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P09403

- PGK_THET8

UniProt

P09403 - PGK_THET8

Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei34 – 341SubstrateBy similarity
    Binding sitei115 – 1151SubstrateBy similarity
    Binding sitei148 – 1481SubstrateBy similarity
    Binding sitei198 – 1981ATPBy similarity
    Binding sitei289 – 2891ATP; via carbonyl oxygenBy similarity
    Binding sitei320 – 3201ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi347 – 3504ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTTHE300852:GH8R-939-MONOMER.
    UniPathwayiUPA00109; UER00185.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoglycerate kinase (EC:2.7.2.3)
    Gene namesi
    Name:pgk
    Ordered Locus Names:TTHA0906
    OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
    Taxonomic identifieri300852 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
    ProteomesiUP000000532: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed
    Chaini2 – 390389Phosphoglycerate kinasePRO_0000146027Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.

    Protein-protein interaction databases

    STRINGi300852.TTHA0906.

    Structurei

    Secondary structure

    1
    390
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi4 – 63
    Beta strandi13 – 175
    Beta strandi28 – 303
    Helixi33 – 4715
    Beta strandi51 – 555
    Helixi66 – 683
    Helixi71 – 8010
    Beta strandi84 – 863
    Helixi94 – 1018
    Beta strandi108 – 1103
    Helixi114 – 1163
    Turni118 – 1236
    Helixi125 – 1317
    Helixi132 – 1343
    Beta strandi136 – 1405
    Helixi143 – 1453
    Turni151 – 1555
    Helixi156 – 1583
    Beta strandi162 – 1643
    Helixi166 – 17611
    Turni177 – 1793
    Beta strandi184 – 1907
    Helixi195 – 1973
    Helixi199 – 2057
    Helixi206 – 2083
    Beta strandi210 – 2145
    Helixi219 – 2257
    Helixi237 – 2393
    Helixi240 – 25314
    Beta strandi256 – 2583
    Beta strandi261 – 2688
    Beta strandi276 – 2794
    Beta strandi288 – 2925
    Helixi294 – 30310
    Turni304 – 3063
    Beta strandi308 – 3147
    Turni322 – 3254
    Helixi326 – 33611
    Beta strandi342 – 3476
    Helixi348 – 3558
    Turni356 – 3583
    Helixi360 – 3623
    Beta strandi363 – 3664
    Beta strandi369 – 3713
    Helixi372 – 3798
    Helixi383 – 3864

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1V6SX-ray1.50A/B1-390[»]
    ProteinModelPortaliP09403.
    SMRiP09403. Positions 1-390.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP09403.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni19 – 213Substrate bindingBy similarity
    Regioni57 – 604Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the phosphoglycerate kinase family.Curated

    Phylogenomic databases

    eggNOGiCOG0126.
    HOGENOMiHOG000227108.
    KOiK00927.
    OMAiAGHPVGK.
    OrthoDBiEOG64N9Z0.
    PhylomeDBiP09403.

    Family and domain databases

    Gene3Di3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPiMF_00145. Phosphoglyc_kinase.
    InterProiIPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view]
    PANTHERiPTHR11406. PTHR11406. 1 hit.
    PfamiPF00162. PGK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000724. Pgk. 1 hit.
    PRINTSiPR00477. PHGLYCKINASE.
    SUPFAMiSSF53748. SSF53748. 1 hit.
    PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P09403-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRTLLDLDPK GKRVLVRVDY NVPVQDGKVQ DETRILESLP TLRHLLAGGA    50
    SLVLLSHLGR PKGPDPKYSL APVGEALRAH LPEARFAPFP PGSEEARREA 100
    EALRPGEVLL LENVRFEPGE EKNDPELSAR YARLGEAFVL DAFGSAHRAH 150
    ASVVGVARLL PAYAGFLMEK EVRALSRLLK DPERPYAVVL GGAKVSDKIG 200
    VIESLLPRID RLLIGGAMAF TFLKALGGEV GRSLVEEDRL DLAKDLLGRA 250
    EALGVRVYLP EDVVAAERIE AGVETRVFPA RAIPVPYMGL DIGPKTREAF 300
    ARALEGARTV FWNGPMGVFE VPPFDEGTLA VGQAIAALEG AFTVVGGGDS 350
    VAAVNRLGLK ERFGHVSTGG GASLEFLEKG TLPGLEVLEG 390
    Length:390
    Mass (Da):41,777
    Last modified:January 23, 2007 - v3
    Checksum:i3829E89FCEDC90B3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X12464 Genomic DNA. Translation: CAA31006.1.
    AP008226 Genomic DNA. Translation: BAD70729.1.
    RefSeqiWP_011228285.1. NC_006461.1.
    YP_144172.1. NC_006461.1.

    Genome annotation databases

    EnsemblBacteriaiBAD70729; BAD70729; BAD70729.
    GeneIDi3169950.
    KEGGittj:TTHA0906.
    PATRICi23956792. VBITheThe93045_0898.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X12464 Genomic DNA. Translation: CAA31006.1 .
    AP008226 Genomic DNA. Translation: BAD70729.1 .
    RefSeqi WP_011228285.1. NC_006461.1.
    YP_144172.1. NC_006461.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1V6S X-ray 1.50 A/B 1-390 [» ]
    ProteinModelPortali P09403.
    SMRi P09403. Positions 1-390.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 300852.TTHA0906.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD70729 ; BAD70729 ; BAD70729 .
    GeneIDi 3169950.
    KEGGi ttj:TTHA0906.
    PATRICi 23956792. VBITheThe93045_0898.

    Phylogenomic databases

    eggNOGi COG0126.
    HOGENOMi HOG000227108.
    KOi K00927.
    OMAi AGHPVGK.
    OrthoDBi EOG64N9Z0.
    PhylomeDBi P09403.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00185 .
    BioCyci TTHE300852:GH8R-939-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P09403.

    Family and domain databases

    Gene3Di 3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPi MF_00145. Phosphoglyc_kinase.
    InterProi IPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view ]
    PANTHERi PTHR11406. PTHR11406. 1 hit.
    Pfami PF00162. PGK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000724. Pgk. 1 hit.
    PRINTSi PR00477. PHGLYCKINASE.
    SUPFAMi SSF53748. SSF53748. 1 hit.
    PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of the phosphoglycerate kinase gene from the extreme thermophile Thermus thermophilus. Comparison of the deduced amino acid sequence with that of the mesophilic yeast phosphoglycerate kinase."
      Bowen D., Littlechild J.A., Fothergill J.E., Watson H.C., Hall L.
      Biochem. J. 254:509-517(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
    2. "Complete genome sequence of Thermus thermophilus HB8."
      Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HB8 / ATCC 27634 / DSM 579.

    Entry informationi

    Entry nameiPGK_THET8
    AccessioniPrimary (citable) accession number: P09403
    Secondary accession number(s): Q5SJV2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 106 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3