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Protein

Spermatid nuclear transition protein 1

Gene

TNP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.By similarity

GO - Molecular functioni

  • DNA binding Source: UniProtKB

GO - Biological processi

  • chromatin remodeling Source: UniProtKB
  • chromatin silencing Source: UniProtKB
  • fertilization, exchange of chromosomal proteins Source: UniProtKB
  • flagellated sperm motility Source: UniProtKB
  • multicellular organism development Source: UniProtKB-KW
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • nucleosome disassembly Source: UniProtKB
  • positive regulation of protein processing Source: UniProtKB
  • sexual reproduction Source: UniProtKB
  • single strand break repair Source: UniProtKB
  • spermatid development Source: UniProtKB
  • spermatid nucleus differentiation Source: UniProtKB
  • spermatid nucleus elongation Source: UniProtKB
  • spermatogenesis, exchange of chromosomal proteins Source: UniProtKB

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Spermatid nuclear transition protein 1
Short name:
STP-1
Short name:
TP-1
Gene namesi
Name:TNP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:11951. TNP1.

Subcellular locationi

  • Nucleus By similarity
  • Chromosome By similarity

  • Note: Loaded onto the nucleosomes of condensing spermatids.By similarity

GO - Cellular componenti

  • male germ cell nucleus Source: GO_Central
  • nuclear nucleosome Source: UniProtKB
  • nucleosome Source: UniProtKB
  • nucleus Source: UniProtKB

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7141.
OpenTargetsiENSG00000118245.
PharmGKBiPA36640.

Polymorphism and mutation databases

BioMutaiTNP1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001914172 – 55Spermatid nuclear transition protein 1Add BLAST54

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9PhosphoserineBy similarity1
Modified residuei40PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP09430.
PRIDEiP09430.

PTM databases

iPTMnetiP09430.
PhosphoSitePlusiP09430.

Expressioni

Tissue specificityi

Expressed by spermatids (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000118245.
CleanExiHS_TNP1.
ExpressionAtlasiP09430. baseline and differential.
GenevisibleiP09430. HS.

Organism-specific databases

HPAiHPA044387.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SDCBP2Q9H1903EBI-10196343,EBI-742426

Protein-protein interaction databases

BioGridi112995. 9 interactors.
IntActiP09430. 2 interactors.
STRINGi9606.ENSP00000236979.

Structurei

3D structure databases

ProteinModelPortaliP09430.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410JJTU. Eukaryota.
ENOG4111B50. LUCA.
GeneTreeiENSGT00390000000539.
HOGENOMiHOG000136637.
HOVERGENiHBG004485.
InParanoidiP09430.
OMAiKRCDDAN.
PhylomeDBiP09430.
TreeFamiTF338391.

Family and domain databases

InterProiView protein in InterPro
IPR001319. Nuclear_transition_prot1.
IPR020062. Nuclear_transition_prot1_CS.
PANTHERiPTHR17486. PTHR17486. 1 hit.
PfamiView protein in Pfam
PF02079. TP1. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD010292. TP1. 1 hit.
PROSITEiView protein in PROSITE
PS00541. TP1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09430-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTSRKLKSH GMRRSKSRSP HKGVKRGGSK RKYRKGNLKS RKRGDDANRN

YRSHL
Length:55
Mass (Da):6,424
Last modified:January 23, 2007 - v2
Checksum:iE29C58EB2AADF3BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59924 Genomic DNA. Translation: AAA61202.1.
X07948 mRNA. Translation: CAA30774.1.
BC029516 mRNA. Translation: AAH29516.1.
CCDSiCCDS2406.1.
PIRiA37106. BGHU.
RefSeqiNP_003275.1. NM_003284.3.
UniGeneiHs.3017.

Genome annotation databases

EnsembliENST00000236979; ENSP00000236979; ENSG00000118245.
GeneIDi7141.
KEGGihsa:7141.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiSTP1_HUMAN
AccessioniPrimary (citable) accession number: P09430
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: July 5, 2017
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families