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P09254

- DUT_VZVD

UniProt

P09254 - DUT_VZVD

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Protein
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Gene
ORF8
Organism
Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA By similarity.

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.

Cofactori

Magnesium By similarity.

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. dUTP metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
dUTP pyrophosphatase
Gene namesi
ORF Names:ORF8
OrganismiVaricella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3)
Taxonomic identifieri10338 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000002602: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396Deoxyuridine 5'-triphosphate nucleotidohydrolase
PRO_0000182956Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP09254.

Family & Domainsi

Sequence similaritiesi

Belongs to the dUTPase family.

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 3 hits.

Sequencei

Sequence statusi: Complete.

P09254-1 [UniParc]FASTAAdd to Basket

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MNEAVIDPIL ETAVNTGDMF CSQTIPNRCL KDTILIEVQP ECADTLQCVL    50
DDKVSRHQPL LLRNHKKLEL PSEKSVTRGG FYMQQLELLV KSAPPNEYAL 100
LLIQCKDTAL ADEDNFFVAN GVIDAGYRGV ISALLYYRPG VTVILPGHLT 150
IYLFPVKLRQ SRLLPKNVLK HLDPIFKSIQ VQPLSNSPSN YEKPVIPEFA 200
DISTVQQGQP LHRDSAEYHI DVPLTYKHII NPKRQEDAGY DICVPYNLYL 250
KRNEFIKIVL PIIRDWDLQH PSINAYIFGR SSKSRSGIIV CPTAWPAGEH 300
CKFYVYNLTG DDIRIKTGDR LAQVLLIDHN TQIHLKHNVL SNIAFPYAIR 350
GKCGIPGVQW YFTKTLDLIA TPSERGTRGF GSTDKETNDV DFLLKH 396
Length:396
Mass (Da):44,819
Last modified:July 1, 1989 - v1
Checksum:iECD0B8109DA3923D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X04370 Genomic DNA. Translation: CAA27891.1.
PIRiH27212. WZBE8.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X04370 Genomic DNA. Translation: CAA27891.1 .
PIRi H27212. WZBE8.

3D structure databases

ProteinModelPortali P09254.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.70.40.10. 1 hit.
InterProi IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view ]
Pfami PF00692. dUTPase. 1 hit.
[Graphical view ]
SUPFAMi SSF51283. SSF51283. 3 hits.
ProtoNeti Search...

Publicationsi

  1. "The complete DNA sequence of varicella-zoster virus."
    Davison A.J., Scott J.E.
    J. Gen. Virol. 67:1759-1816(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiDUT_VZVD
AccessioniPrimary (citable) accession number: P09254
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: June 11, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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