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P09430

- STP1_HUMAN

UniProt

P09430 - STP1_HUMAN

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Protein

Spermatid nuclear transition protein 1

Gene

TNP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

In the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, non-nucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins.

GO - Molecular functioni

  1. DNA binding Source: UniProtKB

GO - Biological processi

  1. chromatin remodeling Source: UniProtKB
  2. chromatin silencing Source: UniProtKB
  3. fertilization, exchange of chromosomal proteins Source: UniProtKB
  4. multicellular organismal development Source: UniProtKB-KW
  5. negative regulation of transcription, DNA-templated Source: UniProtKB
  6. nucleosome disassembly Source: UniProtKB
  7. sexual reproduction Source: UniProtKB
  8. single strand break repair Source: UniProtKB
  9. spermatid development Source: UniProtKB
  10. spermatid nucleus differentiation Source: UniProtKB
  11. spermatid nucleus elongation Source: UniProtKB
  12. sperm motility Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Spermatid nuclear transition protein 1
Short name:
STP-1
Short name:
TP-1
Gene namesi
Name:TNP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:11951. TNP1.

Subcellular locationi

GO - Cellular componenti

  1. male germ cell nucleus Source: Ensembl
  2. nucleosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36640.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 5554Spermatid nuclear transition protein 1PRO_0000191417Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei9 – 91PhosphoserineBy similarity
Modified residuei40 – 401PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP09430.

PTM databases

PhosphoSiteiP09430.

Expressioni

Tissue specificityi

Expressed by spermatids (at protein level).1 Publication

Gene expression databases

BgeeiP09430.
CleanExiHS_TNP1.
ExpressionAtlasiP09430. baseline and differential.
GenevestigatoriP09430.

Organism-specific databases

HPAiHPA044387.

Interactioni

Protein-protein interaction databases

BioGridi112995. 8 interactions.
STRINGi9606.ENSP00000236979.

Structurei

3D structure databases

ProteinModelPortaliP09430.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG43993.
HOGENOMiHOG000136637.
HOVERGENiHBG004485.
InParanoidiP09430.
OMAiKRCDDAN.
OrthoDBiEOG7MSMS7.
PhylomeDBiP09430.
TreeFamiTF338391.

Family and domain databases

InterProiIPR001319. Nuclear_transition_prot1.
IPR020062. Nuclear_transition_prot1_CS.
[Graphical view]
PANTHERiPTHR17486. PTHR17486. 1 hit.
PfamiPF02079. TP1. 1 hit.
[Graphical view]
ProDomiPD010292. TP1. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00541. TP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09430-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTSRKLKSH GMRRSKSRSP HKGVKRGGSK RKYRKGNLKS RKRGDDANRN

YRSHL
Length:55
Mass (Da):6,424
Last modified:January 23, 2007 - v2
Checksum:iE29C58EB2AADF3BB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M59924 Genomic DNA. Translation: AAA61202.1.
X07948 mRNA. Translation: CAA30774.1.
BC029516 mRNA. Translation: AAH29516.1.
CCDSiCCDS2406.1.
PIRiA37106. BGHU.
RefSeqiNP_003275.1. NM_003284.3.
UniGeneiHs.3017.

Genome annotation databases

EnsembliENST00000236979; ENSP00000236979; ENSG00000118245.
GeneIDi7141.
KEGGihsa:7141.
UCSCiuc002vgk.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M59924 Genomic DNA. Translation: AAA61202.1 .
X07948 mRNA. Translation: CAA30774.1 .
BC029516 mRNA. Translation: AAH29516.1 .
CCDSi CCDS2406.1.
PIRi A37106. BGHU.
RefSeqi NP_003275.1. NM_003284.3.
UniGenei Hs.3017.

3D structure databases

ProteinModelPortali P09430.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112995. 8 interactions.
STRINGi 9606.ENSP00000236979.

PTM databases

PhosphoSitei P09430.

Proteomic databases

PRIDEi P09430.

Protocols and materials databases

DNASUi 7141.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000236979 ; ENSP00000236979 ; ENSG00000118245 .
GeneIDi 7141.
KEGGi hsa:7141.
UCSCi uc002vgk.3. human.

Organism-specific databases

CTDi 7141.
GeneCardsi GC02M217724.
HGNCi HGNC:11951. TNP1.
HPAi HPA044387.
MIMi 190231. gene.
neXtProti NX_P09430.
PharmGKBi PA36640.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG43993.
HOGENOMi HOG000136637.
HOVERGENi HBG004485.
InParanoidi P09430.
OMAi KRCDDAN.
OrthoDBi EOG7MSMS7.
PhylomeDBi P09430.
TreeFami TF338391.

Miscellaneous databases

GeneWikii TNP1.
GenomeRNAii 7141.
NextBioi 27953.
PROi P09430.
SOURCEi Search...

Gene expression databases

Bgeei P09430.
CleanExi HS_TNP1.
ExpressionAtlasi P09430. baseline and differential.
Genevestigatori P09430.

Family and domain databases

InterProi IPR001319. Nuclear_transition_prot1.
IPR020062. Nuclear_transition_prot1_CS.
[Graphical view ]
PANTHERi PTHR17486. PTHR17486. 1 hit.
Pfami PF02079. TP1. 1 hit.
[Graphical view ]
ProDomi PD010292. TP1. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
PROSITEi PS00541. TP1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of human transition protein 1 cDNA."
    Luerssen H., Hoyer-Fender S., Engel W.
    Nucleic Acids Res. 16:7723-7723(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Nucleotide sequence of the gene for human transition protein 1 and its chromosomal localization on chromosome 2."
    Luerssen H., Mattei M.-G., Schroeter M., Grzeschik K.H., Adham I.M., Engel W.
    Genomics 8:324-330(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. "Expression of mRNA and protein of nucleoproteins during human spermiogenesis."
    Steger K., Klonisch T., Gavenis K., Drabent B., Doenecke D., Bergmann M.
    Mol. Hum. Reprod. 4:939-945(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiSTP1_HUMAN
AccessioniPrimary (citable) accession number: P09430
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3