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Protein

Exfoliative toxin B

Gene

etb

Organism
Staphylococcus aureus
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Has serine protease-like properties and binds to the skin protein profilaggrin. Cleaves substrates after acidic residues. Exfoliative toxins cause impetigous diseases commonly referred as staphylococcal scalded skin syndrome (SSSS).2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei96Charge relay systemPROSITE-ProRule annotation1
Active sitei145Charge relay systemPROSITE-ProRule annotation1
Active sitei217Charge relay systemPROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine protease, Toxin

Protein family/group databases

MEROPSiS01.270.

Names & Taxonomyi

Protein namesi
Recommended name:
Exfoliative toxin B (EC:3.4.21.-)
Alternative name(s):
Epidermolytic toxin B
Gene namesi
Name:etb
Encoded oniPlasmid pRW0010 Publication
OrganismiStaphylococcus aureus
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Add BLAST31
ChainiPRO_000002690632 – 277Exfoliative toxin BAdd BLAST246

Structurei

Secondary structure

1277
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi36 – 45Combined sources10
Turni53 – 55Combined sources3
Beta strandi56 – 58Combined sources3
Helixi67 – 69Combined sources3
Beta strandi70 – 75Combined sources6
Turni76 – 78Combined sources3
Beta strandi79 – 87Combined sources9
Beta strandi90 – 93Combined sources4
Helixi95 – 98Combined sources4
Helixi99 – 101Combined sources3
Helixi105 – 107Combined sources3
Beta strandi108 – 112Combined sources5
Turni118 – 121Combined sources4
Beta strandi130 – 137Combined sources8
Beta strandi147 – 151Combined sources5
Helixi160 – 163Combined sources4
Beta strandi180 – 185Combined sources6
Turni188 – 190Combined sources3
Beta strandi196 – 210Combined sources15
Helixi214 – 216Combined sources3
Beta strandi220 – 222Combined sources3
Beta strandi228 – 236Combined sources9
Turni237 – 240Combined sources4
Beta strandi241 – 246Combined sources6
Turni253 – 255Combined sources3
Helixi265 – 274Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DT2X-ray2.80A33-277[»]
1QTFX-ray2.40A32-277[»]
ProteinModelPortaliP09332.
SMRiP09332.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP09332.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S1B family.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR009003. Peptidase_S1_PA.
IPR008256. Peptidase_S1B.
IPR008353. Peptidase_S1B_tx.
IPR028301. V8_his_AS.
IPR000126. V8_ser_AS.
PRINTSiPR01774. EXFOLTOXIN.
PR00839. V8PROTEASE.
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiView protein in PROSITE
PS00672. V8_HIS. 1 hit.
PS00673. V8_SER. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09332-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKNMFKKII LAASIFTISL PVIPFESTLQ AKEYSAEEIR KLKQKFEVPP
60 70 80 90 100
TDKELYTHIT DNARSPYNSV GTVFVKGSTL ATGVLIGKNT IVTNYHVARE
110 120 130 140 150
AAKNPSNIIF TPAQNRDAEK NEFPTPYGKF EAEEIKESPY GQGLDLAIIK
160 170 180 190 200
LKPNEKGESA GDLIQPANIP DHIDIQKGDK YSLLGYPYNY SAYSLYQSQI
210 220 230 240 250
EMFNDSQYFG YTEVGNSGSG IFNLKGELIG IHSGKGGQHN LPIGVFFNRK
260 270
ISSLYSVDNT FGDTLGNDLK KRAKLDK
Length:277
Mass (Da):30,765
Last modified:July 1, 1989 - v1
Checksum:iDE1A7BEE273CF92F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17348 Genomic DNA. Translation: AAA26628.1.
PIRiA26050.
B26680. PRSAEB.
RefSeqiNP_478350.1. NC_003265.1.
WP_010994026.1. NZ_FKXW01000027.1.
YP_006938189.1. NC_013334.1.
YP_008709833.1. NC_022598.1.

Genome annotation databases

GeneIDi13875352.
17374496.
4594894.

Similar proteinsi

Entry informationi

Entry nameiETB_STAAU
AccessioniPrimary (citable) accession number: P09332
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 22, 2017
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Plasmid

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families