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Protein

Alcohol dehydrogenase 1

Gene

Adh1

Organism
Drosophila mojavensis (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei138SubstrateBy similarity1
Active sitei151Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 33NADBy similarityAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 1 (EC:1.1.1.1)
Gene namesi
Name:Adh1
ORF Names:GI17644
OrganismiDrosophila mojavensis (Fruit fly)
Taxonomic identifieri7230 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
Proteomesi
  • UP000009192 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0012566. Dmoj\Adh1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000544782 – 254Alcohol dehydrogenase 1Add BLAST253

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliP09370.
SMRiP09370.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

InParanoidiP09370.
KOiK00001.
OMAiTSLECAQ.
OrthoDBiEOG091G0OC9.
PhylomeDBiP09370.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiView protein in InterPro
IPR002425. ADH_Drosophila-type.
IPR002424. ADH_insect.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PRINTSiPR01168. ALCDHDRGNASE.
PR01167. INSADHFAMILY.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00061. ADH_SHORT. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09370-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIANKNIIF VAGLGGIGFD TSREIVKKGP KNLVILDRIE NPAAIAELKA
60 70 80 90 100
LNPKVTVTFY LYDVTVSVAE STKLLQKIFD QLKTVDLLIN GAGILDDHQI
110 120 130 140 150
ERTIAVNFTG TVNTITAIMS FWDKRKGGPG GVIANVCSVT GFNAIYQVPV
160 170 180 190 200
YSASKAAALS FTNSLAKLAP ITGVTAYSIN PGITKTPLLH KFNSWLDVEP
210 220 230 240 250
RVGELLLEHP TQTSLECAQN FVKAIEANQN GAIWKVDLGT LEAIEWTKHW

DSHI
Length:254
Mass (Da):27,561
Last modified:October 14, 2008 - v3
Checksum:i4ECDEF98EB9A99ED
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti187P → T in strain: VRF. 2 Publications1
Natural varianti189L → V in strain: VRF. 2 Publications1
Natural varianti236V → L in strain: VRF. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37276 Genomic DNA. Translation: AAA28335.1.
X12536 Genomic DNA. Translation: CAA31055.1.
AY154827 Genomic DNA. Translation: AAN86863.1.
AY154828 Genomic DNA. Translation: AAN86864.1.
AY154829 Genomic DNA. Translation: AAN86865.1.
AY154830 Genomic DNA. Translation: AAN86866.1.
AY154831 Genomic DNA. Translation: AAN86867.1.
AY154832 Genomic DNA. Translation: AAN86868.1.
AY154833 Genomic DNA. Translation: AAN86869.1.
AY154834 Genomic DNA. Translation: AAN86870.1.
AY154835 Genomic DNA. Translation: AAN86871.1.
AY154836 Genomic DNA. Translation: AAN86872.1.
AY154837 Genomic DNA. Translation: AAN86873.1.
AY154838 Genomic DNA. Translation: AAN86874.1.
AY154839 Genomic DNA. Translation: AAN86875.1.
AY364493 Genomic DNA. Translation: AAR12927.1.
AY364494 Genomic DNA. Translation: AAR12928.1.
AY364495 Genomic DNA. Translation: AAR12929.1.
AY364496 Genomic DNA. Translation: AAR12930.1.
AY364497 Genomic DNA. Translation: AAR12931.1.
AY364498 Genomic DNA. Translation: AAR12932.1.
AY364499 Genomic DNA. Translation: AAR12933.1.
AY364500 Genomic DNA. Translation: AAR12934.1.
AY364501 Genomic DNA. Translation: AAR12935.1.
AY364502 Genomic DNA. Translation: AAR12936.1.
AY364503 Genomic DNA. Translation: AAR12937.1.
AY364504 Genomic DNA. Translation: AAR12938.1.
AY364505 Genomic DNA. Translation: AAR12939.1.
AY364506 Genomic DNA. Translation: AAR12940.1.
AY364507 Genomic DNA. Translation: AAR12941.1.
CH933807 Genomic DNA. Translation: EDW12372.1.
PIRiS01902.
RefSeqiXP_002002930.1. XM_002002894.2.

Genome annotation databases

EnsemblMetazoaiFBtr0168369; FBpp0166861; FBgn0012566.
GeneIDi6576953.
KEGGidmo:Dmoj_GI17644.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37276 Genomic DNA. Translation: AAA28335.1.
X12536 Genomic DNA. Translation: CAA31055.1.
AY154827 Genomic DNA. Translation: AAN86863.1.
AY154828 Genomic DNA. Translation: AAN86864.1.
AY154829 Genomic DNA. Translation: AAN86865.1.
AY154830 Genomic DNA. Translation: AAN86866.1.
AY154831 Genomic DNA. Translation: AAN86867.1.
AY154832 Genomic DNA. Translation: AAN86868.1.
AY154833 Genomic DNA. Translation: AAN86869.1.
AY154834 Genomic DNA. Translation: AAN86870.1.
AY154835 Genomic DNA. Translation: AAN86871.1.
AY154836 Genomic DNA. Translation: AAN86872.1.
AY154837 Genomic DNA. Translation: AAN86873.1.
AY154838 Genomic DNA. Translation: AAN86874.1.
AY154839 Genomic DNA. Translation: AAN86875.1.
AY364493 Genomic DNA. Translation: AAR12927.1.
AY364494 Genomic DNA. Translation: AAR12928.1.
AY364495 Genomic DNA. Translation: AAR12929.1.
AY364496 Genomic DNA. Translation: AAR12930.1.
AY364497 Genomic DNA. Translation: AAR12931.1.
AY364498 Genomic DNA. Translation: AAR12932.1.
AY364499 Genomic DNA. Translation: AAR12933.1.
AY364500 Genomic DNA. Translation: AAR12934.1.
AY364501 Genomic DNA. Translation: AAR12935.1.
AY364502 Genomic DNA. Translation: AAR12936.1.
AY364503 Genomic DNA. Translation: AAR12937.1.
AY364504 Genomic DNA. Translation: AAR12938.1.
AY364505 Genomic DNA. Translation: AAR12939.1.
AY364506 Genomic DNA. Translation: AAR12940.1.
AY364507 Genomic DNA. Translation: AAR12941.1.
CH933807 Genomic DNA. Translation: EDW12372.1.
PIRiS01902.
RefSeqiXP_002002930.1. XM_002002894.2.

3D structure databases

ProteinModelPortaliP09370.
SMRiP09370.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0168369; FBpp0166861; FBgn0012566.
GeneIDi6576953.
KEGGidmo:Dmoj_GI17644.

Organism-specific databases

FlyBaseiFBgn0012566. Dmoj\Adh1.

Phylogenomic databases

InParanoidiP09370.
KOiK00001.
OMAiTSLECAQ.
OrthoDBiEOG091G0OC9.
PhylomeDBiP09370.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiView protein in InterPro
IPR002425. ADH_Drosophila-type.
IPR002424. ADH_insect.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PRINTSiPR01168. ALCDHDRGNASE.
PR01167. INSADHFAMILY.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00061. ADH_SHORT. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADH1_DROMO
AccessioniPrimary (citable) accession number: P09370
Secondary accession number(s): Q6UPV9
, Q6UPW6, Q6UPX2, Q867T9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: October 14, 2008
Last modified: March 15, 2017
This is version 101 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.