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Protein

Histone H4

Gene

hhf1

more
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi17 – 215

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-SPO-3214841. PKMTs methylate histone lysines.
R-SPO-3214842. HDMs demethylate histones.
R-SPO-3214847. HATs acetylate histones.
R-SPO-3214858. RMTs methylate histone arginines.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H4
Gene namesi
Name:hhf1
Synonyms:h4.1
ORF Names:SPAC1834.03c
AND
Name:hhf2
Synonyms:h4.2
ORF Names:pi061, SPBC8D2.03c
AND
Name:hhf3
Synonyms:h4.3
ORF Names:SPBC1105.12
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componentsi: Chromosome I, Chromosome II

Organism-specific databases

PomBaseiSPAC1834.03c. hhf1.
SPBC8D2.03c. hhf2.
SPBC1105.12. hhf3.

Subcellular locationi

GO - Cellular componenti

  • nuclear nucleosome Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved
Chaini2 – 103102Histone H4PRO_0000158357Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei48 – 481Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP09322.
PRIDEiP09322.

PTM databases

iPTMnetiP09322.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

Protein-protein interaction databases

BioGridi276535. 10 interactions.
277714. 67 interactions.
278924. 56 interactions.
MINTiMINT-4687105.

Structurei

3D structure databases

ProteinModelPortaliP09322.
SMRiP09322. Positions 9-103.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H4 family.Curated

Phylogenomic databases

HOGENOMiHOG000234654.
InParanoidiP09322.
KOiK11254.
OMAiVMDVVYA.
OrthoDBiEOG092C5WME.
PhylomeDBiP09322.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR001951. Histone_H4.
IPR019809. Histone_H4_CS.
[Graphical view]
PRINTSiPR00623. HISTONEH4.
SMARTiSM00417. H4. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00047. HISTONE_H4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09322-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGRGKGGKG LGKGGAKRHR KILRDNIQGI TKPAIRRLAR RGGVKRISAL
60 70 80 90 100
VYEETRAVLK LFLENVIRDA VTYTEHAKRK TVTSLDVVYS LKRQGRTIYG

FGG
Length:103
Mass (Da):11,423
Last modified:January 23, 2007 - v2
Checksum:i6D9C9F96ABEB0D98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05222 Genomic DNA. Translation: CAA28850.1.
X05223 Genomic DNA. Translation: CAA28853.1.
X05224 Genomic DNA. Translation: CAA28855.1.
AB004538 Genomic DNA. Translation: BAA21442.1.
CU329670 Genomic DNA. Translation: CAB75771.1.
CU329671 Genomic DNA. Translation: CAA17818.1.
CU329671 Genomic DNA. Translation: CAB50975.1.
PIRiD27399. HSZP4.
RefSeqiNP_594682.1. NM_001020111.2.
NP_595566.1. NM_001021461.2.
NP_596468.1. NM_001022387.2.

Genome annotation databases

EnsemblFungiiSPAC1834.03c.1; SPAC1834.03c.1:pep; SPAC1834.03c.
SPBC1105.12.1; SPBC1105.12.1:pep; SPBC1105.12.
SPBC8D2.03c.1; SPBC8D2.03c.1:pep; SPBC8D2.03c.
GeneIDi2539991.
2541200.
2542463.
KEGGispo:SPAC1834.03c.
spo:SPBC1105.12.
spo:SPBC8D2.03c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05222 Genomic DNA. Translation: CAA28850.1.
X05223 Genomic DNA. Translation: CAA28853.1.
X05224 Genomic DNA. Translation: CAA28855.1.
AB004538 Genomic DNA. Translation: BAA21442.1.
CU329670 Genomic DNA. Translation: CAB75771.1.
CU329671 Genomic DNA. Translation: CAA17818.1.
CU329671 Genomic DNA. Translation: CAB50975.1.
PIRiD27399. HSZP4.
RefSeqiNP_594682.1. NM_001020111.2.
NP_595566.1. NM_001021461.2.
NP_596468.1. NM_001022387.2.

3D structure databases

ProteinModelPortaliP09322.
SMRiP09322. Positions 9-103.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276535. 10 interactions.
277714. 67 interactions.
278924. 56 interactions.
MINTiMINT-4687105.

PTM databases

iPTMnetiP09322.

Proteomic databases

MaxQBiP09322.
PRIDEiP09322.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC1834.03c.1; SPAC1834.03c.1:pep; SPAC1834.03c.
SPBC1105.12.1; SPBC1105.12.1:pep; SPBC1105.12.
SPBC8D2.03c.1; SPBC8D2.03c.1:pep; SPBC8D2.03c.
GeneIDi2539991.
2541200.
2542463.
KEGGispo:SPAC1834.03c.
spo:SPBC1105.12.
spo:SPBC8D2.03c.

Organism-specific databases

PomBaseiSPAC1834.03c. hhf1.
SPBC8D2.03c. hhf2.
SPBC1105.12. hhf3.

Phylogenomic databases

HOGENOMiHOG000234654.
InParanoidiP09322.
KOiK11254.
OMAiVMDVVYA.
OrthoDBiEOG092C5WME.
PhylomeDBiP09322.

Enzyme and pathway databases

ReactomeiR-SPO-3214841. PKMTs methylate histone lysines.
R-SPO-3214842. HDMs demethylate histones.
R-SPO-3214847. HATs acetylate histones.
R-SPO-3214858. RMTs methylate histone arginines.

Miscellaneous databases

PROiP09322.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR001951. Histone_H4.
IPR019809. Histone_H4_CS.
[Graphical view]
PRINTSiPR00623. HISTONEH4.
SMARTiSM00417. H4. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00047. HISTONE_H4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiH4_SCHPO
AccessioniPrimary (citable) accession number: P09322
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.