Reviewed, UniProtKB/Swiss-Prot P09248 (RIR1_VZVD)

Names and origin

Protein names

Recommended name:
    Ribonucleoside-diphosphate reductase large subunit
      Short name=R1
    EC=1.17.4.1
Alternative name(s):
    Ribonucleotide reductase large subunit

Gene names

ORF Names:

ORF19

Organism

Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3)

Taxonomic identifier

10338 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Varicellovirus

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	775 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Catalytic activity	2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.
Pathway	Genetic information processing; DNA replication.
Subunit structure	Heterodimer of a large ORF19 subunit and the a ORF18 subunit By similarity.
Sequence similarities	Belongs to the ribonucleoside diphosphate reductase large chain family.

Ontologies

Keywords
Biological process	DNA replication
Developmental stage	Early protein
Ligand	ATP-binding Nucleotide-binding
Molecular function	Oxidoreductase
Technical term	Allosteric enzyme Complete proteome Virus reference strain
Gene Ontology (GO)
Biological process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	ribonucleoside-diphosphate reductase complex Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ribonucleoside-diphosphate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 775	775	Ribonucleoside-diphosphate reductase large subunit		PRO_0000187245
Sites
	Active site	216	1	Hydrogen atom transfer By similarity
	Active site	427	1	Proton acceptor By similarity
	Active site	429	1	Proton acceptor By similarity
	Active site	431	1	Proton acceptor By similarity
	Active site	444	1	Hydrogen atom transfer By similarity
	Active site	750	1	Electron transfer By similarity
	Active site	751	1	Electron transfer By similarity
	Site	770	1	Interacts with thioredoxin/glutaredoxin By similarity
	Site	773	1	Interacts with thioredoxin/glutaredoxin By similarity

Sequences

	Sequence		Length	Mass (Da)
	P09248-1 [UniParc]. Last modified July 1, 1989. Version 1. Checksum: 187695A65EB91B9D	FASTA	775	86,828
	10 20 30 40 50 60 MEFKRIFNTV HDIINRLCQH GYKEYIIPPE STTPVELMEY ISTIVSKLKA VTRQDERVYR 70 80 90 100 110 120 CCGELIHCRI NLRSVSMETW LTSPILCLTP RVRQAIEGRR DEIRRAILEP FLKDQYPALA 130 140 150 160 170 180 TLGLQSALKY EDFYLTKLEE GKLESLCQFF LRLAATVTTE IVNLPKIATL IPGINDGYTW 190 200 210 220 230 240 TDVCRVFFTA LACQKIVPAT PVMMFLGRET GATASCYLMD PESITVGRAV RAITGDVGTV 250 260 270 280 290 300 LQSRGGVGIS LQSLNLIPTE NQTKGLLAVL KLLDCMVMAI NSDCERPTGV CVYIEPWHVD 310 320 330 340 350 360 LQTVLATRGM LVRDEIFRCD NIFCCLWTPD LFFERYLSYL KGASNVQWTL FDNRADILRT 370 380 390 400 410 420 LHGEAFTSTY LRLEREGLGV SSVPIQDIAF TIIRSAAVTG SPFLMFKDAC NRNYHMNTQG 430 440 450 460 470 480 NAITGSNLCT EIVQKADAHQ HGVCNLASIN LTTCLSKGPV SFNLNDLQLT ARTTVIFLNG 490 500 510 520 530 540 VLAAGNFPCK KSCKGVKNNR SLGIGIQGLH TTCLRLGFDL TSQPARRLNV QIAELMLYET 550 560 570 580 590 600 MKTSMEMCKI GGLAPFKGFT ESKYAKGWLH QDGFSTISYL DLPWCTLRDD ICAYGLYNSQ 610 620 630 640 650 660 FLALMPTVSS AQVTECSEGF SPIYNNMFSK VTTSGELLRP NLDLMDELRD MYSCEEKRLE 670 680 690 700 710 720 VINILEKNQW SVIRSFGCLS NSHPLLKYKT AFEYEQEDLV DMCAERAPFI DQSQSMTLFI 730 740 750 760 770 EERPDGTIPA SKIMNLLIRA YKAGLKTGMY YCKIRKATNS GLFAGGELTC TSCAL

References

[1]	"The complete DNA sequence of varicella-zoster virus." Davison A.J., Scott J.E. J. Gen. Virol. 67:1759-1816(1986) [PubMed: 3018124] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	X04370 Genomic DNA. Translation: CAA27902.1.
PIR	WMBE19. A27343.
RefSeq	NP_040142.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1487716.
Family and domain databases
InterPro	IPR013346. NrdE_NrdA. IPR013509. Ribncl_Rdtase_lsu_N. IPR000788. Ribncl_red_lg_C. [Graphical view]
PANTHER	PTHR11573. Ribncl_red_lg_C. 1 hit.
Pfam	PF02867. Ribonuc_red_lgC. 1 hit. PF00317. Ribonuc_red_lgN. 1 hit. [Graphical view]
PRINTS	PR01183. RIBORDTASEM1.
TIGRFAMs	TIGR02506. NrdE_NrdA. 1 hit.
PROSITE	PS00089. RIBORED_LARGE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RIR1_VZVD

Accession

Primary (citable) accession number: P09248

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	September 22, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Virus (Virus annotation project)