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P09425

- VG25_BPT4

UniProt

P09425 - VG25_BPT4

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Protein

Tail lysozyme

Gene
25
Organism
Enterobacteria phage T4 (Bacteriophage T4)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

This protein is a structural component of the outer wedge of the baseplate and has acidic lysozyme activity.1 Publication

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. lysozyme activity Source: UniProtKB-EC
  3. quinone binding Source: InterPro

GO - Biological processi

  1. amine metabolic process Source: InterPro
  2. cytolysis Source: UniProtKB-KW
  3. defense response to bacterium Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Protein family/group databases

TCDBi1.K.1.1.1. the gp27/5 t4-baseplate (t4-bp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Tail lysozyme (EC:3.2.1.17)
Alternative name(s):
Outer wedge of baseplate protein
Protein Gp25
Gene namesi
Name:25
OrganismiEnterobacteria phage T4 (Bacteriophage T4)
Taxonomic identifieri10665 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaeTevenvirinaeT4likevirus
Virus hostiEscherichia coli [TaxID: 562]
ProteomesiUP000009087: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 132132Tail lysozymePRO_0000165013Add
BLAST

Expressioni

Keywords - Developmental stagei

Late protein

Structurei

Secondary structure

1
132
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi21 – 4020
Helixi60 – 634
Helixi69 – 8416
Beta strandi88 – 9811
Turni99 – 1024
Beta strandi103 – 11210
Beta strandi115 – 12612

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4HRZX-ray2.47A/B1-132[»]
ProteinModelPortaliP09425.

Family & Domainsi

Sequence similaritiesi

Belongs to the GpW/Gp25 family.

Family and domain databases

Gene3Di3.10.450.40. 1 hit.
InterProiIPR015801. Cu_amine_oxidase_N2/3.
IPR007048. GpW/Gp25/IraD.
[Graphical view]
PfamiPF04965. GPW_gp25. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P09425-1 [UniParc]FASTAAdd to Basket

« Hide

MANINKLYSD IDPEMKMDWN KDVSRSLGLR SIKNSLLGII TTRKGSRPFD    50
PEFGCDLSDQ LFENMTPLTA DTVERNIESA VRNYEPRIDK LAVNVIPVYD 100
DYTLIVEIRF SVIDNPDDIE QIKLQLASSN RV 132
Length:132
Mass (Da):15,095
Last modified:July 1, 1989 - v1
Checksum:i16C2803EE5B12B0B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X05134 Genomic DNA. Translation: CAA28777.1.
M77695 Genomic DNA. Translation: AAA32549.1.
AF158101 Genomic DNA. Translation: AAD42433.1.
X04856 Genomic DNA. Translation: CAA28547.1.
PIRiJF0054. GYBPT4.
RefSeqiNP_049800.1. NC_000866.4.

Genome annotation databases

GeneIDi1258633.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X05134 Genomic DNA. Translation: CAA28777.1 .
M77695 Genomic DNA. Translation: AAA32549.1 .
AF158101 Genomic DNA. Translation: AAD42433.1 .
X04856 Genomic DNA. Translation: CAA28547.1 .
PIRi JF0054. GYBPT4.
RefSeqi NP_049800.1. NC_000866.4.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4HRZ X-ray 2.47 A/B 1-132 [» ]
ProteinModelPortali P09425.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

TCDBi 1.K.1.1.1. the gp27/5 t4-baseplate (t4-bp) family.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1258633.

Family and domain databases

Gene3Di 3.10.450.40. 1 hit.
InterProi IPR015801. Cu_amine_oxidase_N2/3.
IPR007048. GpW/Gp25/IraD.
[Graphical view ]
Pfami PF04965. GPW_gp25. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
    Strain: D.
  2. "Two bacteriophage T4 base plate genes (25 and 26) and the DNA repair gene uvsY belong to spatially and temporally overlapping transcription units."
    Gruidl M.E., Chen T.C., Gargano S., Storlazzi A., Cascino A., Mosig G.
    Virology 184:359-369(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Sequence and transcripts of the bacteriophage T4 DNA repair gene uvsY."
    Gruidl M.E., Mosig G.
    Genetics 114:1061-1079(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 6-132.

Entry informationi

Entry nameiVG25_BPT4
AccessioniPrimary (citable) accession number: P09425
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: May 14, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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