P09404 (PGK_ZYMMO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoglycerate kinase
EC=2.7.2.3

Gene names

Name:	pgk
Ordered Locus Names:	ZMO0178

Organism

Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4) [Complete proteome] [HAMAP]

Taxonomic identifier

264203 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Sphingomonadales › Sphingomonadaceae › Zymomonas › Zymomonas mobilis › Zymomonas mobilis subsp. mobilis

Protein attributes

Sequence length	397 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145
Subunit structure	Monomer.
Subcellular location	Cytoplasm HAMAP-Rule MF_00145.
Sequence similarities	Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
Biological process	Glycolysis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoglycerate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 397	397	Phosphoglycerate kinase HAMAP-Rule MF_00145		PRO_0000146048
Regions
	Nucleotide binding	354 – 357	4	ATP By similarity
	Region	22 – 24	3	Substrate binding By similarity
	Region	60 – 63	4	Substrate binding By similarity
Sites
	Binding site	37	1	Substrate By similarity
	Binding site	119	1	Substrate By similarity
	Binding site	152	1	Substrate By similarity
	Binding site	202	1	ATP By similarity
	Binding site	324	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P09404 [UniParc]. Last modified July 1, 1989. Version 1. Checksum: F4EABD81139C5E20	FASTA	397	41,388
	10 20 30 40 50 60 MAFRTLDDIG DVKGKRVLVR EDLNVPMDGD RVTDDTRLRA AIPTVNELAE KGAKVLILAH 70 80 90 100 110 120 FGRPKGQPNP EMSLARIKDA LAGVLGRPVH FINDIKGEAA AKAVDALNPG AVALLENTRF 130 140 150 160 170 180 YAGEEKNDPA LAAEVAKLGD FYVNDAFSAA HRAHVSTEGL AHKLPAFAGR AMQKELEALE 190 200 210 220 230 240 AALGKPTHPV AAVVGGAKVS TKLDVLTNLV SKVDHLIIGG GMANTFLAAQ GVDVGKSLCE 250 260 270 280 290 300 HELKDTVKGI FAAAEKTGCK IHLPSDVVVA KEFKANPPIR TIPVSDVAAD EMILDVGPKA 310 320 330 340 350 360 VAALTEVLKA SKTLVWNGPL GAFEIEPFDK ATVALAKEAA ALTKAGSLIS VAGGGDTVAA 370 380 390 LNHAGVAKDF SFVSTAGGAF LEWMEGKELP GVKALEA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Phosphoglycerate kinase gene from Zymomonas mobilis: cloning, sequencing, and localization within the gap operon." Conway T., Ingram L.O. J. Bacteriol. 170:1926-1933(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The genome sequence of the ethanologenic bacterium Zymomonas mobilis ZM4." Seo J.-S., Chong H., Park H.S., Yoon K.-O., Jung C., Kim J.J., Hong J.H., Kim H., Kim J.-H., Kil J.-I., Park C.J., Oh H.-M., Lee J.-S., Jin S.-J., Um H.-W., Lee H.-J., Oh S.-J., Kim J.Y. , Kang H.L., Lee S.Y., Lee K.J., Kang H.S. Nat. Biotechnol. 23:63-68(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 31821 / ZM4 / CP4.
[3]	"Glyceraldehyde-3-phosphate dehydrogenase gene from Zymomonas mobilis: cloning, sequencing, and identification of promoter region." Conway T., Sewell G.W., Ingram L.O. J. Bacteriol. 169:5653-5662(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-30.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M19376 Genomic DNA. Translation: AAA27699.1. AE008692 Genomic DNA. Translation: AAV88802.1. M18802 Genomic DNA. Translation: AAA27689.1.
PIR	KIZYG. A27745.
RefSeq	YP_161913.1. NC_006526.2.
3D structure databases
ProteinModelPortal	P09404.
ModBase	Search...
Protein-protein interaction databases
STRING	264203.ZMO0178.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAV88802; AAV88802; ZMO0178.
GeneID	3188246.
KEGG	zmo:ZMO0178.
PATRIC	32565710. VBIZymMob102260_0172.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0126.
HOGENOM	HOG000227107.
KO	K00927.
OMA	MANDSIG.
ProtClustDB	PRK00073.
Enzyme and pathway databases
SABIO-RK	P09404.
UniPathway	UPA00109; UER00185.
Family and domain databases
Gene3D	3.40.50.1260. 1 hit. 3.40.50.1270. 1 hit.
HAMAP	MF_00145. Phosphoglyc_kinase.
InterPro	IPR001576. Phosphoglycerate_kinase. IPR015901. Phosphoglycerate_kinase_C. IPR015911. Phosphoglycerate_kinase_CS. IPR015824. Phosphoglycerate_kinase_N. [Graphical view]
PANTHER	PTHR11406. PTHR11406. 1 hit.
Pfam	PF00162. PGK. 1 hit. [Graphical view]
PIRSF	PIRSF000724. Pgk. 1 hit.
PRINTS	PR00477. PHGLYCKINASE.
SUPFAM	SSF53748. PGK. 1 hit.
PROSITE	PS00111. PGLYCERATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGK_ZYMMO

Accession

Primary (citable) accession number: P09404
Secondary accession number(s): Q5NR52

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	May 1, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program