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P09254

- DUT_VZVD

UniProt

P09254 - DUT_VZVD

Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

ORF8

Organism
Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA.By similarity

    Catalytic activityi

    dUTP + H2O = dUMP + diphosphate.

    Cofactori

    Magnesium.By similarity

    GO - Molecular functioni

    1. dUTP diphosphatase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. dUTP metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide metabolism

    Keywords - Ligandi

    Magnesium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
    Short name:
    dUTPase
    Alternative name(s):
    dUTP pyrophosphatase
    Gene namesi
    ORF Names:ORF8
    OrganismiVaricella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3)
    Taxonomic identifieri10338 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000002602: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 396396Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000182956Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP09254.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the dUTPase family.Curated

    Family and domain databases

    Gene3Di2.70.40.10. 1 hit.
    InterProiIPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    [Graphical view]
    PfamiPF00692. dUTPase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51283. SSF51283. 3 hits.

    Sequencei

    Sequence statusi: Complete.

    P09254-1 [UniParc]FASTAAdd to Basket

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    MNEAVIDPIL ETAVNTGDMF CSQTIPNRCL KDTILIEVQP ECADTLQCVL    50
    DDKVSRHQPL LLRNHKKLEL PSEKSVTRGG FYMQQLELLV KSAPPNEYAL 100
    LLIQCKDTAL ADEDNFFVAN GVIDAGYRGV ISALLYYRPG VTVILPGHLT 150
    IYLFPVKLRQ SRLLPKNVLK HLDPIFKSIQ VQPLSNSPSN YEKPVIPEFA 200
    DISTVQQGQP LHRDSAEYHI DVPLTYKHII NPKRQEDAGY DICVPYNLYL 250
    KRNEFIKIVL PIIRDWDLQH PSINAYIFGR SSKSRSGIIV CPTAWPAGEH 300
    CKFYVYNLTG DDIRIKTGDR LAQVLLIDHN TQIHLKHNVL SNIAFPYAIR 350
    GKCGIPGVQW YFTKTLDLIA TPSERGTRGF GSTDKETNDV DFLLKH 396
    Length:396
    Mass (Da):44,819
    Last modified:July 1, 1989 - v1
    Checksum:iECD0B8109DA3923D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X04370 Genomic DNA. Translation: CAA27891.1.
    PIRiH27212. WZBE8.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X04370 Genomic DNA. Translation: CAA27891.1 .
    PIRi H27212. WZBE8.

    3D structure databases

    ProteinModelPortali P09254.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.70.40.10. 1 hit.
    InterProi IPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    [Graphical view ]
    Pfami PF00692. dUTPase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51283. SSF51283. 3 hits.
    ProtoNeti Search...

    Publicationsi

    1. "The complete DNA sequence of varicella-zoster virus."
      Davison A.J., Scott J.E.
      J. Gen. Virol. 67:1759-1816(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiDUT_VZVD
    AccessioniPrimary (citable) accession number: P09254
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3