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Protein

Interleukin-1 beta

Gene

IL1B

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production.By similarity

Miscellaneous

IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Mitogen, Pyrogen
Biological processInflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 beta
Short name:
IL-1 beta
Gene namesi
Name:IL1B
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Lysosome, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000152831 – 113Add BLAST113
ChainiPRO_0000015284114 – 266Interleukin-1 betaAdd BLAST153

Proteomic databases

PaxDbiP09428.
PRIDEiP09428.

Interactioni

Subunit structurei

Monomer. Interacts with MEFV (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001745.

Structurei

3D structure databases

ProteinModelPortaliP09428.
SMRiP09428.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-1 family.Curated

Phylogenomic databases

eggNOGiENOG410IGSZ. Eukaryota.
ENOG410XU2E. LUCA.
HOGENOMiHOG000246399.
HOVERGENiHBG007328.
InParanoidiP09428.
KOiK04519.
TreeFamiTF300203.

Family and domain databases

InterProiView protein in InterPro
IPR003296. IL-1_beta.
IPR020877. IL-1_CS.
IPR000975. IL-1_fam.
IPR003502. IL-1_propep.
IPR008996. IL1/FGF.
PANTHERiPTHR10078:SF42. PTHR10078:SF42. 1 hit.
PfamiView protein in Pfam
PF00340. IL1. 1 hit.
PF02394. IL1_propep. 1 hit.
PRINTSiPR00264. INTERLEUKIN1.
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiView protein in PROSITE
PS00253. INTERLEUKIN_1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09428-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATVPEPINE MMAYYSDENE LLFEADDPKQ MKSCIQHLDL GSMGDGNIQL
60 70 80 90 100
QISHQFYNKS FRQVVSVIVA MEKLRNSAYA HVFHDDDLRS ILSFIFEEEP
110 120 130 140 150
VIFETSSDEF LCDAPVQSIK CKLQDREQKS LVLASPCVLK ALHLLSQEMN
160 170 180 190 200
REVVFCMSFV QGEERDNKIP VALGIKDKNL YLSCVKKGDT PTLQLEEVDP
210 220 230 240 250
KVYPKRNMEK RFVFYKTEIK NTVEFESVLY PNWYISTSQI EERPVFLGHF
260
RGGQDITDFR METLSP
Length:266
Mass (Da):30,760
Last modified:March 18, 2008 - v2
Checksum:i9D1EF8F575070218
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27D → G in ABX72065 (Ref. 3) Curated1
Sequence conflicti252G → A in AAA30585 (PubMed:3262866).Curated1
Sequence conflicti252G → A in CAA31018 (PubMed:3262866).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35589 mRNA. Translation: AAA30585.1.
X12498 mRNA. Translation: CAA31018.1.
M37211 mRNA. Translation: AAA30584.1.
EU276067 mRNA. Translation: ABX72065.1.
PIRiJL0010. ICBO1B.
RefSeqiNP_776518.1. NM_174093.1.
UniGeneiBt.4856.

Genome annotation databases

GeneIDi281251.
KEGGibta:281251.

Similar proteinsi

Entry informationi

Entry nameiIL1B_BOVIN
AccessioniPrimary (citable) accession number: P09428
Secondary accession number(s): A9QWQ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: March 18, 2008
Last modified: August 30, 2017
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families