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P09430 (STP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Spermatid nuclear transition protein 1

Short name=STP-1
Short name=TP-1
Gene names
Name:TNP1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length55 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

In the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, non-nucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins.

Subcellular location

Nucleus. Chromosome.

Tissue specificity

Expressed by spermatids (at protein level). Ref.4

Sequence similarities

Belongs to the nuclear transition protein 1 family.

Ontologies

Keywords
   Biological processDifferentiation
Spermatogenesis
   Cellular componentChromosome
Nucleosome core
Nucleus
   LigandDNA-binding
   Molecular functionDevelopmental protein
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processchromatin remodeling

Inferred from direct assay PubMed 12743712. Source: UniProtKB

chromatin silencing

Inferred from expression pattern PubMed 11315969. Source: UniProtKB

fertilization, exchange of chromosomal proteins

Traceable author statement PubMed 12743712. Source: UniProtKB

multicellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

negative regulation of transcription, DNA-templated

Inferred from direct assay PubMed 12743712. Source: UniProtKB

nucleosome disassembly

Inferred from mutant phenotype PubMed 10781074. Source: UniProtKB

sexual reproduction

Inferred from mutant phenotype PubMed 10781074. Source: UniProtKB

single strand break repair

Inferred from direct assay PubMed 12743712. Source: UniProtKB

sperm motility

Inferred from mutant phenotype PubMed 10781074. Source: UniProtKB

spermatid development

Inferred from direct assay PubMed 12743712. Source: UniProtKB

spermatid nucleus differentiation

Traceable author statement PubMed 12743712. Source: UniProtKB

spermatid nucleus elongation

Inferred from mutant phenotype PubMed 10781074. Source: UniProtKB

   Cellular_componentmale germ cell nucleus

Inferred from electronic annotation. Source: Ensembl

nucleosome

Inferred from direct assay PubMed 12743712. Source: UniProtKB

   Molecular_functionDNA binding

Inferred from mutant phenotype PubMed 12743712. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 5554Spermatid nuclear transition protein 1
PRO_0000191417

Amino acid modifications

Modified residue91Phosphoserine By similarity
Modified residue401Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
P09430 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: E29C58EB2AADF3BB

FASTA556,424
        10         20         30         40         50 
MSTSRKLKSH GMRRSKSRSP HKGVKRGGSK RKYRKGNLKS RKRGDDANRN YRSHL 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of human transition protein 1 cDNA."
Luerssen H., Hoyer-Fender S., Engel W.
Nucleic Acids Res. 16:7723-7723(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Nucleotide sequence of the gene for human transition protein 1 and its chromosomal localization on chromosome 2."
Luerssen H., Mattei M.-G., Schroeter M., Grzeschik K.H., Adham I.M., Engel W.
Genomics 8:324-330(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[4]"Expression of mRNA and protein of nucleoproteins during human spermiogenesis."
Steger K., Klonisch T., Gavenis K., Drabent B., Doenecke D., Bergmann M.
Mol. Hum. Reprod. 4:939-945(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M59924 Genomic DNA. Translation: AAA61202.1.
X07948 mRNA. Translation: CAA30774.1.
BC029516 mRNA. Translation: AAH29516.1.
PIRBGHU. A37106.
RefSeqNP_003275.1. NM_003284.3.
UniGeneHs.3017.

3D structure databases

ProteinModelPortalP09430.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112995. 8 interactions.
STRING9606.ENSP00000236979.

PTM databases

PhosphoSiteP09430.

Proteomic databases

PRIDEP09430.

Protocols and materials databases

DNASU7141.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000236979; ENSP00000236979; ENSG00000118245.
GeneID7141.
KEGGhsa:7141.
UCSCuc002vgk.3. human.

Organism-specific databases

CTD7141.
GeneCardsGC02M217724.
HGNCHGNC:11951. TNP1.
HPAHPA044387.
MIM190231. gene.
neXtProtNX_P09430.
PharmGKBPA36640.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG43993.
HOGENOMHOG000136637.
HOVERGENHBG004485.
InParanoidP09430.
OMAKRCDDAN.
OrthoDBEOG7MSMS7.
PhylomeDBP09430.
TreeFamTF338391.

Gene expression databases

ArrayExpressP09430.
BgeeP09430.
CleanExHS_TNP1.
GenevestigatorP09430.

Family and domain databases

InterProIPR001319. Nuclear_transition_prot1.
IPR020062. Nuclear_transition_prot1_CS.
[Graphical view]
PANTHERPTHR17486. PTHR17486. 1 hit.
PfamPF02079. TP1. 1 hit.
[Graphical view]
ProDomPD010292. TP1. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEPS00541. TP1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiTNP1.
GenomeRNAi7141.
NextBio27953.
PROP09430.
SOURCESearch...

Entry information

Entry nameSTP1_HUMAN
AccessionPrimary (citable) accession number: P09430
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM