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Protein

Galectin-1

Gene

LGALS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei53Beta-galactoside1
Binding sitei62Beta-galactoside1

GO - Molecular functioni

  • glycoprotein binding Source: Ensembl
  • lactose binding Source: Ensembl
  • poly(A) RNA binding Source: UniProtKB
  • signal transducer activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

Lectin

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100097-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-1
Short name:
Gal-1
Alternative name(s):
14 kDa laminin-binding protein
Short name:
HLBP14
14 kDa lectin
Beta-galactoside-binding lectin L-14-I
Galaptin
HBL
HPL
Lactose-binding lectin 1
Lectin galactoside-binding soluble 1
Putative MAPK-activating protein PM12
S-Lac lectin 1
Gene namesi
Name:LGALS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:6561. LGALS1.

Subcellular locationi

GO - Cellular componenti

  • cell surface Source: Ensembl
  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • extracellular matrix Source: BHF-UCL
  • extracellular space Source: BHF-UCL
  • intracellular Source: LIFEdb
  • nucleus Source: Ensembl
  • proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3956.
OpenTargetsiENSG00000100097.
PharmGKBiPA30337.

Chemistry databases

ChEMBLiCHEMBL4915.

Polymorphism and mutation databases

BioMutaiLGALS1.
DMDMi126155.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources3 Publications
ChainiPRO_00000769172 – 135Galectin-1Add BLAST134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei13N6-acetyllysineBy similarity1
Modified residuei29N6-acetyllysineCombined sources1
Modified residuei30Phosphoserine; by FAM20C1 Publication1
Modified residuei108N6-acetyllysine; alternateBy similarity1
Modified residuei108N6-succinyllysine; alternateBy similarity1
Modified residuei128N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP09382.
MaxQBiP09382.
PaxDbiP09382.
PeptideAtlasiP09382.
PRIDEiP09382.
TopDownProteomicsiP09382.

2D gel databases

DOSAC-COBS-2DPAGEP09382.
REPRODUCTION-2DPAGEIPI00219219.
P09382.
SWISS-2DPAGEP09382.
UCD-2DPAGEP09382.

PTM databases

iPTMnetiP09382.
PhosphoSitePlusiP09382.
SwissPalmiP09382.

Miscellaneous databases

PMAP-CutDBP09382.

Expressioni

Tissue specificityi

Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal membranes, expressed in amnion, chorioamniotic mesenchyma and chorion (at protein level). Expressed in cardiac, smooth, and skeletal muscle, neurons, thymus, kidney and hematopoietic cells.2 Publications

Gene expression databases

BgeeiENSG00000100097.
CleanExiHS_LGALS1.
ExpressionAtlasiP09382. baseline and differential.
GenevisibleiP09382. HS.

Organism-specific databases

HPAiCAB002157.
HPA000646.
HPA000687.
HPA001130.

Interactioni

Subunit structurei

Homodimer. Binds LGALS3BP. Interacts with CD2, CD3, CD4, CD6, CD7, CD43, ALCAM and CD45. Interacts with laminin (via poly-N-acetyllactosamine). Interacts with SUSD2.6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ALCAMQ137403EBI-1048875,EBI-1188108
CD6P302032EBI-1048875,EBI-2873748
KDRP359683EBI-1048875,EBI-1005487
PTPRCP085752EBI-1048875,EBI-1341

Protein-protein interaction databases

BioGridi110147. 95 interactors.
DIPiDIP-46153N.
IntActiP09382. 21 interactors.
MINTiMINT-3306493.
STRINGi9606.ENSP00000215909.

Chemistry databases

BindingDBiP09382.

Structurei

Secondary structure

1135
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 12Combined sources10
Beta strandi18 – 24Combined sources7
Beta strandi30 – 38Combined sources9
Beta strandi41 – 52Combined sources12
Beta strandi55 – 65Combined sources11
Beta strandi73 – 76Combined sources4
Beta strandi84 – 92Combined sources9
Beta strandi94 – 100Combined sources7
Helixi102 – 104Combined sources3
Beta strandi106 – 110Combined sources5
Beta strandi116 – 133Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GZWX-ray1.70A/B2-135[»]
1W6MX-ray2.30A/B2-135[»]
1W6NX-ray1.65A/B2-135[»]
1W6OX-ray1.90A/B2-135[»]
1W6PX-ray1.80A/B2-135[»]
1W6QX-ray2.10A/B2-135[»]
2KM2NMR-A/B2-135[»]
2ZKNX-ray1.86A/B2-135[»]
3OY8X-ray2.19A/B2-135[»]
3OYWX-ray2.50A/B2-135[»]
3T2TX-ray1.90A/B1-135[»]
3W58X-ray1.58A/B/C/D2-135[»]
3W59X-ray2.10A/B/C/D2-135[»]
4Q1PX-ray1.46A/B1-135[»]
4Q1RX-ray1.47A/B1-135[»]
4Q26X-ray1.40A/B/G/H1-135[»]
4Q27X-ray1.20A/B1-135[»]
4Q2FX-ray1.40A/B1-135[»]
4XBLX-ray1.93A/B1-135[»]
4Y1UX-ray1.76A/B3-135[»]
4Y1VX-ray2.32A/B3-135[»]
4Y1XX-ray2.45A/B3-135[»]
4Y1YX-ray1.86A/B4-135[»]
4Y1ZX-ray2.23A/B3-135[»]
4Y20X-ray2.20A/B3-135[»]
4Y22X-ray2.50A/B3-135[»]
4Y24X-ray2.32A/B3-135[»]
ProteinModelPortaliP09382.
SMRiP09382.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP09382.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 135GalectinPROSITE-ProRule annotationAdd BLAST132

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni45 – 49Beta-galactoside binding5
Regioni69 – 72Beta-galactoside binding4

Sequence similaritiesi

Contains 1 galectin domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3587. Eukaryota.
ENOG4111EA0. LUCA.
GeneTreeiENSGT00440000034263.
HOGENOMiHOG000059539.
HOVERGENiHBG006255.
InParanoidiP09382.
KOiK06830.
OMAiCNSKEDG.
OrthoDBiEOG091G0S7H.
PhylomeDBiP09382.
TreeFamiTF315551.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001079. Galectin_CRD.
[Graphical view]
PfamiPF00337. Gal-bind_lectin. 1 hit.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 1 hit.
SM00276. GLECT. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS51304. GALECTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09382-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACGLVASNL NLKPGECLRV RGEVAPDAKS FVLNLGKDSN NLCLHFNPRF
60 70 80 90 100
NAHGDANTIV CNSKDGGAWG TEQREAVFPF QPGSVAEVCI TFDQANLTVK
110 120 130
LPDGYEFKFP NRLNLEAINY MAADGDFKIK CVAFD
Length:135
Mass (Da):14,716
Last modified:January 23, 2007 - v2
Checksum:i2FBB8D7A1FC0F1F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14829 mRNA. Translation: CAA32938.1.
J04456 mRNA. Translation: AAA36170.1.
X15256 mRNA. Translation: CAA33328.1.
EU363770 mRNA. Translation: ACA58297.1.
M57678 Genomic DNA. Translation: AAB00777.1.
AB097036 mRNA. Translation: BAC77389.1.
CR456511 mRNA. Translation: CAG30397.1.
AK312161 mRNA. Translation: BAG35095.1.
BT006775 mRNA. Translation: AAP35421.1.
Z83844 Genomic DNA. Translation: CAB42897.1.
CH471095 Genomic DNA. Translation: EAW60178.1.
BC001693 mRNA. Translation: AAH01693.1.
BC020675 mRNA. Translation: AAH20675.1.
CCDSiCCDS13954.1.
PIRiA37134. LNHUGB.
RefSeqiNP_002296.1. NM_002305.3.
UniGeneiHs.445351.

Genome annotation databases

EnsembliENST00000215909; ENSP00000215909; ENSG00000100097.
GeneIDi3956.
KEGGihsa:3956.
UCSCiuc003atn.4. human.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Galectin-1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14829 mRNA. Translation: CAA32938.1.
J04456 mRNA. Translation: AAA36170.1.
X15256 mRNA. Translation: CAA33328.1.
EU363770 mRNA. Translation: ACA58297.1.
M57678 Genomic DNA. Translation: AAB00777.1.
AB097036 mRNA. Translation: BAC77389.1.
CR456511 mRNA. Translation: CAG30397.1.
AK312161 mRNA. Translation: BAG35095.1.
BT006775 mRNA. Translation: AAP35421.1.
Z83844 Genomic DNA. Translation: CAB42897.1.
CH471095 Genomic DNA. Translation: EAW60178.1.
BC001693 mRNA. Translation: AAH01693.1.
BC020675 mRNA. Translation: AAH20675.1.
CCDSiCCDS13954.1.
PIRiA37134. LNHUGB.
RefSeqiNP_002296.1. NM_002305.3.
UniGeneiHs.445351.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GZWX-ray1.70A/B2-135[»]
1W6MX-ray2.30A/B2-135[»]
1W6NX-ray1.65A/B2-135[»]
1W6OX-ray1.90A/B2-135[»]
1W6PX-ray1.80A/B2-135[»]
1W6QX-ray2.10A/B2-135[»]
2KM2NMR-A/B2-135[»]
2ZKNX-ray1.86A/B2-135[»]
3OY8X-ray2.19A/B2-135[»]
3OYWX-ray2.50A/B2-135[»]
3T2TX-ray1.90A/B1-135[»]
3W58X-ray1.58A/B/C/D2-135[»]
3W59X-ray2.10A/B/C/D2-135[»]
4Q1PX-ray1.46A/B1-135[»]
4Q1RX-ray1.47A/B1-135[»]
4Q26X-ray1.40A/B/G/H1-135[»]
4Q27X-ray1.20A/B1-135[»]
4Q2FX-ray1.40A/B1-135[»]
4XBLX-ray1.93A/B1-135[»]
4Y1UX-ray1.76A/B3-135[»]
4Y1VX-ray2.32A/B3-135[»]
4Y1XX-ray2.45A/B3-135[»]
4Y1YX-ray1.86A/B4-135[»]
4Y1ZX-ray2.23A/B3-135[»]
4Y20X-ray2.20A/B3-135[»]
4Y22X-ray2.50A/B3-135[»]
4Y24X-ray2.32A/B3-135[»]
ProteinModelPortaliP09382.
SMRiP09382.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110147. 95 interactors.
DIPiDIP-46153N.
IntActiP09382. 21 interactors.
MINTiMINT-3306493.
STRINGi9606.ENSP00000215909.

Chemistry databases

BindingDBiP09382.
ChEMBLiCHEMBL4915.

PTM databases

iPTMnetiP09382.
PhosphoSitePlusiP09382.
SwissPalmiP09382.

Polymorphism and mutation databases

BioMutaiLGALS1.
DMDMi126155.

2D gel databases

DOSAC-COBS-2DPAGEP09382.
REPRODUCTION-2DPAGEIPI00219219.
P09382.
SWISS-2DPAGEP09382.
UCD-2DPAGEP09382.

Proteomic databases

EPDiP09382.
MaxQBiP09382.
PaxDbiP09382.
PeptideAtlasiP09382.
PRIDEiP09382.
TopDownProteomicsiP09382.

Protocols and materials databases

DNASUi3956.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000215909; ENSP00000215909; ENSG00000100097.
GeneIDi3956.
KEGGihsa:3956.
UCSCiuc003atn.4. human.

Organism-specific databases

CTDi3956.
DisGeNETi3956.
GeneCardsiLGALS1.
HGNCiHGNC:6561. LGALS1.
HPAiCAB002157.
HPA000646.
HPA000687.
HPA001130.
MIMi150570. gene.
neXtProtiNX_P09382.
OpenTargetsiENSG00000100097.
PharmGKBiPA30337.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3587. Eukaryota.
ENOG4111EA0. LUCA.
GeneTreeiENSGT00440000034263.
HOGENOMiHOG000059539.
HOVERGENiHBG006255.
InParanoidiP09382.
KOiK06830.
OMAiCNSKEDG.
OrthoDBiEOG091G0S7H.
PhylomeDBiP09382.
TreeFamiTF315551.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100097-MONOMER.

Miscellaneous databases

ChiTaRSiLGALS1. human.
EvolutionaryTraceiP09382.
GeneWikiiGalectin-1.
LGALS1.
GenomeRNAii3956.
PMAP-CutDBP09382.
PROiP09382.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100097.
CleanExiHS_LGALS1.
ExpressionAtlasiP09382. baseline and differential.
GenevisibleiP09382. HS.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001079. Galectin_CRD.
[Graphical view]
PfamiPF00337. Gal-bind_lectin. 1 hit.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 1 hit.
SM00276. GLECT. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS51304. GALECTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLEG1_HUMAN
AccessioniPrimary (citable) accession number: P09382
Secondary accession number(s): B2R5E8, Q9UDK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 203 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.