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Protein

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

Gene

Pde6g

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

Catalytic activityi

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Sensory transduction, Vision

Keywords - Ligandi

cGMP

Enzyme and pathway databases

ReactomeiR-MMU-2485179. Activation of the phototransduction cascade.
R-MMU-2514859. Inactivation, recovery and regulation of the phototransduction cascade.
R-MMU-4086398. Ca2+ pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC:3.1.4.35)
Short name:
GMP-PDE gamma
Gene namesi
Name:Pde6g
Synonyms:Pdeg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:97526. Pde6g.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Involvement in diseasei

Deficiency in GMP-PDE activity cause accumulation of cGMP in visual cells. The elevated cGMP levels are associated with degeneration of the photoreceptors and blindness.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001661181 – 87Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammaAdd BLAST87

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP09174.
PRIDEiP09174.

PTM databases

iPTMnetiP09174.
PhosphoSitePlusiP09174.

Expressioni

Gene expression databases

BgeeiENSMUSG00000025386.
CleanExiMM_PDE6G.
ExpressionAtlasiP09174. baseline and differential.
GenevisibleiP09174. MM.

Interactioni

Subunit structurei

Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202085. 1 interactor.
STRINGi10090.ENSMUSP00000026452.

Structurei

3D structure databases

ProteinModelPortaliP09174.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi24 – 45Arg/Lys-rich (basic)Add BLAST22

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IZA8. Eukaryota.
ENOG410YN07. LUCA.
GeneTreeiENSGT00390000013260.
HOGENOMiHOG000261673.
HOVERGENiHBG000447.
InParanoidiP09174.
KOiK13759.
OMAiDCSRRES.
OrthoDBiEOG091G14J5.
PhylomeDBiP09174.
TreeFamiTF333297.

Family and domain databases

Gene3Di4.10.1120.10. 1 hit.
InterProiIPR006952. PDE6_gamma.
[Graphical view]
PANTHERiPTHR12122. PTHR12122. 1 hit.
PfamiPF04868. PDE6_gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF000969. 35-cGMP_Pdiase_g. 1 hit.

Sequencei

Sequence statusi: Complete.

P09174-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLEPPKGEI RSATRVIGGP VTPRKGPPKF KQRQTRQFKS KPPKKGVQGF
60 70 80
GDDIPGMEGL GTDITVICPW EAFNHLELHE LAQYGII
Length:87
Mass (Da):9,637
Last modified:July 1, 1989 - v1
Checksum:i415CE37E2CF14B99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00746 mRNA. Translation: CAA68714.1.
BC082288 mRNA. Translation: AAH82288.1.
CCDSiCCDS36389.1.
PIRiS00612. ESMSGM.
RefSeqiNP_036197.1. NM_012065.3.
XP_006532518.1. XM_006532455.3.
UniGeneiMm.39200.

Genome annotation databases

EnsembliENSMUST00000026452; ENSMUSP00000026452; ENSMUSG00000025386.
GeneIDi18588.
KEGGimmu:18588.
UCSCiuc007mss.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00746 mRNA. Translation: CAA68714.1.
BC082288 mRNA. Translation: AAH82288.1.
CCDSiCCDS36389.1.
PIRiS00612. ESMSGM.
RefSeqiNP_036197.1. NM_012065.3.
XP_006532518.1. XM_006532455.3.
UniGeneiMm.39200.

3D structure databases

ProteinModelPortaliP09174.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202085. 1 interactor.
STRINGi10090.ENSMUSP00000026452.

PTM databases

iPTMnetiP09174.
PhosphoSitePlusiP09174.

Proteomic databases

PaxDbiP09174.
PRIDEiP09174.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026452; ENSMUSP00000026452; ENSMUSG00000025386.
GeneIDi18588.
KEGGimmu:18588.
UCSCiuc007mss.2. mouse.

Organism-specific databases

CTDi5148.
MGIiMGI:97526. Pde6g.

Phylogenomic databases

eggNOGiENOG410IZA8. Eukaryota.
ENOG410YN07. LUCA.
GeneTreeiENSGT00390000013260.
HOGENOMiHOG000261673.
HOVERGENiHBG000447.
InParanoidiP09174.
KOiK13759.
OMAiDCSRRES.
OrthoDBiEOG091G14J5.
PhylomeDBiP09174.
TreeFamiTF333297.

Enzyme and pathway databases

ReactomeiR-MMU-2485179. Activation of the phototransduction cascade.
R-MMU-2514859. Inactivation, recovery and regulation of the phototransduction cascade.
R-MMU-4086398. Ca2+ pathway.

Miscellaneous databases

PROiP09174.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025386.
CleanExiMM_PDE6G.
ExpressionAtlasiP09174. baseline and differential.
GenevisibleiP09174. MM.

Family and domain databases

Gene3Di4.10.1120.10. 1 hit.
InterProiIPR006952. PDE6_gamma.
[Graphical view]
PANTHERiPTHR12122. PTHR12122. 1 hit.
PfamiPF04868. PDE6_gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF000969. 35-cGMP_Pdiase_g. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCNRG_MOUSE
AccessioniPrimary (citable) accession number: P09174
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 30, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.