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Protein

Cholecystokinin

Gene

Cck

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.

GO - Molecular functioni

  • neuropeptide hormone activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Cholecystokinin
Short name:
CCK
Cleaved into the following 3 chains:
Cholecystokinin-33
Short name:
CCK33
Cholecystokinin-12
Short name:
CCK12
Cholecystokinin-8
Short name:
CCK8
Gene namesi
Name:Cck
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:88297. Cck.

Subcellular locationi

GO - Cellular componenti

  • axon Source: MGI
  • axon hillock Source: Ensembl
  • axon initial segment Source: Ensembl
  • dendrite Source: Ensembl
  • extracellular space Source: Ensembl
  • perikaryon Source: Ensembl
  • terminal bouton Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20By similarityAdd BLAST20
ChainiPRO_000001055221 – 115CholecystokininAdd BLAST95
PropeptideiPRO_000001055321 – 70Add BLAST50
PeptideiPRO_000001055471 – 103Cholecystokinin-33Add BLAST33
PeptideiPRO_000001055592 – 103Cholecystokinin-12Add BLAST12
PeptideiPRO_000001055696 – 103Cholecystokinin-88
PropeptideiPRO_0000010557107 – 1159

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei97SulfotyrosineBy similarity1
Modified residuei103Phenylalanine amide1
Modified residuei111SulfotyrosineBy similarity1
Modified residuei113SulfotyrosineBy similarity1

Post-translational modificationi

The precursor is cleaved by proteases to produce a number of active cholecystokinins.

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Sulfation

Proteomic databases

PaxDbiP09240.
PeptideAtlasiP09240.
PRIDEiP09240.

PTM databases

PhosphoSitePlusiP09240.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032532.
CleanExiMM_CCK.
GenevisibleiP09240. MM.

Interactioni

Subunit structurei

Binds to CCK-A receptors in the pancreas and CCK-B receptors in the brain.By similarity

GO - Molecular functioni

  • neuropeptide hormone activity Source: MGI

Protein-protein interaction databases

MINTiMINT-1534401.
STRINGi10090.ENSMUSP00000035120.

Structurei

3D structure databases

ProteinModelPortaliP09240.
SMRiP09240.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the gastrin/cholecystokinin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXQ9. Eukaryota.
ENOG411211F. LUCA.
GeneTreeiENSGT00390000003571.
HOGENOMiHOG000073533.
HOVERGENiHBG005806.
InParanoidiP09240.
KOiK05226.
OMAiDGEPRAH.
OrthoDBiEOG091G11B3.
PhylomeDBiP09240.
TreeFamiTF333419.

Family and domain databases

InterProiIPR015499. CCK-like.
IPR001651. Gastrin.
IPR013152. Gastrin/cholecystokinin_CS.
[Graphical view]
PANTHERiPTHR10786. PTHR10786. 1 hit.
PfamiPF00918. Gastrin. 1 hit.
[Graphical view]
PROSITEiPS00259. GASTRIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09240-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSGVCLCVV MAVLAAGALA QPVVPAEATD PVEQRAQEAP RRQLRAVLRT
60 70 80 90 100
DGEPRARLGA LLARYIQQVR KAPSGRMSVL KNLQSLDPSH RISDRDYMGW
110
MDFGRRSAED YEYPS
Length:115
Mass (Da):12,770
Last modified:April 8, 2008 - v3
Checksum:i7841B11D39BB52DA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37Q → E in CAB94216 (PubMed:2011497).Curated1
Sequence conflicti50T → P in CAB94216 (PubMed:2011497).Curated1
Sequence conflicti52G → R in CAB94216 (PubMed:2011497).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59521, X59522 Genomic DNA. Translation: CAB94216.1.
AK002677 mRNA. Translation: BAB22279.1.
M11739 mRNA. Translation: AAA37382.1.
CCDSiCCDS23631.1.
PIRiS22563.
RefSeqiNP_001271437.1. NM_001284508.2.
NP_112438.1. NM_031161.4.
XP_017168605.1. XM_017313116.1.
UniGeneiMm.2619.

Genome annotation databases

EnsembliENSMUST00000035120; ENSMUSP00000035120; ENSMUSG00000032532.
GeneIDi12424.
KEGGimmu:12424.
UCSCiuc009sdg.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59521, X59522 Genomic DNA. Translation: CAB94216.1.
AK002677 mRNA. Translation: BAB22279.1.
M11739 mRNA. Translation: AAA37382.1.
CCDSiCCDS23631.1.
PIRiS22563.
RefSeqiNP_001271437.1. NM_001284508.2.
NP_112438.1. NM_031161.4.
XP_017168605.1. XM_017313116.1.
UniGeneiMm.2619.

3D structure databases

ProteinModelPortaliP09240.
SMRiP09240.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1534401.
STRINGi10090.ENSMUSP00000035120.

PTM databases

PhosphoSitePlusiP09240.

Proteomic databases

PaxDbiP09240.
PeptideAtlasiP09240.
PRIDEiP09240.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035120; ENSMUSP00000035120; ENSMUSG00000032532.
GeneIDi12424.
KEGGimmu:12424.
UCSCiuc009sdg.3. mouse.

Organism-specific databases

CTDi885.
MGIiMGI:88297. Cck.

Phylogenomic databases

eggNOGiENOG410IXQ9. Eukaryota.
ENOG411211F. LUCA.
GeneTreeiENSGT00390000003571.
HOGENOMiHOG000073533.
HOVERGENiHBG005806.
InParanoidiP09240.
KOiK05226.
OMAiDGEPRAH.
OrthoDBiEOG091G11B3.
PhylomeDBiP09240.
TreeFamiTF333419.

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.

Miscellaneous databases

ChiTaRSiCck. mouse.
PROiP09240.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032532.
CleanExiMM_CCK.
GenevisibleiP09240. MM.

Family and domain databases

InterProiIPR015499. CCK-like.
IPR001651. Gastrin.
IPR013152. Gastrin/cholecystokinin_CS.
[Graphical view]
PANTHERiPTHR10786. PTHR10786. 1 hit.
PfamiPF00918. Gastrin. 1 hit.
[Graphical view]
PROSITEiPS00259. GASTRIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCKN_MOUSE
AccessioniPrimary (citable) accession number: P09240
Secondary accession number(s): Q53WS9, Q9DCL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: April 8, 2008
Last modified: November 2, 2016
This is version 132 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.