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Protein

Glutathione S-transferase A2

Gene

GSTA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei9Glutathione1 Publication1
Binding sitei45Glutathione1 Publication1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

BioCyciMetaCyc:HS01846-MONOMER.
ZFISH:HS01846-MONOMER.
BRENDAi2.5.1.18. 2681.
ReactomeiR-HSA-156590. Glutathione conjugation.
SABIO-RKP09210.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase A2 (EC:2.5.1.18)
Alternative name(s):
GST HA subunit 2
GST class-alpha member 2
GST-gamma
GSTA2-2
GTH2
Gene namesi
Name:GSTA2
Synonyms:GST2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4627. GSTA2.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi2939.
OpenTargetsiENSG00000244067.
PharmGKBiPA29017.

Chemistry databases

ChEMBLiCHEMBL2241.
DrugBankiDB00993. Azathioprine.
DB01008. Busulfan.
DB00608. Chloroquine.
DB00636. Clofibrate.
DB00903. Ethacrynic acid.
DB00143. Glutathione.
DB00163. Vitamin E.

Polymorphism and mutation databases

BioMutaiGSTA2.
DMDMi126302551.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity1 Publication
ChainiPRO_00001857842 – 222Glutathione S-transferase A2Add BLAST221

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei4N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP09210.
MaxQBiP09210.
PaxDbiP09210.
PeptideAtlasiP09210.
PRIDEiP09210.

2D gel databases

REPRODUCTION-2DPAGEIPI00745233.

PTM databases

iPTMnetiP09210.
PhosphoSitePlusiP09210.

Expressioni

Tissue specificityi

Liver.

Gene expression databases

BgeeiENSG00000244067.
CleanExiHS_GSTA2.
ExpressionAtlasiP09210. baseline and differential.

Organism-specific databases

HPAiHPA004342.
HPA048934.
HPA053817.

Interactioni

Subunit structurei

Homodimer or heterodimer of GSTA1 and GSTA2.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GSTA4O152175EBI-10196201,EBI-752440

Protein-protein interaction databases

BioGridi109194. 5 interactors.
IntActiP09210. 1 interactor.
STRINGi9606.ENSP00000420168.

Chemistry databases

BindingDBiP09210.

Structurei

Secondary structure

1222
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 9Combined sources4
Beta strandi11 – 13Combined sources3
Turni14 – 16Combined sources3
Helixi17 – 25Combined sources9
Beta strandi31 – 34Combined sources4
Helixi38 – 46Combined sources9
Beta strandi57 – 60Combined sources4
Beta strandi63 – 67Combined sources5
Helixi68 – 78Combined sources11
Helixi86 – 108Combined sources23
Helixi109 – 111Combined sources3
Turni114 – 116Combined sources3
Helixi117 – 130Combined sources14
Helixi132 – 143Combined sources12
Beta strandi146 – 149Combined sources4
Helixi155 – 170Combined sources16
Turni172 – 177Combined sources6
Helixi179 – 190Combined sources12
Helixi192 – 197Combined sources6
Helixi210 – 220Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AGSX-ray2.50A/B2-222[»]
2VCTX-ray2.10A/B/C/D/E/F/G/H1-222[»]
2WJUX-ray2.30A/B/C/D/E/F/G/H1-222[»]
4ACSX-ray2.10A/B/C/D1-221[»]
ProteinModelPortaliP09210.
SMRiP09210.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP09210.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 83GST N-terminalAdd BLAST81
Domaini85 – 207GST C-terminalAdd BLAST123

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni54 – 55Glutathione binding1 Publication2
Regioni67 – 68Glutathione binding1 Publication2

Sequence similaritiesi

Belongs to the GST superfamily. Alpha family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiKOG1695. Eukaryota.
ENOG4111VAU. LUCA.
GeneTreeiENSGT00670000097856.
HOGENOMiHOG000115734.
HOVERGENiHBG053749.
InParanoidiP09210.
KOiK00799.
OMAiIEMIMYL.
OrthoDBiEOG091G0O3D.
PhylomeDBiP09210.
TreeFamiTF105321.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR003080. GST_alpha.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF14497. GST_C_3. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01266. GSTRNSFRASEA.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09210-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEKPKLHYS NIRGRMESIR WLLAAAGVEF EEKFIKSAED LDKLRNDGYL
60 70 80 90 100
MFQQVPMVEI DGMKLVQTRA ILNYIASKYN LYGKDIKEKA LIDMYIEGIA
110 120 130 140 150
DLGEMILLLP FSQPEEQDAK LALIQEKTKN RYFPAFEKVL KSHGQDYLVG
160 170 180 190 200
NKLSRADIHL VELLYYVEEL DSSLISSFPL LKALKTRISN LPTVKKFLQP
210 220
GSPRKPPMDE KSLEESRKIF RF
Length:222
Mass (Da):25,664
Last modified:February 20, 2007 - v4
Checksum:i2823565A693A30AC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10 – 12SNI → FNA AA sequence (PubMed:8431482).Curated3
Sequence conflicti12I → T in CAA46642 (PubMed:1497629).Curated1
Sequence conflicti19I → T AA sequence (PubMed:8431482).Curated1
Sequence conflicti89K → R AA sequence (PubMed:8431482).Curated1
Sequence conflicti128T → I AA sequence (PubMed:8431482).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_014495110P → S.Corresponds to variant rs2234951dbSNPEnsembl.1
Natural variantiVAR_012205112S → T.Combined sources3 PublicationsCorresponds to variant rs2180314dbSNPEnsembl.1
Natural variantiVAR_014496149V → A.Corresponds to variant rs2266631dbSNPEnsembl.1
Natural variantiVAR_012206210E → A.3 PublicationsCorresponds to variant rs6577dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16594 mRNA. Translation: AAA52616.1.
S45640
, S45627, S45629, S45636, S45637, S45639 Genomic DNA. Translation: AAB23672.1.
X65727
, X65728, X65729, X65730, X65731, X65732 Genomic DNA. Translation: CAA46642.1.
AL109918 Genomic DNA. Translation: CAB92770.1.
BC002895 mRNA. Translation: AAH02895.1.
CCDSiCCDS4944.1.
PIRiS24330.
S29658.
RefSeqiNP_000837.3. NM_000846.4.
XP_011512834.1. XM_011514532.2.
UniGeneiHs.94107.

Genome annotation databases

EnsembliENST00000493422; ENSP00000420168; ENSG00000244067.
GeneIDi2939.
KEGGihsa:2939.
UCSCiuc003pay.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16594 mRNA. Translation: AAA52616.1.
S45640
, S45627, S45629, S45636, S45637, S45639 Genomic DNA. Translation: AAB23672.1.
X65727
, X65728, X65729, X65730, X65731, X65732 Genomic DNA. Translation: CAA46642.1.
AL109918 Genomic DNA. Translation: CAB92770.1.
BC002895 mRNA. Translation: AAH02895.1.
CCDSiCCDS4944.1.
PIRiS24330.
S29658.
RefSeqiNP_000837.3. NM_000846.4.
XP_011512834.1. XM_011514532.2.
UniGeneiHs.94107.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AGSX-ray2.50A/B2-222[»]
2VCTX-ray2.10A/B/C/D/E/F/G/H1-222[»]
2WJUX-ray2.30A/B/C/D/E/F/G/H1-222[»]
4ACSX-ray2.10A/B/C/D1-221[»]
ProteinModelPortaliP09210.
SMRiP09210.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109194. 5 interactors.
IntActiP09210. 1 interactor.
STRINGi9606.ENSP00000420168.

Chemistry databases

BindingDBiP09210.
ChEMBLiCHEMBL2241.
DrugBankiDB00993. Azathioprine.
DB01008. Busulfan.
DB00608. Chloroquine.
DB00636. Clofibrate.
DB00903. Ethacrynic acid.
DB00143. Glutathione.
DB00163. Vitamin E.

PTM databases

iPTMnetiP09210.
PhosphoSitePlusiP09210.

Polymorphism and mutation databases

BioMutaiGSTA2.
DMDMi126302551.

2D gel databases

REPRODUCTION-2DPAGEIPI00745233.

Proteomic databases

EPDiP09210.
MaxQBiP09210.
PaxDbiP09210.
PeptideAtlasiP09210.
PRIDEiP09210.

Protocols and materials databases

DNASUi2939.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000493422; ENSP00000420168; ENSG00000244067.
GeneIDi2939.
KEGGihsa:2939.
UCSCiuc003pay.4. human.

Organism-specific databases

CTDi2939.
DisGeNETi2939.
GeneCardsiGSTA2.
H-InvDBHIX0200871.
HGNCiHGNC:4627. GSTA2.
HPAiHPA004342.
HPA048934.
HPA053817.
MIMi138360. gene.
neXtProtiNX_P09210.
OpenTargetsiENSG00000244067.
PharmGKBiPA29017.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1695. Eukaryota.
ENOG4111VAU. LUCA.
GeneTreeiENSGT00670000097856.
HOGENOMiHOG000115734.
HOVERGENiHBG053749.
InParanoidiP09210.
KOiK00799.
OMAiIEMIMYL.
OrthoDBiEOG091G0O3D.
PhylomeDBiP09210.
TreeFamiTF105321.

Enzyme and pathway databases

BioCyciMetaCyc:HS01846-MONOMER.
ZFISH:HS01846-MONOMER.
BRENDAi2.5.1.18. 2681.
ReactomeiR-HSA-156590. Glutathione conjugation.
SABIO-RKP09210.

Miscellaneous databases

EvolutionaryTraceiP09210.
GeneWikiiGSTA2.
GenomeRNAii2939.
PROiP09210.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000244067.
CleanExiHS_GSTA2.
ExpressionAtlasiP09210. baseline and differential.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR003080. GST_alpha.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF14497. GST_C_3. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01266. GSTRNSFRASEA.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGSTA2_HUMAN
AccessioniPrimary (citable) accession number: P09210
Secondary accession number(s): Q12759, Q16491, Q9NTY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: February 20, 2007
Last modified: November 30, 2016
This is version 184 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.