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Protein

Spermatid nuclear transition protein 1

Gene

TNP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

In the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, non-nucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins.

GO - Molecular functioni

  • DNA binding Source: UniProtKB

GO - Biological processi

  • chromatin remodeling Source: UniProtKB
  • chromatin silencing Source: UniProtKB
  • fertilization, exchange of chromosomal proteins Source: UniProtKB
  • multicellular organismal development Source: UniProtKB-KW
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • nucleosome disassembly Source: UniProtKB
  • sexual reproduction Source: UniProtKB
  • single strand break repair Source: UniProtKB
  • spermatid development Source: UniProtKB
  • spermatid nucleus differentiation Source: UniProtKB
  • spermatid nucleus elongation Source: UniProtKB
  • sperm motility Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Spermatid nuclear transition protein 1
Short name:
STP-1
Short name:
TP-1
Gene namesi
Name:TNP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:11951. TNP1.

Subcellular locationi

GO - Cellular componenti

  • male germ cell nucleus Source: Ensembl
  • nucleosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36640.

Polymorphism and mutation databases

BioMutaiTNP1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 5554Spermatid nuclear transition protein 1PRO_0000191417Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei9 – 91PhosphoserineBy similarity
Modified residuei40 – 401PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP09430.

PTM databases

PhosphoSiteiP09430.

Expressioni

Tissue specificityi

Expressed by spermatids (at protein level).1 Publication

Gene expression databases

BgeeiP09430.
CleanExiHS_TNP1.
ExpressionAtlasiP09430. baseline and differential.
GenevestigatoriP09430.

Organism-specific databases

HPAiHPA044387.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SDCBP2Q9H1903EBI-10196343,EBI-742426

Protein-protein interaction databases

BioGridi112995. 9 interactions.
IntActiP09430. 1 interaction.
STRINGi9606.ENSP00000236979.

Structurei

3D structure databases

ProteinModelPortaliP09430.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG43993.
HOGENOMiHOG000136637.
HOVERGENiHBG004485.
InParanoidiP09430.
OMAiKRCDDAN.
OrthoDBiEOG7MSMS7.
PhylomeDBiP09430.
TreeFamiTF338391.

Family and domain databases

InterProiIPR001319. Nuclear_transition_prot1.
IPR020062. Nuclear_transition_prot1_CS.
[Graphical view]
PANTHERiPTHR17486. PTHR17486. 1 hit.
PfamiPF02079. TP1. 1 hit.
[Graphical view]
ProDomiPD010292. TP1. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00541. TP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09430-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTSRKLKSH GMRRSKSRSP HKGVKRGGSK RKYRKGNLKS RKRGDDANRN

YRSHL
Length:55
Mass (Da):6,424
Last modified:January 23, 2007 - v2
Checksum:iE29C58EB2AADF3BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59924 Genomic DNA. Translation: AAA61202.1.
X07948 mRNA. Translation: CAA30774.1.
BC029516 mRNA. Translation: AAH29516.1.
CCDSiCCDS2406.1.
PIRiA37106. BGHU.
RefSeqiNP_003275.1. NM_003284.3.
UniGeneiHs.3017.

Genome annotation databases

EnsembliENST00000236979; ENSP00000236979; ENSG00000118245.
GeneIDi7141.
KEGGihsa:7141.
UCSCiuc002vgk.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59924 Genomic DNA. Translation: AAA61202.1.
X07948 mRNA. Translation: CAA30774.1.
BC029516 mRNA. Translation: AAH29516.1.
CCDSiCCDS2406.1.
PIRiA37106. BGHU.
RefSeqiNP_003275.1. NM_003284.3.
UniGeneiHs.3017.

3D structure databases

ProteinModelPortaliP09430.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112995. 9 interactions.
IntActiP09430. 1 interaction.
STRINGi9606.ENSP00000236979.

PTM databases

PhosphoSiteiP09430.

Polymorphism and mutation databases

BioMutaiTNP1.

Proteomic databases

PRIDEiP09430.

Protocols and materials databases

DNASUi7141.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000236979; ENSP00000236979; ENSG00000118245.
GeneIDi7141.
KEGGihsa:7141.
UCSCiuc002vgk.3. human.

Organism-specific databases

CTDi7141.
GeneCardsiGC02M217724.
HGNCiHGNC:11951. TNP1.
HPAiHPA044387.
MIMi190231. gene.
neXtProtiNX_P09430.
PharmGKBiPA36640.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG43993.
HOGENOMiHOG000136637.
HOVERGENiHBG004485.
InParanoidiP09430.
OMAiKRCDDAN.
OrthoDBiEOG7MSMS7.
PhylomeDBiP09430.
TreeFamiTF338391.

Miscellaneous databases

GeneWikiiTNP1.
GenomeRNAii7141.
NextBioi27953.
PROiP09430.
SOURCEiSearch...

Gene expression databases

BgeeiP09430.
CleanExiHS_TNP1.
ExpressionAtlasiP09430. baseline and differential.
GenevestigatoriP09430.

Family and domain databases

InterProiIPR001319. Nuclear_transition_prot1.
IPR020062. Nuclear_transition_prot1_CS.
[Graphical view]
PANTHERiPTHR17486. PTHR17486. 1 hit.
PfamiPF02079. TP1. 1 hit.
[Graphical view]
ProDomiPD010292. TP1. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00541. TP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of human transition protein 1 cDNA."
    Luerssen H., Hoyer-Fender S., Engel W.
    Nucleic Acids Res. 16:7723-7723(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Nucleotide sequence of the gene for human transition protein 1 and its chromosomal localization on chromosome 2."
    Luerssen H., Mattei M.-G., Schroeter M., Grzeschik K.H., Adham I.M., Engel W.
    Genomics 8:324-330(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. "Expression of mRNA and protein of nucleoproteins during human spermiogenesis."
    Steger K., Klonisch T., Gavenis K., Drabent B., Doenecke D., Bergmann M.
    Mol. Hum. Reprod. 4:939-945(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiSTP1_HUMAN
AccessioniPrimary (citable) accession number: P09430
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: April 29, 2015
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.