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Protein

Alcohol dehydrogenase 2

Gene

Adh2

Organism
Drosophila mojavensis (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei138SubstrateBy similarity1
Active sitei151Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 33NADBy similarityAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 2 (EC:1.1.1.1)
Gene namesi
Name:Adh2
ORF Names:GI17643
OrganismiDrosophila mojavensis (Fruit fly)
Taxonomic identifieri7230 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
Proteomesi
  • UP000009192 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0012567. Dmoj\Adh2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000544792 – 254Alcohol dehydrogenase 2Add BLAST253

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliP09369.
SMRiP09369.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

InParanoidiP09369.
KOiK00001.
OMAiWSKHWDS.
OrthoDBiEOG091G0OC9.
PhylomeDBiP09369.

Family and domain databases

InterProiView protein in InterPro
IPR002425. ADH_Drosophila-type.
IPR002424. ADH_insect.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PRINTSiPR01168. ALCDHDRGNASE.
PR01167. INSADHFAMILY.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00061. ADH_SHORT. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09369-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIANKNIIF VAGLGGIGFD TSREIVKRGP KNLVILDRIE NPAAIAELKA
60 70 80 90 100
LNPKVTVTFY PYDVTVSVAE TTKLLKTIFD KLKTVDLLIN GAGILDDHQI
110 120 130 140 150
ERTIAVNFTG TVNTITAIMS FWDKRKGGPG GVIANVCSVT GFNAIYQVPV
160 170 180 190 200
YSASKAAALS FTNSLARLAP ITGVTAYSIN PGITKTTLVH KFNSWLDVEP
210 220 230 240 250
RVAELLLEHP TQTTLQCAQN FVKAIEANQN GAIWKVDLGT LEAIEWTKHW

DSHI
Length:254
Mass (Da):27,605
Last modified:October 14, 2008 - v3
Checksum:iDE52DEA5DA7508D2
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti28R → S in strain: MJBC 95.1, MJS 93 and VRF. 4 Publications1
Natural varianti71T → S in strain: MJBC 33.3. 1 Publication1
Natural varianti92A → T in strain: VRF. 2 Publications1
Natural varianti98H → Y in strain: MJS 115, MJS 147.2F, MJS 16F, MJS 122, MJS 127, MJS 132, MJS 14, MJS 154, MJS 36, MJS 58.2, MJS 68, MJS 84 and MJS 87. 1 Publication1
Natural varianti112V → L in strain: VRF. 2 Publications1
Natural varianti115I → T in strain: MJS 115, MJS 122, MJS 127, MJS 132, MJS 133, MJS 14, MJS 147.2F, MJS 154, MJS 16F, MJS 36, MJS 58.2, MJS 68, MJS 84, MJS 87, MJS 93 and VRF. 3 Publications1
Natural varianti136V → I in strain: MJS 115, MJS 122, MJS 127, MJS 132, MJS 133, MJS 14, MJS 147.2F, MJS 154, MJS 16F, MJS 36, MJS 58.2, MJS 68, MJS 84, MJS 87, MJS 93 and VRF. 3 Publications1
Natural varianti146Y → L in strain: VRF. 2 Publications1
Natural varianti147Q → P in strain: VRF. 2 Publications1
Natural varianti226E → Q in strain: VRF. 2 Publications1
Natural varianti236V → L in strain: MJS 115, MJS 122, MJS 127, MJS 132, MJS 133, MJS 14, MJS 147.2F, MJS 154, MJS 16F, MJS 36, MJS 58.2, MJS 68, MJS 84, MJS 87, MJS 93 and VRF. 3 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37276 Genomic DNA. Translation: AAA28334.1.
X12536 Genomic DNA. Translation: CAA31054.1.
AY154864 Genomic DNA. Translation: AAN86900.1.
AY154865 Genomic DNA. Translation: AAN86901.1.
AY154866 Genomic DNA. Translation: AAN86902.1.
AY154867 Genomic DNA. Translation: AAN86903.1.
AY154868 Genomic DNA. Translation: AAN86904.1.
AY154869 Genomic DNA. Translation: AAN86905.1.
AY154870 Genomic DNA. Translation: AAN86906.1.
AY154871 Genomic DNA. Translation: AAN86907.1.
AY154872 Genomic DNA. Translation: AAN86908.1.
AY154873 Genomic DNA. Translation: AAN86909.1.
AY154874 Genomic DNA. Translation: AAN86910.1.
AY154875 Genomic DNA. Translation: AAN86911.1.
AY154876 Genomic DNA. Translation: AAN86912.1.
AY364508 Genomic DNA. Translation: AAR21255.1.
AY364509 Genomic DNA. Translation: AAR21256.1.
AY364510 Genomic DNA. Translation: AAR21257.1.
AY364511 Genomic DNA. Translation: AAR21258.1.
AY364512 Genomic DNA. Translation: AAR21259.1.
AY364513 Genomic DNA. Translation: AAR21260.1.
AY364514 Genomic DNA. Translation: AAR21261.1.
AY364515 Genomic DNA. Translation: AAR21262.1.
AY364516 Genomic DNA. Translation: AAR21263.1.
AY364517 Genomic DNA. Translation: AAR21264.1.
AY364518 Genomic DNA. Translation: AAR21265.1.
AY364519 Genomic DNA. Translation: AAR21266.1.
AY364520 Genomic DNA. Translation: AAR21267.1.
AY364521 Genomic DNA. Translation: AAR21268.1.
AY364522 Genomic DNA. Translation: AAR21269.1.
CH933807 Genomic DNA. Translation: EDW12371.1.
PIRiS01901.
RefSeqiXP_002002929.1. XM_002002893.2.

Genome annotation databases

EnsemblMetazoaiFBtr0168368; FBpp0166860; FBgn0012567.
GeneIDi6576952.
KEGGidmo:Dmoj_GI17643.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37276 Genomic DNA. Translation: AAA28334.1.
X12536 Genomic DNA. Translation: CAA31054.1.
AY154864 Genomic DNA. Translation: AAN86900.1.
AY154865 Genomic DNA. Translation: AAN86901.1.
AY154866 Genomic DNA. Translation: AAN86902.1.
AY154867 Genomic DNA. Translation: AAN86903.1.
AY154868 Genomic DNA. Translation: AAN86904.1.
AY154869 Genomic DNA. Translation: AAN86905.1.
AY154870 Genomic DNA. Translation: AAN86906.1.
AY154871 Genomic DNA. Translation: AAN86907.1.
AY154872 Genomic DNA. Translation: AAN86908.1.
AY154873 Genomic DNA. Translation: AAN86909.1.
AY154874 Genomic DNA. Translation: AAN86910.1.
AY154875 Genomic DNA. Translation: AAN86911.1.
AY154876 Genomic DNA. Translation: AAN86912.1.
AY364508 Genomic DNA. Translation: AAR21255.1.
AY364509 Genomic DNA. Translation: AAR21256.1.
AY364510 Genomic DNA. Translation: AAR21257.1.
AY364511 Genomic DNA. Translation: AAR21258.1.
AY364512 Genomic DNA. Translation: AAR21259.1.
AY364513 Genomic DNA. Translation: AAR21260.1.
AY364514 Genomic DNA. Translation: AAR21261.1.
AY364515 Genomic DNA. Translation: AAR21262.1.
AY364516 Genomic DNA. Translation: AAR21263.1.
AY364517 Genomic DNA. Translation: AAR21264.1.
AY364518 Genomic DNA. Translation: AAR21265.1.
AY364519 Genomic DNA. Translation: AAR21266.1.
AY364520 Genomic DNA. Translation: AAR21267.1.
AY364521 Genomic DNA. Translation: AAR21268.1.
AY364522 Genomic DNA. Translation: AAR21269.1.
CH933807 Genomic DNA. Translation: EDW12371.1.
PIRiS01901.
RefSeqiXP_002002929.1. XM_002002893.2.

3D structure databases

ProteinModelPortaliP09369.
SMRiP09369.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0168368; FBpp0166860; FBgn0012567.
GeneIDi6576952.
KEGGidmo:Dmoj_GI17643.

Organism-specific databases

FlyBaseiFBgn0012567. Dmoj\Adh2.

Phylogenomic databases

InParanoidiP09369.
KOiK00001.
OMAiWSKHWDS.
OrthoDBiEOG091G0OC9.
PhylomeDBiP09369.

Family and domain databases

InterProiView protein in InterPro
IPR002425. ADH_Drosophila-type.
IPR002424. ADH_insect.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PRINTSiPR01168. ALCDHDRGNASE.
PR01167. INSADHFAMILY.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00061. ADH_SHORT. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADH2_DROMO
AccessioniPrimary (citable) accession number: P09369
Secondary accession number(s): Q6YFE3, Q867G0, Q86LV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: October 14, 2008
Last modified: May 10, 2017
This is version 103 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.