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P09324 (YES_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Tyrosine-protein kinase Yes
EC=2.7.10.2
Alternative name(s):
p61-Yes
Gene names
Name:YES1
Synonyms:YES
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length541 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, differentiation, G2/M progression and cytokinesis By similarity.

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subcellular location

Cell membrane By similarity. Cytoplasm › cytoskeleton › centrosome By similarity. Cytoplasm › cytosol By similarity.

Post-translational modification

Autophosphorylation at Tyr-424 maintains enzyme activity By similarity.

Palmitoylation at Cys-3 promotes membrane localization By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.

Contains 1 protein kinase domain.

Contains 1 SH2 domain.

Contains 1 SH3 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 541540Tyrosine-protein kinase Yes
PRO_0000088183

Regions

Domain89 – 15062SH3
Domain156 – 25398SH2
Domain275 – 528254Protein kinase
Nucleotide binding281 – 2899ATP By similarity

Sites

Active site3941Proton acceptor By similarity
Binding site3031ATP By similarity

Amino acid modifications

Modified residue4241Phosphotyrosine; by autocatalysis By similarity
Modified residue5351Phosphotyrosine; by CSK By similarity
Lipidation21N-myristoyl glycine By similarity
Lipidation31S-palmitoyl cysteine; in membrane form By similarity

Experimental info

Sequence conflict67 – 715TPFGG → IHPLR in CAA31595. Ref.3
Sequence conflict821P → Q in CAA31595. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P09324 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: BEA849CC7D1755AF

FASTA54160,792
        10         20         30         40         50         60 
MGCIKSKEDK GPAMKYRTDN TPEPISSHVS HYGSDSSQAT QSPAIKGSAV NFNSHSMTPF 

        70         80         90        100        110        120 
GGPSGMTPFG GASSSFSAVP SPYPSTLTGG VTVFVALYDY EARTTDDLSF KKGERFQIIN 

       130        140        150        160        170        180 
NTEGDWWEAR SIATGKTGYI PSNYVAPADS IQAEEWYFGK MGRKDAERLL LNPGNQRGIF 

       190        200        210        220        230        240 
LVRESETTKG AYSLSIRDWD EVRGDNVKHY KIRKLDNGGY YITTRAQFES LQKLVKHYRE 

       250        260        270        280        290        300 
HADGLCHKLT TVCPTVKPQT QGLAKDAWEI PRESLRLEVK LGQGCFGEVW MGTWNGTTKV 

       310        320        330        340        350        360 
AIKTLKPGTM MPEAFLQEAQ IMKKLRHDKL VPLYAVVSEE PIYIVTEFMT KGSLLDFLKE 

       370        380        390        400        410        420 
GEGKFLKLPQ LVDMAAQIAD GMAYIERMNY IHRDLRAANI LVGDNLVCKI ADFGLARLIE 

       430        440        450        460        470        480 
DNEYTARQGA KFPIKWTAPE AALYGRFTIK SDVWSFGILL TELVTKGRVP YPGMVNREVL 

       490        500        510        520        530        540 
EQVERGYRMP CPQGCPESLH ELMKLCWKKD PDERPTFEYI QSFLEDYFTA TEPQYQPGDN 


L

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References

[1]"Nucleotide sequence of a cDNA for the chick yes proto-oncogene: comparison with the viral yes gene."
Sudol M., Kieswetter C., Zhao Y.H., Dorai T., Wang L.H., Hanafusa H.
Nucleic Acids Res. 16:9876-9876(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Sudol M.
Submitted (NOV-1988) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION TO 233.
[3]"The sequence of chicken c-yes and p61c-yes."
Zheng X., Podell S., Sefton B.M., Kaplan P.L.
Oncogene 4:99-104(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain and Kidney.
[4]"Molecular cloning of a family of protein kinase genes expressed in the avian embryo."
Marcelle C., Eichmann A.
Oncogene 7:2479-2487(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 396-451.
[5]"Yes-associated protein (YAP65) is a proline-rich phosphoprotein that binds to the SH3 domain of the Yes proto-oncogene product."
Sudol M.
Oncogene 9:2145-2152(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH YAP1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X12461 mRNA. Translation: CAA31002.1.
X13207 mRNA. Translation: CAA31595.1.
X69695 mRNA. Translation: CAA49365.1.
IPIIPI00584249.
PIRTVCHYS. S03324.
RefSeqNP_990632.1. NM_205301.1.
UniGeneGga.1891.

3D structure databases

ProteinModelPortalP09324.
SMRP09324. Positions 91-541.
ModBaseSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000023934.

Proteomic databases

PaxDbP09324.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID396238.
KEGGgga:396238.

Organism-specific databases

CTD7525.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000233858.
HOVERGENHBG008761.
InParanoidP09324.
KOK05705.
OrthoDBEOG4KKZ2S.

Enzyme and pathway databases

BRENDA2.7.10.2. 1306.

Family and domain databases

Gene3D3.30.505.10. 1 hit.
InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. Kinase_like. 1 hit.
SSF50044. SH3. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20816290.

Entry information

Entry nameYES_CHICK
AccessionPrimary (citable) accession number: P09324
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: April 3, 2013
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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