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P09240

- CCKN_MOUSE

UniProt

P09240 - CCKN_MOUSE

Protein

Cholecystokinin

Gene

Cck

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.

    GO - Molecular functioni

    1. neuropeptide hormone activity Source: MGI
    2. protein binding Source: MGI

    GO - Biological processi

    1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
    2. axonogenesis Source: MGI
    3. behavioral fear response Source: Ensembl
    4. eating behavior Source: MGI
    5. negative regulation of appetite Source: Ensembl
    6. neuron migration Source: MGI
    7. positive regulation of apoptotic process Source: Ensembl
    8. positive regulation of cell proliferation Source: Ensembl
    9. positive regulation of mitochondrial depolarization Source: Ensembl
    10. positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
    11. positive regulation of protein oligomerization Source: Ensembl
    12. protein kinase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
    13. regulation of sensory perception of pain Source: Ensembl
    14. release of cytochrome c from mitochondria Source: Ensembl

    Keywords - Molecular functioni

    Hormone

    Enzyme and pathway databases

    ReactomeiREACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cholecystokinin
    Short name:
    CCK
    Cleaved into the following 3 chains:
    Cholecystokinin-33
    Short name:
    CCK33
    Cholecystokinin-12
    Short name:
    CCK12
    Cholecystokinin-8
    Short name:
    CCK8
    Gene namesi
    Name:Cck
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:88297. Cck.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: MGI
    2. axon hillock Source: Ensembl
    3. axon initial segment Source: Ensembl
    4. dendrite Source: Ensembl
    5. extracellular space Source: Ensembl
    6. perikaryon Source: Ensembl
    7. terminal bouton Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020By similarityAdd
    BLAST
    Chaini21 – 11595CholecystokininPRO_0000010552Add
    BLAST
    Propeptidei21 – 7050PRO_0000010553Add
    BLAST
    Peptidei71 – 10333Cholecystokinin-33PRO_0000010554Add
    BLAST
    Peptidei92 – 10312Cholecystokinin-12PRO_0000010555Add
    BLAST
    Peptidei96 – 1038Cholecystokinin-8PRO_0000010556
    Propeptidei107 – 1159PRO_0000010557

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei97 – 971SulfotyrosineBy similarity
    Modified residuei103 – 1031Phenylalanine amide
    Modified residuei111 – 1111SulfotyrosineBy similarity
    Modified residuei113 – 1131SulfotyrosineBy similarity

    Post-translational modificationi

    The precursor is cleaved by proteases to produce a number of active cholecystokinins.

    Keywords - PTMi

    Amidation, Cleavage on pair of basic residues, Sulfation

    Proteomic databases

    PaxDbiP09240.
    PRIDEiP09240.

    PTM databases

    PhosphoSiteiP09240.

    Expressioni

    Gene expression databases

    BgeeiP09240.
    CleanExiMM_CCK.
    GenevestigatoriP09240.

    Interactioni

    Subunit structurei

    Binds to CCK-A receptors in the pancreas and CCK-B receptors in the brain.By similarity

    Protein-protein interaction databases

    MINTiMINT-1534401.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the gastrin/cholecystokinin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG40485.
    GeneTreeiENSGT00390000003571.
    HOGENOMiHOG000073533.
    HOVERGENiHBG005806.
    KOiK05226.
    OMAiPSGRMSI.
    OrthoDBiEOG7F7WBS.
    PhylomeDBiP09240.
    TreeFamiTF333419.

    Family and domain databases

    InterProiIPR015499. CCK_like.
    IPR001651. Gastrin.
    IPR013152. Gastrin/cholecystokinin_CS.
    [Graphical view]
    PANTHERiPTHR10786. PTHR10786. 1 hit.
    PfamiPF00918. Gastrin. 1 hit.
    [Graphical view]
    SMARTiSM00029. GASTRIN. 1 hit.
    [Graphical view]
    PROSITEiPS00259. GASTRIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P09240-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSGVCLCVV MAVLAAGALA QPVVPAEATD PVEQRAQEAP RRQLRAVLRT    50
    DGEPRARLGA LLARYIQQVR KAPSGRMSVL KNLQSLDPSH RISDRDYMGW 100
    MDFGRRSAED YEYPS 115
    Length:115
    Mass (Da):12,770
    Last modified:April 8, 2008 - v3
    Checksum:i7841B11D39BB52DA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti37 – 371Q → E in CAB94216. (PubMed:2011497)Curated
    Sequence conflicti50 – 501T → P in CAB94216. (PubMed:2011497)Curated
    Sequence conflicti52 – 521G → R in CAB94216. (PubMed:2011497)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59521, X59522 Genomic DNA. Translation: CAB94216.1.
    AK002677 mRNA. Translation: BAB22279.1.
    M11739 mRNA. Translation: AAA37382.1.
    CCDSiCCDS23631.1.
    PIRiS22563.
    RefSeqiNP_001271437.1. NM_001284508.1.
    NP_112438.1. NM_031161.4.
    XP_006511991.1. XM_006511928.1.
    UniGeneiMm.2619.

    Genome annotation databases

    EnsembliENSMUST00000035120; ENSMUSP00000035120; ENSMUSG00000032532.
    GeneIDi12424.
    KEGGimmu:12424.
    UCSCiuc009sdg.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59521 , X59522 Genomic DNA. Translation: CAB94216.1 .
    AK002677 mRNA. Translation: BAB22279.1 .
    M11739 mRNA. Translation: AAA37382.1 .
    CCDSi CCDS23631.1.
    PIRi S22563.
    RefSeqi NP_001271437.1. NM_001284508.1.
    NP_112438.1. NM_031161.4.
    XP_006511991.1. XM_006511928.1.
    UniGenei Mm.2619.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-1534401.

    PTM databases

    PhosphoSitei P09240.

    Proteomic databases

    PaxDbi P09240.
    PRIDEi P09240.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000035120 ; ENSMUSP00000035120 ; ENSMUSG00000032532 .
    GeneIDi 12424.
    KEGGi mmu:12424.
    UCSCi uc009sdg.2. mouse.

    Organism-specific databases

    CTDi 885.
    MGIi MGI:88297. Cck.

    Phylogenomic databases

    eggNOGi NOG40485.
    GeneTreei ENSGT00390000003571.
    HOGENOMi HOG000073533.
    HOVERGENi HBG005806.
    KOi K05226.
    OMAi PSGRMSI.
    OrthoDBi EOG7F7WBS.
    PhylomeDBi P09240.
    TreeFami TF333419.

    Enzyme and pathway databases

    Reactomei REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    ChiTaRSi CCK. mouse.
    NextBioi 281228.
    PROi P09240.
    SOURCEi Search...

    Gene expression databases

    Bgeei P09240.
    CleanExi MM_CCK.
    Genevestigatori P09240.

    Family and domain databases

    InterProi IPR015499. CCK_like.
    IPR001651. Gastrin.
    IPR013152. Gastrin/cholecystokinin_CS.
    [Graphical view ]
    PANTHERi PTHR10786. PTHR10786. 1 hit.
    Pfami PF00918. Gastrin. 1 hit.
    [Graphical view ]
    SMARTi SM00029. GASTRIN. 1 hit.
    [Graphical view ]
    PROSITEi PS00259. GASTRIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of the mouse CCK gene: expression in different brain regions and during cortical development."
      Vitale M., Vashishtha A., Linzer E., Powell D.J., Friedman J.M.
      Nucleic Acids Res. 19:169-177(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/3J.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Kidney.
    3. "Differential expression of the mouse cholecystokinin gene during brain and gut development."
      Friedman J.M., Schneider B.S., Powell D.J.
      Proc. Natl. Acad. Sci. U.S.A. 82:5593-5597(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 55-115.

    Entry informationi

    Entry nameiCCKN_MOUSE
    AccessioniPrimary (citable) accession number: P09240
    Secondary accession number(s): Q53WS9, Q9DCL5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 117 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3