Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P09324

- YES_CHICK

UniProt

P09324 - YES_CHICK

Protein

Tyrosine-protein kinase Yes

Gene

YES1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, differentiation, G2/M progression and cytokinesis.By similarity

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei303 – 3031ATPPROSITE-ProRule annotation
    Active sitei394 – 3941Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi281 – 2899ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glucose transport Source: Ensembl

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.2. 1306.
    ReactomeiREACT_194391. Signaling by SCF-KIT.
    REACT_196766. Regulation of KIT signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein kinase Yes (EC:2.7.10.2)
    Alternative name(s):
    p61-Yes
    Gene namesi
    Name:YES1
    Synonyms:YES
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 2

    Subcellular locationi

    Cell membrane By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Cytoplasmcytosol By similarity

    GO - Cellular componenti

    1. cytosol Source: UniProtKB-SubCell
    2. Golgi apparatus Source: Ensembl
    3. microtubule organizing center Source: UniProtKB-SubCell
    4. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Cytoskeleton, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 541540Tyrosine-protein kinase YesPRO_0000088183Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi2 – 21N-myristoyl glycineBy similarity
    Lipidationi3 – 31S-palmitoyl cysteine; in membrane formBy similarity
    Modified residuei424 – 4241Phosphotyrosine; by autocatalysisBy similarity
    Modified residuei535 – 5351Phosphotyrosine; by CSKBy similarity

    Post-translational modificationi

    Autophosphorylation at Tyr-424 maintains enzyme activity.By similarity
    Palmitoylation at Cys-3 promotes membrane localization.By similarity

    Keywords - PTMi

    Lipoprotein, Myristate, Palmitate, Phosphoprotein

    Proteomic databases

    PaxDbiP09324.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000023934.

    Structurei

    3D structure databases

    ProteinModelPortaliP09324.
    SMRiP09324. Positions 91-541.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini89 – 15062SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini156 – 25398SH2PROSITE-ProRule annotationAdd
    BLAST
    Domaini275 – 528254Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 1 SH2 domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain, SH3 domain

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00620000087702.
    HOGENOMiHOG000233858.
    HOVERGENiHBG008761.
    InParanoidiP09324.
    KOiK05705.
    PhylomeDBiP09324.

    Family and domain databases

    Gene3Di3.30.505.10. 1 hit.
    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view]
    PfamiPF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view]
    PRINTSiPR00401. SH2DOMAIN.
    PR00452. SH3DOMAIN.
    PR00109. TYRKINASE.
    SMARTiSM00252. SH2. 1 hit.
    SM00326. SH3. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P09324-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGCIKSKEDK GPAMKYRTDN TPEPISSHVS HYGSDSSQAT QSPAIKGSAV    50
    NFNSHSMTPF GGPSGMTPFG GASSSFSAVP SPYPSTLTGG VTVFVALYDY 100
    EARTTDDLSF KKGERFQIIN NTEGDWWEAR SIATGKTGYI PSNYVAPADS 150
    IQAEEWYFGK MGRKDAERLL LNPGNQRGIF LVRESETTKG AYSLSIRDWD 200
    EVRGDNVKHY KIRKLDNGGY YITTRAQFES LQKLVKHYRE HADGLCHKLT 250
    TVCPTVKPQT QGLAKDAWEI PRESLRLEVK LGQGCFGEVW MGTWNGTTKV 300
    AIKTLKPGTM MPEAFLQEAQ IMKKLRHDKL VPLYAVVSEE PIYIVTEFMT 350
    KGSLLDFLKE GEGKFLKLPQ LVDMAAQIAD GMAYIERMNY IHRDLRAANI 400
    LVGDNLVCKI ADFGLARLIE DNEYTARQGA KFPIKWTAPE AALYGRFTIK 450
    SDVWSFGILL TELVTKGRVP YPGMVNREVL EQVERGYRMP CPQGCPESLH 500
    ELMKLCWKKD PDERPTFEYI QSFLEDYFTA TEPQYQPGDN L 541
    Length:541
    Mass (Da):60,792
    Last modified:January 23, 2007 - v3
    Checksum:iBEA849CC7D1755AF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti67 – 715TPFGG → IHPLR in CAA31595. (PubMed:2464785)Curated
    Sequence conflicti82 – 821P → Q in CAA31595. (PubMed:2464785)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X12461 mRNA. Translation: CAA31002.1.
    X13207 mRNA. Translation: CAA31595.1.
    X69695 mRNA. Translation: CAA49365.1.
    PIRiS03324. TVCHYS.
    RefSeqiNP_990632.1. NM_205301.1.
    UniGeneiGga.1891.

    Genome annotation databases

    EnsembliENSGALT00000023980; ENSGALP00000023934; ENSGALG00000014860.
    GeneIDi396238.
    KEGGigga:396238.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X12461 mRNA. Translation: CAA31002.1 .
    X13207 mRNA. Translation: CAA31595.1 .
    X69695 mRNA. Translation: CAA49365.1 .
    PIRi S03324. TVCHYS.
    RefSeqi NP_990632.1. NM_205301.1.
    UniGenei Gga.1891.

    3D structure databases

    ProteinModelPortali P09324.
    SMRi P09324. Positions 91-541.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000023934.

    Proteomic databases

    PaxDbi P09324.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000023980 ; ENSGALP00000023934 ; ENSGALG00000014860 .
    GeneIDi 396238.
    KEGGi gga:396238.

    Organism-specific databases

    CTDi 7525.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00620000087702.
    HOGENOMi HOG000233858.
    HOVERGENi HBG008761.
    InParanoidi P09324.
    KOi K05705.
    PhylomeDBi P09324.

    Enzyme and pathway databases

    BRENDAi 2.7.10.2. 1306.
    Reactomei REACT_194391. Signaling by SCF-KIT.
    REACT_196766. Regulation of KIT signaling.

    Miscellaneous databases

    NextBioi 20816290.
    PROi P09324.

    Family and domain databases

    Gene3Di 3.30.505.10. 1 hit.
    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view ]
    Pfami PF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00401. SH2DOMAIN.
    PR00452. SH3DOMAIN.
    PR00109. TYRKINASE.
    SMARTi SM00252. SH2. 1 hit.
    SM00326. SH3. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of a cDNA for the chick yes proto-oncogene: comparison with the viral yes gene."
      Sudol M., Kieswetter C., Zhao Y.H., Dorai T., Wang L.H., Hanafusa H.
      Nucleic Acids Res. 16:9876-9876(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Sudol M.
      Submitted (NOV-1988) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO 233.
    3. "The sequence of chicken c-yes and p61c-yes."
      Zheng X., Podell S., Sefton B.M., Kaplan P.L.
      Oncogene 4:99-104(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain and Kidney.
    4. "Molecular cloning of a family of protein kinase genes expressed in the avian embryo."
      Marcelle C., Eichmann A.
      Oncogene 7:2479-2487(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 396-451.
    5. "Yes-associated protein (YAP65) is a proline-rich phosphoprotein that binds to the SH3 domain of the Yes proto-oncogene product."
      Sudol M.
      Oncogene 9:2145-2152(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH YAP1.

    Entry informationi

    Entry nameiYES_CHICK
    AccessioniPrimary (citable) accession number: P09324
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 126 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3