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P09382

- LEG1_HUMAN

UniProt

P09382 - LEG1_HUMAN

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Protein
Galectin-1
Gene
LGALS1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.3 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei53 – 531Beta-galactoside
Binding sitei62 – 621Beta-galactoside

GO - Molecular functioni

  1. galactoside binding Source: InterPro
  2. lactose binding Source: Ensembl
  3. poly(A) RNA binding Source: UniProtKB
  4. protein binding Source: IntAct
  5. signal transducer activity Source: UniProtKB

GO - Biological processi

  1. T cell costimulation Source: Ensembl
  2. apoptotic process Source: ProtInc
  3. cellular response to glucose stimulus Source: Ensembl
  4. cellular response to organic cyclic compound Source: Ensembl
  5. multicellular organismal response to stress Source: Ensembl
  6. myoblast differentiation Source: Ensembl
  7. negative regulation of cell-substrate adhesion Source: Ensembl
  8. negative regulation of neuron projection development Source: Ensembl
  9. plasma cell differentiation Source: Ensembl
  10. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  11. positive regulation of erythrocyte aggregation Source: Ensembl
  12. regulation of apoptotic process Source: UniProtKB
  13. response to axon injury Source: Ensembl
  14. response to drug Source: Ensembl
  15. signal transduction Source: GOC
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-1
Short name:
Gal-1
Alternative name(s):
14 kDa laminin-binding protein
Short name:
HLBP14
14 kDa lectin
Beta-galactoside-binding lectin L-14-I
Galaptin
HBL
HPL
Lactose-binding lectin 1
Lectin galactoside-binding soluble 1
Putative MAPK-activating protein PM12
S-Lac lectin 1
Gene namesi
Name:LGALS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:6561. LGALS1.

Subcellular locationi

Secretedextracellular spaceextracellular matrix 1 Publication

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. cytoplasm Source: UniProtKB
  3. extracellular space Source: BHF-UCL
  4. extracellular vesicular exosome Source: UniProt
  5. intracellular Source: LIFEdb
  6. nucleus Source: Ensembl
  7. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30337.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed4 Publications
Chaini2 – 135134Galectin-1
PRO_0000076917Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine2 Publications
Modified residuei13 – 131N6-acetyllysine By similarity
Modified residuei29 – 291N6-acetyllysine1 Publication
Modified residuei108 – 1081N6-acetyllysine; alternate By similarity
Modified residuei108 – 1081N6-succinyllysine; alternate By similarity
Modified residuei128 – 1281N6-acetyllysine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP09382.
PaxDbiP09382.
PeptideAtlasiP09382.
PRIDEiP09382.

2D gel databases

DOSAC-COBS-2DPAGEP09382.
REPRODUCTION-2DPAGEIPI00219219.
P09382.
SWISS-2DPAGEP09382.
UCD-2DPAGEP09382.

PTM databases

PhosphoSiteiP09382.

Miscellaneous databases

PMAP-CutDBP09382.

Expressioni

Tissue specificityi

Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal membranes, expressed in amnion, chorioamniotic mesenchyma and chorion (at protein level). Expressed in cardiac, smooth, and skeletal muscle, neurons, thymus, kidney and hematopoietic cells.2 Publications

Gene expression databases

ArrayExpressiP09382.
BgeeiP09382.
CleanExiHS_LGALS1.
GenevestigatoriP09382.

Organism-specific databases

HPAiCAB002157.
HPA000646.
HPA000687.
HPA001130.

Interactioni

Subunit structurei

Homodimer. Binds LGALS3BP. Interacts with CD2, CD3, CD4, CD7, CD43 and CD45. Interacts with laminin (via poly-N-acetyllactosamine).4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PTPRCP085752EBI-1048875,EBI-1341

Protein-protein interaction databases

BioGridi110147. 39 interactions.
DIPiDIP-46153N.
IntActiP09382. 7 interactions.
MINTiMINT-3306493.
STRINGi9606.ENSP00000215909.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 127
Beta strandi17 – 248
Beta strandi30 – 389
Beta strandi41 – 5212
Beta strandi55 – 6511
Beta strandi73 – 764
Beta strandi82 – 9211
Beta strandi94 – 1007
Helixi102 – 1043
Beta strandi106 – 1105
Beta strandi118 – 13518

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1GZWX-ray1.70A/B2-135[»]
1W6MX-ray2.30A/B2-135[»]
1W6NX-ray1.65A/B2-135[»]
1W6OX-ray1.90A/B2-135[»]
1W6PX-ray1.80A/B2-135[»]
1W6QX-ray2.10A/B2-135[»]
2KM2NMR-A/B2-135[»]
2ZKNX-ray1.86A/B2-135[»]
3OY8X-ray2.19A/B2-135[»]
3OYWX-ray2.50A/B2-135[»]
3T2TX-ray1.90A/B1-135[»]
3W58X-ray1.58A/B/C/D2-135[»]
3W59X-ray2.10A/B/C/D2-135[»]
ProteinModelPortaliP09382.
SMRiP09382. Positions 2-135.

Miscellaneous databases

EvolutionaryTraceiP09382.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 135132Galectin
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni45 – 495Beta-galactoside binding
Regioni69 – 724Beta-galactoside binding

Sequence similaritiesi

Contains 1 galectin domain.

Phylogenomic databases

eggNOGiNOG279327.
HOGENOMiHOG000059539.
HOVERGENiHBG006255.
InParanoidiP09382.
KOiK06830.
OMAiGHEFKFP.
OrthoDBiEOG7NKKN0.
PhylomeDBiP09382.
TreeFamiTF315551.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR015535. Galectin_1.
IPR001079. Galectin_CRD.
[Graphical view]
PANTHERiPTHR11346:SF30. PTHR11346:SF30. 1 hit.
PfamiPF00337. Gal-bind_lectin. 1 hit.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 1 hit.
SM00276. GLECT. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS51304. GALECTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09382-1 [UniParc]FASTAAdd to Basket

« Hide

MACGLVASNL NLKPGECLRV RGEVAPDAKS FVLNLGKDSN NLCLHFNPRF    50
NAHGDANTIV CNSKDGGAWG TEQREAVFPF QPGSVAEVCI TFDQANLTVK 100
LPDGYEFKFP NRLNLEAINY MAADGDFKIK CVAFD 135
Length:135
Mass (Da):14,716
Last modified:January 23, 2007 - v2
Checksum:i2FBB8D7A1FC0F1F9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14829 mRNA. Translation: CAA32938.1.
J04456 mRNA. Translation: AAA36170.1.
X15256 mRNA. Translation: CAA33328.1.
EU363770 mRNA. Translation: ACA58297.1.
M57678 Genomic DNA. Translation: AAB00777.1.
AB097036 mRNA. Translation: BAC77389.1.
CR456511 mRNA. Translation: CAG30397.1.
AK312161 mRNA. Translation: BAG35095.1.
BT006775 mRNA. Translation: AAP35421.1.
Z83844 Genomic DNA. Translation: CAB42897.1.
CH471095 Genomic DNA. Translation: EAW60178.1.
BC001693 mRNA. Translation: AAH01693.1.
BC020675 mRNA. Translation: AAH20675.1.
CCDSiCCDS13954.1.
PIRiA37134. LNHUGB.
RefSeqiNP_002296.1. NM_002305.3.
UniGeneiHs.445351.

Genome annotation databases

EnsembliENST00000215909; ENSP00000215909; ENSG00000100097.
GeneIDi3956.
KEGGihsa:3956.
UCSCiuc003atn.3. human.

Polymorphism databases

DMDMi126155.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Galectin-1

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14829 mRNA. Translation: CAA32938.1 .
J04456 mRNA. Translation: AAA36170.1 .
X15256 mRNA. Translation: CAA33328.1 .
EU363770 mRNA. Translation: ACA58297.1 .
M57678 Genomic DNA. Translation: AAB00777.1 .
AB097036 mRNA. Translation: BAC77389.1 .
CR456511 mRNA. Translation: CAG30397.1 .
AK312161 mRNA. Translation: BAG35095.1 .
BT006775 mRNA. Translation: AAP35421.1 .
Z83844 Genomic DNA. Translation: CAB42897.1 .
CH471095 Genomic DNA. Translation: EAW60178.1 .
BC001693 mRNA. Translation: AAH01693.1 .
BC020675 mRNA. Translation: AAH20675.1 .
CCDSi CCDS13954.1.
PIRi A37134. LNHUGB.
RefSeqi NP_002296.1. NM_002305.3.
UniGenei Hs.445351.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1GZW X-ray 1.70 A/B 2-135 [» ]
1W6M X-ray 2.30 A/B 2-135 [» ]
1W6N X-ray 1.65 A/B 2-135 [» ]
1W6O X-ray 1.90 A/B 2-135 [» ]
1W6P X-ray 1.80 A/B 2-135 [» ]
1W6Q X-ray 2.10 A/B 2-135 [» ]
2KM2 NMR - A/B 2-135 [» ]
2ZKN X-ray 1.86 A/B 2-135 [» ]
3OY8 X-ray 2.19 A/B 2-135 [» ]
3OYW X-ray 2.50 A/B 2-135 [» ]
3T2T X-ray 1.90 A/B 1-135 [» ]
3W58 X-ray 1.58 A/B/C/D 2-135 [» ]
3W59 X-ray 2.10 A/B/C/D 2-135 [» ]
ProteinModelPortali P09382.
SMRi P09382. Positions 2-135.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110147. 39 interactions.
DIPi DIP-46153N.
IntActi P09382. 7 interactions.
MINTi MINT-3306493.
STRINGi 9606.ENSP00000215909.

Chemistry

BindingDBi P09382.
ChEMBLi CHEMBL4915.

PTM databases

PhosphoSitei P09382.

Polymorphism databases

DMDMi 126155.

2D gel databases

DOSAC-COBS-2DPAGE P09382.
REPRODUCTION-2DPAGE IPI00219219.
P09382.
SWISS-2DPAGE P09382.
UCD-2DPAGE P09382.

Proteomic databases

MaxQBi P09382.
PaxDbi P09382.
PeptideAtlasi P09382.
PRIDEi P09382.

Protocols and materials databases

DNASUi 3956.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000215909 ; ENSP00000215909 ; ENSG00000100097 .
GeneIDi 3956.
KEGGi hsa:3956.
UCSCi uc003atn.3. human.

Organism-specific databases

CTDi 3956.
GeneCardsi GC22P038071.
HGNCi HGNC:6561. LGALS1.
HPAi CAB002157.
HPA000646.
HPA000687.
HPA001130.
MIMi 150570. gene.
neXtProti NX_P09382.
PharmGKBi PA30337.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG279327.
HOGENOMi HOG000059539.
HOVERGENi HBG006255.
InParanoidi P09382.
KOi K06830.
OMAi GHEFKFP.
OrthoDBi EOG7NKKN0.
PhylomeDBi P09382.
TreeFami TF315551.

Miscellaneous databases

ChiTaRSi LGALS1. human.
EvolutionaryTracei P09382.
GeneWikii Galectin-1.
LGALS1.
GenomeRNAii 3956.
NextBioi 15523.
PMAP-CutDB P09382.
PROi P09382.
SOURCEi Search...

Gene expression databases

ArrayExpressi P09382.
Bgeei P09382.
CleanExi HS_LGALS1.
Genevestigatori P09382.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR015535. Galectin_1.
IPR001079. Galectin_CRD.
[Graphical view ]
PANTHERi PTHR11346:SF30. PTHR11346:SF30. 1 hit.
Pfami PF00337. Gal-bind_lectin. 1 hit.
[Graphical view ]
SMARTi SM00908. Gal-bind_lectin. 1 hit.
SM00276. GLECT. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
PROSITEi PS51304. GALECTIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and nucleotide sequence of a full-length cDNA for human 14 kDa beta-galactoside-binding lectin."
    Hirabayashi J., Ayaki K., Soma G., Kasai K.
    Biochim. Biophys. Acta 1008:85-91(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  2. "Molecular cloning, characterization, and expression of a human 14-kDa lectin."
    Couraud P.-O., Casentini-Borocz D., Bringman T.S., Griffith J., McGrogan M., Nedwin G.E.
    J. Biol. Chem. 264:1310-1316(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta and Promyelocytic leukemia.
  3. "Evidence that the 14 kDa soluble beta-galactoside-binding lectin in man is encoded by a single gene."
    Abbott W.M., Feizi T.
    Biochem. J. 259:291-294(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hepatoma.
  4. "Emergence of hormonal and redox regulation of galectin-1 in placental mammals: implication in maternal-fetal immune tolerance."
    Than N.G., Romero R., Erez O., Weckle A., Tarca A.L., Hotra J., Abbas A., Han Y.M., Kim S.S., Kusanovic J.P., Gotsch F., Hou Z., Santolaya-Forgas J., Benirschke K., Papp Z., Grossman L.I., Goodman M., Wildman D.E.
    Proc. Natl. Acad. Sci. U.S.A. 105:15819-15824(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Placenta.
  5. "Genomic sequence and organization of two members of a human lectin gene family."
    Gitt M.A., Barondes S.H.
    Biochemistry 30:82-89(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Lymphocyte.
  6. "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways."
    Matsuda A., Suzuki Y., Honda G., Muramatsu S., Matsuzaki O., Nagano Y., Doi T., Shimotohno K., Harada T., Nishida E., Hayashi H., Sugano S.
    Oncogene 22:3307-3318(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung fibroblast.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  8. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thalamus.
  9. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  10. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  12. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta and Skin.
  13. "Complete amino acid sequence of a beta-galactoside-binding lectin from human placenta."
    Hirabayashi J., Kasai K.
    J. Biochem. 104:1-4(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-135.
    Tissue: Placenta.
  14. "Beta-galactosidase soluble lectin from human brain: complete amino acid sequence."
    Bladier D., le Caer J.-P., Joubert R., Caron M., Rossier J.
    Neurochem. Int. 18:275-281(1991)
    Cited for: PROTEIN SEQUENCE OF 2-135.
    Tissue: Brain.
  15. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
    Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
    Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-19.
    Tissue: Platelet.
  16. Lubec G., Vishwanath V., Chen W.-Q., Sun Y.
    Submitted (DEC-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 38-49; 101-108 AND 113-128, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Brain, Cajal-Retzius cell and Fetal brain cortex.
  17. "Further characterization and structural studies on human placenta lectin."
    Hirabayashi J., Kawasaki H., Suzuki K., Kasai K.
    J. Biochem. 101:987-995(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 70-87 AND 122-133.
    Tissue: Placenta.
  18. "Identification of a 14-kDa laminin binding protein (HLBP14) in human melanoma cells that is identical to the 14-kDa galactoside binding lectin."
    Castronovo V., Luyten F., van den Brule F., Sobel M.E.
    Arch. Biochem. Biophys. 297:132-138(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 20-29; 50-74 AND 132-135, INTERACTION WITH LAMININ.
    Tissue: Melanoma.
  19. "Human splenic galaptin: physicochemical characterization."
    Sharma A., Chemelli R., Allen H.J.
    Biochemistry 29:5309-5314(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE.
    Tissue: Spleen.
  20. Cited for: CHARACTERIZATION.
  21. "Galectin-1, a natural ligand for the receptor-type protein tyrosine phosphatase CD45."
    Walzel H., Schulz U., Neels P., Brock J.
    Immunol. Lett. 67:193-202(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
    Tissue: Placenta.
  22. "Regulation of CD45-induced signaling by galectin-1 in Burkitt lymphoma B cells."
    Fouillit M., Joubert-Caron R., Poirier F., Bourin P., Monostori E., Levi-Strauss M., Raphael M., Bladier D., Caron M.
    Glycobiology 10:413-419(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  23. "Glycoprotein 90K/MAC-2BP interacts with galectin-1 and mediates galectin-1-induced cell aggregation."
    Tinari N., Kuwabara I., Huflejt M.E., Shen P.F., Iacobelli S., Liu F.-T.
    Int. J. Cancer 91:167-172(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH LGALS3BP.
  24. "Presentation of galectin-1 by extracellular matrix triggers T cell death."
    He J., Baum L.G.
    J. Biol. Chem. 279:4705-4712(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, FUNCTION.
  25. "Abnormal proteins in primary breast cancer tissues from 25 Sudanese patients."
    Ahamed M.E., Ahmed M.E., Eltoum A.M., Altahir G.O., Ahmed K.M., Harbi S.O., Stansalas J., Mohamed A.O.
    Eur. J. Inflamm. 6:115-121(2008)
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Mammary cancer.
  26. Cited for: FUNCTION, TISSUE SPECIFICITY.
  27. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-29, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  28. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  29. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  30. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  31. "Growth-regulatory human galectin-1: crystallographic characterisation of the structural changes induced by single-site mutations and their impact on the thermodynamics of ligand binding."
    Lopez-Lucendo M.F., Solis D., Andre S., Hirabayashi J., Kasai K., Kaltner H., Gabius H.-J., Romero A.
    J. Mol. Biol. 343:957-970(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) IN COMPLEX WITH CARBOHYDRATE, SUBUNIT.
  32. "Functional and structural bases of a cysteine-less mutant as a long-lasting substitute for galectin-1."
    Nishi N., Abe A., Iwaki J., Yoshida H., Itoh A., Shoji H., Kamitori S., Hirabayashi J., Nakamura T.
    Glycobiology 18:1065-1073(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.86 ANGSTROMS) OF 2-135 IN COMPLEX WITH LACTOSE, INTERACTION WITH CD2; CD3; CD7; CD43 AND CD45, SUBUNIT, FUNCTION.
  33. "Critical role of the solvent environment in galectin-1 binding to the disaccharide lactose."
    Di Lella S., Ma L., Ricci J.C., Rabinovich G.A., Asher S.A., Alvarez R.M.S.
    Biochemistry 48:786-791(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS).

Entry informationi

Entry nameiLEG1_HUMAN
AccessioniPrimary (citable) accession number: P09382
Secondary accession number(s): B2R5E8, Q9UDK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 180 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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