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Protein

Mucorpepsin

Gene
N/A
Organism
Rhizomucor pusillus
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This enzyme, capable of clotting milk is frequently used for cheese production.

Catalytic activityi

Hydrolysis of proteins, favoring hydrophobic residues at P1 and P1'. Clots milk. Does not accept Lys at P1, and hence does not activate trypsinogen.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1041
Active sitei3031

GO - Molecular functioni

Keywordsi

Molecular functionAspartyl protease, Hydrolase, Protease

Protein family/group databases

MEROPSiA01.013

Names & Taxonomyi

Protein namesi
Recommended name:
Mucorpepsin (EC:3.4.23.23)
Alternative name(s):
Mucor rennin
OrganismiRhizomucor pusillus
Taxonomic identifieri4840 [NCBI]
Taxonomic lineageiEukaryotaFungiFungi incertae sedisMucoromycotaMucoromycotinaMucoralesLichtheimiaceaeRhizomucor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Add BLAST22
PropeptideiPRO_000002589523 – 66Activation peptide1 PublicationAdd BLAST44
ChainiPRO_000002589667 – 427MucorpepsinAdd BLAST361

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi117 ↔ 123
Glycosylationi254N-linked (GlcNAc...) asparagine1
Disulfide bondi338 ↔ 382

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Structurei

Secondary structure

1427
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi73 – 80Combined sources8
Turni81 – 84Combined sources4
Beta strandi85 – 92Combined sources8
Turni93 – 96Combined sources4
Beta strandi97 – 104Combined sources8
Beta strandi111 – 114Combined sources4
Helixi119 – 121Combined sources3
Helixi131 – 133Combined sources3
Beta strandi138 – 147Combined sources10
Beta strandi152 – 164Combined sources13
Beta strandi167 – 182Combined sources16
Helixi183 – 185Combined sources3
Beta strandi197 – 200Combined sources4
Helixi204 – 206Combined sources3
Helixi208 – 213Combined sources6
Helixi220 – 226Combined sources7
Beta strandi229 – 238Combined sources10
Beta strandi242 – 252Combined sources11
Helixi255 – 257Combined sources3
Beta strandi258 – 260Combined sources3
Beta strandi263 – 266Combined sources4
Beta strandi268 – 270Combined sources3
Beta strandi273 – 286Combined sources14
Beta strandi289 – 303Combined sources15
Beta strandi308 – 312Combined sources5
Helixi313 – 323Combined sources11
Beta strandi328 – 330Combined sources3
Beta strandi333 – 337Combined sources5
Helixi338 – 341Combined sources4
Beta strandi347 – 353Combined sources7
Beta strandi361 – 367Combined sources7
Helixi368 – 371Combined sources4
Beta strandi372 – 374Combined sources3
Beta strandi376 – 379Combined sources4
Beta strandi381 – 392Combined sources12
Beta strandi395 – 397Combined sources3
Helixi398 – 401Combined sources4
Beta strandi404 – 409Combined sources6
Turni410 – 413Combined sources4
Beta strandi414 – 420Combined sources7
Turni422 – 424Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MPPX-ray2.00A67-426[»]
ProteinModelPortaliP09177
SMRiP09177
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP09177

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini86 – 418Peptidase A1PROSITE-ProRule annotationAdd BLAST333

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

KOiK01386

Family and domain databases

CDDicd05471 pepsin_like, 1 hit
Gene3Di2.40.70.10, 2 hits
InterProiView protein in InterPro
IPR001461 Aspartic_peptidase_A1
IPR001969 Aspartic_peptidase_AS
IPR034164 Pepsin-like_dom
IPR033121 PEPTIDASE_A1
IPR021109 Peptidase_aspartic_dom_sf
PANTHERiPTHR13683 PTHR13683, 1 hit
PfamiView protein in Pfam
PF00026 Asp, 1 hit
PRINTSiPR00792 PEPSIN
SUPFAMiSSF50630 SSF50630, 1 hit
PROSITEiView protein in PROSITE
PS00141 ASP_PROTEASE, 2 hits
PS51767 PEPTIDASE_A1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P09177-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFSKISSAI LLTAASFALT SARPVSKQSD ADDKLLALPL TSVNRKYSQT
60 70 80 90 100
KHGQQAAEKL GGIKAFAEGD GSVDTPGLYD FDLEEYAIPV SIGTPGQDFY
110 120 130 140 150
LLFDTGSSDT WVPHKGCDNS EGCVGKRFFD PSSSSTFKET DYNLNITYGT
160 170 180 190 200
GGANGIYFRD SITVGGATVK QQTLAYVDNV SGPTAEQSPD SELFLDGMFG
210 220 230 240 250
AAYPDNTAME AEYGDTYNTV HVNLYKQGLI SSPVFSVYMN TNDGGGQVVF
260 270 280 290 300
GGANNTLLGG DIQYTDVLKS RGGYFFWDAP VTGVKIDGAD AVSFDGAQAF
310 320 330 340 350
TIDTGTNFFI APSSFAEKVV KAALPDATES QQGYTVPCSK YQDSKTTFSL
360 370 380 390 400
VLQKSGSSSD TIDVSVPISK MLLPVDKSGE TCMFIVLPDG GNQFIVGNLF
410 420
LRFFVNVYDF GKNRIGFAPL ASGYENN
Length:427
Mass (Da):45,646
Last modified:January 1, 1990 - v2
Checksum:iDB560157A5D99BCF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti427N → D AA sequence (PubMed:3042459).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06219 Genomic DNA Translation: CAA29568.1 Sequence problems.
PIRiA25767

Genome annotation databases

KEGGiag:CAA29568

Similar proteinsi

Entry informationi

Entry nameiCARP_RHIPU
AccessioniPrimary (citable) accession number: P09177
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 1, 1990
Last modified: May 23, 2018
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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