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Protein

CD48 antigen

Gene

CD48

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation.

GO - Molecular functioni

GO - Biological processi

  • defense response Source: ProtInc
  • leukocyte migration Source: Reactome
  • regulation of adaptive immune response Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000117091-MONOMER.
ReactomeiR-HSA-202733. Cell surface interactions at the vascular wall.

Names & Taxonomyi

Protein namesi
Recommended name:
CD48 antigen
Alternative name(s):
B-lymphocyte activation marker BLAST-1
BCM1 surface antigen
Leukocyte antigen MEM-102
SLAM family member 2
Short name:
SLAMF2
Signaling lymphocytic activation molecule 2
TCT.1
CD_antigen: CD48
Gene namesi
Name:CD48
Synonyms:BCM1, BLAST1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:1683. CD48.

Subcellular locationi

GO - Cellular componenti

  • anchored component of membrane Source: UniProtKB-KW
  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • membrane Source: UniProtKB
  • membrane raft Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi962.
OpenTargetsiENSG00000117091.
PharmGKBiPA26223.

Polymorphism and mutation databases

BioMutaiCD48.
DMDMi114871.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000001488127 – 220CD48 antigenAdd BLAST194
PropeptideiPRO_0000014882221 – 243Removed in mature formBy similarityAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi40N-linked (GlcNAc...)Sequence analysis1
Glycosylationi44N-linked (GlcNAc...)Sequence analysis1
Glycosylationi104N-linked (GlcNAc...)1 Publication1
Disulfide bondi154 ↔ 196PROSITE-ProRule annotation
Glycosylationi162N-linked (GlcNAc...)Sequence analysis1
Glycosylationi178N-linked (GlcNAc...); atypical1 Publication1
Glycosylationi189N-linked (GlcNAc...)1 Publication1
Lipidationi220GPI-anchor amidated serineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDiP09326.
MaxQBiP09326.
PaxDbiP09326.
PeptideAtlasiP09326.
PRIDEiP09326.
TopDownProteomicsiP09326-1. [P09326-1]

PTM databases

iPTMnetiP09326.
PhosphoSitePlusiP09326.
SwissPalmiP09326.

Expressioni

Gene expression databases

BgeeiENSG00000117091.
CleanExiHS_CD48.
ExpressionAtlasiP09326. baseline and differential.
GenevisibleiP09326. HS.

Organism-specific databases

HPAiCAB002497.

Interactioni

Subunit structurei

Interacts with CD244 in a heterophilic manner.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CD244Q9BZW83EBI-714770,EBI-1580565

Protein-protein interaction databases

BioGridi107400. 6 interactors.
IntActiP09326. 4 interactors.
MINTiMINT-1427578.
STRINGi9606.ENSP00000357025.

Structurei

Secondary structure

1243
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi34 – 36Combined sources3
Beta strandi41 – 43Combined sources3
Beta strandi51 – 61Combined sources11
Beta strandi64 – 69Combined sources6
Beta strandi74 – 76Combined sources3
Turni80 – 84Combined sources5
Turni89 – 91Combined sources3
Beta strandi94 – 98Combined sources5
Helixi101 – 103Combined sources3
Beta strandi105 – 113Combined sources9
Turni114 – 116Combined sources3
Beta strandi117 – 120Combined sources4
Beta strandi126 – 128Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EDONMR-A27-140[»]
ProteinModelPortaliP09326.
SMRiP09326.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP09326.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 127Ig-like C2-type 1Add BLAST99
Domaini132 – 212Ig-like C2-type 2Add BLAST81

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410J3RS. Eukaryota.
ENOG410ZR3T. LUCA.
GeneTreeiENSGT00510000049275.
HOGENOMiHOG000111487.
HOVERGENiHBG004490.
InParanoidiP09326.
KOiK06479.
OMAiSSGVAWI.
PhylomeDBiP09326.
TreeFamiTF334964.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR033548. CD48.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PANTHERiPTHR12080:SF47. PTHR12080:SF47. 1 hit.
PfamiPF13895. Ig_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P09326-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCSRGWDSCL ALELLLLPLS LLVTSIQGHL VHMTVVSGSN VTLNISESLP
60 70 80 90 100
ENYKQLTWFY TFDQKIVEWD SRKSKYFESK FKGRVRLDPQ SGALYISKVQ
110 120 130 140 150
KEDNSTYIMR VLKKTGNEQE WKIKLQVLDP VPKPVIKIEK IEDMDDNCYL
160 170 180 190 200
KLSCVIPGES VNYTWYGDKR PFPKELQNSV LETTLMPHNY SRCYTCQVSN
210 220 230 240
SVSSKNGTVC LSPPCTLARS FGVEWIASWL VVTVPTILGL LLT
Length:243
Mass (Da):27,683
Last modified:November 1, 1991 - v2
Checksum:i9E46D76FC36A512C
GO
Isoform 2 (identifier: P09326-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     129-169: DPVPKPVIKI...SVNYTWYGDK → GESGEPKSKS...EEERKTSGQV
     170-243: Missing.

Note: No experimental confirmation available.
Show »
Length:169
Mass (Da):19,429
Checksum:i0E528B574BD04C5B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2C → W in AAA62834 (PubMed:1999351).Curated1
Sequence conflicti66I → N in CAA29647 (PubMed:2828034).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020082102E → Q.Corresponds to variant rs2295615dbSNPEnsembl.1
Natural variantiVAR_049909241L → S.Corresponds to variant rs16832307dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055598129 – 169DPVPK…WYGDK → GESGEPKSKSPLQWPQMDHC RASWEAWGTLGEEERKTSGQ V in isoform 2. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_055599170 – 243Missing in isoform 2. 1 PublicationAdd BLAST74

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59904 mRNA. Translation: AAA62834.1.
X06341 mRNA. Translation: CAA29647.1.
M37766 mRNA. Translation: AAA36211.1.
BT019813 mRNA. Translation: AAV38616.1.
AL121985 Genomic DNA. Translation: CAC00578.1.
CH471121 Genomic DNA. Translation: EAW52705.1.
BC016182 mRNA. Translation: AAH16182.1.
BC030224 mRNA. Translation: AAH30224.1.
M63911 Genomic DNA. Translation: AAA35602.1.
CCDSiCCDS1208.1. [P09326-1]
PIRiA53244.
RefSeqiNP_001769.2. NM_001778.3. [P09326-1]
UniGeneiHs.243564.

Genome annotation databases

EnsembliENST00000368045; ENSP00000357024; ENSG00000117091. [P09326-2]
ENST00000368046; ENSP00000357025; ENSG00000117091. [P09326-1]
GeneIDi962.
KEGGihsa:962.
UCSCiuc001fwn.4. human. [P09326-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59904 mRNA. Translation: AAA62834.1.
X06341 mRNA. Translation: CAA29647.1.
M37766 mRNA. Translation: AAA36211.1.
BT019813 mRNA. Translation: AAV38616.1.
AL121985 Genomic DNA. Translation: CAC00578.1.
CH471121 Genomic DNA. Translation: EAW52705.1.
BC016182 mRNA. Translation: AAH16182.1.
BC030224 mRNA. Translation: AAH30224.1.
M63911 Genomic DNA. Translation: AAA35602.1.
CCDSiCCDS1208.1. [P09326-1]
PIRiA53244.
RefSeqiNP_001769.2. NM_001778.3. [P09326-1]
UniGeneiHs.243564.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EDONMR-A27-140[»]
ProteinModelPortaliP09326.
SMRiP09326.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107400. 6 interactors.
IntActiP09326. 4 interactors.
MINTiMINT-1427578.
STRINGi9606.ENSP00000357025.

PTM databases

iPTMnetiP09326.
PhosphoSitePlusiP09326.
SwissPalmiP09326.

Polymorphism and mutation databases

BioMutaiCD48.
DMDMi114871.

Proteomic databases

EPDiP09326.
MaxQBiP09326.
PaxDbiP09326.
PeptideAtlasiP09326.
PRIDEiP09326.
TopDownProteomicsiP09326-1. [P09326-1]

Protocols and materials databases

DNASUi962.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368045; ENSP00000357024; ENSG00000117091. [P09326-2]
ENST00000368046; ENSP00000357025; ENSG00000117091. [P09326-1]
GeneIDi962.
KEGGihsa:962.
UCSCiuc001fwn.4. human. [P09326-1]

Organism-specific databases

CTDi962.
DisGeNETi962.
GeneCardsiCD48.
HGNCiHGNC:1683. CD48.
HPAiCAB002497.
MIMi109530. gene.
neXtProtiNX_P09326.
OpenTargetsiENSG00000117091.
PharmGKBiPA26223.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J3RS. Eukaryota.
ENOG410ZR3T. LUCA.
GeneTreeiENSGT00510000049275.
HOGENOMiHOG000111487.
HOVERGENiHBG004490.
InParanoidiP09326.
KOiK06479.
OMAiSSGVAWI.
PhylomeDBiP09326.
TreeFamiTF334964.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000117091-MONOMER.
ReactomeiR-HSA-202733. Cell surface interactions at the vascular wall.

Miscellaneous databases

EvolutionaryTraceiP09326.
GeneWikiiCD48.
GenomeRNAii962.
PROiP09326.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000117091.
CleanExiHS_CD48.
ExpressionAtlasiP09326. baseline and differential.
GenevisibleiP09326. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR033548. CD48.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PANTHERiPTHR12080:SF47. PTHR12080:SF47. 1 hit.
PfamiPF13895. Ig_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD48_HUMAN
AccessioniPrimary (citable) accession number: P09326
Secondary accession number(s): Q5U055, Q8MGR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1991
Last modified: November 2, 2016
This is version 187 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.