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Protein

Triplex capsid protein 1

Gene

TRX1

Organism
Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Structural component of the T=16 icosahedral capsid. The capsid is composed of pentamers and hexamers of major capsid protein/MCP, which are linked together by heterotrimers called triplexes. These triplexes are formed by a single molecule of triplex protein 1/TRX1 and two copies of triplex protein 2/TRX2. Additionally, TRX1 is required for efficient transport of TRX2 to the nucleus, which is the site of capsid assembly.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Triplex capsid protein 1UniRule annotation
Gene namesi
Name:TRX1UniRule annotation
Ordered Locus Names:20
OrganismiVaricella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3)
Taxonomic identifieri10338 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000002602 Componenti: Genome

Subcellular locationi

  • Virion UniRule annotation
  • Host nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001157211 – 483Triplex capsid protein 1Add BLAST483

Interactioni

Subunit structurei

Interacts with TRX2, MCP and capsid vertex component 2/CVC2.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae TRX1 protein family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG09000074.

Family and domain databases

HAMAPiMF_04018. HSV_TRX1. 1 hit.
InterProiView protein in InterPro
IPR004999. Herpes_1.
PfamiView protein in Pfam
PF03327. Herpes_VP19C. 1 hit.

Sequencei

Sequence statusi: Complete.

P09276-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSQPTNSHF TLNEQTLCGT NISLLGNNRF IQIGNGLHMT YAPGFFGNWS
60 70 80 90 100
RDLTIGPRFG GLNKQPIHVP PKRTETASIQ VTPRSIVINR MNNIQINPTS
110 120 130 140 150
IGNPQVTIRL PLNNFKSTTQ LIQQVSLTDF FRPDIEHAGS IVLILRHPSD
160 170 180 190 200
MIGEANTLTQ AGRDPDVLLE GLRNLFNACT APWTVGEGGG LRAYVTSLSF
210 220 230 240 250
IAACRAEEYT DKQAADANRT AIVSAYGCSR METRLIRFSE CLRAMVQCHV
260 270 280 290 300
FPHRFISFFG SLLEYTIQDN LCNITAVAKG PQEAARTDKT STRRVTANIP
310 320 330 340 350
ACVFWDVDKD LHLSADGLKH VFLVFVYTQR RQREGVRLHL ALSQLNEQCF
360 370 380 390 400
GRGIGFLLGR IRAENAAWGT EGVANTHQPY NTRALPLVQL SNDPTSPRCS
410 420 430 440 450
IGEITGVNWN LARQRLYQWT GDFRGLPTQL SCMYAAYTLI GTIPSESVRY
460 470 480
TRRMERFGGY NVPTIWLEGV VWGGTNTWNE CYY
Length:483
Mass (Da):53,971
Last modified:July 1, 1989 - v1
Checksum:iA584CF73D689BF91
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04370 Genomic DNA. Translation: CAA27903.1.
PIRiB27343. WZBE20.

Similar proteinsi

Entry informationi

Entry nameiTRX1_VZVD
AccessioniPrimary (citable) accession number: P09276
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: March 15, 2017
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families