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Protein

Histone H4

Gene

hhf1

more
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi17 – 215

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-SPO-3214841. PKMTs methylate histone lysines.
R-SPO-3214842. HDMs demethylate histones.
R-SPO-3214847. HATs acetylate histones.
R-SPO-3214858. RMTs methylate histone arginines.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H4
Gene namesi
Name:hhf1
Synonyms:h4.1
ORF Names:SPAC1834.03c
AND
Name:hhf2
Synonyms:h4.2
ORF Names:pi061, SPBC8D2.03c
AND
Name:hhf3
Synonyms:h4.3
ORF Names:SPBC1105.12
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componentsi: Chromosome I, Chromosome II

Organism-specific databases

PomBaseiSPAC1834.03c. hhf1.
SPBC8D2.03c. hhf2.
SPBC1105.12. hhf3.

Subcellular locationi

GO - Cellular componenti

  • nuclear nucleosome Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved
Chaini2 – 103102Histone H4PRO_0000158357Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei48 – 481Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP09322.
PRIDEiP09322.

PTM databases

iPTMnetiP09322.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

Protein-protein interaction databases

BioGridi276535. 10 interactions.
277714. 67 interactions.
278924. 55 interactions.
MINTiMINT-4687105.

Structurei

3D structure databases

ProteinModelPortaliP09322.
SMRiP09322. Positions 9-103.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H4 family.Curated

Phylogenomic databases

HOGENOMiHOG000234654.
InParanoidiP09322.
KOiK11254.
OMAiYEEVRVV.
OrthoDBiEOG7HQNNQ.
PhylomeDBiP09322.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR001951. Histone_H4.
IPR019809. Histone_H4_CS.
[Graphical view]
PRINTSiPR00623. HISTONEH4.
SMARTiSM00417. H4. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00047. HISTONE_H4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09322-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGRGKGGKG LGKGGAKRHR KILRDNIQGI TKPAIRRLAR RGGVKRISAL
60 70 80 90 100
VYEETRAVLK LFLENVIRDA VTYTEHAKRK TVTSLDVVYS LKRQGRTIYG

FGG
Length:103
Mass (Da):11,423
Last modified:January 23, 2007 - v2
Checksum:i6D9C9F96ABEB0D98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05222 Genomic DNA. Translation: CAA28850.1.
X05223 Genomic DNA. Translation: CAA28853.1.
X05224 Genomic DNA. Translation: CAA28855.1.
AB004538 Genomic DNA. Translation: BAA21442.1.
CU329670 Genomic DNA. Translation: CAB75771.1.
CU329671 Genomic DNA. Translation: CAA17818.1.
CU329671 Genomic DNA. Translation: CAB50975.1.
PIRiD27399. HSZP4.
RefSeqiNP_594682.1. NM_001020111.2.
NP_595566.1. NM_001021461.2.
NP_596468.1. NM_001022387.2.

Genome annotation databases

EnsemblFungiiSPAC1834.03c.1; SPAC1834.03c.1:pep; SPAC1834.03c.
SPBC1105.12.1; SPBC1105.12.1:pep; SPBC1105.12.
SPBC8D2.03c.1; SPBC8D2.03c.1:pep; SPBC8D2.03c.
GeneIDi2539991.
2541200.
2542463.
KEGGispo:SPAC1834.03c.
spo:SPBC1105.12.
spo:SPBC8D2.03c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05222 Genomic DNA. Translation: CAA28850.1.
X05223 Genomic DNA. Translation: CAA28853.1.
X05224 Genomic DNA. Translation: CAA28855.1.
AB004538 Genomic DNA. Translation: BAA21442.1.
CU329670 Genomic DNA. Translation: CAB75771.1.
CU329671 Genomic DNA. Translation: CAA17818.1.
CU329671 Genomic DNA. Translation: CAB50975.1.
PIRiD27399. HSZP4.
RefSeqiNP_594682.1. NM_001020111.2.
NP_595566.1. NM_001021461.2.
NP_596468.1. NM_001022387.2.

3D structure databases

ProteinModelPortaliP09322.
SMRiP09322. Positions 9-103.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276535. 10 interactions.
277714. 67 interactions.
278924. 55 interactions.
MINTiMINT-4687105.

PTM databases

iPTMnetiP09322.

Proteomic databases

MaxQBiP09322.
PRIDEiP09322.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC1834.03c.1; SPAC1834.03c.1:pep; SPAC1834.03c.
SPBC1105.12.1; SPBC1105.12.1:pep; SPBC1105.12.
SPBC8D2.03c.1; SPBC8D2.03c.1:pep; SPBC8D2.03c.
GeneIDi2539991.
2541200.
2542463.
KEGGispo:SPAC1834.03c.
spo:SPBC1105.12.
spo:SPBC8D2.03c.

Organism-specific databases

PomBaseiSPAC1834.03c. hhf1.
SPBC8D2.03c. hhf2.
SPBC1105.12. hhf3.

Phylogenomic databases

HOGENOMiHOG000234654.
InParanoidiP09322.
KOiK11254.
OMAiYEEVRVV.
OrthoDBiEOG7HQNNQ.
PhylomeDBiP09322.

Enzyme and pathway databases

ReactomeiR-SPO-3214841. PKMTs methylate histone lysines.
R-SPO-3214842. HDMs demethylate histones.
R-SPO-3214847. HATs acetylate histones.
R-SPO-3214858. RMTs methylate histone arginines.

Miscellaneous databases

NextBioi20801134.
PROiP09322.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR001951. Histone_H4.
IPR019809. Histone_H4_CS.
[Graphical view]
PRINTSiPR00623. HISTONEH4.
SMARTiSM00417. H4. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00047. HISTONE_H4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Histone gene organization of fission yeast: a common upstream sequence."
    Matsumoto S., Yanagida M.
    EMBO J. 4:3531-3538(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (HHF1; HHF2 AND HHF3).
  2. "A 38 kb segment containing the cdc2 gene from the left arm of fission yeast chromosome II: sequence analysis and characterization of the genomic DNA and cDNAs encoded on the segment."
    Machida M., Yamazaki S., Kunihiro S., Tanaka T., Kushida N., Jinno K., Haikawa Y., Yamazaki J., Yamamoto S., Sekine M., Oguchi A., Nagai Y., Sakai M., Aoki K., Ogura K., Kudoh Y., Kikuchi H., Zhang M.Q., Yanagida M.
    Yeast 16:71-80(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (HHF2).
    Strain: 972 / ATCC 24843.
  3. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (HHF1; HHF2 AND HHF3).
    Strain: 972 / ATCC 24843.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-48, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiH4_SCHPO
AccessioniPrimary (citable) accession number: P09322
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: January 20, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.