P09425 (VG25_BPT4) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tail lysozyme
EC=3.2.1.17

Alternative name(s):
Outer wedge of baseplate protein
Protein Gp25

Gene names

Name:

25

Organism

Enterobacteria phage T4 (Bacteriophage T4) [Reference proteome]

Taxonomic identifier

10665 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Caudovirales › Myoviridae › Tevenvirinae › T4likevirus › Enterobacteria phage T4 sensu lato

Virus host

Escherichia coli [TaxID: 562]

Protein attributes

Sequence length	132 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This protein is a structural component of the outer wedge of the baseplate and has acidic lysozyme activity. Ref.1
Catalytic activity	Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.
Sequence similarities	Belongs to the GpW/Gp25 family.

Ontologies

Keywords
Developmental stage	Late protein
Molecular function	Antimicrobial Bacteriolytic enzyme Glycosidase Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	amine metabolic process Inferred from electronic annotation. Source: InterPro cytolysis Inferred from electronic annotation. Source: UniProtKB-KW defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	copper ion binding Inferred from electronic annotation. Source: InterPro lysozyme activity Inferred from electronic annotation. Source: EC quinone binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 132	132	Tail lysozyme		PRO_0000165013

Sequences

	Sequence		Length	Mass (Da)
	P09425 [UniParc]. Last modified July 1, 1989. Version 1. Checksum: 16C2803EE5B12B0B	FASTA	132	15,095
	10 20 30 40 50 60 MANINKLYSD IDPEMKMDWN KDVSRSLGLR SIKNSLLGII TTRKGSRPFD PEFGCDLSDQ 70 80 90 100 110 120 LFENMTPLTA DTVERNIESA VRNYEPRIDK LAVNVIPVYD DYTLIVEIRF SVIDNPDDIE 130 QIKLQLASSN RV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Bacteriophage T4 gene 25." Gruidl M.E., Canan N., Mosig G. Nucleic Acids Res. 16:9862-9862(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION. Strain: D.
[2]	"Two bacteriophage T4 base plate genes (25 and 26) and the DNA repair gene uvsY belong to spatially and temporally overlapping transcription units." Gruidl M.E., Chen T.C., Gargano S., Storlazzi A., Cascino A., Mosig G. Virology 184:359-369(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Bacteriophage T4 genome." Miller E.S., Kutter E., Mosig G., Arisaka F., Kunisawa T., Ruger W. Microbiol. Mol. Biol. Rev. 67:86-156(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Sequence and transcripts of the bacteriophage T4 DNA repair gene uvsY." Gruidl M.E., Mosig G. Genetics 114:1061-1079(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 6-132.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X05134 Genomic DNA. Translation: CAA28777.1. M77695 Genomic DNA. Translation: AAA32549.1. AF158101 Genomic DNA. Translation: AAD42433.1. X04856 Genomic DNA. Translation: CAA28547.1.
PIR	GYBPT4. JF0054.
RefSeq	NP_049800.1. NC_000866.4.
3D structure databases
ProteinModelPortal	P09425.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1258633.
Phylogenomic databases
ProtClustDB	PHA0415.
Family and domain databases
Gene3D	3.10.450.40. 1 hit.
InterPro	IPR015801. Cu_amine_oxidase_N2/3. IPR007048. GpW/Gp25/IraD. [Graphical view]
Pfam	PF04965. GPW_gp25. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VG25_BPT4

Accession

Primary (citable) accession number: P09425

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	May 29, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program