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P09241 (OPSD_ENTDO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Rhodopsin
Gene names
Name:RHO
OrganismEnteroctopus dofleini (Giant octopus) (Octopus dofleini)
Taxonomic identifier267067 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Lophotrochozoa › Mollusca › Cephalopoda › Coleoidea › Neocoleoidea › Octopodiformes › Octopoda › Incirrata › Octopodidae › Enteroctopus

Protein attributes

Sequence length455 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Visual pigments such as rhodopsin and porphyropsin are light-absorbing molecules that mediate vision. Rhodopsin consists of an apoprotein, opsin, covalently linked to 11-cis-retinal. This receptor is coupled to the activation of phospholipase C. Porphyropsin consists of opsin covalently linked to 11-cis 3,4-didehydroretinal.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Rod shaped photoreceptor cells which mediates vision in dim light.

Post-translational modification

Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 455455Rhodopsin
PRO_0000197734

Regions

Topological domain1 – 3434Extracellular
Transmembrane35 – 5925Helical; Name=1; Potential
Topological domain60 – 7112Cytoplasmic
Transmembrane72 – 9827Helical; Name=2; Potential
Topological domain99 – 11214Extracellular
Transmembrane113 – 13220Helical; Name=3; Potential
Topological domain133 – 15220Cytoplasmic
Transmembrane153 – 17624Helical; Name=4; Potential
Topological domain177 – 20024Extracellular
Transmembrane201 – 22828Helical; Name=5; Potential
Topological domain229 – 26234Cytoplasmic
Transmembrane263 – 28624Helical; Name=6; Potential
Topological domain287 – 2948Extracellular
Transmembrane295 – 31925Helical; Name=7; Potential
Topological domain320 – 455136Cytoplasmic
Repeat395 – 39951-1
Repeat400 – 40451-2
Repeat412 – 41652-1
Repeat417 – 42152-2
Repeat422 – 42653-1
Repeat427 – 43153-2
Region395 – 431376 X 5 AA repeats of G-Y-P-P-Q
Compositional bias370 – 38011Met-rich
Compositional bias381 – 45575Gln/Pro-rich

Amino acid modifications

Modified residue3061N6-(retinylidene)lysine
Lipidation3371S-palmitoyl cysteine By similarity
Lipidation3381S-palmitoyl cysteine By similarity
Glycosylation91N-linked (GlcNAc...) Probable
Glycosylation151N-linked (GlcNAc...) Probable
Disulfide bond109 ↔ 187 By similarity

Sequences

Sequence LengthMass (Da)Tools
P09241 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: AECF4FC30ED1346C

FASTA45550,489
        10         20         30         40         50         60 
MVESTTLVNQ TWWYNPTVDI HPHWAKFDPI PDAVYYSVGI FIGVVGIIGI LGNGVVIYLF 

        70         80         90        100        110        120 
SKTKSLQTPA NMFIINLAMS DLSFSAINGF PLKTISAFMK KWIFGKVACQ LYGLLGGIFG 

       130        140        150        160        170        180 
FMSINTMAMI SIDRYNVIGR PMAASKKMSH RRAFLMIIFV WMWSIVWSVG PVFNWGAYVP 

       190        200        210        220        230        240 
EGILTSCSFD YLSTDPSTRS FILCMYFCGF MLPIIIIAFC YFNIVMSVSN HEKEMAAMAK 

       250        260        270        280        290        300 
RLNAKELRKA QAGASAEMKL AKISMVIITQ FMLSWSPYAI IALLAQFGPA EWVTPYAAEL 

       310        320        330        340        350        360 
PVLFAKASAI HNPIVYSVSH PKFREAIQTT FPWLLTCCQF DEKECEDAND AEEEVVASER 

       370        380        390        400        410        420 
GGESRDAAQM KEMMAMMQKM QAQQAAYQPP PPPQGYPPQG YPPQGAYPPP QGYPPQGYPP 

       430        440        450 
QGYPPQGYPP QGAPPQVEAP QGAPPQGVDN QAYQA

« Hide

References

[1]"Octopus rhodopsin. Amino acid sequence deduced from cDNA."
Ovchinnikov Y.A., Abdulaev N.G., Zolotarev A.S., Artamonov I.D., Bespalov I.A., Dergachev A.E., Tsuda M.
FEBS Lett. 232:69-72(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Abdulaev N.G.
Submitted (OCT-1988) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION TO 399.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X07797 mRNA. Translation: CAA30644.1.
PIROOOCG. S00610.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2AULmodel-A1-363[»]
ProteinModelPortalP09241.
SMRP09241. Positions 9-359.
ModBaseSearch...

Protein family/group databases

GPCRDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001760. Opsin.
IPR006031. XYPPX.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
PF02162. XYPPX. 4 hits.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00238. OPSIN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameOPSD_ENTDO
AccessionPrimary (citable) accession number: P09241
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: April 3, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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