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P09240 (CCKN_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cholecystokinin

Short name=CCK

Cleaved into the following 3 chains:

  1. Cholecystokinin-33
    Short name=CCK33
  2. Cholecystokinin-12
    Short name=CCK12
  3. Cholecystokinin-8
    Short name=CCK8
Gene names
Name:Cck
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length115 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.

Subunit structure

Binds to CCK-A receptors in the pancreas and CCK-B receptors in the brain By similarity.

Subcellular location

Secreted.

Post-translational modification

The precursor is cleaved by proteases to produce a number of active cholecystokinins.

Sequence similarities

Belongs to the gastrin/cholecystokinin family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionHormone
   PTMAmidation
Cleavage on pair of basic residues
Sulfation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process

Inferred from electronic annotation. Source: Ensembl

axonogenesis

Inferred from direct assay PubMed 15152034. Source: MGI

behavioral fear response

Inferred from electronic annotation. Source: Ensembl

eating behavior

Inferred from direct assay PubMed 15374756. Source: MGI

negative regulation of appetite

Inferred from electronic annotation. Source: Ensembl

neuron migration

Inferred from direct assay PubMed 15152034. Source: MGI

positive regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of mitochondrial depolarization

Inferred from electronic annotation. Source: Ensembl

positive regulation of peptidyl-tyrosine phosphorylation

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein oligomerization

Inferred from electronic annotation. Source: Ensembl

protein kinase C-activating G-protein coupled receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

regulation of sensory perception of pain

Inferred from electronic annotation. Source: Ensembl

release of cytochrome c from mitochondria

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentaxon

Inferred from direct assay PubMed 15152034. Source: MGI

axon hillock

Inferred from electronic annotation. Source: Ensembl

axon initial segment

Inferred from electronic annotation. Source: Ensembl

dendrite

Inferred from electronic annotation. Source: Ensembl

extracellular space

Inferred from electronic annotation. Source: Ensembl

perikaryon

Inferred from electronic annotation. Source: Ensembl

terminal bouton

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionneuropeptide hormone activity

Inferred from direct assay PubMed 15374756. Source: MGI

protein binding

Inferred from physical interaction PubMed 8876222. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 By similarity
Chain21 – 11595Cholecystokinin
PRO_0000010552
Propeptide21 – 7050
PRO_0000010553
Peptide71 – 10333Cholecystokinin-33
PRO_0000010554
Peptide92 – 10312Cholecystokinin-12
PRO_0000010555
Peptide96 – 1038Cholecystokinin-8
PRO_0000010556
Propeptide107 – 1159
PRO_0000010557

Amino acid modifications

Modified residue971Sulfotyrosine By similarity
Modified residue1031Phenylalanine amide
Modified residue1111Sulfotyrosine By similarity
Modified residue1131Sulfotyrosine By similarity

Experimental info

Sequence conflict371Q → E in CAB94216. Ref.1
Sequence conflict501T → P in CAB94216. Ref.1
Sequence conflict521G → R in CAB94216. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P09240 [UniParc].

Last modified April 8, 2008. Version 3.
Checksum: 7841B11D39BB52DA

FASTA11512,770
        10         20         30         40         50         60 
MKSGVCLCVV MAVLAAGALA QPVVPAEATD PVEQRAQEAP RRQLRAVLRT DGEPRARLGA 

        70         80         90        100        110 
LLARYIQQVR KAPSGRMSVL KNLQSLDPSH RISDRDYMGW MDFGRRSAED YEYPS 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of the mouse CCK gene: expression in different brain regions and during cortical development."
Vitale M., Vashishtha A., Linzer E., Powell D.J., Friedman J.M.
Nucleic Acids Res. 19:169-177(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/3J.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Kidney.
[3]"Differential expression of the mouse cholecystokinin gene during brain and gut development."
Friedman J.M., Schneider B.S., Powell D.J.
Proc. Natl. Acad. Sci. U.S.A. 82:5593-5597(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 55-115.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X59521, X59522 Genomic DNA. Translation: CAB94216.1.
AK002677 mRNA. Translation: BAB22279.1.
M11739 mRNA. Translation: AAA37382.1.
CCDSCCDS23631.1.
PIRS22563.
RefSeqNP_001271437.1. NM_001284508.1.
NP_112438.1. NM_031161.4.
XP_006511991.1. XM_006511928.1.
UniGeneMm.2619.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-1534401.

PTM databases

PhosphoSiteP09240.

Proteomic databases

PaxDbP09240.
PRIDEP09240.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000035120; ENSMUSP00000035120; ENSMUSG00000032532.
GeneID12424.
KEGGmmu:12424.
UCSCuc009sdg.2. mouse.

Organism-specific databases

CTD885.
MGIMGI:88297. Cck.

Phylogenomic databases

eggNOGNOG40485.
GeneTreeENSGT00390000003571.
HOGENOMHOG000073533.
HOVERGENHBG005806.
KOK05226.
OMAPSGRMSI.
OrthoDBEOG7F7WBS.
PhylomeDBP09240.
TreeFamTF333419.

Gene expression databases

BgeeP09240.
CleanExMM_CCK.
GenevestigatorP09240.

Family and domain databases

InterProIPR015499. CCK_like.
IPR001651. Gastrin.
IPR013152. Gastrin/cholecystokinin_CS.
[Graphical view]
PANTHERPTHR10786. PTHR10786. 1 hit.
PfamPF00918. Gastrin. 1 hit.
[Graphical view]
SMARTSM00029. GASTRIN. 1 hit.
[Graphical view]
PROSITEPS00259. GASTRIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCCK. mouse.
NextBio281228.
PROP09240.
SOURCESearch...

Entry information

Entry nameCCKN_MOUSE
AccessionPrimary (citable) accession number: P09240
Secondary accession number(s): Q53WS9, Q9DCL5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: April 8, 2008
Last modified: July 9, 2014
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot