Alcohol dehydrogenase 2 - Drosophila mojavensis (Fruit fly)

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Reviewed, UniProtKB/Swiss-Prot P09369 (ADH2_DROMO)

Last modified June 16, 2009. Version 62. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
Alcohol dehydrogenase 2
EC=1.1.1.1

Gene names

Name:	Adh2
ORF Names:	GI17643

Organism

Drosophila mojavensis (Fruit fly)

Taxonomic identifier

7230 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila

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Protein attributes

Sequence length	254 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

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General annotation (Comments)

Catalytic activity	An alcohol + NAD⁺ = an aldehyde or ketone + NADH.
Subunit structure	Homodimer.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

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Ontologies

Keywords
Coding sequence diversity	Polymorphism
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	cellular alcohol metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alcohol dehydrogenase activity Inferred from electronic annotation. Source: EC binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

Removed

Chain

2 – 254

253

Alcohol dehydrogenase 2

PRO_0000054479

Regions

Nucleotide binding

10 – 33

NAD By similarity

Sites

Active site

151

Proton acceptor By similarity

Binding site

138

Substrate By similarity

Natural variations

Natural variant

R → S in strain: MJBC 95.1, MJS 93 and VRF. Ref.1 Ref.2 Ref.3 Ref.4

Natural variant

T → S in strain: MJBC 33.3. Ref.3

Natural variant

A → T in strain: VRF. Ref.1 Ref.2

Natural variant

H → Y in strain: MJS 115, MJS 147.2F, MJS 16F, MJS 122, MJS 127, MJS 132, MJS 14, MJS 154, MJS 36, MJS 58.2, MJS 68, MJS 84 and MJS 87. Ref.4

Natural variant

112

V → L in strain: VRF. Ref.1 Ref.2

Natural variant

115

I → T in strain: MJS 115, MJS 122, MJS 127, MJS 132, MJS 133, MJS 14, MJS 147.2F, MJS 154, MJS 16F, MJS 36, MJS 58.2, MJS 68, MJS 84, MJS 87, MJS 93 and VRF. Ref.1 Ref.2 Ref.4

Natural variant

136

V → I in strain: MJS 115, MJS 122, MJS 127, MJS 132, MJS 133, MJS 14, MJS 147.2F, MJS 154, MJS 16F, MJS 36, MJS 58.2, MJS 68, MJS 84, MJS 87, MJS 93 and VRF. Ref.1 Ref.2 Ref.4

Natural variant

146

Y → L in strain: VRF. Ref.1 Ref.2

Natural variant

147

Q → P in strain: VRF. Ref.1 Ref.2

Natural variant

226

E → Q in strain: VRF. Ref.1 Ref.2

Natural variant

236

V → L in strain: MJS 115, MJS 122, MJS 127, MJS 132, MJS 133, MJS 14, MJS 147.2F, MJS 154, MJS 16F, MJS 36, MJS 58.2, MJS 68, MJS 84, MJS 87, MJS 93 and VRF. Ref.1 Ref.2 Ref.4

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Sequences

Sequence

Length

Mass (Da)

Tools

P09369-1 [UniParc].

Last modified October 14, 2008. Version 3.
Checksum: DE52DEA5DA7508D2
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FASTA

254

27,605

        10         20         30         40         50         60 
MAIANKNIIF VAGLGGIGFD TSREIVKRGP KNLVILDRIE NPAAIAELKA LNPKVTVTFY 

        70         80         90        100        110        120 
PYDVTVSVAE TTKLLKTIFD KLKTVDLLIN GAGILDDHQI ERTIAVNFTG TVNTITAIMS 

       130        140        150        160        170        180 
FWDKRKGGPG GVIANVCSVT GFNAIYQVPV YSASKAAALS FTNSLARLAP ITGVTAYSIN 

       190        200        210        220        230        240 
PGITKTTLVH KFNSWLDVEP RVAELLLEHP TQTTLQCAQN FVKAIEANQN GAIWKVDLGT 

       250 
LEAIEWTKHW DSHI

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure and evolution of the Adh genes of Drosophila mojavensis." Atkinson P.W., Mills L.E., Starmer W.T., Sullivan D.T. Genetics 120:713-723(1988) [PubMed: 3224808] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-28; THR-92; LEU-112; THR-115; ILE-136; LEU-146; PRO-147; GLN-226 AND LEU-236. Strain: VRF.
[2]	"Delineation of cis-acting sequences required for expression of Drosophila mojavensis Adh-1." Bayer C.A., Curtiss S.W., Weaver J.A., Sullivan D.T. Genetics 131:143-153(1992) [PubMed: 1317314] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-28; THR-92; LEU-112; THR-115; ILE-136; LEU-146; PRO-147; GLN-226 AND LEU-236. Strain: VRF.
[3]	"Sequence variation of alcohol dehydrogenase (Adh) paralogs in cactophilic Drosophila." Matzkin L.M., Eanes W.F. Genetics 163:181-194(2003) [PubMed: 12586706] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-28 AND SER-71. Strain: MJBC 103.3, MJBC 108.5, MJBC 115.4, MJBC 157.3, MJBC 202.2, MJBC 205.1, MJBC 25.3, MJBC 33.3, MJBC 35.1, MJBC 39.3, MJBC 47.3, MJBC 80 and MJBC 95.1.
[4]	"Population genetics and geographic variation of alcohol dehydrogenase (Adh) paralogs and glucose-6-phosphate dehydrogenase (G6pd) in Drosophila mojavensis." Matzkin L.M. Mol. Biol. Evol. 21:276-285(2004) [PubMed: 14660699] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-28; TYR-98; THR-115; ILE-136 AND LEU-236. Strain: MJS 115, MJS 122, MJS 127, MJS 132, MJS 133, MJS 14, MJS 147.2F, MJS 154, MJS 16F, MJS 36, MJS 58.2, MJS 68, MJS 84, MJS 87 and MJS 93.
[5]	"Evolution of genes and genomes on the Drosophila phylogeny." Drosophila 12 genomes consortium Nature 450:203-218(2007) [PubMed: 17994087] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tucson 15081-1352.22.

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Cross-references

Sequence databases
	M37276 Genomic DNA. Translation: AAA28334.1. X12536 Genomic DNA. Translation: CAA31054.1. AY154864 Genomic DNA. Translation: AAN86900.1. AY154865 Genomic DNA. Translation: AAN86901.1. AY154866 Genomic DNA. Translation: AAN86902.1. AY154867 Genomic DNA. Translation: AAN86903.1. AY154868 Genomic DNA. Translation: AAN86904.1. AY154869 Genomic DNA. Translation: AAN86905.1. AY154870 Genomic DNA. Translation: AAN86906.1. AY154871 Genomic DNA. Translation: AAN86907.1. AY154872 Genomic DNA. Translation: AAN86908.1. AY154873 Genomic DNA. Translation: AAN86909.1. AY154874 Genomic DNA. Translation: AAN86910.1. AY154875 Genomic DNA. Translation: AAN86911.1. AY154876 Genomic DNA. Translation: AAN86912.1. AY364508 Genomic DNA. Translation: AAR21255.1. AY364509 Genomic DNA. Translation: AAR21256.1. AY364510 Genomic DNA. Translation: AAR21257.1. AY364511 Genomic DNA. Translation: AAR21258.1. AY364512 Genomic DNA. Translation: AAR21259.1. AY364513 Genomic DNA. Translation: AAR21260.1. AY364514 Genomic DNA. Translation: AAR21261.1. AY364515 Genomic DNA. Translation: AAR21262.1. AY364516 Genomic DNA. Translation: AAR21263.1. AY364517 Genomic DNA. Translation: AAR21264.1. AY364518 Genomic DNA. Translation: AAR21265.1. AY364519 Genomic DNA. Translation: AAR21266.1. AY364520 Genomic DNA. Translation: AAR21267.1. AY364521 Genomic DNA. Translation: AAR21268.1. AY364522 Genomic DNA. Translation: AAR21269.1. CH933807 Genomic DNA. Translation: EDW12371.1.
PIR	S01901.
RefSeq	XP_002002929.1.
3D structure databases
HSSP	HSSP built from PDB template 1B16 based on UniProtKB P10807.
SMR	P09369. Positions 1-254.
ModBase	Search...
Genome annotation databases
GeneID	6576952.
KEGG	dmo:Dmoj_GI17643.
Organism-specific databases
FlyBase	FBgn0012567. Dmoj\Adh2.
Enzyme and pathway databases
BRENDA	1.1.1.1. 38735.
Family and domain databases
InterPro	IPR002198. DH_sc/Rdtase_SDR. IPR002425. Insect_ADH. IPR002424. Insect_AlcDH_fam. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR19410. ADH_short_C2. 1 hit.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR01168. ALCDHDRGNASE. PR01167. INSADHFAMILY. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...

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Entry information

Entry name

ADH2_DROMO

Accession

Primary (citable) accession number: P09369
Secondary accession number(s): Q6YFE3, Q867G0, Q86LV9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	October 14, 2008
Last modified:	June 16, 2009
This is version 62 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project

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Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Natural variations

Sequences

References

Cross-references

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents