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P09324

- YES_CHICK

UniProt

P09324 - YES_CHICK

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Protein

Tyrosine-protein kinase Yes

Gene
YES1, YES
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, differentiation, G2/M progression and cytokinesis By similarity.

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei303 – 3031ATP By similarity
Active sitei394 – 3941Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi281 – 2899ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glucose transport Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 1306.
ReactomeiREACT_194391. Signaling by SCF-KIT.
REACT_196766. Regulation of KIT signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase Yes (EC:2.7.10.2)
Alternative name(s):
p61-Yes
Gene namesi
Name:YES1
Synonyms:YES
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 2

Subcellular locationi

Cell membrane By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Cytoplasmcytosol By similarity

GO - Cellular componenti

  1. cytosol Source: UniProtKB-SubCell
  2. Golgi apparatus Source: Ensembl
  3. microtubule organizing center Source: UniProtKB-SubCell
  4. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 541540Tyrosine-protein kinase YesPRO_0000088183Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycine By similarity
Lipidationi3 – 31S-palmitoyl cysteine; in membrane form By similarity
Modified residuei424 – 4241Phosphotyrosine; by autocatalysis By similarity
Modified residuei535 – 5351Phosphotyrosine; by CSK By similarity

Post-translational modificationi

Autophosphorylation at Tyr-424 maintains enzyme activity By similarity.
Palmitoylation at Cys-3 promotes membrane localization By similarity.

Keywords - PTMi

Lipoprotein, Myristate, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP09324.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000023934.

Structurei

3D structure databases

ProteinModelPortaliP09324.
SMRiP09324. Positions 91-541.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini89 – 15062SH3Add
BLAST
Domaini156 – 25398SH2Add
BLAST
Domaini275 – 528254Protein kinaseAdd
BLAST

Sequence similaritiesi

Contains 1 SH2 domain.
Contains 1 SH3 domain.

Keywords - Domaini

SH2 domain, SH3 domain

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00620000087702.
HOGENOMiHOG000233858.
HOVERGENiHBG008761.
InParanoidiP09324.
KOiK05705.
PhylomeDBiP09324.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09324-1 [UniParc]FASTAAdd to Basket

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MGCIKSKEDK GPAMKYRTDN TPEPISSHVS HYGSDSSQAT QSPAIKGSAV    50
NFNSHSMTPF GGPSGMTPFG GASSSFSAVP SPYPSTLTGG VTVFVALYDY 100
EARTTDDLSF KKGERFQIIN NTEGDWWEAR SIATGKTGYI PSNYVAPADS 150
IQAEEWYFGK MGRKDAERLL LNPGNQRGIF LVRESETTKG AYSLSIRDWD 200
EVRGDNVKHY KIRKLDNGGY YITTRAQFES LQKLVKHYRE HADGLCHKLT 250
TVCPTVKPQT QGLAKDAWEI PRESLRLEVK LGQGCFGEVW MGTWNGTTKV 300
AIKTLKPGTM MPEAFLQEAQ IMKKLRHDKL VPLYAVVSEE PIYIVTEFMT 350
KGSLLDFLKE GEGKFLKLPQ LVDMAAQIAD GMAYIERMNY IHRDLRAANI 400
LVGDNLVCKI ADFGLARLIE DNEYTARQGA KFPIKWTAPE AALYGRFTIK 450
SDVWSFGILL TELVTKGRVP YPGMVNREVL EQVERGYRMP CPQGCPESLH 500
ELMKLCWKKD PDERPTFEYI QSFLEDYFTA TEPQYQPGDN L 541
Length:541
Mass (Da):60,792
Last modified:January 23, 2007 - v3
Checksum:iBEA849CC7D1755AF
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti67 – 715TPFGG → IHPLR in CAA31595. 1 Publication
Sequence conflicti82 – 821P → Q in CAA31595. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X12461 mRNA. Translation: CAA31002.1.
X13207 mRNA. Translation: CAA31595.1.
X69695 mRNA. Translation: CAA49365.1.
PIRiS03324. TVCHYS.
RefSeqiNP_990632.1. NM_205301.1.
UniGeneiGga.1891.

Genome annotation databases

EnsembliENSGALT00000023980; ENSGALP00000023934; ENSGALG00000014860.
GeneIDi396238.
KEGGigga:396238.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X12461 mRNA. Translation: CAA31002.1 .
X13207 mRNA. Translation: CAA31595.1 .
X69695 mRNA. Translation: CAA49365.1 .
PIRi S03324. TVCHYS.
RefSeqi NP_990632.1. NM_205301.1.
UniGenei Gga.1891.

3D structure databases

ProteinModelPortali P09324.
SMRi P09324. Positions 91-541.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000023934.

Proteomic databases

PaxDbi P09324.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000023980 ; ENSGALP00000023934 ; ENSGALG00000014860 .
GeneIDi 396238.
KEGGi gga:396238.

Organism-specific databases

CTDi 7525.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00620000087702.
HOGENOMi HOG000233858.
HOVERGENi HBG008761.
InParanoidi P09324.
KOi K05705.
PhylomeDBi P09324.

Enzyme and pathway databases

BRENDAi 2.7.10.2. 1306.
Reactomei REACT_194391. Signaling by SCF-KIT.
REACT_196766. Regulation of KIT signaling.

Miscellaneous databases

NextBioi 20816290.
PROi P09324.

Family and domain databases

Gene3Di 3.30.505.10. 1 hit.
InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view ]
Pfami PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
PRINTSi PR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTi SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of a cDNA for the chick yes proto-oncogene: comparison with the viral yes gene."
    Sudol M., Kieswetter C., Zhao Y.H., Dorai T., Wang L.H., Hanafusa H.
    Nucleic Acids Res. 16:9876-9876(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Sudol M.
    Submitted (NOV-1988) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 233.
  3. "The sequence of chicken c-yes and p61c-yes."
    Zheng X., Podell S., Sefton B.M., Kaplan P.L.
    Oncogene 4:99-104(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain and Kidney.
  4. "Molecular cloning of a family of protein kinase genes expressed in the avian embryo."
    Marcelle C., Eichmann A.
    Oncogene 7:2479-2487(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 396-451.
  5. "Yes-associated protein (YAP65) is a proline-rich phosphoprotein that binds to the SH3 domain of the Yes proto-oncogene product."
    Sudol M.
    Oncogene 9:2145-2152(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH YAP1.

Entry informationi

Entry nameiYES_CHICK
AccessioniPrimary (citable) accession number: P09324
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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