ID ADH1_DROMO Reviewed; 254 AA. AC P09370; Q6UPV9; Q6UPW6; Q6UPX2; Q867T9; DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot. DT 14-OCT-2008, sequence version 3. DT 16-JUN-2009, entry version 62. DE RecName: Full=Alcohol dehydrogenase 1; DE EC=1.1.1.1; GN Name=Adh1; ORFNames=GI17644; OS Drosophila mojavensis (Fruit fly). OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila. OX NCBI_TaxID=7230; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS THR-187; VAL-189 AND RP LEU-236. RC STRAIN=VRF; RX MEDLINE=89137903; PubMed=3224808; RA Atkinson P.W., Mills L.E., Starmer W.T., Sullivan D.T.; RT "Structure and evolution of the Adh genes of Drosophila mojavensis."; RL Genetics 120:713-723(1988). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS THR-187; VAL-189 AND RP LEU-236. RC STRAIN=VRF; RX PubMed=1317314; RA Bayer C.A., Curtiss S.W., Weaver J.A., Sullivan D.T.; RT "Delineation of cis-acting sequences required for expression of RT Drosophila mojavensis Adh-1."; RL Genetics 131:143-153(1992). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=MJBC 103.3, MJBC 108.5, MJBC 115.4, MJBC 157.3, MJBC 202.2, RC MJBC 205.1, MJBC 25.3, MJBC 33.3, MJBC 35.1, MJBC 39.3, MJBC 47.3, RC MJBC 80, and MJBC 95.1; RX MEDLINE=22474227; PubMed=12586706; RA Matzkin L.M., Eanes W.F.; RT "Sequence variation of alcohol dehydrogenase (Adh) paralogs in RT cactophilic Drosophila."; RL Genetics 163:181-194(2003). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=MJS 115, MJS 122, MJS 127, MJS 132, MJS 14, MJS 154, MJS 36, RC MJS 58.2, MJS 68, MJS 84, and MJS 87; RX PubMed=14660699; DOI=10.1093/molbev/msh019; RA Matzkin L.M.; RT "Population genetics and geographic variation of alcohol dehydrogenase RT (Adh) paralogs and glucose-6-phosphate dehydrogenase (G6pd) in RT Drosophila mojavensis."; RL Mol. Biol. Evol. 21:276-285(2004). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tucson 15081-1352.22; RX PubMed=17994087; DOI=10.1038/nature06341; RG Drosophila 12 genomes consortium; RT "Evolution of genes and genomes on the Drosophila phylogeny."; RL Nature 450:203-218(2007). CC -!- CATALYTIC ACTIVITY: An alcohol + NAD(+) = an aldehyde or ketone + CC NADH. CC -!- SUBUNIT: Homodimer. CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases CC (SDR) family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; M37276; AAA28335.1; -; Genomic_DNA. DR EMBL; X12536; CAA31055.1; -; Genomic_DNA. DR EMBL; AY154827; AAN86863.1; -; Genomic_DNA. DR EMBL; AY154828; AAN86864.1; -; Genomic_DNA. DR EMBL; AY154829; AAN86865.1; -; Genomic_DNA. DR EMBL; AY154830; AAN86866.1; -; Genomic_DNA. DR EMBL; AY154831; AAN86867.1; -; Genomic_DNA. DR EMBL; AY154832; AAN86868.1; -; Genomic_DNA. DR EMBL; AY154833; AAN86869.1; -; Genomic_DNA. DR EMBL; AY154834; AAN86870.1; -; Genomic_DNA. DR EMBL; AY154835; AAN86871.1; -; Genomic_DNA. DR EMBL; AY154836; AAN86872.1; -; Genomic_DNA. DR EMBL; AY154837; AAN86873.1; -; Genomic_DNA. DR EMBL; AY154838; AAN86874.1; -; Genomic_DNA. DR EMBL; AY154839; AAN86875.1; -; Genomic_DNA. DR EMBL; AY364493; AAR12927.1; -; Genomic_DNA. DR EMBL; AY364494; AAR12928.1; -; Genomic_DNA. DR EMBL; AY364495; AAR12929.1; -; Genomic_DNA. DR EMBL; AY364496; AAR12930.1; -; Genomic_DNA. DR EMBL; AY364497; AAR12931.1; -; Genomic_DNA. DR EMBL; AY364498; AAR12932.1; -; Genomic_DNA. DR EMBL; AY364499; AAR12933.1; -; Genomic_DNA. DR EMBL; AY364500; AAR12934.1; -; Genomic_DNA. DR EMBL; AY364501; AAR12935.1; -; Genomic_DNA. DR EMBL; AY364502; AAR12936.1; -; Genomic_DNA. DR EMBL; AY364503; AAR12937.1; -; Genomic_DNA. DR EMBL; AY364504; AAR12938.1; -; Genomic_DNA. DR EMBL; AY364505; AAR12939.1; -; Genomic_DNA. DR EMBL; AY364506; AAR12940.1; -; Genomic_DNA. DR EMBL; AY364507; AAR12941.1; -; Genomic_DNA. DR EMBL; CH933807; EDW12372.1; -; Genomic_DNA. DR PIR; S01902; S01902. DR RefSeq; XP_002002930.1; -. DR HSSP; P10807; 1B16. DR SMR; P09370; 1-254. DR GeneID; 6576953; -. DR KEGG; dmo:Dmoj_GI17644; -. DR FlyBase; FBgn0012566; Dmoj\Adh1. DR BRENDA; 1.1.1.1; 38735. DR GO; GO:0004022; F:alcohol dehydrogenase activity; IEA:EC. DR GO; GO:0005488; F:binding; IEA:InterPro. DR GO; GO:0006066; P:cellular alcohol metabolic process; IEA:InterPro. DR GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW. DR InterPro; IPR002198; DH_sc/Rdtase_SDR. DR InterPro; IPR002425; Insect_ADH. DR InterPro; IPR002424; Insect_AlcDH_fam. DR InterPro; IPR016040; NAD(P)-bd_dom. DR Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1. DR PANTHER; PTHR19410; ADH_short_C2; 1. DR Pfam; PF00106; adh_short; 1. DR PRINTS; PR01168; ALCDHDRGNASE. DR PRINTS; PR01167; INSADHFAMILY. DR PRINTS; PR00080; SDRFAMILY. DR PROSITE; PS00061; ADH_SHORT; 1. PE 3: Inferred from homology; KW NAD; Oxidoreductase; Polymorphism. FT INIT_MET 1 1 Removed. FT CHAIN 2 254 Alcohol dehydrogenase 1. FT /FTId=PRO_0000054478. FT NP_BIND 10 33 NAD (By similarity). FT ACT_SITE 151 151 Proton acceptor (By similarity). FT BINDING 138 138 Substrate (By similarity). FT VARIANT 187 187 P -> T (in strain: VRF). FT VARIANT 189 189 L -> V (in strain: VRF). FT VARIANT 236 236 V -> L (in strain: VRF). SQ SEQUENCE 254 AA; 27561 MW; 4ECDEF98EB9A99ED CRC64; MAIANKNIIF VAGLGGIGFD TSREIVKKGP KNLVILDRIE NPAAIAELKA LNPKVTVTFY LYDVTVSVAE STKLLQKIFD QLKTVDLLIN GAGILDDHQI ERTIAVNFTG TVNTITAIMS FWDKRKGGPG GVIANVCSVT GFNAIYQVPV YSASKAAALS FTNSLAKLAP ITGVTAYSIN PGITKTPLLH KFNSWLDVEP RVGELLLEHP TQTSLECAQN FVKAIEANQN GAIWKVDLGT LEAIEWTKHW DSHI //