ID ADH2_DROMO Reviewed; 254 AA. AC P09369; Q6YFE3; Q867G0; Q86LV9; DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot. DT 14-OCT-2008, sequence version 3. DT 16-JUN-2009, entry version 62. DE RecName: Full=Alcohol dehydrogenase 2; DE EC=1.1.1.1; GN Name=Adh2; ORFNames=GI17643; OS Drosophila mojavensis (Fruit fly). OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila. OX NCBI_TaxID=7230; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS SER-28; THR-92; RP LEU-112; THR-115; ILE-136; LEU-146; PRO-147; GLN-226 AND LEU-236. RC STRAIN=VRF; RX MEDLINE=89137903; PubMed=3224808; RA Atkinson P.W., Mills L.E., Starmer W.T., Sullivan D.T.; RT "Structure and evolution of the Adh genes of Drosophila mojavensis."; RL Genetics 120:713-723(1988). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS SER-28; THR-92; RP LEU-112; THR-115; ILE-136; LEU-146; PRO-147; GLN-226 AND LEU-236. RC STRAIN=VRF; RX PubMed=1317314; RA Bayer C.A., Curtiss S.W., Weaver J.A., Sullivan D.T.; RT "Delineation of cis-acting sequences required for expression of RT Drosophila mojavensis Adh-1."; RL Genetics 131:143-153(1992). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS SER-28 AND SER-71. RC STRAIN=MJBC 103.3, MJBC 108.5, MJBC 115.4, MJBC 157.3, MJBC 202.2, RC MJBC 205.1, MJBC 25.3, MJBC 33.3, MJBC 35.1, MJBC 39.3, MJBC 47.3, RC MJBC 80, and MJBC 95.1; RX MEDLINE=22474227; PubMed=12586706; RA Matzkin L.M., Eanes W.F.; RT "Sequence variation of alcohol dehydrogenase (Adh) paralogs in RT cactophilic Drosophila."; RL Genetics 163:181-194(2003). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS SER-28; TYR-98; RP THR-115; ILE-136 AND LEU-236. RC STRAIN=MJS 115, MJS 122, MJS 127, MJS 132, MJS 133, MJS 14, RC MJS 147.2F, MJS 154, MJS 16F, MJS 36, MJS 58.2, MJS 68, MJS 84, RC MJS 87, and MJS 93; RX PubMed=14660699; DOI=10.1093/molbev/msh019; RA Matzkin L.M.; RT "Population genetics and geographic variation of alcohol dehydrogenase RT (Adh) paralogs and glucose-6-phosphate dehydrogenase (G6pd) in RT Drosophila mojavensis."; RL Mol. Biol. Evol. 21:276-285(2004). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tucson 15081-1352.22; RX PubMed=17994087; DOI=10.1038/nature06341; RG Drosophila 12 genomes consortium; RT "Evolution of genes and genomes on the Drosophila phylogeny."; RL Nature 450:203-218(2007). CC -!- CATALYTIC ACTIVITY: An alcohol + NAD(+) = an aldehyde or ketone + CC NADH. CC -!- SUBUNIT: Homodimer. CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases CC (SDR) family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; M37276; AAA28334.1; -; Genomic_DNA. DR EMBL; X12536; CAA31054.1; -; Genomic_DNA. DR EMBL; AY154864; AAN86900.1; -; Genomic_DNA. DR EMBL; AY154865; AAN86901.1; -; Genomic_DNA. DR EMBL; AY154866; AAN86902.1; -; Genomic_DNA. DR EMBL; AY154867; AAN86903.1; -; Genomic_DNA. DR EMBL; AY154868; AAN86904.1; -; Genomic_DNA. DR EMBL; AY154869; AAN86905.1; -; Genomic_DNA. DR EMBL; AY154870; AAN86906.1; -; Genomic_DNA. DR EMBL; AY154871; AAN86907.1; -; Genomic_DNA. DR EMBL; AY154872; AAN86908.1; -; Genomic_DNA. DR EMBL; AY154873; AAN86909.1; -; Genomic_DNA. DR EMBL; AY154874; AAN86910.1; -; Genomic_DNA. DR EMBL; AY154875; AAN86911.1; -; Genomic_DNA. DR EMBL; AY154876; AAN86912.1; -; Genomic_DNA. DR EMBL; AY364508; AAR21255.1; -; Genomic_DNA. DR EMBL; AY364509; AAR21256.1; -; Genomic_DNA. DR EMBL; AY364510; AAR21257.1; -; Genomic_DNA. DR EMBL; AY364511; AAR21258.1; -; Genomic_DNA. DR EMBL; AY364512; AAR21259.1; -; Genomic_DNA. DR EMBL; AY364513; AAR21260.1; -; Genomic_DNA. DR EMBL; AY364514; AAR21261.1; -; Genomic_DNA. DR EMBL; AY364515; AAR21262.1; -; Genomic_DNA. DR EMBL; AY364516; AAR21263.1; -; Genomic_DNA. DR EMBL; AY364517; AAR21264.1; -; Genomic_DNA. DR EMBL; AY364518; AAR21265.1; -; Genomic_DNA. DR EMBL; AY364519; AAR21266.1; -; Genomic_DNA. DR EMBL; AY364520; AAR21267.1; -; Genomic_DNA. DR EMBL; AY364521; AAR21268.1; -; Genomic_DNA. DR EMBL; AY364522; AAR21269.1; -; Genomic_DNA. DR EMBL; CH933807; EDW12371.1; -; Genomic_DNA. DR PIR; S01901; S01901. DR RefSeq; XP_002002929.1; -. DR HSSP; P10807; 1B16. DR SMR; P09369; 1-254. DR GeneID; 6576952; -. DR KEGG; dmo:Dmoj_GI17643; -. DR FlyBase; FBgn0012567; Dmoj\Adh2. DR BRENDA; 1.1.1.1; 38735. DR GO; GO:0004022; F:alcohol dehydrogenase activity; IEA:EC. DR GO; GO:0005488; F:binding; IEA:InterPro. DR GO; GO:0006066; P:cellular alcohol metabolic process; IEA:InterPro. DR GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW. DR InterPro; IPR002198; DH_sc/Rdtase_SDR. DR InterPro; IPR002425; Insect_ADH. DR InterPro; IPR002424; Insect_AlcDH_fam. DR InterPro; IPR016040; NAD(P)-bd_dom. DR Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1. DR PANTHER; PTHR19410; ADH_short_C2; 1. DR Pfam; PF00106; adh_short; 1. DR PRINTS; PR01168; ALCDHDRGNASE. DR PRINTS; PR01167; INSADHFAMILY. DR PRINTS; PR00080; SDRFAMILY. DR PROSITE; PS00061; ADH_SHORT; 1. PE 3: Inferred from homology; KW NAD; Oxidoreductase; Polymorphism. FT INIT_MET 1 1 Removed. FT CHAIN 2 254 Alcohol dehydrogenase 2. FT /FTId=PRO_0000054479. FT NP_BIND 10 33 NAD (By similarity). FT ACT_SITE 151 151 Proton acceptor (By similarity). FT BINDING 138 138 Substrate (By similarity). FT VARIANT 28 28 R -> S (in strain: MJBC 95.1, MJS 93 and FT VRF). FT VARIANT 71 71 T -> S (in strain: MJBC 33.3). FT VARIANT 92 92 A -> T (in strain: VRF). FT VARIANT 98 98 H -> Y (in strain: MJS 115, MJS 147.2F, FT MJS 16F, MJS 122, MJS 127, MJS 132, MJS FT 14, MJS 154, MJS 36, MJS 58.2, MJS 68, FT MJS 84 and MJS 87). FT VARIANT 112 112 V -> L (in strain: VRF). FT VARIANT 115 115 I -> T (in strain: MJS 115, MJS 122, MJS FT 127, MJS 132, MJS 133, MJS 14, MJS FT 147.2F, MJS 154, MJS 16F, MJS 36, MJS FT 58.2, MJS 68, MJS 84, MJS 87, MJS 93 and FT VRF). FT VARIANT 136 136 V -> I (in strain: MJS 115, MJS 122, MJS FT 127, MJS 132, MJS 133, MJS 14, MJS FT 147.2F, MJS 154, MJS 16F, MJS 36, MJS FT 58.2, MJS 68, MJS 84, MJS 87, MJS 93 and FT VRF). FT VARIANT 146 146 Y -> L (in strain: VRF). FT VARIANT 147 147 Q -> P (in strain: VRF). FT VARIANT 226 226 E -> Q (in strain: VRF). FT VARIANT 236 236 V -> L (in strain: MJS 115, MJS 122, MJS FT 127, MJS 132, MJS 133, MJS 14, MJS FT 147.2F, MJS 154, MJS 16F, MJS 36, MJS FT 58.2, MJS 68, MJS 84, MJS 87, MJS 93 and FT VRF). SQ SEQUENCE 254 AA; 27605 MW; DE52DEA5DA7508D2 CRC64; MAIANKNIIF VAGLGGIGFD TSREIVKRGP KNLVILDRIE NPAAIAELKA LNPKVTVTFY PYDVTVSVAE TTKLLKTIFD KLKTVDLLIN GAGILDDHQI ERTIAVNFTG TVNTITAIMS FWDKRKGGPG GVIANVCSVT GFNAIYQVPV YSASKAAALS FTNSLARLAP ITGVTAYSIN PGITKTTLVH KFNSWLDVEP RVAELLLEHP TQTTLQCAQN FVKAIEANQN GAIWKVDLGT LEAIEWTKHW DSHI //