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Protein

Major capsid protein

Gene

MCP

Organism
Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Self-assembles to form an icosahedral capsid with a T=16 symmetry, about 200 nm in diameter, and consisting of 150 hexons and 12 pentons (total of 162 capsomers). Hexons form the edges and faces of the capsid and are each composed of six MCP molecules. In contrast, one penton is found at each of the 12 vertices. Eleven of the pentons are MCP pentamers, while the last vertex is occupied by the portal complex. The capsid is surrounded by a layer of proteinaceous material designated the tegument which, in turn, is enclosed in an envelope of host cell-derived lipids containing virus-encoded glycoproteins.UniRule annotation

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Major capsid proteinUniRule annotation
Short name:
MCPUniRule annotation
Gene namesi
Name:MCPUniRule annotation
Synonyms:40
OrganismiVaricella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3)
Taxonomic identifieri10338 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000002602 Componenti: Genome

Subcellular locationi

  • Virion UniRule annotation
  • Host nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Host nucleus, T=16 icosahedral capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001157071 – 1396Major capsid proteinAdd BLAST1396

Interactioni

Subunit structurei

Homomultimer. Makes the hexons and eleven out of twelve pentons. Interacts with triplex proteins 1/TRX1 and 2/TRX2; adjacent capsomers are linked together in groups of three by triplexes, heterotrimeric complexes composed of one molecule of TRX1 and two molecules of TRX2. Interacts with scaffold protein; this interaction allows efficient MCP transport to the host nucleus. Interacts with capsid vertex component 2/CVC2. Interacts with the small capsomere-interacting protein/SCP.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP09245.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae major capsid protein family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG0900000D.

Family and domain databases

HAMAPiMF_04016. HSV_MCP. 1 hit.
InterProiView protein in InterPro
IPR000912. Herpes_MCP.
IPR023233. Herpes_MCP_upper.
PfamiView protein in Pfam
PF03122. Herpes_MCP. 1 hit.
PRINTSiPR00235. HSVCAPSIDMCP.
SUPFAMiSSF103417. SSF103417. 1 hit.

Sequencei

Sequence statusi: Complete.

P09245-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTVSCPANV ITTTESDRIA GLFNIPAGII PTGNVLSTIE VCAHRCIFDF
60 70 80 90 100
FKQIRSDDNS LYSAQFDILL GTYCNTLNFV RFLELGLSVA CICTKFPELA
110 120 130 140 150
YVRDGVIQFE VQQPMIARDG PHPVDQPVHN YMVKRIHKRS LSAAFAIASE
160 170 180 190 200
ALSLLSNTYV DGTEIDSSLR IRAIQQMARN LRTVLDSFER GTADQLLGVL
210 220 230 240 250
LEKAPPLSLL SPINKFQPEG HLNRVARAAL LSDLKRRVCA DMFFMTRHAR
260 270 280 290 300
EPRLISAYLS DMVSCTQPSV MVSRITHTNT RGRQVDGVLV TTATLKRQLL
310 320 330 340 350
QGILQIDDTA ADVPVTYGEM VLQGTNLVTA LVMGKAVRGM DDVARHLLDI
360 370 380 390 400
TDPNTLNIPS IPPQSNSDST TAGLPVNARV PADLVIVGDK LVFLEALERR
410 420 430 440 450
VYQATRVAYP LIGNIDITFI MPMGVFQANS MDRYTRHAGD FSTVSEQDPR
460 470 480 490 500
QFPPQGIFFY NKDGILTQLT LRDAMGTICH SSLLDVEATL VALRQQHLDR
510 520 530 540 550
QCYFGVYVAE GTEDTLDVQM GRFMETWADM MPHHPHWVNE HLTILQFIAP
560 570 580 590 600
SNPRLRFELN PAFDFFVAPG DVDLPGPQRP PEAMPTVNAT LRIINGNIPV
610 620 630 640 650
PLCPISFRDC RGTQLGLGRH TMTPATIKAV KDTFEDRAYP TIFYMLEAVI
660 670 680 690 700
HGNERNFCAL LRLLTQCIRG YWEQSHRVAF VNNFHMLMYI TTYLGNGELP
710 720 730 740 750
EVCINIYRDL LQHVRALRQT ITDFTIQGEG HNGETSEALN NILTDDTFIA
760 770 780 790 800
PILWDCDALI YRDEAARDRL PAIRVSGRNG YQALHFVDMA GHNFQRRDNV
810 820 830 840 850
LIHGRPVRGD TGQGIPITPH HDREWGILSK IYYYIVIPAF SRGSCCTMGV
860 870 880 890 900
RYDRLYPALQ AVIVPEIPAD EEAPTTPEDP RHPLHAHQLV PNSLNVYFHN
910 920 930 940 950
AHLTVDGDAL LTLQELMGDM AERTTAILVS SAPDAGAATA TTRNMRIYDG
960 970 980 990 1000
ALYHGLIMMA YQAYDETIAT GTFFYPVPVN PLFACPEHLA SLRGMTNARR
1010 1020 1030 1040 1050
VLAKMVPPIP PFLGANHHAT IRQPVAYHVT HSKSDFNTLT YSLLGGYFKF
1060 1070 1080 1090 1100
TPISLTHQLR TGFHPGIAFT VVRQDRFATE QLLYAERASE SYFVGQIQVH
1110 1120 1130 1140 1150
HHDAIGGVNF TLTQPRAHVD LGVGYTAVCA TAALRCPLTD MGNTAQNLFF
1160 1170 1180 1190 1200
SRGGVPMLHD NVTESLRRIT ASGGRLNPTE PLPIFGGLRP ATSAGIARGQ
1210 1220 1230 1240 1250
ASVCEFVAMP VSTDLQYFRT ACNPRGRASG MLYMGDRDAD IEAIMFDHTQ
1260 1270 1280 1290 1300
SDVAYTDRAT LNPWASQKHS YGDRLYNGTY NLTGASPIYS PCFKFFTPAE
1310 1320 1330 1340 1350
VNTNCNTLDR LLMEAKAVAS QSSTDTEYQF KRPPGSTEMT QDPCGLFQEA
1360 1370 1380 1390
YPPLCSSDAA MLRTAHAGET GADEVHLAQY LIRDASPLRG CLPLPR
Length:1,396
Mass (Da):154,980
Last modified:July 1, 1989 - v1
Checksum:iE509272D8D77242F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04370 Genomic DNA. Translation: CAA27923.1.
PIRiE27341. VCBE40.

Similar proteinsi

Entry informationi

Entry nameiMCP_VZVD
AccessioniPrimary (citable) accession number: P09245
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: March 15, 2017
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families