P09430 (STP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Spermatid nuclear transition protein 1
Short name=STP-1
Short name=TP-1

Gene names

Name:

TNP1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	55 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	In the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, non-nucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins.
Subcellular location	Nucleus. Chromosome.
Tissue specificity	Expressed by spermatids (at protein level). Ref.4
Sequence similarities	Belongs to the nuclear transition protein 1 family.

Ontologies

Keywords
Biological process	Differentiation Spermatogenesis
Cellular component	Chromosome Nucleosome core Nucleus
Ligand	DNA-binding
Molecular function	Developmental protein
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chromatin silencing Inferred from expression pattern PubMed 11315969. Source: UniProtKB fertilization, exchange of chromosomal proteins Traceable author statement PubMed 12743712. Source: UniProtKB multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW nucleosome disassembly Inferred from mutant phenotype PubMed 10781074. Source: UniProtKB single strand break repair Inferred from direct assay PubMed 12743712. Source: UniProtKB sperm motility Inferred from mutant phenotype PubMed 10781074. Source: UniProtKB spermatid nucleus elongation Inferred from mutant phenotype PubMed 10781074. Source: UniProtKB
Cellular_component	male germ cell nucleus Inferred from electronic annotation. Source: Compara nucleosome Inferred from direct assay PubMed 12743712. Source: UniProtKB
Molecular_function	DNA binding Inferred from mutant phenotype PubMed 12743712. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed
	Chain	2 – 55	54	Spermatid nuclear transition protein 1		PRO_0000191417
Amino acid modifications
	Modified residue	9	1	Phosphoserine By similarity
	Modified residue	40	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P09430 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: E29C58EB2AADF3BB	FASTA	55	6,424
	10 20 30 40 50 MSTSRKLKSH GMRRSKSRSP HKGVKRGGSK RKYRKGNLKS RKRGDDANRN YRSHL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of human transition protein 1 cDNA." Luerssen H., Hoyer-Fender S., Engel W. Nucleic Acids Res. 16:7723-7723(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Nucleotide sequence of the gene for human transition protein 1 and its chromosomal localization on chromosome 2." Luerssen H., Mattei M.-G., Schroeter M., Grzeschik K.H., Adham I.M., Engel W. Genomics 8:324-330(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[4]	"Expression of mRNA and protein of nucleoproteins during human spermiogenesis." Steger K., Klonisch T., Gavenis K., Drabent B., Doenecke D., Bergmann M. Mol. Hum. Reprod. 4:939-945(1998) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M59924 Genomic DNA. Translation: AAA61202.1. X07948 mRNA. Translation: CAA30774.1. BC029516 mRNA. Translation: AAH29516.1.
IPI	IPI00216238.
PIR	BGHU. A37106.
RefSeq	NP_003275.1. NM_003284.3.
UniGene	Hs.3017.
3D structure databases
ProteinModelPortal	P09430.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000236979.
PTM databases
PhosphoSite	P09430.
Polymorphism databases
DMDM	134978.
Proteomic databases
PRIDE	P09430.
Protocols and materials databases
DNASU	7141.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000236979; ENSP00000236979; ENSG00000118245.
GeneID	7141.
KEGG	hsa:7141.
UCSC	uc002vgk.3. human.
Organism-specific databases
CTD	7141.
GeneCards	GC02M217724.
HGNC	HGNC:11951. TNP1.
HPA	HPA044387.
MIM	190231. gene.
neXtProt	NX_P09430.
PharmGKB	PA36640.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG43993.
HOGENOM	HOG000136637.
HOVERGEN	HBG004485.
InParanoid	P09430.
OMA	KRCDDAN.
OrthoDB	EOG4VHK87.
PhylomeDB	P09430.
Gene expression databases
ArrayExpress	P09430.
Bgee	P09430.
CleanEx	HS_TNP1.
Genevestigator	P09430.
GermOnline	ENSG00000118245. Homo sapiens.
Family and domain databases
InterPro	IPR001319. Nuclear_transition_prot1. IPR020062. Nuclear_transition_prot1_CS. [Graphical view]
PANTHER	PTHR17486. PTHR17486. 1 hit.
Pfam	PF02079. TP1. 1 hit. [Graphical view]
ProDom	PD010292. TP1. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00541. TP1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	7141.
NextBio	27953.
SOURCE	Search...

Entry information

Entry name

STP1_HUMAN

Accession

Primary (citable) accession number: P09430

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 107 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.