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P09247 (RIR2_VZVD) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonucleoside-diphosphate reductase small chain

Short name=R2
EC=1.17.4.1
Alternative name(s):
Ribonucleotide reductase small subunit
Gene names
ORF Names:ORF18
OrganismVaricella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3) [Reference proteome]
Taxonomic identifier10338 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length306 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. The N-terminal region confers antiapoptotic activity in differentiated cells such as neurons and is important for viral reactivation to increase neural survivability By similarity.

Catalytic activity

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactor

Binds 2 iron ions per subunit By similarity.

Pathway

Genetic information processing; DNA replication.

Subunit structure

Heterotetramer composed of a homodimer of the large subunit ORF19 (R1) and a homodimer of the small subunit ORF18 (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n By similarity.

Subcellular location

Host membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the ribonucleoside diphosphate reductase small chain family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 306306Ribonucleoside-diphosphate reductase small chain
PRO_0000190512

Regions

Transmembrane153 – 17321Helical; Potential

Sites

Active site1031 By similarity
Metal binding661Iron 1 By similarity
Metal binding961Iron 1 By similarity
Metal binding961Iron 2 By similarity
Metal binding991Iron 1 By similarity
Metal binding1591Iron 2 By similarity
Metal binding1931Iron 2 By similarity
Metal binding1961Iron 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
P09247 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: 76CD3F8BB8C1B094

FASTA30635,397
        10         20         30         40         50         60 
MDQKDCSHFF YRPECPDINN LRALSISNRW LESDFIIEDD YQYLDCLTED ELIFYRFIFT 

        70         80         90        100        110        120 
FLSAADDLVN VNLGSLTQLF SQKDIHHYYI EQECIEVVHA RVYSQIQLML FRGDESLRVQ 

       130        140        150        160        170        180 
YVNVTINNPS IQQKVQWLEE KVRDNPSVAE KYILMILIEG IFFVSSFAAI AYLRNNGLFV 

       190        200        210        220        230        240 
VTCQFNDLIS RDEAIHTSAS CCIYNNYVPE KPAITRIHQL FSEAVEIECA FLKSHAPKTR 

       250        260        270        280        290        300 
LVNVDAITQY VKFSADRLLS AINVPKLFNT PPPDSDFPLA FMIADKNTNF FERHSTSYAG 


TVINDL 

« Hide

References

« Hide 'large scale' references
[1]"The complete DNA sequence of varicella-zoster virus."
Davison A.J., Scott J.E.
J. Gen. Virol. 67:1759-1816(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Tinkering with a viral ribonucleotide reductase."
Lembo D., Brune W.
Trends Biochem. Sci. 34:25-32(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X04370 Genomic DNA. Translation: CAA27901.1.
PIRWMBE18. I27342.

3D structure databases

ProteinModelPortalP09247.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

ProtClustDBCLSP2509600.

Enzyme and pathway databases

UniPathwayUPA00326.

Family and domain databases

Gene3D1.10.620.20. 1 hit.
InterProIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERPTHR23409. PTHR23409. 1 hit.
PfamPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
PROSITEPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRIR2_VZVD
AccessionPrimary (citable) accession number: P09247
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: February 19, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways