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P09188

- PGK_PENCH

UniProt

P09188 - PGK_PENCH

Protein

Phosphoglycerate kinase

Gene

PGKA

Organism
Penicillium chrysogenum (Penicillium notatum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei40 – 401SubstrateBy similarity
    Binding sitei123 – 1231SubstrateBy similarity
    Binding sitei170 – 1701SubstrateBy similarity
    Binding sitei219 – 2191ATPBy similarity
    Binding sitei311 – 3111ATP; via carbonyl oxygenBy similarity
    Binding sitei342 – 3421ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi371 – 3744ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoglycerate kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00185.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoglycerate kinase (EC:2.7.2.3)
    Gene namesi
    Name:PGKA
    Synonyms:PGK
    OrganismiPenicillium chrysogenum (Penicillium notatum)
    Taxonomic identifieri5076 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaePenicilliumPenicillium chrysogenum complex

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 415415Phosphoglycerate kinasePRO_0000145884Add
    BLAST

    Proteomic databases

    PRIDEiP09188.

    Interactioni

    Subunit structurei

    Monomer.

    Structurei

    3D structure databases

    ProteinModelPortaliP09188.
    SMRiP09188. Positions 2-414.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni24 – 263Substrate bindingBy similarity
    Regioni64 – 674Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the phosphoglycerate kinase family.Curated

    Family and domain databases

    Gene3Di3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPiMF_00145. Phosphoglyc_kinase.
    InterProiIPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view]
    PANTHERiPTHR11406. PTHR11406. 1 hit.
    PfamiPF00162. PGK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000724. Pgk. 1 hit.
    PRINTSiPR00477. PHGLYCKINASE.
    SUPFAMiSSF53748. SSF53748. 1 hit.
    PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P09188-1 [UniParc]FASTAAdd to Basket

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    MSLSNKLPVT DVDLKGKRVL IRVDFNVPLD ENENVTNPQR IVGALPTIKY    50
    AIDNGRKAVV LMSHLGRPDG KVNPKYSLKP VVPVLEELLG KSVTFTEDCI 100
    GPQTEETVNK ASDGQVILLE NLRFHAEEEG SSKDAEGKKV KADKADVDRS 150
    ASLTALGDVY VNDAFGTAQR AHSSMVGVDL PQKAAGFLVK KELEYFAKAL 200
    ESPARPFLAI LGGAKVSDKI PVIDNLLPKV NSLIIIGGMA LTFKKTLENV 250
    KIGNSLFDEA GSKILGEIVE KAKKHNVEIV LPVDYVTADK FSADATVGSA 300
    TTQRIPDGYM GSDVGPESVK LYQKTIAEAK TILWNGPPGV FELKPSPRPT 350
    EATLDAAVKA AESGSIVIIG GGDTATVAAK YKAEDKISHV STGGGASLEL 400
    LEGKELPGVA ALSSK 415
    Length:415
    Mass (Da):44,022
    Last modified:July 1, 1989 - v1
    Checksum:i508AC3F76CE35E81
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X13379 Genomic DNA. Translation: CAA31756.1.
    S71096 Genomic DNA. Translation: AAB30809.1.
    PIRiS02040. TVPLGC.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X13379 Genomic DNA. Translation: CAA31756.1 .
    S71096 Genomic DNA. Translation: AAB30809.1 .
    PIRi S02040. TVPLGC.

    3D structure databases

    ProteinModelPortali P09188.
    SMRi P09188. Positions 2-414.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P09188.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00185 .

    Family and domain databases

    Gene3Di 3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPi MF_00145. Phosphoglyc_kinase.
    InterProi IPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view ]
    PANTHERi PTHR11406. PTHR11406. 1 hit.
    Pfami PF00162. PGK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000724. Pgk. 1 hit.
    PRINTSi PR00477. PHGLYCKINASE.
    SUPFAMi SSF53748. SSF53748. 1 hit.
    PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence of the Penicillium chrysogenum phosphoglycerate kinase gene."
      van Solingen P., Muurling H., Koekman B., van den Berg J.
      Nucleic Acids Res. 16:11823-11823(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: GB 533.
    2. "Expression of the 3-phosphoglycerate kinase gene (pgkA) of Penicillium chrysogenum."
      Hoskins I.C., Roberts C.F.
      Mol. Gen. Genet. 243:270-276(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22.
      Strain: ATCC 9480 / CBS 307.48 / NRRL 1951 / GB8 / QM 941.

    Entry informationi

    Entry nameiPGK_PENCH
    AccessioniPrimary (citable) accession number: P09188
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3