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P09240

- CCKN_MOUSE

UniProt

P09240 - CCKN_MOUSE

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Protein
Cholecystokinin
Gene
Cck
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.

GO - Molecular functioni

  1. neuropeptide hormone activity Source: MGI
  2. protein binding Source: MGI

GO - Biological processi

  1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  2. axonogenesis Source: MGI
  3. behavioral fear response Source: Ensembl
  4. eating behavior Source: MGI
  5. negative regulation of appetite Source: Ensembl
  6. neuron migration Source: MGI
  7. positive regulation of apoptotic process Source: Ensembl
  8. positive regulation of cell proliferation Source: Ensembl
  9. positive regulation of mitochondrial depolarization Source: Ensembl
  10. positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
  11. positive regulation of protein oligomerization Source: Ensembl
  12. protein kinase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
  13. regulation of sensory perception of pain Source: Ensembl
  14. release of cytochrome c from mitochondria Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Cholecystokinin
Short name:
CCK
Cleaved into the following 3 chains:
Cholecystokinin-33
Short name:
CCK33
Cholecystokinin-12
Short name:
CCK12
Cholecystokinin-8
Short name:
CCK8
Gene namesi
Name:Cck
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:88297. Cck.

Subcellular locationi

GO - Cellular componenti

  1. axon Source: MGI
  2. axon hillock Source: Ensembl
  3. axon initial segment Source: Ensembl
  4. dendrite Source: Ensembl
  5. extracellular space Source: Ensembl
  6. perikaryon Source: Ensembl
  7. terminal bouton Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 By similarity
Add
BLAST
Chaini21 – 11595Cholecystokinin
PRO_0000010552Add
BLAST
Propeptidei21 – 7050
PRO_0000010553Add
BLAST
Peptidei71 – 10333Cholecystokinin-33
PRO_0000010554Add
BLAST
Peptidei92 – 10312Cholecystokinin-12
PRO_0000010555Add
BLAST
Peptidei96 – 1038Cholecystokinin-8
PRO_0000010556
Propeptidei107 – 1159
PRO_0000010557

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei97 – 971Sulfotyrosine By similarity
Modified residuei103 – 1031Phenylalanine amide
Modified residuei111 – 1111Sulfotyrosine By similarity
Modified residuei113 – 1131Sulfotyrosine By similarity

Post-translational modificationi

The precursor is cleaved by proteases to produce a number of active cholecystokinins.

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Sulfation

Proteomic databases

PaxDbiP09240.
PRIDEiP09240.

PTM databases

PhosphoSiteiP09240.

Expressioni

Gene expression databases

BgeeiP09240.
CleanExiMM_CCK.
GenevestigatoriP09240.

Interactioni

Subunit structurei

Binds to CCK-A receptors in the pancreas and CCK-B receptors in the brain By similarity.

Protein-protein interaction databases

MINTiMINT-1534401.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG40485.
GeneTreeiENSGT00390000003571.
HOGENOMiHOG000073533.
HOVERGENiHBG005806.
KOiK05226.
OMAiPSGRMSI.
OrthoDBiEOG7F7WBS.
PhylomeDBiP09240.
TreeFamiTF333419.

Family and domain databases

InterProiIPR015499. CCK_like.
IPR001651. Gastrin.
IPR013152. Gastrin/cholecystokinin_CS.
[Graphical view]
PANTHERiPTHR10786. PTHR10786. 1 hit.
PfamiPF00918. Gastrin. 1 hit.
[Graphical view]
SMARTiSM00029. GASTRIN. 1 hit.
[Graphical view]
PROSITEiPS00259. GASTRIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09240-1 [UniParc]FASTAAdd to Basket

« Hide

MKSGVCLCVV MAVLAAGALA QPVVPAEATD PVEQRAQEAP RRQLRAVLRT    50
DGEPRARLGA LLARYIQQVR KAPSGRMSVL KNLQSLDPSH RISDRDYMGW 100
MDFGRRSAED YEYPS 115
Length:115
Mass (Da):12,770
Last modified:April 8, 2008 - v3
Checksum:i7841B11D39BB52DA
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti37 – 371Q → E in CAB94216. 1 Publication
Sequence conflicti50 – 501T → P in CAB94216. 1 Publication
Sequence conflicti52 – 521G → R in CAB94216. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59521, X59522 Genomic DNA. Translation: CAB94216.1.
AK002677 mRNA. Translation: BAB22279.1.
M11739 mRNA. Translation: AAA37382.1.
CCDSiCCDS23631.1.
PIRiS22563.
RefSeqiNP_001271437.1. NM_001284508.1.
NP_112438.1. NM_031161.4.
XP_006511991.1. XM_006511928.1.
UniGeneiMm.2619.

Genome annotation databases

EnsembliENSMUST00000035120; ENSMUSP00000035120; ENSMUSG00000032532.
GeneIDi12424.
KEGGimmu:12424.
UCSCiuc009sdg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59521 , X59522 Genomic DNA. Translation: CAB94216.1 .
AK002677 mRNA. Translation: BAB22279.1 .
M11739 mRNA. Translation: AAA37382.1 .
CCDSi CCDS23631.1.
PIRi S22563.
RefSeqi NP_001271437.1. NM_001284508.1.
NP_112438.1. NM_031161.4.
XP_006511991.1. XM_006511928.1.
UniGenei Mm.2619.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-1534401.

PTM databases

PhosphoSitei P09240.

Proteomic databases

PaxDbi P09240.
PRIDEi P09240.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000035120 ; ENSMUSP00000035120 ; ENSMUSG00000032532 .
GeneIDi 12424.
KEGGi mmu:12424.
UCSCi uc009sdg.2. mouse.

Organism-specific databases

CTDi 885.
MGIi MGI:88297. Cck.

Phylogenomic databases

eggNOGi NOG40485.
GeneTreei ENSGT00390000003571.
HOGENOMi HOG000073533.
HOVERGENi HBG005806.
KOi K05226.
OMAi PSGRMSI.
OrthoDBi EOG7F7WBS.
PhylomeDBi P09240.
TreeFami TF333419.

Enzyme and pathway databases

Reactomei REACT_207651. G alpha (q) signalling events.

Miscellaneous databases

ChiTaRSi CCK. mouse.
NextBioi 281228.
PROi P09240.
SOURCEi Search...

Gene expression databases

Bgeei P09240.
CleanExi MM_CCK.
Genevestigatori P09240.

Family and domain databases

InterProi IPR015499. CCK_like.
IPR001651. Gastrin.
IPR013152. Gastrin/cholecystokinin_CS.
[Graphical view ]
PANTHERi PTHR10786. PTHR10786. 1 hit.
Pfami PF00918. Gastrin. 1 hit.
[Graphical view ]
SMARTi SM00029. GASTRIN. 1 hit.
[Graphical view ]
PROSITEi PS00259. GASTRIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of the mouse CCK gene: expression in different brain regions and during cortical development."
    Vitale M., Vashishtha A., Linzer E., Powell D.J., Friedman J.M.
    Nucleic Acids Res. 19:169-177(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/3J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney.
  3. "Differential expression of the mouse cholecystokinin gene during brain and gut development."
    Friedman J.M., Schneider B.S., Powell D.J.
    Proc. Natl. Acad. Sci. U.S.A. 82:5593-5597(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 55-115.

Entry informationi

Entry nameiCCKN_MOUSE
AccessioniPrimary (citable) accession number: P09240
Secondary accession number(s): Q53WS9, Q9DCL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: April 8, 2008
Last modified: September 3, 2014
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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