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Protein

Modification methylase SPBetaI

Gene
N/A
Organism
Bacillus phage SPbeta (Bacillus phage SPBc2) (Bacteriophage SP-beta)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This enzyme methylates the first cytosine within the sequences GGCC and GCNGC.

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei78PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processRestriction system
LigandS-adenosyl-L-methionine

Protein family/group databases

REBASEi2833 M.SPBetaI

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase SPBetaI (EC:2.1.1.37)
Short name:
M.SPBetaI
Alternative name(s):
Cytosine-specific methyltransferase SPBetaI
OrganismiBacillus phage SPbeta (Bacillus phage SPBc2) (Bacteriophage SP-beta)
Taxonomic identifieri66797 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesSiphoviridaeSpbetavirus
Virus hostiBacillus pumilus (Bacillus mesentericus) [TaxID: 1408]
Bacillus subtilis [TaxID: 1423]

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000878671 – ›257Modification methylase SPBetaIAdd BLAST›257

Structurei

3D structure databases

ProteinModelPortaliP09389
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 257SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd BLAST254

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation

Family and domain databases

InterProiView protein in InterPro
IPR018117 C5_DNA_meth_AS
IPR001525 C5_MeTfrase
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF00145 DNA_methylase, 2 hits
SUPFAMiSSF53335 SSF53335, 3 hits
PROSITEiView protein in PROSITE
PS00094 C5_MTASE_1, 1 hit
PS51679 SAM_MT_C5, 1 hit

Sequencei

Sequence statusi: Fragments.

P09389-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKLRVMSLF SGIGAFEAAL RNIGVDYELI GFSEIDKYAI KSYCAIHNVS
60 70 80 90 100
ETLNVGDISK AKKDNIPYFD LLTSGFPCPT FSVAGGRDGM EYKCSNCSHE
110 120 130 140 150
HLITYEDYKK GVKCPKCEAV SKAKDERGTL FFETALLAEE KKPLMVGHVD
160 170 180 190 200
LKGHDAIKRV YSPEGLSPTL TTMGGGHREP KIAEKQKEVR AVLTPEREEK
210 220 230 240 250
RQNGRRFKEN GEPAFTVNTI DRHGVAIGEY PKYKIRKLSP LECWRLQAFD

DEDFEKA
Length:257
Mass (Da):28,880
Last modified:July 1, 1989 - v1
Checksum:i33063418AD8187BB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-adjacent residuesi143 – 144Curated2
Non-terminal residuei2571

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19513 Genomic DNA Translation: AAA32601.1
M19514 Genomic DNA Translation: AAA32602.1

Entry informationi

Entry nameiMTBB_BPSPB
AccessioniPrimary (citable) accession number: P09389
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: March 28, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

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