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P09326

- CD48_HUMAN

UniProt

P09326 - CD48_HUMAN

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Protein

CD48 antigen

Gene

CD48

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation.

GO - Molecular functioni

  1. antigen binding Source: Ensembl
  2. receptor activity Source: InterPro

GO - Biological processi

  1. blood coagulation Source: Reactome
  2. defense response Source: ProtInc
  3. leukocyte migration Source: Reactome
  4. mast cell activation Source: Ensembl
  5. signal transduction Source: Ensembl
  6. T cell activation Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_12051. Cell surface interactions at the vascular wall.

Names & Taxonomyi

Protein namesi
Recommended name:
CD48 antigen
Alternative name(s):
B-lymphocyte activation marker BLAST-1
BCM1 surface antigen
Leukocyte antigen MEM-102
SLAM family member 2
Short name:
SLAMF2
Signaling lymphocytic activation molecule 2
TCT.1
CD_antigen: CD48
Gene namesi
Name:CD48
Synonyms:BCM1, BLAST1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:1683. CD48.

Subcellular locationi

Cell membrane By similarity; Lipid-anchorGPI-anchor By similarity

GO - Cellular componenti

  1. anchored component of plasma membrane Source: Ensembl
  2. external side of plasma membrane Source: Ensembl
  3. extracellular vesicular exosome Source: UniProt
  4. integral component of plasma membrane Source: ProtInc
  5. membrane Source: UniProtKB
  6. membrane raft Source: UniProtKB
  7. plasma membrane Source: Reactome
  8. protein complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26223.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 220194CD48 antigenPRO_0000014881Add
BLAST
Propeptidei221 – 24323Removed in mature formBy similarityPRO_0000014882Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi40 – 401N-linked (GlcNAc...)Sequence Analysis
Glycosylationi44 – 441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi104 – 1041N-linked (GlcNAc...)1 Publication
Disulfide bondi154 ↔ 196PROSITE-ProRule annotation
Glycosylationi162 – 1621N-linked (GlcNAc...)Sequence Analysis
Glycosylationi178 – 1781N-linked (GlcNAc...); atypical1 Publication
Glycosylationi189 – 1891N-linked (GlcNAc...)1 Publication
Lipidationi220 – 2201GPI-anchor amidated serineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiP09326.
PaxDbiP09326.
PeptideAtlasiP09326.
PRIDEiP09326.

PTM databases

PhosphoSiteiP09326.

Expressioni

Gene expression databases

BgeeiP09326.
CleanExiHS_CD48.
ExpressionAtlasiP09326. baseline and differential.
GenevestigatoriP09326.

Organism-specific databases

HPAiCAB002497.

Interactioni

Subunit structurei

Interacts with CD244 in an heterophilic manner.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CD244Q9BZW82EBI-714770,EBI-1580565

Protein-protein interaction databases

BioGridi107400. 5 interactions.
IntActiP09326. 4 interactions.
MINTiMINT-1427578.
STRINGi9606.ENSP00000357025.

Structurei

Secondary structure

1
243
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi34 – 363
Beta strandi41 – 433
Beta strandi51 – 6111
Beta strandi64 – 696
Beta strandi74 – 763
Turni80 – 845
Turni89 – 913
Beta strandi94 – 985
Helixi101 – 1033
Beta strandi105 – 1139
Turni114 – 1163
Beta strandi117 – 1204
Beta strandi126 – 1283

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2EDONMR-A27-140[»]
ProteinModelPortaliP09326.
SMRiP09326. Positions 29-140.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP09326.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 12799Ig-like C2-type 1Add
BLAST
Domaini132 – 21281Ig-like C2-type 2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG40265.
GeneTreeiENSGT00510000049275.
HOGENOMiHOG000111487.
HOVERGENiHBG004490.
InParanoidiP09326.
KOiK06479.
OMAiAWIATWL.
OrthoDBiEOG7JQBPS.
PhylomeDBiP09326.
TreeFamiTF334964.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR015631. SLAM_fam_rcpts.
[Graphical view]
PANTHERiPTHR12080. PTHR12080. 1 hit.
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P09326-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCSRGWDSCL ALELLLLPLS LLVTSIQGHL VHMTVVSGSN VTLNISESLP
60 70 80 90 100
ENYKQLTWFY TFDQKIVEWD SRKSKYFESK FKGRVRLDPQ SGALYISKVQ
110 120 130 140 150
KEDNSTYIMR VLKKTGNEQE WKIKLQVLDP VPKPVIKIEK IEDMDDNCYL
160 170 180 190 200
KLSCVIPGES VNYTWYGDKR PFPKELQNSV LETTLMPHNY SRCYTCQVSN
210 220 230 240
SVSSKNGTVC LSPPCTLARS FGVEWIASWL VVTVPTILGL LLT
Length:243
Mass (Da):27,683
Last modified:November 1, 1991 - v2
Checksum:i9E46D76FC36A512C
GO
Isoform 2 (identifier: P09326-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     129-169: DPVPKPVIKI...SVNYTWYGDK → GESGEPKSKS...EEERKTSGQV
     170-243: Missing.

Note: No experimental confirmation available.

Show »
Length:169
Mass (Da):19,429
Checksum:i0E528B574BD04C5B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21C → W in AAA62834. (PubMed:1999351)Curated
Sequence conflicti66 – 661I → N in CAA29647. (PubMed:2828034)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti102 – 1021E → Q.
Corresponds to variant rs2295615 [ dbSNP | Ensembl ].
VAR_020082
Natural varianti241 – 2411L → S.
Corresponds to variant rs16832307 [ dbSNP | Ensembl ].
VAR_049909

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei129 – 16941DPVPK…WYGDK → GESGEPKSKSPLQWPQMDHC RASWEAWGTLGEEERKTSGQ V in isoform 2. 1 PublicationVSP_055598Add
BLAST
Alternative sequencei170 – 24374Missing in isoform 2. 1 PublicationVSP_055599Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M59904 mRNA. Translation: AAA62834.1.
X06341 mRNA. Translation: CAA29647.1.
M37766 mRNA. Translation: AAA36211.1.
BT019813 mRNA. Translation: AAV38616.1.
AL121985 Genomic DNA. Translation: CAC00578.1.
CH471121 Genomic DNA. Translation: EAW52705.1.
BC016182 mRNA. Translation: AAH16182.1.
BC030224 mRNA. Translation: AAH30224.1.
M63911 Genomic DNA. Translation: AAA35602.1.
CCDSiCCDS1208.1. [P09326-1]
PIRiA53244.
RefSeqiNP_001769.2. NM_001778.3. [P09326-1]
UniGeneiHs.243564.

Genome annotation databases

EnsembliENST00000368045; ENSP00000357024; ENSG00000117091. [P09326-2]
ENST00000368046; ENSP00000357025; ENSG00000117091. [P09326-1]
GeneIDi962.
KEGGihsa:962.
UCSCiuc001fwn.4. human. [P09326-1]

Polymorphism databases

DMDMi114871.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M59904 mRNA. Translation: AAA62834.1 .
X06341 mRNA. Translation: CAA29647.1 .
M37766 mRNA. Translation: AAA36211.1 .
BT019813 mRNA. Translation: AAV38616.1 .
AL121985 Genomic DNA. Translation: CAC00578.1 .
CH471121 Genomic DNA. Translation: EAW52705.1 .
BC016182 mRNA. Translation: AAH16182.1 .
BC030224 mRNA. Translation: AAH30224.1 .
M63911 Genomic DNA. Translation: AAA35602.1 .
CCDSi CCDS1208.1. [P09326-1 ]
PIRi A53244.
RefSeqi NP_001769.2. NM_001778.3. [P09326-1 ]
UniGenei Hs.243564.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2EDO NMR - A 27-140 [» ]
ProteinModelPortali P09326.
SMRi P09326. Positions 29-140.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107400. 5 interactions.
IntActi P09326. 4 interactions.
MINTi MINT-1427578.
STRINGi 9606.ENSP00000357025.

PTM databases

PhosphoSitei P09326.

Polymorphism databases

DMDMi 114871.

Proteomic databases

MaxQBi P09326.
PaxDbi P09326.
PeptideAtlasi P09326.
PRIDEi P09326.

Protocols and materials databases

DNASUi 962.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000368045 ; ENSP00000357024 ; ENSG00000117091 . [P09326-2 ]
ENST00000368046 ; ENSP00000357025 ; ENSG00000117091 . [P09326-1 ]
GeneIDi 962.
KEGGi hsa:962.
UCSCi uc001fwn.4. human. [P09326-1 ]

Organism-specific databases

CTDi 962.
GeneCardsi GC01M160648.
HGNCi HGNC:1683. CD48.
HPAi CAB002497.
MIMi 109530. gene.
neXtProti NX_P09326.
PharmGKBi PA26223.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG40265.
GeneTreei ENSGT00510000049275.
HOGENOMi HOG000111487.
HOVERGENi HBG004490.
InParanoidi P09326.
KOi K06479.
OMAi AWIATWL.
OrthoDBi EOG7JQBPS.
PhylomeDBi P09326.
TreeFami TF334964.

Enzyme and pathway databases

Reactomei REACT_12051. Cell surface interactions at the vascular wall.

Miscellaneous databases

EvolutionaryTracei P09326.
GeneWikii CD48.
GenomeRNAii 962.
NextBioi 4020.
PROi P09326.
SOURCEi Search...

Gene expression databases

Bgeei P09326.
CleanExi HS_CD48.
ExpressionAtlasi P09326. baseline and differential.
Genevestigatori P09326.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR015631. SLAM_fam_rcpts.
[Graphical view ]
PANTHERi PTHR12080. PTHR12080. 1 hit.
Pfami PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The human leucocyte antigen CD48 (MEM-102) is closely related to the activation marker Blast-1."
    Korinek V., Stefanova I., Angelisova P., Hilbert I., Horejsi V.
    Immunogenetics 33:108-112(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Molecular cloning of the lymphocyte activation marker Blast-1."
    Staunton D.E., Thorley-Lawson D.A.
    EMBO J. 6:3695-3701(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: B-cell and Pancreas.
  8. "Characterization of the Epstein-Barr virus-inducible gene encoding the human leukocyte adhesion and activation antigen BLAST-1 (CD48)."
    Fisher R.C., Thorley-Lawson D.A.
    Mol. Cell. Biol. 11:1614-1623(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-27.
  9. "TCT.1, a target molecule for gamma/delta T cells, is encoded by an immunoglobulin superfamily gene (Blast-1) located in the CD1 region of human chromosome 1."
    del Porto P., Mami-Chouaib F., Bruneau J.-M., Jitsukawa S., Dumas J., Harnois M., Hercend T.
    J. Exp. Med. 173:1339-1344(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE.
  10. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-104; ASN-178 AND ASN-189.
    Tissue: Leukemic T-cell.
  11. "Solution structure of the first Ig-like domain from human CD48 antigen."
    RIKEN structural genomics initiative (RSGI)
    Submitted (AUG-2007) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 24-140.

Entry informationi

Entry nameiCD48_HUMAN
AccessioniPrimary (citable) accession number: P09326
Secondary accession number(s): Q5U055, Q8MGR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1991
Last modified: October 29, 2014
This is version 167 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3