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P09324

- YES_CHICK

UniProt

P09324 - YES_CHICK

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Protein

Tyrosine-protein kinase Yes

Gene

YES1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, differentiation, G2/M progression and cytokinesis.By similarity

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei303 – 3031ATPPROSITE-ProRule annotation
Active sitei394 – 3941Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi281 – 2899ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glucose transport Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 1306.
ReactomeiREACT_194391. Signaling by SCF-KIT.
REACT_196766. Regulation of KIT signaling.
REACT_230783. CTLA4 inhibitory signaling.
REACT_235751. EPHB-mediated forward signaling.
REACT_248632. EPH-Ephrin signaling.
REACT_253932. EPHA-mediated growth cone collapse.
REACT_257494. EPH-ephrin mediated repulsion of cells.
REACT_262164. CD28 co-stimulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase Yes (EC:2.7.10.2)
Alternative name(s):
p61-Yes
Gene namesi
Name:YES1
Synonyms:YES
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 2

Subcellular locationi

Cell membrane By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Cytoplasmcytosol By similarity

GO - Cellular componenti

  1. cytoskeleton Source: UniProtKB-KW
  2. extracellular vesicular exosome Source: Ensembl
  3. Golgi apparatus Source: Ensembl
  4. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 541540Tyrosine-protein kinase YesPRO_0000088183Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity
Lipidationi3 – 31S-palmitoyl cysteine; in membrane formBy similarity
Modified residuei424 – 4241Phosphotyrosine; by autocatalysisBy similarity
Modified residuei535 – 5351Phosphotyrosine; by CSKBy similarity

Post-translational modificationi

Autophosphorylation at Tyr-424 maintains enzyme activity.By similarity
Palmitoylation at Cys-3 promotes membrane localization.By similarity

Keywords - PTMi

Lipoprotein, Myristate, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP09324.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000023934.

Structurei

3D structure databases

ProteinModelPortaliP09324.
SMRiP09324. Positions 91-541.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini89 – 15062SH3PROSITE-ProRule annotationAdd
BLAST
Domaini156 – 25398SH2PROSITE-ProRule annotationAdd
BLAST
Domaini275 – 528254Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain, SH3 domain

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118938.
HOGENOMiHOG000233858.
HOVERGENiHBG008761.
InParanoidiP09324.
KOiK05705.
PhylomeDBiP09324.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09324-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGCIKSKEDK GPAMKYRTDN TPEPISSHVS HYGSDSSQAT QSPAIKGSAV
60 70 80 90 100
NFNSHSMTPF GGPSGMTPFG GASSSFSAVP SPYPSTLTGG VTVFVALYDY
110 120 130 140 150
EARTTDDLSF KKGERFQIIN NTEGDWWEAR SIATGKTGYI PSNYVAPADS
160 170 180 190 200
IQAEEWYFGK MGRKDAERLL LNPGNQRGIF LVRESETTKG AYSLSIRDWD
210 220 230 240 250
EVRGDNVKHY KIRKLDNGGY YITTRAQFES LQKLVKHYRE HADGLCHKLT
260 270 280 290 300
TVCPTVKPQT QGLAKDAWEI PRESLRLEVK LGQGCFGEVW MGTWNGTTKV
310 320 330 340 350
AIKTLKPGTM MPEAFLQEAQ IMKKLRHDKL VPLYAVVSEE PIYIVTEFMT
360 370 380 390 400
KGSLLDFLKE GEGKFLKLPQ LVDMAAQIAD GMAYIERMNY IHRDLRAANI
410 420 430 440 450
LVGDNLVCKI ADFGLARLIE DNEYTARQGA KFPIKWTAPE AALYGRFTIK
460 470 480 490 500
SDVWSFGILL TELVTKGRVP YPGMVNREVL EQVERGYRMP CPQGCPESLH
510 520 530 540
ELMKLCWKKD PDERPTFEYI QSFLEDYFTA TEPQYQPGDN L
Length:541
Mass (Da):60,792
Last modified:January 23, 2007 - v3
Checksum:iBEA849CC7D1755AF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti67 – 715TPFGG → IHPLR in CAA31595. (PubMed:2464785)Curated
Sequence conflicti82 – 821P → Q in CAA31595. (PubMed:2464785)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12461 mRNA. Translation: CAA31002.1.
X13207 mRNA. Translation: CAA31595.1.
X69695 mRNA. Translation: CAA49365.1.
PIRiS03324. TVCHYS.
RefSeqiNP_990632.1. NM_205301.1.
UniGeneiGga.1891.

Genome annotation databases

EnsembliENSGALT00000023980; ENSGALP00000023934; ENSGALG00000014860.
GeneIDi396238.
KEGGigga:396238.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12461 mRNA. Translation: CAA31002.1 .
X13207 mRNA. Translation: CAA31595.1 .
X69695 mRNA. Translation: CAA49365.1 .
PIRi S03324. TVCHYS.
RefSeqi NP_990632.1. NM_205301.1.
UniGenei Gga.1891.

3D structure databases

ProteinModelPortali P09324.
SMRi P09324. Positions 91-541.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000023934.

Proteomic databases

PaxDbi P09324.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000023980 ; ENSGALP00000023934 ; ENSGALG00000014860 .
GeneIDi 396238.
KEGGi gga:396238.

Organism-specific databases

CTDi 7525.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000118938.
HOGENOMi HOG000233858.
HOVERGENi HBG008761.
InParanoidi P09324.
KOi K05705.
PhylomeDBi P09324.

Enzyme and pathway databases

BRENDAi 2.7.10.2. 1306.
Reactomei REACT_194391. Signaling by SCF-KIT.
REACT_196766. Regulation of KIT signaling.
REACT_230783. CTLA4 inhibitory signaling.
REACT_235751. EPHB-mediated forward signaling.
REACT_248632. EPH-Ephrin signaling.
REACT_253932. EPHA-mediated growth cone collapse.
REACT_257494. EPH-ephrin mediated repulsion of cells.
REACT_262164. CD28 co-stimulation.

Miscellaneous databases

NextBioi 20816290.
PROi P09324.

Family and domain databases

Gene3Di 3.30.505.10. 1 hit.
InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view ]
Pfami PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
PRINTSi PR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTi SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of a cDNA for the chick yes proto-oncogene: comparison with the viral yes gene."
    Sudol M., Kieswetter C., Zhao Y.H., Dorai T., Wang L.H., Hanafusa H.
    Nucleic Acids Res. 16:9876-9876(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Sudol M.
    Submitted (NOV-1988) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 233.
  3. "The sequence of chicken c-yes and p61c-yes."
    Zheng X., Podell S., Sefton B.M., Kaplan P.L.
    Oncogene 4:99-104(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain and Kidney.
  4. "Molecular cloning of a family of protein kinase genes expressed in the avian embryo."
    Marcelle C., Eichmann A.
    Oncogene 7:2479-2487(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 396-451.
  5. "Yes-associated protein (YAP65) is a proline-rich phosphoprotein that binds to the SH3 domain of the Yes proto-oncogene product."
    Sudol M.
    Oncogene 9:2145-2152(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH YAP1.

Entry informationi

Entry nameiYES_CHICK
AccessioniPrimary (citable) accession number: P09324
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3