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P09403

- PGK_THET8

UniProt

P09403 - PGK_THET8

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Protein

Phosphoglycerate kinase

Gene
pgk, TTHA0906
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei34 – 341Substrate By similarity
Binding sitei115 – 1151Substrate By similarity
Binding sitei148 – 1481Substrate By similarity
Binding sitei198 – 1981ATP By similarity
Binding sitei289 – 2891ATP; via carbonyl oxygen By similarity
Binding sitei320 – 3201ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi347 – 3504ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-939-MONOMER.
UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:pgk
Ordered Locus Names:TTHA0906
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000532: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedUniRule annotation
Chaini2 – 390389Phosphoglycerate kinaseUniRule annotationPRO_0000146027Add
BLAST

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

STRINGi300852.TTHA0906.

Structurei

Secondary structure

1
390
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 63
Beta strandi13 – 175
Beta strandi28 – 303
Helixi33 – 4715
Beta strandi51 – 555
Helixi66 – 683
Helixi71 – 8010
Beta strandi84 – 863
Helixi94 – 1018
Beta strandi108 – 1103
Helixi114 – 1163
Turni118 – 1236
Helixi125 – 1317
Helixi132 – 1343
Beta strandi136 – 1405
Helixi143 – 1453
Turni151 – 1555
Helixi156 – 1583
Beta strandi162 – 1643
Helixi166 – 17611
Turni177 – 1793
Beta strandi184 – 1907
Helixi195 – 1973
Helixi199 – 2057
Helixi206 – 2083
Beta strandi210 – 2145
Helixi219 – 2257
Helixi237 – 2393
Helixi240 – 25314
Beta strandi256 – 2583
Beta strandi261 – 2688
Beta strandi276 – 2794
Beta strandi288 – 2925
Helixi294 – 30310
Turni304 – 3063
Beta strandi308 – 3147
Turni322 – 3254
Helixi326 – 33611
Beta strandi342 – 3476
Helixi348 – 3558
Turni356 – 3583
Helixi360 – 3623
Beta strandi363 – 3664
Beta strandi369 – 3713
Helixi372 – 3798
Helixi383 – 3864

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1V6SX-ray1.50A/B1-390[»]
ProteinModelPortaliP09403.
SMRiP09403. Positions 1-390.

Miscellaneous databases

EvolutionaryTraceiP09403.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni19 – 213Substrate binding By similarity
Regioni57 – 604Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0126.
HOGENOMiHOG000227108.
KOiK00927.
OMAiAGHPVGK.
OrthoDBiEOG64N9Z0.
PhylomeDBiP09403.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09403-1 [UniParc]FASTAAdd to Basket

« Hide

MRTLLDLDPK GKRVLVRVDY NVPVQDGKVQ DETRILESLP TLRHLLAGGA    50
SLVLLSHLGR PKGPDPKYSL APVGEALRAH LPEARFAPFP PGSEEARREA 100
EALRPGEVLL LENVRFEPGE EKNDPELSAR YARLGEAFVL DAFGSAHRAH 150
ASVVGVARLL PAYAGFLMEK EVRALSRLLK DPERPYAVVL GGAKVSDKIG 200
VIESLLPRID RLLIGGAMAF TFLKALGGEV GRSLVEEDRL DLAKDLLGRA 250
EALGVRVYLP EDVVAAERIE AGVETRVFPA RAIPVPYMGL DIGPKTREAF 300
ARALEGARTV FWNGPMGVFE VPPFDEGTLA VGQAIAALEG AFTVVGGGDS 350
VAAVNRLGLK ERFGHVSTGG GASLEFLEKG TLPGLEVLEG 390
Length:390
Mass (Da):41,777
Last modified:January 23, 2007 - v3
Checksum:i3829E89FCEDC90B3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X12464 Genomic DNA. Translation: CAA31006.1.
AP008226 Genomic DNA. Translation: BAD70729.1.
RefSeqiWP_011228285.1. NC_006461.1.
YP_144172.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD70729; BAD70729; BAD70729.
GeneIDi3169950.
KEGGittj:TTHA0906.
PATRICi23956792. VBITheThe93045_0898.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X12464 Genomic DNA. Translation: CAA31006.1 .
AP008226 Genomic DNA. Translation: BAD70729.1 .
RefSeqi WP_011228285.1. NC_006461.1.
YP_144172.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1V6S X-ray 1.50 A/B 1-390 [» ]
ProteinModelPortali P09403.
SMRi P09403. Positions 1-390.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 300852.TTHA0906.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD70729 ; BAD70729 ; BAD70729 .
GeneIDi 3169950.
KEGGi ttj:TTHA0906.
PATRICi 23956792. VBITheThe93045_0898.

Phylogenomic databases

eggNOGi COG0126.
HOGENOMi HOG000227108.
KOi K00927.
OMAi AGHPVGK.
OrthoDBi EOG64N9Z0.
PhylomeDBi P09403.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00185 .
BioCyci TTHE300852:GH8R-939-MONOMER.

Miscellaneous databases

EvolutionaryTracei P09403.

Family and domain databases

Gene3Di 3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPi MF_00145. Phosphoglyc_kinase.
InterProi IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view ]
PANTHERi PTHR11406. PTHR11406. 1 hit.
Pfami PF00162. PGK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000724. Pgk. 1 hit.
PRINTSi PR00477. PHGLYCKINASE.
SUPFAMi SSF53748. SSF53748. 1 hit.
PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of the phosphoglycerate kinase gene from the extreme thermophile Thermus thermophilus. Comparison of the deduced amino acid sequence with that of the mesophilic yeast phosphoglycerate kinase."
    Bowen D., Littlechild J.A., Fothergill J.E., Watson H.C., Hall L.
    Biochem. J. 254:509-517(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
  2. "Complete genome sequence of Thermus thermophilus HB8."
    Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB8 / ATCC 27634 / DSM 579.

Entry informationi

Entry nameiPGK_THET8
AccessioniPrimary (citable) accession number: P09403
Secondary accession number(s): Q5SJV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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