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P09174 (CNRG_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

Short name=GMP-PDE gamma
EC=3.1.4.35
Gene names
Name:Pde6g
Synonyms:Pdeg
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length87 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

Catalytic activity

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.

Subunit structure

Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain.

Involvement in disease

Deficiency in GMP-PDE activity cause accumulation of cGMP in visual cells. The elevated cGMP levels are associated with degeneration of the photoreceptors and blindness.

Sequence similarities

Belongs to the rod/cone cGMP-PDE gamma subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 8787Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
PRO_0000166118

Regions

Compositional bias24 – 4522Arg/Lys-rich (basic)

Amino acid modifications

Modified residue11N-acetylmethionine By similarity

Sequences

Sequence LengthMass (Da)Tools
P09174 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: 415CE37E2CF14B99

FASTA879,637
        10         20         30         40         50         60 
MNLEPPKGEI RSATRVIGGP VTPRKGPPKF KQRQTRQFKS KPPKKGVQGF GDDIPGMEGL 

        70         80 
GTDITVICPW EAFNHLELHE LAQYGII 

« Hide

References

« Hide 'large scale' references
[1]"Gamma-subunit of mouse retinal cyclic-GMP phosphodiesterase: cDNA and corresponding amino acid sequence."
Tuteja N., Farber D.B.
FEBS Lett. 232:182-186(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Retina.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y00746 mRNA. Translation: CAA68714.1.
BC082288 mRNA. Translation: AAH82288.1.
CCDSCCDS36389.1.
PIRESMSGM. S00612.
RefSeqNP_036197.1. NM_012065.2.
XP_006532517.1. XM_006532454.1.
XP_006532518.1. XM_006532455.1.
XP_006532519.1. XM_006532456.1.
UniGeneMm.39200.

3D structure databases

ProteinModelPortalP09174.
SMRP09174. Positions 1-87.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid202085. 1 interaction.

PTM databases

PhosphoSiteP09174.

Proteomic databases

PRIDEP09174.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000026452; ENSMUSP00000026452; ENSMUSG00000025386.
GeneID18588.
KEGGmmu:18588.
UCSCuc007mss.1. mouse.

Organism-specific databases

CTD5148.
MGIMGI:97526. Pde6g.

Phylogenomic databases

eggNOGNOG44345.
HOGENOMHOG000261673.
HOVERGENHBG000447.
InParanoidP09174.
KOK13759.
OMATRVMGGP.
OrthoDBEOG7SN8FW.
PhylomeDBP09174.
TreeFamTF333297.

Enzyme and pathway databases

ReactomeREACT_188257. Signal Transduction.

Gene expression databases

BgeeP09174.
CleanExMM_PDE6G.
GenevestigatorP09174.

Family and domain databases

Gene3D4.10.1120.10. 1 hit.
InterProIPR006952. PDE6_gamma.
[Graphical view]
PANTHERPTHR12122. PTHR12122. 1 hit.
PfamPF04868. PDE6_gamma. 1 hit.
[Graphical view]
PIRSFPIRSF000969. 35-cGMP_Pdiase_g. 1 hit.
ProtoNetSearch...

Other

NextBio294468.
PROP09174.
SOURCESearch...

Entry information

Entry nameCNRG_MOUSE
AccessionPrimary (citable) accession number: P09174
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: July 9, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot