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Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

DUT

Organism
Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA.UniRule annotation

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolaseUniRule annotation (EC:3.6.1.23UniRule annotation)
Short name:
dUTPaseUniRule annotation
Alternative name(s):
dUTP pyrophosphataseUniRule annotation
Gene namesi
Name:DUTUniRule annotation
Ordered Locus Names:ORF8
OrganismiVaricella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3)
Taxonomic identifieri10338 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000002602 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001829561 – 396Deoxyuridine 5'-triphosphate nucleotidohydrolaseAdd BLAST396

Proteomic databases

PRIDEiP09254

Structurei

3D structure databases

ProteinModelPortaliP09254
SMRiP09254
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni280 – 282Substrate bindingUniRule annotation3
Regioni380 – 381Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the dUTPase family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG0900009U

Family and domain databases

Gene3Di2.70.40.10, 1 hit
HAMAPiMF_04031 HSV_DUT, 1 hit
InterProiView protein in InterPro
IPR029054 dUTPase-like
IPR036157 dUTPase-like_sf
IPR034745 HSV_DUT
PfamiView protein in Pfam
PF00692 dUTPase, 1 hit
SUPFAMiSSF51283 SSF51283, 3 hits

Sequencei

Sequence statusi: Complete.

P09254-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEAVIDPIL ETAVNTGDMF CSQTIPNRCL KDTILIEVQP ECADTLQCVL
60 70 80 90 100
DDKVSRHQPL LLRNHKKLEL PSEKSVTRGG FYMQQLELLV KSAPPNEYAL
110 120 130 140 150
LLIQCKDTAL ADEDNFFVAN GVIDAGYRGV ISALLYYRPG VTVILPGHLT
160 170 180 190 200
IYLFPVKLRQ SRLLPKNVLK HLDPIFKSIQ VQPLSNSPSN YEKPVIPEFA
210 220 230 240 250
DISTVQQGQP LHRDSAEYHI DVPLTYKHII NPKRQEDAGY DICVPYNLYL
260 270 280 290 300
KRNEFIKIVL PIIRDWDLQH PSINAYIFGR SSKSRSGIIV CPTAWPAGEH
310 320 330 340 350
CKFYVYNLTG DDIRIKTGDR LAQVLLIDHN TQIHLKHNVL SNIAFPYAIR
360 370 380 390
GKCGIPGVQW YFTKTLDLIA TPSERGTRGF GSTDKETNDV DFLLKH
Length:396
Mass (Da):44,819
Last modified:July 1, 1989 - v1
Checksum:iECD0B8109DA3923D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04370 Genomic DNA Translation: CAA27891.1
PIRiH27212 WZBE8

Similar proteinsi

Entry informationi

Entry nameiDUT_VZVD
AccessioniPrimary (citable) accession number: P09254
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: May 23, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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