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Protein

60 kDa chaperonin 2

Gene

groL2

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

Miscellaneous

Purified 65 kDa antigen can elicit a strong delayed-type hypersensitivity reaction in experimental animals infected with Mycobacterium tuberculosis.
This protein is one of the major immunoreactive proteins of the Mycobacteria. This antigen contains epitopes that are common to various species of Mycobacteria.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMLEP272631:G1GT5-360-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperonin 2UniRule annotation
Alternative name(s):
65 kDa antigen
GroEL protein 2UniRule annotation
Protein Cpn60 2UniRule annotation
Gene namesi
Name:groL2UniRule annotation
Synonyms:groEL-2UniRule annotation, groEL2UniRule annotation
Ordered Locus Names:ML0317
ORF Names:MLCB1450.05c
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML0317

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000634372 – 54160 kDa chaperonin 2Add BLAST540

Proteomic databases

PRIDEiP09239

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

Protein-protein interaction databases

STRINGi272631.ML0317

Structurei

3D structure databases

ProteinModelPortaliP09239
SMRiP09239
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ9 Bacteria
COG0459 LUCA
HOGENOMiHOG000076290
KOiK04077
OMAiTDTDKME
OrthoDBiPOG091H00E7

Family and domain databases

CDDicd03344 GroEL, 1 hit
Gene3Di1.10.560.10, 2 hits
3.30.260.10, 2 hits
3.50.7.10, 1 hit
HAMAPiMF_00600 CH60, 1 hit
InterProiView protein in InterPro
IPR018370 Chaperonin_Cpn60_CS
IPR001844 Chaprnin_Cpn60
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00298 CHAPERONIN60
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 1 hit
TIGRFAMsiTIGR02348 GroEL, 1 hit
PROSITEiView protein in PROSITE
PS00296 CHAPERONINS_CPN60, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09239-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKTIAYDEE ARRGLERGLN SLADAVKVTL GPKGRNVVLE KKWGAPTITN
60 70 80 90 100
DGVSIAKEIE LEDPYEKIGA ELVKEVAKKT DDVAGDGTTT ATVLAQALVK
110 120 130 140 150
EGLRNVAAGA NPLGLKRGIE KAVDKVTETL LKDAKEVETK EQIAATAAIS
160 170 180 190 200
AGDQSIGDLI AEAMDKVGNE GVITVEESNT FGLQLELTEG MRFDKGYISG
210 220 230 240 250
YFVTDAERQE AVLEEPYILL VSSKVSTVKD LLPLLEKVIQ AGKSLLIIAE
260 270 280 290 300
DVEGEALSTL VVNKIRGTFK SVAVKAPGFG DRRKAMLQDM AILTGAQVIS
310 320 330 340 350
EEVGLTLENT DLSLLGKARK VVMTKDETTI VEGAGDTDAI AGRVAQIRTE
360 370 380 390 400
IENSDSDYDR EKLQERLAKL AGGVAVIKAG AATEVELKER KHRIEDAVRN
410 420 430 440 450
AKAAVEEGIV AGGGVTLLQA APALDKLKLT GDEATGANIV KVALEAPLKQ
460 470 480 490 500
IAFNSGMEPG VVAEKVRNLS VGHGLNAATG EYEDLLKAGV ADPVKVTRSA
510 520 530 540
LQNAASIAGL FLTTEAVVAD KPEKTAAPAS DPTGGMGGMD F
Length:541
Mass (Da):56,892
Last modified:January 23, 2007 - v3
Checksum:i38E498AFA76708F0
GO

Sequence cautioni

The sequence AAA25354 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14341 Genomic DNA Translation: AAA25354.1 Different initiation.
AL035159 Genomic DNA Translation: CAA22689.1
AL583918 Genomic DNA Translation: CAC29825.1
PIRiA25902
T44725
RefSeqiNP_301345.1, NC_002677.1
WP_010907669.1, NC_002677.1

Genome annotation databases

EnsemblBacteriaiCAC29825; CAC29825; CAC29825
GeneIDi908906
KEGGimle:ML0317
PATRICifig|272631.5.peg.511

Similar proteinsi

Entry informationi

Entry nameiCH602_MYCLE
AccessioniPrimary (citable) accession number: P09239
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 131 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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