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Protein

Histone H4

Gene

hhf1

more
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi17 – 215

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

ReactomeiR-SPO-2559580 Oxidative Stress Induced Senescence
R-SPO-3214841 PKMTs methylate histone lysines
R-SPO-3214847 HATs acetylate histones
R-SPO-3214858 RMTs methylate histone arginines
R-SPO-427359 SIRT1 negatively regulates rRNA expression
R-SPO-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H4
Gene namesi
Name:hhf1
Synonyms:h4.1
ORF Names:SPAC1834.03c
AND
Name:hhf2
Synonyms:h4.2
ORF Names:pi061, SPBC8D2.03c
AND
Name:hhf3
Synonyms:h4.3
ORF Names:SPBC1105.12
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componentsi: Chromosome I, Chromosome II

Organism-specific databases

PomBaseiSPAC1834.03c hhf1
SPBC8D2.03c hhf2
SPBC1105.12 hhf3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCurated
ChainiPRO_00001583572 – 103Histone H4Add BLAST102

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei48Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP09322
PaxDbiP09322
PRIDEiP09322

PTM databases

iPTMnetiP09322

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi27653510 interactors.
27771468 interactors.
27892458 interactors.
STRINGi4896.SPBC8D2.03c.1

Structurei

3D structure databases

ProteinModelPortaliP09322
SMRiP09322
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H4 family.Curated

Phylogenomic databases

HOGENOMiHOG000234654
InParanoidiP09322
KOiK11254
OMAiHINGITK
OrthoDBiEOG092C5WME
PhylomeDBiP09322

Family and domain databases

CDDicd00076 H4, 1 hit
Gene3Di1.10.20.101 hit
InterProiView protein in InterPro
IPR035425 CENP-T/H4_C
IPR009072 Histone-fold
IPR001951 Histone_H4
IPR019809 Histone_H4_CS
PfamiView protein in Pfam
PF15511 CENP-T_C, 1 hit
PRINTSiPR00623 HISTONEH4
SMARTiView protein in SMART
SM00417 H4, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00047 HISTONE_H4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09322-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGRGKGGKG LGKGGAKRHR KILRDNIQGI TKPAIRRLAR RGGVKRISAL
60 70 80 90 100
VYEETRAVLK LFLENVIRDA VTYTEHAKRK TVTSLDVVYS LKRQGRTIYG

FGG
Length:103
Mass (Da):11,423
Last modified:January 23, 2007 - v2
Checksum:i6D9C9F96ABEB0D98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05222 Genomic DNA Translation: CAA28850.1
X05223 Genomic DNA Translation: CAA28853.1
X05224 Genomic DNA Translation: CAA28855.1
AB004538 Genomic DNA Translation: BAA21442.1
CU329670 Genomic DNA Translation: CAB75771.1
CU329671 Genomic DNA Translation: CAA17818.1
CU329671 Genomic DNA Translation: CAB50975.1
PIRiD27399 HSZP4
RefSeqiNP_594682.1, NM_001020111.2
NP_595566.1, NM_001021461.2
NP_596468.1, NM_001022387.2

Genome annotation databases

EnsemblFungiiSPAC1834.03c.1; SPAC1834.03c.1:pep; SPAC1834.03c
SPBC1105.12.1; SPBC1105.12.1:pep; SPBC1105.12
SPBC8D2.03c.1; SPBC8D2.03c.1:pep; SPBC8D2.03c
GeneIDi2539991
2541200
2542463
KEGGispo:SPAC1834.03c
spo:SPBC1105.12
spo:SPBC8D2.03c

Similar proteinsi

Entry informationi

Entry nameiH4_SCHPO
AccessioniPrimary (citable) accession number: P09322
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome