Reviewed, UniProtKB/Swiss-Prot P09370 (ADH1_DROMO)

Names and origin

Protein names

Recommended name:
    Alcohol dehydrogenase 1
    EC=1.1.1.1

Gene names

Name:	Adh1
ORF Names:	GI17644

Organism

Drosophila mojavensis (Fruit fly)

Taxonomic identifier

7230 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila

Protein attributes

Sequence length	254 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	An alcohol + NAD+ = an aldehyde or ketone + NADH.
Subunit structure	Homodimer.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	alcohol metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alcohol dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed
	Chain	2 – 254	253	Alcohol dehydrogenase 1		PRO_0000054478
Regions
	Nucleotide binding	10 – 33	24	NAD By similarity
Sites
	Active site	151	1	Proton acceptor By similarity
	Binding site	138	1	Substrate By similarity
Natural variations
	Natural variant	187	1	P → T in strain: VRF. Ref.1 Ref.2
	Natural variant	189	1	L → V in strain: VRF. Ref.1 Ref.2
	Natural variant	236	1	V → L in strain: VRF. Ref.1 Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P09370-1 [UniParc]. Last modified October 14, 2008. Version 3. Checksum: 4ECDEF98EB9A99ED	FASTA	254	27,561
	10 20 30 40 50 60 MAIANKNIIF VAGLGGIGFD TSREIVKKGP KNLVILDRIE NPAAIAELKA LNPKVTVTFY 70 80 90 100 110 120 LYDVTVSVAE STKLLQKIFD QLKTVDLLIN GAGILDDHQI ERTIAVNFTG TVNTITAIMS 130 140 150 160 170 180 FWDKRKGGPG GVIANVCSVT GFNAIYQVPV YSASKAAALS FTNSLAKLAP ITGVTAYSIN 190 200 210 220 230 240 PGITKTPLLH KFNSWLDVEP RVGELLLEHP TQTSLECAQN FVKAIEANQN GAIWKVDLGT 250 LEAIEWTKHW DSHI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure and evolution of the Adh genes of Drosophila mojavensis." Atkinson P.W., Mills L.E., Starmer W.T., Sullivan D.T. Genetics 120:713-723(1988) [PubMed: 3224808] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-187; VAL-189 AND LEU-236. Strain: VRF.
[2]	"Delineation of cis-acting sequences required for expression of Drosophila mojavensis Adh-1." Bayer C.A., Curtiss S.W., Weaver J.A., Sullivan D.T. Genetics 131:143-153(1992) [PubMed: 1317314] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-187; VAL-189 AND LEU-236. Strain: VRF.
[3]	"Sequence variation of alcohol dehydrogenase (Adh) paralogs in cactophilic Drosophila." Matzkin L.M., Eanes W.F. Genetics 163:181-194(2003) [PubMed: 12586706] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: MJBC 103.3, MJBC 108.5, MJBC 115.4, MJBC 157.3, MJBC 202.2, MJBC 205.1, MJBC 25.3, MJBC 33.3, MJBC 35.1, MJBC 39.3, MJBC 47.3, MJBC 80 and MJBC 95.1.
[4]	"Population genetics and geographic variation of alcohol dehydrogenase (Adh) paralogs and glucose-6-phosphate dehydrogenase (G6pd) in Drosophila mojavensis." Matzkin L.M. Mol. Biol. Evol. 21:276-285(2004) [PubMed: 14660699] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: MJS 115, MJS 122, MJS 127, MJS 132, MJS 14, MJS 154, MJS 36, MJS 58.2, MJS 68, MJS 84 and MJS 87.
[5]	"Evolution of genes and genomes on the Drosophila phylogeny." Drosophila 12 genomes consortium Nature 450:203-218(2007) [PubMed: 17994087] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tucson 15081-1352.22.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M37276 Genomic DNA. Translation: AAA28335.1. X12536 Genomic DNA. Translation: CAA31055.1. AY154827 Genomic DNA. Translation: AAN86863.1. AY154828 Genomic DNA. Translation: AAN86864.1. AY154829 Genomic DNA. Translation: AAN86865.1. AY154830 Genomic DNA. Translation: AAN86866.1. AY154831 Genomic DNA. Translation: AAN86867.1. AY154832 Genomic DNA. Translation: AAN86868.1. AY154833 Genomic DNA. Translation: AAN86869.1. AY154834 Genomic DNA. Translation: AAN86870.1. AY154835 Genomic DNA. Translation: AAN86871.1. AY154836 Genomic DNA. Translation: AAN86872.1. AY154837 Genomic DNA. Translation: AAN86873.1. AY154838 Genomic DNA. Translation: AAN86874.1. AY154839 Genomic DNA. Translation: AAN86875.1. AY364493 Genomic DNA. Translation: AAR12927.1. AY364494 Genomic DNA. Translation: AAR12928.1. AY364495 Genomic DNA. Translation: AAR12929.1. AY364496 Genomic DNA. Translation: AAR12930.1. AY364497 Genomic DNA. Translation: AAR12931.1. AY364498 Genomic DNA. Translation: AAR12932.1. AY364499 Genomic DNA. Translation: AAR12933.1. AY364500 Genomic DNA. Translation: AAR12934.1. AY364501 Genomic DNA. Translation: AAR12935.1. AY364502 Genomic DNA. Translation: AAR12936.1. AY364503 Genomic DNA. Translation: AAR12937.1. AY364504 Genomic DNA. Translation: AAR12938.1. AY364505 Genomic DNA. Translation: AAR12939.1. AY364506 Genomic DNA. Translation: AAR12940.1. AY364507 Genomic DNA. Translation: AAR12941.1. CH933807 Genomic DNA. Translation: EDW12372.1.
PIR	S01902.
RefSeq	XP_002002930.1.
3D structure databases
HSSP	HSSP built from PDB template 1B16 based on UniProtKB P10807.
SMR	P09370. Positions 1-254.
ModBase	Search...
Genome annotation databases
GeneID	6576953.
KEGG	dmo:Dmoj_GI17644.
Organism-specific databases
FlyBase	FBgn0012566. Dmoj\Adh1.
Enzyme and pathway databases
BRENDA	1.1.1.1. 38735.
Family and domain databases
InterPro	IPR002198. DH_sc/Rdtase_SDR. IPR002425. Insect_ADH. IPR002424. Insect_AlcDH_fam. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR19410. ADH_short_C2. 1 hit.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR01168. ALCDHDRGNASE. PR01167. INSADHFAMILY. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADH1_DROMO

Accession

Primary (citable) accession number: P09370
Secondary accession number(s): Q6UPV9 , Q6UPW6, Q6UPX2, Q867T9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	October 14, 2008
Last modified:	September 22, 2009
This is version 63 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project