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P09425

- VG25_BPT4

UniProt

P09425 - VG25_BPT4

Protein

Tail lysozyme

Gene

25

Organism
Enterobacteria phage T4 (Bacteriophage T4)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    This protein is a structural component of the outer wedge of the baseplate and has acidic lysozyme activity.1 Publication

    Catalytic activityi

    Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. lysozyme activity Source: UniProtKB-EC
    3. quinone binding Source: InterPro

    GO - Biological processi

    1. amine metabolic process Source: InterPro
    2. cytolysis Source: UniProtKB-KW
    3. defense response to bacterium Source: UniProtKB-KW

    Keywords - Molecular functioni

    Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

    Protein family/group databases

    TCDBi1.K.1.1.1. the gp27/5 t4-baseplate (t4-bp) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tail lysozyme (EC:3.2.1.17)
    Alternative name(s):
    Outer wedge of baseplate protein
    Protein Gp25
    Gene namesi
    Name:25
    OrganismiEnterobacteria phage T4 (Bacteriophage T4)
    Taxonomic identifieri10665 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaeTevenvirinaeT4likevirus
    Virus hostiEscherichia coli [TaxID: 562]
    ProteomesiUP000009087: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 132132Tail lysozymePRO_0000165013Add
    BLAST

    Expressioni

    Keywords - Developmental stagei

    Late protein

    Structurei

    Secondary structure

    1
    132
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi21 – 4020
    Helixi60 – 634
    Helixi69 – 8416
    Beta strandi88 – 9811
    Turni99 – 1024
    Beta strandi103 – 11210
    Beta strandi115 – 12612

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4HRZX-ray2.47A/B1-132[»]
    ProteinModelPortaliP09425.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GpW/Gp25 family.Curated

    Family and domain databases

    Gene3Di3.10.450.40. 1 hit.
    InterProiIPR015801. Cu_amine_oxidase_N2/3.
    IPR007048. GpW/Gp25/IraD.
    [Graphical view]
    PfamiPF04965. GPW_gp25. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P09425-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANINKLYSD IDPEMKMDWN KDVSRSLGLR SIKNSLLGII TTRKGSRPFD    50
    PEFGCDLSDQ LFENMTPLTA DTVERNIESA VRNYEPRIDK LAVNVIPVYD 100
    DYTLIVEIRF SVIDNPDDIE QIKLQLASSN RV 132
    Length:132
    Mass (Da):15,095
    Last modified:July 1, 1989 - v1
    Checksum:i16C2803EE5B12B0B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X05134 Genomic DNA. Translation: CAA28777.1.
    M77695 Genomic DNA. Translation: AAA32549.1.
    AF158101 Genomic DNA. Translation: AAD42433.1.
    X04856 Genomic DNA. Translation: CAA28547.1.
    PIRiJF0054. GYBPT4.
    RefSeqiNP_049800.1. NC_000866.4.

    Genome annotation databases

    GeneIDi1258633.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X05134 Genomic DNA. Translation: CAA28777.1 .
    M77695 Genomic DNA. Translation: AAA32549.1 .
    AF158101 Genomic DNA. Translation: AAD42433.1 .
    X04856 Genomic DNA. Translation: CAA28547.1 .
    PIRi JF0054. GYBPT4.
    RefSeqi NP_049800.1. NC_000866.4.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4HRZ X-ray 2.47 A/B 1-132 [» ]
    ProteinModelPortali P09425.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    TCDBi 1.K.1.1.1. the gp27/5 t4-baseplate (t4-bp) family.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1258633.

    Family and domain databases

    Gene3Di 3.10.450.40. 1 hit.
    InterProi IPR015801. Cu_amine_oxidase_N2/3.
    IPR007048. GpW/Gp25/IraD.
    [Graphical view ]
    Pfami PF04965. GPW_gp25. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
      Strain: D.
    2. "Two bacteriophage T4 base plate genes (25 and 26) and the DNA repair gene uvsY belong to spatially and temporally overlapping transcription units."
      Gruidl M.E., Chen T.C., Gargano S., Storlazzi A., Cascino A., Mosig G.
      Virology 184:359-369(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Sequence and transcripts of the bacteriophage T4 DNA repair gene uvsY."
      Gruidl M.E., Mosig G.
      Genetics 114:1061-1079(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 6-132.

    Entry informationi

    Entry nameiVG25_BPT4
    AccessioniPrimary (citable) accession number: P09425
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3