Reviewed,
UniProtKB/Swiss-Prot P09174 (CNRG_MOUSE)
Last modified
November 3, 2009.
Version 75.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma Short name=GMP-PDE gamma EC=3.1.4.17 | ||||
| Gene names |
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| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 87 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. |
| Catalytic activity | Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate. |
| Subunit structure | Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain. |
| Involvement in disease | Deficiency in GMP-PDE activity cause accumulation of cGMP in visual cells. The elevated cGMP levels are associated with degeneration of the photoreceptors and blindness. |
| Sequence similarities | Belongs to the rod/cone cGMP-PDE gamma subunit family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Sensory transduction Vision |
| Ligand | cGMP |
| Molecular function | Hydrolase |
| Gene Ontology (GO) | |
| Biological process | activation of MAPK activity Inferred from direct assay. Source: MGI positive regulation of G-protein coupled receptor protein signaling pathwayInferred from direct assay. Source: MGI positive regulation of epidermal growth factor receptor signaling pathwayInferred from direct assay. Source: MGI response to stimulusInferred from electronic annotation. Source: UniProtKB-KW visual perceptionInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | 3',5'-cyclic-nucleotide phosphodiesterase activity Inferred from electronic annotation. Source: EC cGMP bindingInferred from electronic annotation. Source: InterPro protein bindingInferred from physical interaction. Source: MGI |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
References
| « Hide 'large scale' references | |
| [1] | "Gamma-subunit of mouse retinal cyclic-GMP phosphodiesterase: cDNA and corresponding amino acid sequence." Tuteja N., Farber D.B. FEBS Lett. 232:182-186(1988) [PubMed: 2835267] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Retina. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| Y00746 mRNA. Translation: CAA68714.1. BC082288 mRNA. Translation: AAH82288.1. | |
| IPI | IPI00133734. |
| PIR | ESMSGM. S00612. |
| RefSeq | NP_036197.1. |
| UniGene | Mm.39200 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P09174. |
PTM databases | |
| PhosphoSite | P09174. |
Proteomic databases | |
| PRIDE | P09174. |
Genome annotation databases | |
| Ensembl | ENSMUST00000026452; ENSMUSP00000026452; ENSMUSG00000025386; Mus musculus. [Genome view] |
| GeneID | 18588. |
| KEGG | mmu:18588. |
| UCSC | uc007mss.1. mouse. |
Organism-specific databases | |
| CTD | 18588. |
| MGI | MGI:97526. Pde6g. |
Phylogenomic databases | |
| HOGENOM | P09174. |
| HOVERGEN | P09174. |
| OMA | EFRSATR. |
Enzyme and pathway databases | |
| BRENDA | 3.1.4.17. 244. |
Gene expression databases | |
| ArrayExpress | P09174. |
| Bgee | P09174. |
| CleanEx | MM_PDE6G. |
| Genevestigator | P09174. |
| GermOnline | ENSMUSG00000025386. Mus musculus. |
Family and domain databases | |
| InterPro | IPR006952. PDE6_gamma. [Graphical view] |
| PANTHER | PTHR12122. PDE6_gamma. 1 hit. |
| Pfam | PF04868. PDE6_gamma. 1 hit. [Graphical view] |
| PIRSF | PIRSF000969. 35-cGMP_Pdiase_g. 1 hit. |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 294468. |
| SOURCE | Search... |
Entry information
| Entry name | CNRG_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P09174 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


