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Protein

U1 small nuclear ribonucleoprotein C

Gene

SNRPC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.UniRule annotation3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri4 – 36Matrin-typeUniRule annotationAdd BLAST33

GO - Molecular functioni

  • pre-mRNA 5'-splice site binding Source: GO_Central
  • protein homodimerization activity Source: UniProtKB
  • RNA binding Source: UniProtKB
  • single-stranded RNA binding Source: UniProtKB
  • U1 snRNP binding Source: Ensembl
  • zinc ion binding Source: UniProtKB

GO - Biological processi

  • mRNA 5'-splice site recognition Source: GO_Central
  • mRNA splicing, via spliceosome Source: UniProtKB
  • spliceosomal snRNP assembly Source: UniProtKB

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
U1 small nuclear ribonucleoprotein CUniRule annotation
Short name:
U1 snRNP CUniRule annotation
Short name:
U1-CUniRule annotation
Short name:
U1CUniRule annotation
Gene namesi
Name:SNRPCUniRule annotation
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000124562.9
HGNCiHGNC:11157 SNRPC
MIMi603522 gene
neXtProtiNX_P09234

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi6C → S: Abolishes the binding to U1 snRNP. 1 Publication1
Mutagenesisi9C → S: Abolishes the binding to U1 snRNP. 1 Publication1
Mutagenesisi24H → Q: Abolishes the binding to U1 snRNP. 1 Publication1
Mutagenesisi25C → S: No effect. 1 Publication1
Mutagenesisi30H → Q: Abolishes the binding to U1 snRNP. 1 Publication1

Organism-specific databases

DisGeNETi6631
OpenTargetsiENSG00000124562
PharmGKBiPA35998

Polymorphism and mutation databases

BioMutaiSNRPC
DMDMi134093

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000975251 – 159U1 small nuclear ribonucleoprotein CAdd BLAST159

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8PhosphotyrosineCombined sources1
Modified residuei17PhosphoserineCombined sources1
Modified residuei52N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP09234
PaxDbiP09234
PeptideAtlasiP09234
PRIDEiP09234

PTM databases

iPTMnetiP09234
PhosphoSitePlusiP09234
SwissPalmiP09234

Miscellaneous databases

PMAP-CutDBiP09234

Expressioni

Gene expression databases

BgeeiENSG00000124562
CleanExiHS_SNRPC
ExpressionAtlasiP09234 baseline and differential
GenevisibleiP09234 HS

Organism-specific databases

HPAiCAB034338
HPA055490

Interactioni

Subunit structurei

U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.UniRule annotation2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi112515, 90 interactors
CORUMiP09234
DIPiDIP-34235N
IntActiP09234, 81 interactors
MINTiP09234
STRINGi9606.ENSP00000244520

Structurei

Secondary structure

1159
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 6Combined sources3
Turni7 – 10Combined sources4
Beta strandi11 – 15Combined sources5
Helixi18 – 25Combined sources8
Helixi28 – 53Combined sources26
Beta strandi56 – 59Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VRDNMR-A1-61[»]
3CW1X-ray5.490/9/L/l1-77[»]
4PJOX-ray3.30L/M/l/m1-61[»]
ProteinModelPortaliP09234
SMRiP09234
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP09234

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi63 – 157Met/Pro-richAdd BLAST95

Sequence similaritiesi

Belongs to the U1 small nuclear ribonucleoprotein C family.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri4 – 36Matrin-typeUniRule annotationAdd BLAST33

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3454 Eukaryota
COG5136 LUCA
GeneTreeiENSGT00730000110997
HOGENOMiHOG000238970
HOVERGENiHBG017763
InParanoidiP09234
KOiK11095
TreeFamiTF313578

Family and domain databases

HAMAPiMF_03153 U1_C, 1 hit
InterProiView protein in InterPro
IPR000690 Matrin/U1-C_Znf_C2H2
IPR003604 Matrin/U1-like-C_Znf_C2H2
IPR013085 U1-CZ_Znf_C2H2
IPR017340 U1_snRNP-C
IPR036236 Znf_C2H2_sf
PANTHERiPTHR31148 PTHR31148, 1 hit
PfamiView protein in Pfam
PF06220 zf-U1, 1 hit
PIRSFiPIRSF037969 U1_snRNP-C, 1 hit
SMARTiView protein in SMART
SM00451 ZnF_U1, 1 hit
SUPFAMiSSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS50171 ZF_MATRIN, 1 hit

Sequencei

Sequence statusi: Complete.

P09234-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKFYCDYCD TYLTHDSPSV RKTHCSGRKH KENVKDYYQK WMEEQAQSLI
60 70 80 90 100
DKTTAAFQQG KIPPTPFSAP PPAGAMIPPP PSLPGPPRPG MMPAPHMGGP
110 120 130 140 150
PMMPMMGPPP PGMMPVGPAP GMRPPMGGHM PMMPGPPMMR PPARPMMVPT

RPGMTRPDR
Length:159
Mass (Da):17,394
Last modified:July 1, 1989 - v1
Checksum:iEC313A57DEC79D95
GO

Sequence cautioni

The sequence CAI20351 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25 – 27CSG → RSR in AAA36618 (PubMed:2961811).Curated3
Sequence conflicti94 – 98APHMG → TPIW in AAA36618 (PubMed:2961811).Curated5
Sequence conflicti101P → S in AAA36618 (PubMed:2961811).Curated1
Sequence conflicti129 – 131HMP → ICQ in AAA36618 (PubMed:2961811).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12517 mRNA Translation: CAA31037.1
AL139100 Genomic DNA Translation: CAI20351.1 Sequence problems.
M18465 mRNA Translation: AAA36618.1
CCDSiCCDS34436.1
PIRiS01387
RefSeqiNP_003084.1, NM_003093.2
UniGeneiHs.1063

Genome annotation databases

EnsembliENST00000244520; ENSP00000244520; ENSG00000124562
GeneIDi6631
KEGGihsa:6631

Similar proteinsi

Entry informationi

Entry nameiRU1C_HUMAN
AccessioniPrimary (citable) accession number: P09234
Secondary accession number(s): Q5TAL3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: April 25, 2018
This is version 168 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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