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P09450

- JUNB_MOUSE

UniProt

P09450 - JUNB_MOUSE

Protein

Transcription factor jun-B

Gene

Junb

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 138 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3'.

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. double-stranded DNA binding Source: Ensembl
    3. protein binding Source: UniProtKB
    4. RNA polymerase II regulatory region sequence-specific DNA binding Source: MGI
    5. sequence-specific DNA binding transcription factor activity Source: Ensembl

    GO - Biological processi

    1. cellular process Source: MGI
    2. cellular response to calcium ion Source: MGI
    3. cellular response to hormone stimulus Source: Ensembl
    4. decidualization Source: MGI
    5. embryonic process involved in female pregnancy Source: MGI
    6. in utero embryonic development Source: MGI
    7. labyrinthine layer blood vessel development Source: MGI
    8. osteoblast differentiation Source: MGI
    9. osteoblast proliferation Source: MGI
    10. osteoclast differentiation Source: MGI
    11. positive regulation of cell differentiation Source: MGI
    12. regulation of cell cycle Source: MGI
    13. regulation of transcription, DNA-templated Source: MGI
    14. response to cAMP Source: Ensembl
    15. response to corticosterone Source: Ensembl
    16. response to cytokine Source: Ensembl
    17. response to drug Source: Ensembl
    18. response to light stimulus Source: Ensembl
    19. response to mechanical stimulus Source: Ensembl
    20. response to peptide hormone Source: Ensembl
    21. response to progesterone Source: Ensembl
    22. transcription from RNA polymerase II promoter Source: Ensembl
    23. trophectodermal cell differentiation Source: MGI
    24. vasculogenesis Source: MGI

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor jun-B
    Alternative name(s):
    MyD21
    Gene namesi
    Name:Junb
    Synonyms:Jun-b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:96647. Junb.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 344344Transcription factor jun-BPRO_0000076439Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei102 – 1021PhosphothreonineBy similarity
    Modified residuei104 – 1041PhosphothreonineBy similarity
    Modified residuei117 – 1171PhosphoserineBy similarity
    Modified residuei237 – 2371N6-acetyllysine1 Publication
    Modified residuei248 – 2481PhosphoserineBy similarity
    Modified residuei252 – 2521PhosphothreonineBy similarity
    Modified residuei256 – 2561Phosphoserine1 Publication

    Post-translational modificationi

    Ubiquitinated by ITCH, leading to its degradation.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PRIDEiP09450.

    PTM databases

    PhosphoSiteiP09450.

    Expressioni

    Inductioni

    By growth factors.

    Gene expression databases

    ArrayExpressiP09450.
    BgeeiP09450.
    CleanExiMM_JUNB.
    GenevestigatoriP09450.

    Interactioni

    Subunit structurei

    Binds DNA as a homodimer or as a heterodimer with another member of the Jun/Fos family. Interacts with NFE2 (via its WW domains).By similarity

    Protein-protein interaction databases

    BioGridi200872. 4 interactions.
    DIPiDIP-1069N.
    IntActiP09450. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP09450.
    SMRiP09450. Positions 269-326.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini265 – 32864bZIPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni265 – 29228Basic motifPROSITE-ProRule annotationAdd
    BLAST
    Regioni293 – 32129Leucine-zipperPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the bZIP family. Jun subfamily.Curated
    Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG283376.
    HOGENOMiHOG000006648.
    HOVERGENiHBG001722.
    InParanoidiP09450.
    KOiK09028.
    OMAiLNAYCPN.
    OrthoDBiEOG75MVXV.
    PhylomeDBiP09450.

    Family and domain databases

    Gene3Di1.10.880.10. 1 hit.
    InterProiIPR004827. bZIP.
    IPR005643. JNK.
    IPR002112. Leuzip_Jun.
    IPR008917. TF_DNA-bd.
    [Graphical view]
    PfamiPF00170. bZIP_1. 1 hit.
    PF03957. Jun. 1 hit.
    [Graphical view]
    PRINTSiPR00043. LEUZIPPRJUN.
    SMARTiSM00338. BRLZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF47454. SSF47454. 1 hit.
    PROSITEiPS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P09450-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCTKMEQPFY HDDSYAAAGY GRSPGSLSLH DYKLLKPTLA LNLADPYRGL    50
    KGPGARGPGP EGSGAGSYFS GQGSDTGASL KLASTELERL IVPNSNGVIT 100
    TTPTPPGQYF YPRGGGSGGG TGGGVTEEQE GFADGFVKAL DDLHKMNHVT 150
    PPNVSLGASG GPQAGPGGVY AGPEPPPVYT NLSSYSPASA PSGGSGTAVG 200
    TGSSYPTATI SYLPHAPPFA GGHPAQLGLS RGASAFKEEP QTVPEARSRD 250
    ATPPVSPINM EDQERIKVER KRLRNRLAAT KCRKRKLERI ARLEDKVKTL 300
    KAENAGLSSA AGLLREQVAQ LKQKVMTHVS NGCQLLLGVK GHAF 344
    Length:344
    Mass (Da):35,765
    Last modified:July 1, 1989 - v1
    Checksum:i6F52D4FECC32E234
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti53 – 531P → S in BAC40473. (PubMed:16141072)Curated
    Sequence conflicti200 – 2001G → R in AAA74916. (PubMed:8530030)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J03236 mRNA. Translation: AAA39343.1.
    U20735 Genomic DNA. Translation: AAA74916.1.
    AK088643 mRNA. Translation: BAC40473.1.
    BC003790 mRNA. Translation: AAH03790.1.
    X54332 mRNA. No translation available.
    CCDSiCCDS22488.1.
    PIRiA28963. TVMSJB.
    RefSeqiNP_032442.1. NM_008416.3.
    UniGeneiMm.1167.

    Genome annotation databases

    EnsembliENSMUST00000064922; ENSMUSP00000064680; ENSMUSG00000052837.
    GeneIDi16477.
    KEGGimmu:16477.
    UCSCiuc009mop.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J03236 mRNA. Translation: AAA39343.1 .
    U20735 Genomic DNA. Translation: AAA74916.1 .
    AK088643 mRNA. Translation: BAC40473.1 .
    BC003790 mRNA. Translation: AAH03790.1 .
    X54332 mRNA. No translation available.
    CCDSi CCDS22488.1.
    PIRi A28963. TVMSJB.
    RefSeqi NP_032442.1. NM_008416.3.
    UniGenei Mm.1167.

    3D structure databases

    ProteinModelPortali P09450.
    SMRi P09450. Positions 269-326.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200872. 4 interactions.
    DIPi DIP-1069N.
    IntActi P09450. 1 interaction.

    PTM databases

    PhosphoSitei P09450.

    Proteomic databases

    PRIDEi P09450.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000064922 ; ENSMUSP00000064680 ; ENSMUSG00000052837 .
    GeneIDi 16477.
    KEGGi mmu:16477.
    UCSCi uc009mop.1. mouse.

    Organism-specific databases

    CTDi 3726.
    MGIi MGI:96647. Junb.

    Phylogenomic databases

    eggNOGi NOG283376.
    HOGENOMi HOG000006648.
    HOVERGENi HBG001722.
    InParanoidi P09450.
    KOi K09028.
    OMAi LNAYCPN.
    OrthoDBi EOG75MVXV.
    PhylomeDBi P09450.

    Miscellaneous databases

    NextBioi 289767.
    PROi P09450.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P09450.
    Bgeei P09450.
    CleanExi MM_JUNB.
    Genevestigatori P09450.

    Family and domain databases

    Gene3Di 1.10.880.10. 1 hit.
    InterProi IPR004827. bZIP.
    IPR005643. JNK.
    IPR002112. Leuzip_Jun.
    IPR008917. TF_DNA-bd.
    [Graphical view ]
    Pfami PF00170. bZIP_1. 1 hit.
    PF03957. Jun. 1 hit.
    [Graphical view ]
    PRINTSi PR00043. LEUZIPPRJUN.
    SMARTi SM00338. BRLZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47454. SSF47454. 1 hit.
    PROSITEi PS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A gene activated by growth factors is related to the oncogene v-jun."
      Ryder K., Lau L.F., Nathans D.
      Proc. Natl. Acad. Sci. U.S.A. 85:1487-1491(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Complex genetic organization of junB: multiple blocks of flanking evolutionarily conserved sequence at the murine and human junB loci."
      Phinney D.G., Tseng S.W., Ryder K.
      Genomics 28:228-234(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: BALB/c.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: NOD.
      Tissue: Thymus.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary gland.
    5. "Complexity of the immediate early response of myeloid cells to terminal differentiation and growth arrest includes ICAM-1, Jun-B and histone variants."
      Lord K.A., Hoffman-Liebermann B., Liebermann D.A.
      Oncogene 5:387-396(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-30.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-256, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    7. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-237, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiJUNB_MOUSE
    AccessioniPrimary (citable) accession number: P09450
    Secondary accession number(s): Q8C2G9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 138 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3