Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Heat shock 70 kDa protein A

Gene

hsp-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • ATPase activity Source: WormBase
  • ATP binding Source: UniProtKB-KW

GO - Biological processi

  • determination of adult lifespan Source: WormBase
  • response to heat Source: WormBase
  • retrograde transport, endosome to Golgi Source: WormBase

Keywordsi

Biological processStress response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-3371453 Regulation of HSF1-mediated heat shock response
R-CEL-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-CEL-3371571 HSF1-dependent transactivation
R-CEL-6798695 Neutrophil degranulation
R-CEL-72163 mRNA Splicing - Major Pathway
R-CEL-8856828 Clathrin-mediated endocytosis
R-CEL-8876725 Protein methylation

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock 70 kDa protein A
Gene namesi
Name:hsp-1
Synonyms:hsp70a
ORF Names:F26D10.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiF26D10.3 ; CE09682 ; WBGene00002005 ; hsp-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000782981 – 640Heat shock 70 kDa protein AAdd BLAST640

Post-translational modificationi

AMPylated by fic-1.1 Publication

Proteomic databases

EPDiP09446
PaxDbiP09446
PeptideAtlasiP09446
PRIDEiP09446

2D gel databases

World-2DPAGEi0020:P09446

PTM databases

iPTMnetiP09446

Expressioni

Gene expression databases

BgeeiWBGene00002005

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi435836 interactors.
DIPiDIP-26882N
IntActiP09446 10 interactors.
MINTiP09446
STRINGi6239.F26D10.3.2

Structurei

Secondary structure

1640
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi542 – 554Combined sources13
Turni557 – 559Combined sources3
Helixi560 – 562Combined sources3
Helixi565 – 585Combined sources21
Helixi590 – 611Combined sources22

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2P32X-ray3.20A/B/C/D/E/F542-640[»]
4I2WX-ray3.60B631-640[»]
ProteinModelPortaliP09446
SMRiP09446
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP09446

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiKOG0101 Eukaryota
COG0443 LUCA
GeneTreeiENSGT00910000144045
HOGENOMiHOG000228135
InParanoidiP09446
KOiK03283
OMAiAYTKNQD
OrthoDBiEOG091G03SF
PhylomeDBiP09446

Family and domain databases

Gene3Di1.20.1270.101 hit
2.60.34.101 hit
InterProiView protein in InterPro
IPR018181 Heat_shock_70_CS
IPR029048 HSP70_C_sf
IPR029047 HSP70_peptide-bd_sf
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 1 hit
PRINTSiPR00301 HEATSHOCK70
SUPFAMiSSF100920 SSF100920, 1 hit
SSF100934 SSF100934, 1 hit
PROSITEiView protein in PROSITE
PS00297 HSP70_1, 1 hit
PS00329 HSP70_2, 1 hit
PS01036 HSP70_3, 1 hit

Sequencei

Sequence statusi: Complete.

P09446-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKHNAVGID LGTTYSCVGV FMHGKVEIIA NDQGNRTTPS YVAFTDTERL
60 70 80 90 100
IGDAAKNQVA MNPHNTVFDA KRLIGRKFDD PAVQSDMKHW PFKVISAEGA
110 120 130 140 150
KPKVQVEYKG ENKIFTPEEI SSMVLLKMKE TAEAFLGTTV KDAVVTVPAY
160 170 180 190 200
FNDSQRQATK DAGAIAGLNV LRIINEPTAA AIAYGLDKKG HGERNVLIFD
210 220 230 240 250
LGGGTFDVSI LTIEDGIFEV KSTAGDTHLG GEDFDNRMVN HFCAEFKRKH
260 270 280 290 300
KKDLASNPRA LRRLRTACER AKRTLSSSSQ ASIEIDSLFE GIDFYTNITR
310 320 330 340 350
ARFEELCADL FRSTMDPVEK SLRDAKMDKS QVHDIVLVGG STRIPKVQKL
360 370 380 390 400
LSDLFSGKEL NKSINPDEAV AYGAAVQAAI LSGDKSEAVQ DLLLLDVAPL
410 420 430 440 450
SLGIETAGGV MTALIKRNTT IPTKTAQTFT TYSDNQPGVL IQVYEGERAM
460 470 480 490 500
TKDNNLLGKF ELSGIPPAPR GVPQIEVTFD IDANGILNVS ATDKSTGKQN
510 520 530 540 550
KITITNDKGR LSKDDIERMV NEAEKYKADD EAQKDRIGAK NGLESYAFNL
560 570 580 590 600
KQTIEDEKLK DKISPEDKKK IEDKCDEILK WLDSNQTAEK EEFEHQQKDL
610 620 630 640
EGLANPIISK LYQSAGGAPP GAAPGGAAGG AGGPTIEEVD
Length:640
Mass (Da):69,723
Last modified:August 16, 2004 - v2
Checksum:i5D7B46B812E7A1DA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti130E → K in AAA28078 (PubMed:2841196).Curated1
Sequence conflicti137 – 138GT → EP in AAA28078 (PubMed:2841196).Curated2
Sequence conflicti149A → T in AAA28078 (PubMed:2841196).Curated1
Sequence conflicti272 – 273KR → NE in AAA28078 (PubMed:2841196).Curated2
Sequence conflicti279S → C in AAA28078 (PubMed:2841196).Curated1
Sequence conflicti370V → L in AAA28078 (PubMed:2841196).Curated1
Sequence conflicti499 – 501QNK → AKQ in AAA28078 (PubMed:2841196).Curated3
Sequence conflicti509 – 511GRL → DRF in AAA28078 (PubMed:2841196).Curated3
Sequence conflicti595H → S in AAA28078 (PubMed:2841196).Curated1
Sequence conflicti605 – 608NPII → KPDL in AAA28078 (PubMed:2841196).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18540 Genomic DNA Translation: AAA28078.1
Z80223 Genomic DNA Translation: CAB02319.1
PIRiJT0285 HHKW7A
T21394
RefSeqiNP_503068.1, NM_070667.4
UniGeneiCel.5111

Genome annotation databases

EnsemblMetazoaiF26D10.3.1; F26D10.3.1; WBGene00002005
F26D10.3.2; F26D10.3.2; WBGene00002005
GeneIDi178507
KEGGicel:CELE_F26D10.3
UCSCiF26D10.3.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiHSP7A_CAEEL
AccessioniPrimary (citable) accession number: P09446
Secondary accession number(s): Q93601
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: August 16, 2004
Last modified: March 28, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome