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P09389

- MTBB_BPSPB

UniProt

P09389 - MTBB_BPSPB

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Protein

Modification methylase SPBetaI

Gene
N/A
Organism
Bacillus phage SPbeta (Bacillus phage SPBc2) (Bacteriophage SP-beta)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

This enzyme methylates the first cytosine within the sequences GGCC and GCNGC.

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei78 – 781PROSITE-ProRule annotation

GO - Molecular functioni

  1. DNA (cytosine-5-)-methyltransferase activity Source: UniProtKB-EC
  2. DNA binding Source: InterPro

GO - Biological processi

  1. DNA restriction-modification system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Restriction system

Keywords - Ligandi

S-adenosyl-L-methionine

Protein family/group databases

REBASEi2833. M.SPBetaI.

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase SPBetaI (EC:2.1.1.37)
Short name:
M.SPBetaI
Alternative name(s):
Cytosine-specific methyltransferase SPBetaI
OrganismiBacillus phage SPbeta (Bacillus phage SPBc2) (Bacteriophage SP-beta)
Taxonomic identifieri66797 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesSiphoviridaeSpbetalikevirus
Virus hostiBacillus pumilus (Bacillus mesentericus) [TaxID: 1408]
Bacillus subtilis [TaxID: 1423]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›257›257Modification methylase SPBetaIPRO_0000087867Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP09389.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 257254SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation
Contains 1 SAM-dependent MTase C5-type domain.PROSITE-ProRule annotation

Family and domain databases

Gene3Di3.40.50.150. 2 hits.
InterProiIPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PANTHERiPTHR10629. PTHR10629. 1 hit.
PfamiPF00145. DNA_methylase. 2 hits.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 3 hits.
PROSITEiPS00094. C5_MTASE_1. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragments.

P09389 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKLRVMSLF SGIGAFEAAL RNIGVDYELI GFSEIDKYAI KSYCAIHNVS
60 70 80 90 100
ETLNVGDISK AKKDNIPYFD LLTSGFPCPT FSVAGGRDGM EYKCSNCSHE
110 120 130 140 150
HLITYEDYKK GVKCPKCEAV SKAKDERGTL FFETALLAEE KKPLMVGHVD
160 170 180 190 200
LKGHDAIKRV YSPEGLSPTL TTMGGGHREP KIAEKQKEVR AVLTPEREEK
210 220 230 240 250
RQNGRRFKEN GEPAFTVNTI DRHGVAIGEY PKYKIRKLSP LECWRLQAFD

DEDFEKA
Length:257
Mass (Da):28,880
Last modified:July 1, 1989 - v1
Checksum:i33063418AD8187BB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-adjacent residuesi143 – 1442Curated
Non-terminal residuei257 – 2571

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M19513 Genomic DNA. Translation: AAA32601.1.
M19514 Genomic DNA. Translation: AAA32602.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M19513 Genomic DNA. Translation: AAA32601.1 .
M19514 Genomic DNA. Translation: AAA32602.1 .

3D structure databases

ProteinModelPortali P09389.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

REBASEi 2833. M.SPBetaI.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.150. 2 hits.
InterProi IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
PANTHERi PTHR10629. PTHR10629. 1 hit.
Pfami PF00145. DNA_methylase. 2 hits.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 3 hits.
PROSITEi PS00094. C5_MTASE_1. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "DNA methyltransferase genes of Bacillus subtilis phages: comparison of their nucleotide sequences."
    Tran-Betcke A., Behrens B., Noyer-Weidner M., Trautner T.A.
    Gene 42:89-96(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiMTBB_BPSPB
AccessioniPrimary (citable) accession number: P09389
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 1, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3