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Protein

60S ribosomal protein L4

Gene

RpL4

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • structural constituent of ribosome Source: FlyBase

GO - Biological processi

  • centrosome duplication Source: FlyBase
  • cytoplasmic translation Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-DME-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DME-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-DME-72689. Formation of a pool of free 40S subunits.
R-DME-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-DME-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-DME-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L4
Alternative name(s):
L1
Gene namesi
Name:RpL4
Synonyms:RpL1
ORF Names:CG5502
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0003279. RpL4.

Subcellular locationi

GO - Cellular componenti

  • cytosolic large ribosomal subunit Source: GO_Central
  • cytosolic ribosome Source: FlyBase
  • ribosome Source: FlyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001293591 – 40160S ribosomal protein L4Add BLAST401

Proteomic databases

PaxDbiP09180.
PRIDEiP09180.

Expressioni

Gene expression databases

BgeeiFBgn0003279.
GenevisibleiP09180. DM.

Interactioni

Protein-protein interaction databases

BioGridi68230. 23 interactors.
IntActiP09180. 2 interactors.
MINTiMINT-844904.
STRINGi7227.FBpp0084617.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00CC1-401[»]
ProteinModelPortaliP09180.
SMRiP09180.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L4P family.Curated

Phylogenomic databases

eggNOGiKOG1475. Eukaryota.
COG0088. LUCA.
GeneTreeiENSGT00390000018145.
InParanoidiP09180.
KOiK02930.
OMAiDSDMATD.
OrthoDBiEOG091G0A2I.
PhylomeDBiP09180.

Family and domain databases

Gene3Di3.40.1370.10. 1 hit.
InterProiIPR025755. Ribos_L4_C_dom.
IPR002136. Ribosomal_L4/L1e.
IPR013000. Ribosomal_L4/L1e_euk/arc_CS.
IPR023574. Ribosomal_L4_dom.
[Graphical view]
PfamiPF14374. Ribos_L4_asso_C. 1 hit.
PF00573. Ribosomal_L4. 1 hit.
[Graphical view]
SUPFAMiSSF52166. SSF52166. 1 hit.
PROSITEiPS00939. RIBOSOMAL_L1E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P09180-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLGNARPLV SVYTEKNEPA KDKNICLPAV FKAPIRPDVV NEVHQLLRRN
60 70 80 90 100
NRQAYAVSEL AGHQTSAESW GTGRAVARIP RVRGGGTHRS GQGAFGNMCR
110 120 130 140 150
GGRMFAPTKT FRRWHRKVNV NQRRYALVSA IAASGVPALV QSKGHVIDGV
160 170 180 190 200
SEFPLVVSDE VQKVQKTKQA VIFLRRLKIW ADIQKVYKSQ RFRAGRGTMR
210 220 230 240 250
DRRRIARRGP LVVYDKDEGL RKAFRNIPGI ETINVDKLNL LKLAPGGHVG
260 270 280 290 300
RFVIWTESAF ARLNDLFGTW KKPSTLKKGY NLPQPKMANT DLSRLLKSEE
310 320 330 340 350
IRKVLRDPRK RVFRSVRRLN PLTNVRQLIK LNPYAEVLKR RAALAAEKRT
360 370 380 390 400
VAKVLAKAKK QNVELAKSHF ANVATKAAAN RAKLLAARKK KVAAKKPAAK

K
Length:401
Mass (Da):45,026
Last modified:December 7, 2004 - v2
Checksum:iC8B7EF9F732EF497
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti117K → R in CAA29998 (PubMed:3133637).Curated1
Sequence conflicti240L → V in CAA31759 (PubMed:2492096).Curated1
Sequence conflicti378 – 401AANRA…PAAKK → RPIAPSSGRPQEEGRRQEAS GQEVNLLSPE in CAA31759 (PubMed:2492096).CuratedAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13382 mRNA. Translation: CAA31759.1.
AE014297 Genomic DNA. Translation: AAG22173.1.
AY069485 mRNA. Translation: AAL39630.1.
X06881 Genomic DNA. Translation: CAA29998.1.
PIRiS02209. R5FFL1.
RefSeqiNP_524538.2. NM_079814.3.
UniGeneiDm.2104.

Genome annotation databases

EnsemblMetazoaiFBtr0085248; FBpp0084617; FBgn0003279.
GeneIDi43349.
KEGGidme:Dmel_CG5502.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13382 mRNA. Translation: CAA31759.1.
AE014297 Genomic DNA. Translation: AAG22173.1.
AY069485 mRNA. Translation: AAL39630.1.
X06881 Genomic DNA. Translation: CAA29998.1.
PIRiS02209. R5FFL1.
RefSeqiNP_524538.2. NM_079814.3.
UniGeneiDm.2104.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00CC1-401[»]
ProteinModelPortaliP09180.
SMRiP09180.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi68230. 23 interactors.
IntActiP09180. 2 interactors.
MINTiMINT-844904.
STRINGi7227.FBpp0084617.

Proteomic databases

PaxDbiP09180.
PRIDEiP09180.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0085248; FBpp0084617; FBgn0003279.
GeneIDi43349.
KEGGidme:Dmel_CG5502.

Organism-specific databases

CTDi6124.
FlyBaseiFBgn0003279. RpL4.

Phylogenomic databases

eggNOGiKOG1475. Eukaryota.
COG0088. LUCA.
GeneTreeiENSGT00390000018145.
InParanoidiP09180.
KOiK02930.
OMAiDSDMATD.
OrthoDBiEOG091G0A2I.
PhylomeDBiP09180.

Enzyme and pathway databases

ReactomeiR-DME-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DME-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-DME-72689. Formation of a pool of free 40S subunits.
R-DME-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-DME-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-DME-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSiRpL4. fly.
GenomeRNAii43349.
PROiP09180.

Gene expression databases

BgeeiFBgn0003279.
GenevisibleiP09180. DM.

Family and domain databases

Gene3Di3.40.1370.10. 1 hit.
InterProiIPR025755. Ribos_L4_C_dom.
IPR002136. Ribosomal_L4/L1e.
IPR013000. Ribosomal_L4/L1e_euk/arc_CS.
IPR023574. Ribosomal_L4_dom.
[Graphical view]
PfamiPF14374. Ribos_L4_asso_C. 1 hit.
PF00573. Ribosomal_L4. 1 hit.
[Graphical view]
SUPFAMiSSF52166. SSF52166. 1 hit.
PROSITEiPS00939. RIBOSOMAL_L1E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL4_DROME
AccessioniPrimary (citable) accession number: P09180
Secondary accession number(s): Q9I7H6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: December 7, 2004
Last modified: November 2, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.