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Protein

Heat shock 70 kDa protein A

Gene

hsp-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • ATPase activity Source: WormBase
  • ATP binding Source: UniProtKB-KW

GO - Biological processi

  • determination of adult lifespan Source: WormBase
  • response to heat Source: WormBase
  • retrograde transport, endosome to Golgi Source: WormBase
Complete GO annotation...

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-3371453. Regulation of HSF1-mediated heat shock response.
R-CEL-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock 70 kDa protein A
Gene namesi
Name:hsp-1
Synonyms:hsp70a
ORF Names:F26D10.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiF26D10.3; CE09682; WBGene00002005; hsp-1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: WormBase
  • cytosol Source: WormBase
  • nucleus Source: WormBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 640640Heat shock 70 kDa protein APRO_0000078298Add
BLAST

Proteomic databases

EPDiP09446.
PaxDbiP09446.
PRIDEiP09446.

2D gel databases

World-2DPAGE0020:P09446.

PTM databases

iPTMnetiP09446.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
sti-1O162593EBI-322448,EBI-6514174
unc-45G5EG623EBI-322448,EBI-6675165

Protein-protein interaction databases

BioGridi43583. 6 interactions.
DIPiDIP-26882N.
IntActiP09446. 7 interactions.
MINTiMINT-211305.
STRINGi6239.F26D10.3.2.

Structurei

Secondary structure

1
640
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi542 – 55413Combined sources
Turni557 – 5593Combined sources
Helixi560 – 5623Combined sources
Helixi565 – 58521Combined sources
Helixi590 – 61122Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2P32X-ray3.20A/B/C/D/E/F542-640[»]
4I2WX-ray3.60B631-640[»]
ProteinModelPortaliP09446.
SMRiP09446. Positions 1-640.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP09446.

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiKOG0101. Eukaryota.
COG0443. LUCA.
GeneTreeiENSGT00820000127001.
HOGENOMiHOG000228135.
InParanoidiP09446.
KOiK03283.
OMAiGENKIFT.
PhylomeDBiP09446.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P09446-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKHNAVGID LGTTYSCVGV FMHGKVEIIA NDQGNRTTPS YVAFTDTERL
60 70 80 90 100
IGDAAKNQVA MNPHNTVFDA KRLIGRKFDD PAVQSDMKHW PFKVISAEGA
110 120 130 140 150
KPKVQVEYKG ENKIFTPEEI SSMVLLKMKE TAEAFLGTTV KDAVVTVPAY
160 170 180 190 200
FNDSQRQATK DAGAIAGLNV LRIINEPTAA AIAYGLDKKG HGERNVLIFD
210 220 230 240 250
LGGGTFDVSI LTIEDGIFEV KSTAGDTHLG GEDFDNRMVN HFCAEFKRKH
260 270 280 290 300
KKDLASNPRA LRRLRTACER AKRTLSSSSQ ASIEIDSLFE GIDFYTNITR
310 320 330 340 350
ARFEELCADL FRSTMDPVEK SLRDAKMDKS QVHDIVLVGG STRIPKVQKL
360 370 380 390 400
LSDLFSGKEL NKSINPDEAV AYGAAVQAAI LSGDKSEAVQ DLLLLDVAPL
410 420 430 440 450
SLGIETAGGV MTALIKRNTT IPTKTAQTFT TYSDNQPGVL IQVYEGERAM
460 470 480 490 500
TKDNNLLGKF ELSGIPPAPR GVPQIEVTFD IDANGILNVS ATDKSTGKQN
510 520 530 540 550
KITITNDKGR LSKDDIERMV NEAEKYKADD EAQKDRIGAK NGLESYAFNL
560 570 580 590 600
KQTIEDEKLK DKISPEDKKK IEDKCDEILK WLDSNQTAEK EEFEHQQKDL
610 620 630 640
EGLANPIISK LYQSAGGAPP GAAPGGAAGG AGGPTIEEVD
Length:640
Mass (Da):69,723
Last modified:August 16, 2004 - v2
Checksum:i5D7B46B812E7A1DA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti130 – 1301E → K in AAA28078 (PubMed:2841196).Curated
Sequence conflicti137 – 1382GT → EP in AAA28078 (PubMed:2841196).Curated
Sequence conflicti149 – 1491A → T in AAA28078 (PubMed:2841196).Curated
Sequence conflicti272 – 2732KR → NE in AAA28078 (PubMed:2841196).Curated
Sequence conflicti279 – 2791S → C in AAA28078 (PubMed:2841196).Curated
Sequence conflicti370 – 3701V → L in AAA28078 (PubMed:2841196).Curated
Sequence conflicti499 – 5013QNK → AKQ in AAA28078 (PubMed:2841196).Curated
Sequence conflicti509 – 5113GRL → DRF in AAA28078 (PubMed:2841196).Curated
Sequence conflicti595 – 5951H → S in AAA28078 (PubMed:2841196).Curated
Sequence conflicti605 – 6084NPII → KPDL in AAA28078 (PubMed:2841196).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18540 Genomic DNA. Translation: AAA28078.1.
Z80223 Genomic DNA. Translation: CAB02319.1.
PIRiJT0285. HHKW7A.
T21394.
RefSeqiNP_503068.1. NM_070667.4.
UniGeneiCel.5111.

Genome annotation databases

EnsemblMetazoaiF26D10.3.1; F26D10.3.1; WBGene00002005.
F26D10.3.2; F26D10.3.2; WBGene00002005.
GeneIDi178507.
KEGGicel:CELE_F26D10.3.
UCSCiF26D10.3.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18540 Genomic DNA. Translation: AAA28078.1.
Z80223 Genomic DNA. Translation: CAB02319.1.
PIRiJT0285. HHKW7A.
T21394.
RefSeqiNP_503068.1. NM_070667.4.
UniGeneiCel.5111.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2P32X-ray3.20A/B/C/D/E/F542-640[»]
4I2WX-ray3.60B631-640[»]
ProteinModelPortaliP09446.
SMRiP09446. Positions 1-640.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi43583. 6 interactions.
DIPiDIP-26882N.
IntActiP09446. 7 interactions.
MINTiMINT-211305.
STRINGi6239.F26D10.3.2.

PTM databases

iPTMnetiP09446.

2D gel databases

World-2DPAGE0020:P09446.

Proteomic databases

EPDiP09446.
PaxDbiP09446.
PRIDEiP09446.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF26D10.3.1; F26D10.3.1; WBGene00002005.
F26D10.3.2; F26D10.3.2; WBGene00002005.
GeneIDi178507.
KEGGicel:CELE_F26D10.3.
UCSCiF26D10.3.1. c. elegans.

Organism-specific databases

CTDi178507.
WormBaseiF26D10.3; CE09682; WBGene00002005; hsp-1.

Phylogenomic databases

eggNOGiKOG0101. Eukaryota.
COG0443. LUCA.
GeneTreeiENSGT00820000127001.
HOGENOMiHOG000228135.
InParanoidiP09446.
KOiK03283.
OMAiGENKIFT.
PhylomeDBiP09446.

Enzyme and pathway databases

ReactomeiR-CEL-3371453. Regulation of HSF1-mediated heat shock response.
R-CEL-72163. mRNA Splicing - Major Pathway.

Miscellaneous databases

EvolutionaryTraceiP09446.
PROiP09446.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The Caenorhabditis elegans hsp70 gene family: a molecular genetic characterization."
    Snutch T.P., Heschl M.F.P., Baillie D.L.
    Gene 64:241-255(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiHSP7A_CAEEL
AccessioniPrimary (citable) accession number: P09446
Secondary accession number(s): Q93601
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: August 16, 2004
Last modified: June 8, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.