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Protein

HTH-type transcriptional activator RhaR

Gene

rhaR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Activates expression of the rhaSR operon in response to L-rhamnose.2 Publications

Miscellaneous

Its activity is regulated by L-rhamnose. When this sugar becomes available to the cell, basal-level RhaR binds L-rhamnose and becomes activated.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi195 – 214H-T-H motifBy similarityAdd BLAST20
DNA bindingi244 – 267H-T-H motifBy similarityAdd BLAST24

GO - Molecular functioni

  • DNA binding transcription factor activity Source: GO_Central
  • sequence-specific DNA binding Source: EcoCyc

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processRhamnose metabolism, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:PD00222

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional activator RhaR
Alternative name(s):
L-rhamnose operon transcriptional activator RhaR
Gene namesi
Name:rhaR
Synonyms:rhaC1
Ordered Locus Names:b3906, JW3877
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi

Organism-specific databases

EcoGeneiEG10842 rhaR

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001945511 – 282HTH-type transcriptional activator RhaRAdd BLAST282

Proteomic databases

PaxDbiP09378
PRIDEiP09378

Expressioni

Inductioni

Autoregulated. Binding of the cAMP receptor protein (CRP) is required for full expression.1 Publication

Interactioni

Subunit structurei

Binds DNA as a dimer.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei246Interaction with sigma-701

Protein-protein interaction databases

BioGridi4263058, 8 interactors
DIPiDIP-10693N
IntActiP09378, 9 interactors
STRINGi316385.ECDH10B_4096

Structurei

3D structure databases

ProteinModelPortaliP09378
SMRiP09378
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4108BRW Bacteria
ENOG410XYX0 LUCA
HOGENOMiHOG000290513
InParanoidiP09378
KOiK02854
OMAiNREVGMT
PhylomeDBiP09378

Family and domain databases

Gene3Di2.60.120.10, 1 hit
HAMAPiMF_01533 HTH_type_RhaR, 1 hit
InterProiView protein in InterPro
IPR003313 AraC-bd
IPR009057 Homeobox-like_sf
IPR018060 HTH_AraC
IPR018062 HTH_AraC-typ_CS
IPR014710 RmlC-like_jellyroll
IPR011051 RmlC_Cupin_sf
IPR023699 Tscrpt_act_RhaR
IPR020449 Tscrpt_reg_HTH_AraC-type
PfamiView protein in Pfam
PF02311 AraC_binding, 1 hit
PF12833 HTH_18, 1 hit
PRINTSiPR00032 HTHARAC
SMARTiView protein in SMART
SM00342 HTH_ARAC, 1 hit
SUPFAMiSSF46689 SSF46689, 2 hits
SSF51182 SSF51182, 1 hit
PROSITEiView protein in PROSITE
PS00041 HTH_ARAC_FAMILY_1, 1 hit
PS01124 HTH_ARAC_FAMILY_2, 1 hit

Sequencei

Sequence statusi: Complete.

P09378-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHQLKLLKD DFFASDQQAV AVADRYPQDV FAEHTHDFCE LVIVWRGNGL
60 70 80 90 100
HVLNDRPYRI TRGDLFYIHA DDKHSYASVN DLVLQNIIYC PERLKLNLDW
110 120 130 140 150
QGAIPGFNAS AGQPHWRLGS MGMAQARQVI GQLEHESSQH VPFANEMAEL
160 170 180 190 200
LFGQLVMLLN RHRYTSDSLP PTSSETLLDK LITRLAASLK SPFALDKFCD
210 220 230 240 250
EASCSERVLR QQFRQQTGMT INQYLRQVRV CHAQYLLQHS RLLISDISTE
260 270 280
CGFEDSNYFS VVFTRETGMT PSQWRHLNSQ KD
Length:282
Mass (Da):32,373
Last modified:July 24, 2007 - v2
Checksum:i5563D7B0773CEC9D
GO

Sequence cautioni

The sequence AAA24530 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated
The sequence AAB03039 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE77403 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA29453 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06058 Genomic DNA Translation: CAA29453.1 Different initiation.
L19201 Genomic DNA Translation: AAB03039.1 Different initiation.
U00096 Genomic DNA Translation: AAC76888.2
AP009048 Genomic DNA Translation: BAE77403.1 Different initiation.
X60699 Genomic DNA Translation: CAA43110.1
M85158 Genomic DNA Translation: AAA24530.1 Sequence problems.
PIRiS40850
RefSeqiNP_418342.2, NC_000913.3

Genome annotation databases

EnsemblBacteriaiAAC76888; AAC76888; b3906
BAE77403; BAE77403; BAE77403
GeneIDi948396
KEGGiecj:JW3877
eco:b3906
PATRICifig|511145.12.peg.4022

Entry informationi

Entry nameiRHAR_ECOLI
AccessioniPrimary (citable) accession number: P09378
Secondary accession number(s): Q2M8K3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 24, 2007
Last modified: March 28, 2018
This is version 161 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

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