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P09450

- JUNB_MOUSE

UniProt

P09450 - JUNB_MOUSE

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Protein

Transcription factor jun-B

Gene

Junb

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3'.

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. double-stranded DNA binding Source: Ensembl
  3. RNA polymerase II regulatory region sequence-specific DNA binding Source: MGI
  4. sequence-specific DNA binding transcription factor activity Source: Ensembl

GO - Biological processi

  1. cellular process Source: MGI
  2. cellular response to calcium ion Source: MGI
  3. cellular response to hormone stimulus Source: Ensembl
  4. decidualization Source: MGI
  5. embryonic process involved in female pregnancy Source: MGI
  6. in utero embryonic development Source: MGI
  7. labyrinthine layer blood vessel development Source: MGI
  8. osteoblast differentiation Source: MGI
  9. osteoblast proliferation Source: MGI
  10. osteoclast differentiation Source: MGI
  11. positive regulation of cell differentiation Source: MGI
  12. regulation of cell cycle Source: MGI
  13. regulation of transcription, DNA-templated Source: MGI
  14. response to cAMP Source: Ensembl
  15. response to corticosterone Source: Ensembl
  16. response to cytokine Source: Ensembl
  17. response to drug Source: Ensembl
  18. response to light stimulus Source: Ensembl
  19. response to mechanical stimulus Source: Ensembl
  20. response to peptide hormone Source: Ensembl
  21. response to progesterone Source: Ensembl
  22. transcription from RNA polymerase II promoter Source: Ensembl
  23. trophectodermal cell differentiation Source: MGI
  24. vasculogenesis Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor jun-B
Alternative name(s):
MyD21
Gene namesi
Name:Junb
Synonyms:Jun-b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:96647. Junb.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 344344Transcription factor jun-BPRO_0000076439Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei102 – 1021PhosphothreonineBy similarity
Modified residuei104 – 1041PhosphothreonineBy similarity
Modified residuei117 – 1171PhosphoserineBy similarity
Modified residuei237 – 2371N6-acetyllysine1 Publication
Modified residuei248 – 2481PhosphoserineBy similarity
Modified residuei252 – 2521PhosphothreonineBy similarity
Modified residuei256 – 2561Phosphoserine1 Publication

Post-translational modificationi

Ubiquitinated by ITCH, leading to its degradation.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP09450.
PRIDEiP09450.

PTM databases

PhosphoSiteiP09450.

Expressioni

Inductioni

By growth factors.

Gene expression databases

BgeeiP09450.
CleanExiMM_JUNB.
ExpressionAtlasiP09450. baseline and differential.
GenevestigatoriP09450.

Interactioni

Subunit structurei

Binds DNA as a homodimer or as a heterodimer with another member of the Jun/Fos family. Interacts with NFE2 (via its WW domains).By similarity

Protein-protein interaction databases

BioGridi200872. 4 interactions.
DIPiDIP-1069N.
IntActiP09450. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP09450.
SMRiP09450. Positions 269-326.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini265 – 32864bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni265 – 29228Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni293 – 32129Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family. Jun subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG283376.
HOGENOMiHOG000006648.
HOVERGENiHBG001722.
InParanoidiP09450.
KOiK09028.
OMAiLNAYCPN.
OrthoDBiEOG75MVXV.
PhylomeDBiP09450.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiIPR004827. bZIP.
IPR005643. JNK.
IPR002112. Leuzip_Jun.
IPR008917. TF_DNA-bd.
[Graphical view]
PfamiPF00170. bZIP_1. 1 hit.
PF03957. Jun. 1 hit.
[Graphical view]
PRINTSiPR00043. LEUZIPPRJUN.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P09450-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCTKMEQPFY HDDSYAAAGY GRSPGSLSLH DYKLLKPTLA LNLADPYRGL
60 70 80 90 100
KGPGARGPGP EGSGAGSYFS GQGSDTGASL KLASTELERL IVPNSNGVIT
110 120 130 140 150
TTPTPPGQYF YPRGGGSGGG TGGGVTEEQE GFADGFVKAL DDLHKMNHVT
160 170 180 190 200
PPNVSLGASG GPQAGPGGVY AGPEPPPVYT NLSSYSPASA PSGGSGTAVG
210 220 230 240 250
TGSSYPTATI SYLPHAPPFA GGHPAQLGLS RGASAFKEEP QTVPEARSRD
260 270 280 290 300
ATPPVSPINM EDQERIKVER KRLRNRLAAT KCRKRKLERI ARLEDKVKTL
310 320 330 340
KAENAGLSSA AGLLREQVAQ LKQKVMTHVS NGCQLLLGVK GHAF
Length:344
Mass (Da):35,765
Last modified:July 1, 1989 - v1
Checksum:i6F52D4FECC32E234
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti53 – 531P → S in BAC40473. (PubMed:16141072)Curated
Sequence conflicti200 – 2001G → R in AAA74916. (PubMed:8530030)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03236 mRNA. Translation: AAA39343.1.
U20735 Genomic DNA. Translation: AAA74916.1.
AK088643 mRNA. Translation: BAC40473.1.
BC003790 mRNA. Translation: AAH03790.1.
X54332 mRNA. No translation available.
CCDSiCCDS22488.1.
PIRiA28963. TVMSJB.
RefSeqiNP_032442.1. NM_008416.3.
UniGeneiMm.1167.

Genome annotation databases

EnsembliENSMUST00000064922; ENSMUSP00000064680; ENSMUSG00000052837.
GeneIDi16477.
KEGGimmu:16477.
UCSCiuc009mop.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03236 mRNA. Translation: AAA39343.1 .
U20735 Genomic DNA. Translation: AAA74916.1 .
AK088643 mRNA. Translation: BAC40473.1 .
BC003790 mRNA. Translation: AAH03790.1 .
X54332 mRNA. No translation available.
CCDSi CCDS22488.1.
PIRi A28963. TVMSJB.
RefSeqi NP_032442.1. NM_008416.3.
UniGenei Mm.1167.

3D structure databases

ProteinModelPortali P09450.
SMRi P09450. Positions 269-326.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200872. 4 interactions.
DIPi DIP-1069N.
IntActi P09450. 1 interaction.

PTM databases

PhosphoSitei P09450.

Proteomic databases

MaxQBi P09450.
PRIDEi P09450.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000064922 ; ENSMUSP00000064680 ; ENSMUSG00000052837 .
GeneIDi 16477.
KEGGi mmu:16477.
UCSCi uc009mop.1. mouse.

Organism-specific databases

CTDi 3726.
MGIi MGI:96647. Junb.

Phylogenomic databases

eggNOGi NOG283376.
HOGENOMi HOG000006648.
HOVERGENi HBG001722.
InParanoidi P09450.
KOi K09028.
OMAi LNAYCPN.
OrthoDBi EOG75MVXV.
PhylomeDBi P09450.

Miscellaneous databases

NextBioi 289767.
PROi P09450.
SOURCEi Search...

Gene expression databases

Bgeei P09450.
CleanExi MM_JUNB.
ExpressionAtlasi P09450. baseline and differential.
Genevestigatori P09450.

Family and domain databases

Gene3Di 1.10.880.10. 1 hit.
InterProi IPR004827. bZIP.
IPR005643. JNK.
IPR002112. Leuzip_Jun.
IPR008917. TF_DNA-bd.
[Graphical view ]
Pfami PF00170. bZIP_1. 1 hit.
PF03957. Jun. 1 hit.
[Graphical view ]
PRINTSi PR00043. LEUZIPPRJUN.
SMARTi SM00338. BRLZ. 1 hit.
[Graphical view ]
SUPFAMi SSF47454. SSF47454. 1 hit.
PROSITEi PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A gene activated by growth factors is related to the oncogene v-jun."
    Ryder K., Lau L.F., Nathans D.
    Proc. Natl. Acad. Sci. U.S.A. 85:1487-1491(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complex genetic organization of junB: multiple blocks of flanking evolutionarily conserved sequence at the murine and human junB loci."
    Phinney D.G., Tseng S.W., Ryder K.
    Genomics 28:228-234(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/c.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
    Tissue: Thymus.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.
  5. "Complexity of the immediate early response of myeloid cells to terminal differentiation and growth arrest includes ICAM-1, Jun-B and histone variants."
    Lord K.A., Hoffman-Liebermann B., Liebermann D.A.
    Oncogene 5:387-396(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-30.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-256, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  7. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-237, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiJUNB_MOUSE
AccessioniPrimary (citable) accession number: P09450
Secondary accession number(s): Q8C2G9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 29, 2014
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3