response to corticosterone Source: Ensembl
  • response to cytokine Source: GO_Central
  • response to drug Source: GO_Central
  • response to light stimulus Source: Ensembl
  • response to lipopolysaccharide Source: GO_Central
  • response to mechanical stimulus Source: GO_Central
  • response to peptide hormone Source: Ensembl
  • response to progesterone Source: Ensembl
  • response to radiation Source: GO_Central
  • trophectodermal cell differentiation Source: MGI
  • vasculogenesis Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor jun-B
Alternative name(s):
MyD21
Gene namesi
Name:Junb
Synonyms:Jun-b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:96647. Junb.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 344344Transcription factor jun-BPRO_0000076439Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei102 – 1021PhosphothreonineBy similarity
Modified residuei104 – 1041PhosphothreonineBy similarity
Modified residuei117 – 1171PhosphoserineBy similarity
Modified residuei237 – 2371N6-acetyllysine1 Publication
Modified residuei248 – 2481PhosphoserineBy similarity
Modified residuei252 – 2521PhosphothreonineBy similarity
Modified residuei256 – 2561Phosphoserine1 Publication

Post-translational modificationi

Ubiquitinated by ITCH, leading to its degradation.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP09450.
PRIDEiP09450.

PTM databases

PhosphoSiteiP09450.

Expressioni

Inductioni

By growth factors.

Gene expression databases

BgeeiP09450.
CleanExiMM_JUNB.
ExpressionAtlasiP09450. baseline and differential.
GenevisibleiP09450. MM.

Interactioni

Subunit structurei

Binds DNA as a homodimer or as a heterodimer with another member of the Jun/Fos family. Interacts with NFE2 (via its WW domains).By similarity

Protein-protein interaction databases

BioGridi200872. 4 interactions.
DIPiDIP-1069N.
IntActiP09450. 1 interaction.
STRINGi10090.ENSMUSP00000064680.

Structurei

3D structure databases

ProteinModelPortaliP09450.
SMRiP09450. Positions 269-326.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini265 – 32864bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni265 – 29228Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni293 – 32129Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family. Jun subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG283376.
HOGENOMiHOG000006648.
HOVERGENiHBG001722.
InParanoidiP09450.
KOiK09028.
OMAiYHDDSYT.
OrthoDBiEOG75MVXV.
PhylomeDBiP09450.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiIPR004827. bZIP.
IPR005643. JNK.
IPR029822. JunB.
IPR002112. Leuzip_Jun.
IPR008917. TF_DNA-bd.
[Graphical view]
PANTHERiPTHR11462:SF37. PTHR11462:SF37. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
PF03957. Jun. 1 hit.
[Graphical view]
PRINTSiPR00043. LEUZIPPRJUN.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P09450-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCTKMEQPFY HDDSYAAAGY GRSPGSLSLH DYKLLKPTLA LNLADPYRGL
60 70 80 90 100
KGPGARGPGP EGSGAGSYFS GQGSDTGASL KLASTELERL IVPNSNGVIT
110 120 130 140 150
TTPTPPGQYF YPRGGGSGGG TGGGVTEEQE GFADGFVKAL DDLHKMNHVT
160 170 180 190 200
PPNVSLGASG GPQAGPGGVY AGPEPPPVYT NLSSYSPASA PSGGSGTAVG
210 220 230 240 250
TGSSYPTATI SYLPHAPPFA GGHPAQLGLS RGASAFKEEP QTVPEARSRD
260 270 280 290 300
ATPPVSPINM EDQERIKVER KRLRNRLAAT KCRKRKLERI ARLEDKVKTL
310 320 330 340
KAENAGLSSA AGLLREQVAQ LKQKVMTHVS NGCQLLLGVK GHAF
Length:344
Mass (Da):35,765
Last modified:July 1, 1989 - v1
Checksum:i6F52D4FECC32E234
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti53 – 531P → S in BAC40473 (PubMed:16141072).Curated
Sequence conflicti200 – 2001G → R in AAA74916 (PubMed:8530030).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03236 mRNA. Translation: AAA39343.1.
U20735 Genomic DNA. Translation: AAA74916.1.
AK088643 mRNA. Translation: BAC40473.1.
BC003790 mRNA. Translation: AAH03790.1.
X54332 mRNA. No translation available.
CCDSiCCDS22488.1.
PIRiA28963. TVMSJB.
RefSeqiNP_032442.1. NM_008416.3.
UniGeneiMm.1167.

Genome annotation databases

EnsembliENSMUST00000064922; ENSMUSP00000064680; ENSMUSG00000052837.
GeneIDi16477.
KEGGimmu:16477.
UCSCiuc009mop.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03236 mRNA. Translation: AAA39343.1.
U20735 Genomic DNA. Translation: AAA74916.1.
AK088643 mRNA. Translation: BAC40473.1.
BC003790 mRNA. Translation: AAH03790.1.
X54332 mRNA. No translation available.
CCDSiCCDS22488.1.
PIRiA28963. TVMSJB.
RefSeqiNP_032442.1. NM_008416.3.
UniGeneiMm.1167.

3D structure databases

ProteinModelPortaliP09450.
SMRiP09450. Positions 269-326.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200872. 4 interactions.
DIPiDIP-1069N.
IntActiP09450. 1 interaction.
STRINGi10090.ENSMUSP00000064680.

PTM databases

PhosphoSiteiP09450.

Proteomic databases

MaxQBiP09450.
PRIDEiP09450.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064922; ENSMUSP00000064680; ENSMUSG00000052837.
GeneIDi16477.
KEGGimmu:16477.
UCSCiuc009mop.1. mouse.

Organism-specific databases

CTDi3726.
MGIiMGI:96647. Junb.

Phylogenomic databases

eggNOGiNOG283376.
HOGENOMiHOG000006648.
HOVERGENiHBG001722.
InParanoidiP09450.
KOiK09028.
OMAiYHDDSYT.
OrthoDBiEOG75MVXV.
PhylomeDBiP09450.

Miscellaneous databases

NextBioi289767.
PROiP09450.
SOURCEiSearch...

Gene expression databases

BgeeiP09450.
CleanExiMM_JUNB.
ExpressionAtlasiP09450. baseline and differential.
GenevisibleiP09450. MM.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiIPR004827. bZIP.
IPR005643. JNK.
IPR029822. JunB.
IPR002112. Leuzip_Jun.
IPR008917. TF_DNA-bd.
[Graphical view]
PANTHERiPTHR11462:SF37. PTHR11462:SF37. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
PF03957. Jun. 1 hit.
[Graphical view]
PRINTSiPR00043. LEUZIPPRJUN.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A gene activated by growth factors is related to the oncogene v-jun."
    Ryder K., Lau L.F., Nathans D.
    Proc. Natl. Acad. Sci. U.S.A. 85:1487-1491(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complex genetic organization of junB: multiple blocks of flanking evolutionarily conserved sequence at the murine and human junB loci."
    Phinney D.G., Tseng S.W., Ryder K.
    Genomics 28:228-234(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/c.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
    Tissue: Thymus.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.
  5. "Complexity of the immediate early response of myeloid cells to terminal differentiation and growth arrest includes ICAM-1, Jun-B and histone variants."
    Lord K.A., Hoffman-Liebermann B., Liebermann D.A.
    Oncogene 5:387-396(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-30.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-256, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  7. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-237, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiJUNB_MOUSE
AccessioniPrimary (citable) accession number: P09450
Secondary accession number(s): Q8C2G9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: June 24, 2015
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.