P09254 (DUT_VZVD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Short name=dUTPase
EC=3.6.1.23

Alternative name(s):
dUTP pyrophosphatase

Gene names

ORF Names:

ORF8

Organism

Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3) [Reference proteome]

Taxonomic identifier

10338 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Varicellovirus › Human herpesvirus 3

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	396 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA By similarity.
Catalytic activity	dUTP + H2O = dUMP + diphosphate.
Cofactor	Magnesium By similarity.
Sequence similarities	Belongs to the dUTPase family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	dUTP metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	dUTP diphosphatase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 396	396	Deoxyuridine 5'-triphosphate nucleotidohydrolase		PRO_0000182956

Sequences

	Sequence		Length	Mass (Da)
	P09254 [UniParc]. Last modified July 1, 1989. Version 1. Checksum: ECD0B8109DA3923D	FASTA	396	44,819
	10 20 30 40 50 60 MNEAVIDPIL ETAVNTGDMF CSQTIPNRCL KDTILIEVQP ECADTLQCVL DDKVSRHQPL 70 80 90 100 110 120 LLRNHKKLEL PSEKSVTRGG FYMQQLELLV KSAPPNEYAL LLIQCKDTAL ADEDNFFVAN 130 140 150 160 170 180 GVIDAGYRGV ISALLYYRPG VTVILPGHLT IYLFPVKLRQ SRLLPKNVLK HLDPIFKSIQ 190 200 210 220 230 240 VQPLSNSPSN YEKPVIPEFA DISTVQQGQP LHRDSAEYHI DVPLTYKHII NPKRQEDAGY 250 260 270 280 290 300 DICVPYNLYL KRNEFIKIVL PIIRDWDLQH PSINAYIFGR SSKSRSGIIV CPTAWPAGEH 310 320 330 340 350 360 CKFYVYNLTG DDIRIKTGDR LAQVLLIDHN TQIHLKHNVL SNIAFPYAIR GKCGIPGVQW 370 380 390 YFTKTLDLIA TPSERGTRGF GSTDKETNDV DFLLKH

References

[1]	"The complete DNA sequence of varicella-zoster virus." Davison A.J., Scott J.E. J. Gen. Virol. 67:1759-1816(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X04370 Genomic DNA. Translation: CAA27891.1.
PIR	WZBE8. H27212.
3D structure databases
ProteinModelPortal	P09254.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
ProtClustDB	PHA3123.
Family and domain databases
InterPro	IPR008180. dUTP_pyroPase. [Graphical view]
Pfam	PF00692. dUTPase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DUT_VZVD

Accession

Primary (citable) accession number: P09254

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	April 3, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program