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Protein

Capsid vertex component 2

Gene

CVC2

Organism
Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Capsid vertex-specific component that plays a role during viral DNA encapsidation, assuring correct genome cleavage and presumably stabilizing capsids that contain full-length viral genomes. Participates in the interaction between the capsid and the tegument through interaction with the large tegument protein/LTP.UniRule annotation

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Viral genome packaging, Viral penetration into host nucleus, Viral release from host cell, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Capsid vertex component 2UniRule annotation
Gene namesi
Name:CVC2UniRule annotation
Ordered Locus Names:34
OrganismiVaricella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3)
Taxonomic identifieri10338 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000002602 Componenti: Genome

Subcellular locationi

P09287:
  • Virion UniRule annotation
  • Host nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001160011 – 579Capsid vertex component 2Add BLAST579

Interactioni

Subunit structurei

Heterodimerizes with CVC1. Interacts with major capsid protein/MCP and triplex capsid protein 1/TRX1 at the pentamer vertices. Interacts with the large tegument protein/LTP.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP09287.
SMRiP09287.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 50Interaction with major capsid protein/MCPUniRule annotationAdd BLAST50

Sequence similaritiesi

Belongs to the herpesviridae CVC2 protein family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG0900005N.

Family and domain databases

HAMAPiMF_04025. HSV_CVC2. 1 hit.
InterProiView protein in InterPro
IPR002493. Herpes_UL25.
PfamiView protein in Pfam
PF01499. Herpes_UL25. 1 hit.

Sequencei

Sequence statusi: Complete.

P09287-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTARYGFGSI SFPNKCGIFL STTKNFIAPN FPIHYWTAPA FELRGRMNPD
60 70 80 90 100
LEKNTLTLKN AAAVAALDNL RGETITLPTE IDRRLKPLEE QLTRMAKVLD
110 120 130 140 150
SLETAAAEAE EADAQSEECT RTEIIRNESI HPEVQIAKND APLQYDTNFQ
160 170 180 190 200
VDFITLVYLG RARGNNSPGI VFGPWYRTLQ ERLVLDRPVA ARGVDCKDGR
210 220 230 240 250
ISRTFMNTTV TCLQSAGRMY VGDRAYSAFE CAVLCLYLMY RTSNSVHEPQ
260 270 280 290 300
VSSFGNLIEH LPEYTETFVN YMTTHENKNS YQFCYDRLPR DQFHARGGRY
310 320 330 340 350
DQGALTSHSV MDALIRLQVL PPAPGQFNPG VNDIIDRNHT AYVDKIQQAA
360 370 380 390 400
AAYLERAQNV FLMEDQTLLR LTIDTITALL LLRRLLWNGN VYGDKLKNNF
410 420 430 440 450
QLGLIVSEAT GTPTNNVILR GATGFDGKFK SGNNNFQFLC ERYIAPLYTL
460 470 480 490 500
NRTTELTEMF PGLVALCLDA HTQLSRGSLG RTVIDISSGQ YQDRLISLIA
510 520 530 540 550
LELEHRRQNV TSLPIAAVVS IHDSVMLQYE RGLGMLMHQP RVRAALEESR
560 570
RLAQFNVNSD YDLLYFVCLG VIPQFASTP
Length:579
Mass (Da):65,185
Last modified:July 1, 1989 - v1
Checksum:i946720E2C40A50DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04370 Genomic DNA. Translation: CAA27917.1.
PIRiH27214. WZBE34.

Similar proteinsi

Entry informationi

Entry nameiCVC2_VZVD
AccessioniPrimary (citable) accession number: P09287
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 25, 2017
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families