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Protein

Histone H4

Gene

hhf1

more
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi17 – 215

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

ReactomeiR-SPO-2559580. Oxidative Stress Induced Senescence.
R-SPO-3214841. PKMTs methylate histone lysines.
R-SPO-3214847. HATs acetylate histones.
R-SPO-3214858. RMTs methylate histone arginines.
R-SPO-427359. SIRT1 negatively regulates rRNA Expression.
R-SPO-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H4
Gene namesi
Name:hhf1
Synonyms:h4.1
ORF Names:SPAC1834.03c
AND
Name:hhf2
Synonyms:h4.2
ORF Names:pi061, SPBC8D2.03c
AND
Name:hhf3
Synonyms:h4.3
ORF Names:SPBC1105.12
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componentsi: Chromosome I, Chromosome II

Organism-specific databases

PomBaseiSPAC1834.03c. hhf1.
SPBC8D2.03c. hhf2.
SPBC1105.12. hhf3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCurated
ChainiPRO_00001583572 – 103Histone H4Add BLAST102

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei48Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP09322.
PRIDEiP09322.

PTM databases

iPTMnetiP09322.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi276535. 10 interactors.
277714. 68 interactors.
278924. 58 interactors.
MINTiMINT-4687105.
STRINGi4896.SPBC8D2.03c.1.

Structurei

3D structure databases

ProteinModelPortaliP09322.
SMRiP09322.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H4 family.Curated

Phylogenomic databases

HOGENOMiHOG000234654.
InParanoidiP09322.
KOiK11254.
OMAiYEEVRVV.
OrthoDBiEOG092C5WME.
PhylomeDBiP09322.

Family and domain databases

CDDicd00076. H4. 1 hit.
InterProiView protein in InterPro
IPR035425. CENP-T/H4_C.
IPR009072. Histone-fold.
IPR001951. Histone_H4.
IPR019809. Histone_H4_CS.
PfamiView protein in Pfam
PF15511. CENP-T_C. 1 hit.
PRINTSiPR00623. HISTONEH4.
SMARTiView protein in SMART
SM00417. H4. 1 hit.
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiView protein in PROSITE
PS00047. HISTONE_H4. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09322-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGRGKGGKG LGKGGAKRHR KILRDNIQGI TKPAIRRLAR RGGVKRISAL
60 70 80 90 100
VYEETRAVLK LFLENVIRDA VTYTEHAKRK TVTSLDVVYS LKRQGRTIYG

FGG
Length:103
Mass (Da):11,423
Last modified:January 23, 2007 - v2
Checksum:i6D9C9F96ABEB0D98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05222 Genomic DNA. Translation: CAA28850.1.
X05223 Genomic DNA. Translation: CAA28853.1.
X05224 Genomic DNA. Translation: CAA28855.1.
AB004538 Genomic DNA. Translation: BAA21442.1.
CU329670 Genomic DNA. Translation: CAB75771.1.
CU329671 Genomic DNA. Translation: CAA17818.1.
CU329671 Genomic DNA. Translation: CAB50975.1.
PIRiD27399. HSZP4.
RefSeqiNP_594682.1. NM_001020111.2.
NP_595566.1. NM_001021461.2.
NP_596468.1. NM_001022387.2.

Genome annotation databases

EnsemblFungiiSPAC1834.03c.1; SPAC1834.03c.1:pep; SPAC1834.03c.
SPBC1105.12.1; SPBC1105.12.1:pep; SPBC1105.12.
SPBC8D2.03c.1; SPBC8D2.03c.1:pep; SPBC8D2.03c.
GeneIDi2539991.
2541200.
2542463.
KEGGispo:SPAC1834.03c.
spo:SPBC1105.12.
spo:SPBC8D2.03c.

Similar proteinsi

Entry informationi

Entry nameiH4_SCHPO
AccessioniPrimary (citable) accession number: P09322
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families