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P09430

- STP1_HUMAN

UniProt

P09430 - STP1_HUMAN

Protein

Spermatid nuclear transition protein 1

Gene

TNP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    In the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, non-nucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins.

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB

    GO - Biological processi

    1. chromatin remodeling Source: UniProtKB
    2. chromatin silencing Source: UniProtKB
    3. fertilization, exchange of chromosomal proteins Source: UniProtKB
    4. multicellular organismal development Source: UniProtKB-KW
    5. negative regulation of transcription, DNA-templated Source: UniProtKB
    6. nucleosome disassembly Source: UniProtKB
    7. sexual reproduction Source: UniProtKB
    8. single strand break repair Source: UniProtKB
    9. spermatid development Source: UniProtKB
    10. spermatid nucleus differentiation Source: UniProtKB
    11. spermatid nucleus elongation Source: UniProtKB
    12. sperm motility Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Spermatogenesis

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Spermatid nuclear transition protein 1
    Short name:
    STP-1
    Short name:
    TP-1
    Gene namesi
    Name:TNP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:11951. TNP1.

    Subcellular locationi

    GO - Cellular componenti

    1. male germ cell nucleus Source: Ensembl
    2. nucleosome Source: UniProtKB

    Keywords - Cellular componenti

    Chromosome, Nucleosome core, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36640.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 5554Spermatid nuclear transition protein 1PRO_0000191417Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei9 – 91PhosphoserineBy similarity
    Modified residuei40 – 401PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiP09430.

    PTM databases

    PhosphoSiteiP09430.

    Expressioni

    Tissue specificityi

    Expressed by spermatids (at protein level).1 Publication

    Gene expression databases

    ArrayExpressiP09430.
    BgeeiP09430.
    CleanExiHS_TNP1.
    GenevestigatoriP09430.

    Organism-specific databases

    HPAiHPA044387.

    Interactioni

    Protein-protein interaction databases

    BioGridi112995. 8 interactions.
    STRINGi9606.ENSP00000236979.

    Structurei

    3D structure databases

    ProteinModelPortaliP09430.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG43993.
    HOGENOMiHOG000136637.
    HOVERGENiHBG004485.
    InParanoidiP09430.
    OMAiKRCDDAN.
    OrthoDBiEOG7MSMS7.
    PhylomeDBiP09430.
    TreeFamiTF338391.

    Family and domain databases

    InterProiIPR001319. Nuclear_transition_prot1.
    IPR020062. Nuclear_transition_prot1_CS.
    [Graphical view]
    PANTHERiPTHR17486. PTHR17486. 1 hit.
    PfamiPF02079. TP1. 1 hit.
    [Graphical view]
    ProDomiPD010292. TP1. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    PROSITEiPS00541. TP1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P09430-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTSRKLKSH GMRRSKSRSP HKGVKRGGSK RKYRKGNLKS RKRGDDANRN   50
    YRSHL 55
    Length:55
    Mass (Da):6,424
    Last modified:January 23, 2007 - v2
    Checksum:iE29C58EB2AADF3BB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M59924 Genomic DNA. Translation: AAA61202.1.
    X07948 mRNA. Translation: CAA30774.1.
    BC029516 mRNA. Translation: AAH29516.1.
    CCDSiCCDS2406.1.
    PIRiA37106. BGHU.
    RefSeqiNP_003275.1. NM_003284.3.
    UniGeneiHs.3017.

    Genome annotation databases

    EnsembliENST00000236979; ENSP00000236979; ENSG00000118245.
    GeneIDi7141.
    KEGGihsa:7141.
    UCSCiuc002vgk.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M59924 Genomic DNA. Translation: AAA61202.1 .
    X07948 mRNA. Translation: CAA30774.1 .
    BC029516 mRNA. Translation: AAH29516.1 .
    CCDSi CCDS2406.1.
    PIRi A37106. BGHU.
    RefSeqi NP_003275.1. NM_003284.3.
    UniGenei Hs.3017.

    3D structure databases

    ProteinModelPortali P09430.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112995. 8 interactions.
    STRINGi 9606.ENSP00000236979.

    PTM databases

    PhosphoSitei P09430.

    Proteomic databases

    PRIDEi P09430.

    Protocols and materials databases

    DNASUi 7141.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000236979 ; ENSP00000236979 ; ENSG00000118245 .
    GeneIDi 7141.
    KEGGi hsa:7141.
    UCSCi uc002vgk.3. human.

    Organism-specific databases

    CTDi 7141.
    GeneCardsi GC02M217724.
    HGNCi HGNC:11951. TNP1.
    HPAi HPA044387.
    MIMi 190231. gene.
    neXtProti NX_P09430.
    PharmGKBi PA36640.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG43993.
    HOGENOMi HOG000136637.
    HOVERGENi HBG004485.
    InParanoidi P09430.
    OMAi KRCDDAN.
    OrthoDBi EOG7MSMS7.
    PhylomeDBi P09430.
    TreeFami TF338391.

    Miscellaneous databases

    GeneWikii TNP1.
    GenomeRNAii 7141.
    NextBioi 27953.
    PROi P09430.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P09430.
    Bgeei P09430.
    CleanExi HS_TNP1.
    Genevestigatori P09430.

    Family and domain databases

    InterProi IPR001319. Nuclear_transition_prot1.
    IPR020062. Nuclear_transition_prot1_CS.
    [Graphical view ]
    PANTHERi PTHR17486. PTHR17486. 1 hit.
    Pfami PF02079. TP1. 1 hit.
    [Graphical view ]
    ProDomi PD010292. TP1. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    PROSITEi PS00541. TP1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of human transition protein 1 cDNA."
      Luerssen H., Hoyer-Fender S., Engel W.
      Nucleic Acids Res. 16:7723-7723(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Nucleotide sequence of the gene for human transition protein 1 and its chromosomal localization on chromosome 2."
      Luerssen H., Mattei M.-G., Schroeter M., Grzeschik K.H., Adham I.M., Engel W.
      Genomics 8:324-330(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    4. "Expression of mRNA and protein of nucleoproteins during human spermiogenesis."
      Steger K., Klonisch T., Gavenis K., Drabent B., Doenecke D., Bergmann M.
      Mol. Hum. Reprod. 4:939-945(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiSTP1_HUMAN
    AccessioniPrimary (citable) accession number: P09430
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3