Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Growth-regulated alpha protein

Gene

CXCL1

Organism
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Has chemotactic activity for neutrophils.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Growth factor
Biological processInflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
Growth-regulated alpha protein
Alternative name(s):
C-X-C motif chemokine 1
Gene namesi
Name:CXCL1
Synonyms:GRO, SCYB1
OrganismiCricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Taxonomic identifieri10029 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaCricetidaeCricetinaeCricetulus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000000504829 – 101Growth-regulated alpha proteinAdd BLAST73

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi37 ↔ 63By similarity
Disulfide bondi39 ↔ 79By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP09340

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP09340
SMRiP09340
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG107789
KOiK05505

Family and domain databases

CDDicd00273 Chemokine_CXC, 1 hit
InterProiView protein in InterPro
IPR001089 Chemokine_CXC
IPR018048 Chemokine_CXC_CS
IPR001811 Chemokine_IL8-like_dom
IPR033899 CXC_Chemokine_domain
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR10179 PTHR10179, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
PRINTSiPR00437 SMALLCYTKCXC
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00471 SMALL_CYTOKINES_CXC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09340-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPATRSLLR APLLLLLLLL ATSRLATGAP VANELRCQCL QTMTGVHLKN
60 70 80 90 100
IQSLKVTPPG PHCTQTEVIA TLKNGQEACL NPEAPMVQKI VQKMLKSGIR

K
Length:101
Mass (Da):10,893
Last modified:July 1, 1989 - v1
Checksum:i666FB7E9CC512019
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03560 mRNA Translation: AAA36985.1
PIRiB28414
RefSeqiNP_001230973.1, NM_001244044.1

Genome annotation databases

GeneIDi100689059
KEGGicge:100689059

Similar proteinsi

Entry informationi

Entry nameiGROA_CRIGR
AccessioniPrimary (citable) accession number: P09340
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health