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Protein

Growth-regulated alpha protein

Gene

CXCL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity.1 Publication

GO - Molecular functioni

  • chemokine activity Source: ProtInc
  • CXCR chemokine receptor binding Source: GO_Central
  • enzyme activator activity Source: ProtInc
  • receptor binding Source: ProtInc

GO - Biological processi

  • actin cytoskeleton organization Source: ProtInc
  • cell proliferation Source: ProtInc
  • chemokine-mediated signaling pathway Source: GO_Central
  • chemotaxis Source: ProtInc
  • G-protein coupled receptor signaling pathway Source: ProtInc
  • immune response Source: GO_Central
  • inflammatory response Source: ProtInc
  • intracellular signal transduction Source: ProtInc
  • negative regulation of cell proliferation Source: ProtInc
  • nervous system development Source: ProtInc
  • positive regulation of neutrophil chemotaxis Source: GO_Central
  • response to lipopolysaccharide Source: GO_Central
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Keywords - Biological processi

Inflammatory response

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163739-MONOMER.
ReactomeiR-HSA-380108. Chemokine receptors bind chemokines.
R-HSA-418594. G alpha (i) signalling events.
R-HSA-6798695. Neutrophil degranulation.
SIGNORiP09341.

Names & Taxonomyi

Protein namesi
Recommended name:
Growth-regulated alpha protein
Alternative name(s):
C-X-C motif chemokine 1
GRO-alpha(1-73)
Melanoma growth stimulatory activity
Short name:
MGSA
Neutrophil-activating protein 3
Short name:
NAP-3
Cleaved into the following 3 chains:
Gene namesi
Name:CXCL1
Synonyms:GRO, GRO1, GROA, MGSA, SCYB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:4602. CXCL1.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: Reactome
  • extracellular space Source: ProtInc
  • intracellular Source: GOC
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi2919.
OpenTargetsiENSG00000163739.
PharmGKBiPA35050.

Polymorphism and mutation databases

BioMutaiCXCL1.
DMDMi121622.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 345 PublicationsAdd BLAST34
ChainiPRO_000000504935 – 107Growth-regulated alpha proteinAdd BLAST73
ChainiPRO_000000505038 – 107GRO-alpha(4-73)Add BLAST70
ChainiPRO_000000505139 – 107GRO-alpha(5-73)Add BLAST69
ChainiPRO_000000505240 – 107GRO-alpha(6-73)Add BLAST68

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi43 ↔ 69
Disulfide bondi45 ↔ 85

Post-translational modificationi

N-terminal processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) are produced by proteolytic cleavage after secretion from peripheral blood monocytes.1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP09341.
PaxDbiP09341.
PeptideAtlasiP09341.
PRIDEiP09341.

PTM databases

PhosphoSitePlusiP09341.
SwissPalmiP09341.

Miscellaneous databases

PMAP-CutDBP09341.

Expressioni

Gene expression databases

BgeeiENSG00000163739.
CleanExiHS_CXCL1.
GenevisibleiP09341. HS.

Interactioni

GO - Molecular functioni

  • chemokine activity Source: ProtInc
  • CXCR chemokine receptor binding Source: GO_Central
  • receptor binding Source: ProtInc

Protein-protein interaction databases

BioGridi109176. 8 interactors.
DIPiDIP-5896N.
IntActiP09341. 6 interactors.
STRINGi9606.ENSP00000379110.

Structurei

Secondary structure

1107
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi41 – 43Combined sources3
Beta strandi49 – 51Combined sources3
Turni54 – 56Combined sources3
Beta strandi57 – 63Combined sources7
Beta strandi73 – 78Combined sources6
Beta strandi83 – 86Combined sources4
Helixi91 – 103Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MGSNMR-A/B35-107[»]
1MSGNMR-A/B35-106[»]
1MSHNMR-A/B35-106[»]
1RODNMR-A/B40-62[»]
A/B89-107[»]
ProteinModelPortaliP09341.
SMRiP09341.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP09341.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3WE. Eukaryota.
ENOG410ZT1C. LUCA.
GeneTreeiENSGT00530000062901.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiP09341.
KOiK05505.
OMAiLNCDKSN.
OrthoDBiEOG091G14TE.
PhylomeDBiP09341.
TreeFamiTF333433.

Family and domain databases

CDDicd00273. Chemokine_CXC. 1 hit.
InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR033899. CXC_Chemokine_domain.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09341-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARAALSAAP SNPRLLRVAL LLLLLVAAGR RAAGASVATE LRCQCLQTLQ
60 70 80 90 100
GIHPKNIQSV NVKSPGPHCA QTEVIATLKN GRKACLNPAS PIVKKIIEKM

LNSDKSN
Length:107
Mass (Da):11,301
Last modified:July 1, 1989 - v1
Checksum:i17048A6B4D765CA2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03561 mRNA. Translation: AAA35933.1.
X12510 mRNA. Translation: CAA31027.1.
X54489 Genomic DNA. Translation: CAA38361.1.
BT006880 mRNA. Translation: AAP35526.1.
BC011976 mRNA. Translation: AAH11976.1.
CCDSiCCDS47074.1.
PIRiS13669. A28414.
RefSeqiNP_001502.1. NM_001511.3.
UniGeneiHs.708652.
Hs.789.

Genome annotation databases

EnsembliENST00000395761; ENSP00000379110; ENSG00000163739.
GeneIDi2919.
KEGGihsa:2919.
UCSCiuc003hhh.4. human.

Cross-referencesi

Web resourcesi

Wikipedia

CXCL1 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03561 mRNA. Translation: AAA35933.1.
X12510 mRNA. Translation: CAA31027.1.
X54489 Genomic DNA. Translation: CAA38361.1.
BT006880 mRNA. Translation: AAP35526.1.
BC011976 mRNA. Translation: AAH11976.1.
CCDSiCCDS47074.1.
PIRiS13669. A28414.
RefSeqiNP_001502.1. NM_001511.3.
UniGeneiHs.708652.
Hs.789.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MGSNMR-A/B35-107[»]
1MSGNMR-A/B35-106[»]
1MSHNMR-A/B35-106[»]
1RODNMR-A/B40-62[»]
A/B89-107[»]
ProteinModelPortaliP09341.
SMRiP09341.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109176. 8 interactors.
DIPiDIP-5896N.
IntActiP09341. 6 interactors.
STRINGi9606.ENSP00000379110.

PTM databases

PhosphoSitePlusiP09341.
SwissPalmiP09341.

Polymorphism and mutation databases

BioMutaiCXCL1.
DMDMi121622.

Proteomic databases

MaxQBiP09341.
PaxDbiP09341.
PeptideAtlasiP09341.
PRIDEiP09341.

Protocols and materials databases

DNASUi2919.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000395761; ENSP00000379110; ENSG00000163739.
GeneIDi2919.
KEGGihsa:2919.
UCSCiuc003hhh.4. human.

Organism-specific databases

CTDi2919.
DisGeNETi2919.
GeneCardsiCXCL1.
H-InvDBHIX0120073.
HGNCiHGNC:4602. CXCL1.
MIMi155730. gene.
neXtProtiNX_P09341.
OpenTargetsiENSG00000163739.
PharmGKBiPA35050.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J3WE. Eukaryota.
ENOG410ZT1C. LUCA.
GeneTreeiENSGT00530000062901.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiP09341.
KOiK05505.
OMAiLNCDKSN.
OrthoDBiEOG091G14TE.
PhylomeDBiP09341.
TreeFamiTF333433.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163739-MONOMER.
ReactomeiR-HSA-380108. Chemokine receptors bind chemokines.
R-HSA-418594. G alpha (i) signalling events.
R-HSA-6798695. Neutrophil degranulation.
SIGNORiP09341.

Miscellaneous databases

ChiTaRSiCXCL1. human.
EvolutionaryTraceiP09341.
GeneWikiiCXCL1.
GenomeRNAii2919.
PMAP-CutDBP09341.
PROiP09341.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163739.
CleanExiHS_CXCL1.
GenevisibleiP09341. HS.

Family and domain databases

CDDicd00273. Chemokine_CXC. 1 hit.
InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR033899. CXC_Chemokine_domain.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGROA_HUMAN
AccessioniPrimary (citable) accession number: P09341
Secondary accession number(s): Q9UCR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 30, 2016
This is version 174 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.