P09249 (TYSY_VZVD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidylate synthase
Short name=TS
Short name=TSase
EC=2.1.1.45

Gene names

ORF Names:

ORF13

Organism

Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3) [Reference proteome]

Taxonomic identifier

10338 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Varicellovirus › Human herpesvirus 3

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	301 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the reductive methylation of deoxyuridylate to thymidylate By similarity.
Catalytic activity	5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.
Pathway	Pyrimidine metabolism; dTTP biosynthesis.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the thymidylate synthase family.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	dTMP biosynthetic process Inferred from electronic annotation. Source: InterPro dTTP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	thymidylate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 301	301	Thymidylate synthase		PRO_0000141066
Sites
	Active site	183	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P09249 [UniParc]. Last modified July 1, 1989. Version 1. Checksum: 8B84C36E79F95861	FASTA	301	34,533
	10 20 30 40 50 60 MGDLSCWTKV PGFTLTGELQ YLKQVDDILR YGVRKRDRTG IGTLSLFGMQ ARYNLRNEFP 70 80 90 100 110 120 LLTTKRVFWR AVVEELLWFI RGSTDSKELA AKDIHIWDIY GSSKFLNRNG FHKRHTGDLG 130 140 150 160 170 180 PIYGFQWRHF GAEYKDCQSN YLQQGIDQLQ TVIDTIKTNP ESRRMIISSW NPKDIPLMVL 190 200 210 220 230 240 PPCHTLCQFY VANGELSCQV YQRSGDMGLG VPFNIAGYAL LTYIVAHVTG LKTGDLIHTM 250 260 270 280 290 300 GDAHIYLNHI DALKVQLARS PKPFPCLKII RNVTDINDFK WDDFQLDGYN PHPPLKMEMA L

References

[1]	"The complete DNA sequence of varicella-zoster virus." Davison A.J., Scott J.E. J. Gen. Virol. 67:1759-1816(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X04370 Genomic DNA. Translation: CAA27896.1.
PIR	SYBE13. D27342.
3D structure databases
ProteinModelPortal	P09249.
SMR	P09249. Positions 17-301.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
ProtClustDB	CLSP2509595.
Enzyme and pathway databases
UniPathway	UPA00575.
Family and domain databases
Gene3D	3.30.572.10. 1 hit.
InterPro	IPR023451. Thymidate_synth/dCMP_Mease. IPR000398. Thymidylate_synthase. IPR020940. Thymidylate_synthase_AS. [Graphical view]
Pfam	PF00303. Thymidylat_synt. 1 hit. [Graphical view]
PRINTS	PR00108. THYMDSNTHASE.
SUPFAM	SSF55831. Thymidylat_synth_C. 1 hit.
TIGRFAMs	TIGR03284. thym_sym. 1 hit.
PROSITE	PS00091. THYMIDYLATE_SYNTHASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYSY_VZVD

Accession

Primary (citable) accession number: P09249

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	April 3, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program