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P09188 (PGK_PENCH) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase

EC=2.7.2.3
Gene names
Name:PGKA
Synonyms:PGK
OrganismPenicillium chrysogenum (Penicillium notatum)
Taxonomic identifier5076 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaePenicilliumPenicillium chrysogenum complex

Protein attributes

Sequence length415 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer.

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 415415Phosphoglycerate kinase HAMAP-Rule MF_00145
PRO_0000145884

Regions

Nucleotide binding371 – 3744ATP By similarity
Region24 – 263Substrate binding By similarity
Region64 – 674Substrate binding By similarity

Sites

Binding site401Substrate By similarity
Binding site1231Substrate By similarity
Binding site1701Substrate By similarity
Binding site2191ATP By similarity
Binding site3111ATP; via carbonyl oxygen By similarity
Binding site3421ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P09188 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: 508AC3F76CE35E81

FASTA41544,022
        10         20         30         40         50         60 
MSLSNKLPVT DVDLKGKRVL IRVDFNVPLD ENENVTNPQR IVGALPTIKY AIDNGRKAVV 

        70         80         90        100        110        120 
LMSHLGRPDG KVNPKYSLKP VVPVLEELLG KSVTFTEDCI GPQTEETVNK ASDGQVILLE 

       130        140        150        160        170        180 
NLRFHAEEEG SSKDAEGKKV KADKADVDRS ASLTALGDVY VNDAFGTAQR AHSSMVGVDL 

       190        200        210        220        230        240 
PQKAAGFLVK KELEYFAKAL ESPARPFLAI LGGAKVSDKI PVIDNLLPKV NSLIIIGGMA 

       250        260        270        280        290        300 
LTFKKTLENV KIGNSLFDEA GSKILGEIVE KAKKHNVEIV LPVDYVTADK FSADATVGSA 

       310        320        330        340        350        360 
TTQRIPDGYM GSDVGPESVK LYQKTIAEAK TILWNGPPGV FELKPSPRPT EATLDAAVKA 

       370        380        390        400        410 
AESGSIVIIG GGDTATVAAK YKAEDKISHV STGGGASLEL LEGKELPGVA ALSSK 

« Hide

References

[1]"Sequence of the Penicillium chrysogenum phosphoglycerate kinase gene."
van Solingen P., Muurling H., Koekman B., van den Berg J.
Nucleic Acids Res. 16:11823-11823(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: GB 533.
[2]"Expression of the 3-phosphoglycerate kinase gene (pgkA) of Penicillium chrysogenum."
Hoskins I.C., Roberts C.F.
Mol. Gen. Genet. 243:270-276(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22.
Strain: ATCC 9480 / CBS 307.48 / NRRL 1951 / GB8 / QM 941.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X13379 Genomic DNA. Translation: CAA31756.1.
S71096 Genomic DNA. Translation: AAB30809.1.
PIRTVPLGC. S02040.

3D structure databases

ProteinModelPortalP09188.
SMRP09188. Positions 2-414.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP09188.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGK_PENCH
AccessionPrimary (citable) accession number: P09188
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: February 19, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways