Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P09174

- CNRG_MOUSE

UniProt

P09174 - CNRG_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

Gene

Pde6g

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

Catalytic activityi

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.

GO - Molecular functioni

  1. 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB-EC
  2. cGMP binding Source: InterPro
  3. spectrin binding Source: MGI

GO - Biological processi

  1. activation of MAPK activity Source: MGI
  2. positive regulation of epidermal growth factor receptor signaling pathway Source: MGI
  3. positive regulation of G-protein coupled receptor protein signaling pathway Source: MGI
  4. response to stimulus Source: UniProtKB-KW
  5. visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Sensory transduction, Vision

Keywords - Ligandi

cGMP

Enzyme and pathway databases

ReactomeiREACT_188252. Activation of the phototransduction cascade.
REACT_188266. Inactivation, recovery and regulation of the phototransduction cascade.
REACT_221970. Ca2+ pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC:3.1.4.35)
Short name:
GMP-PDE gamma
Gene namesi
Name:Pde6g
Synonyms:Pdeg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:97526. Pde6g.

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: Reactome
Complete GO annotation...

Pathology & Biotechi

Involvement in diseasei

Deficiency in GMP-PDE activity cause accumulation of cGMP in visual cells. The elevated cGMP levels are associated with degeneration of the photoreceptors and blindness.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8787Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammaPRO_0000166118Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP09174.

PTM databases

PhosphoSiteiP09174.

Expressioni

Gene expression databases

BgeeiP09174.
CleanExiMM_PDE6G.
ExpressionAtlasiP09174. differential.
GenevestigatoriP09174.

Interactioni

Subunit structurei

Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain.

Protein-protein interaction databases

BioGridi202085. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP09174.
SMRiP09174. Positions 1-87.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi24 – 4522Arg/Lys-rich (basic)Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG44345.
HOGENOMiHOG000261673.
HOVERGENiHBG000447.
InParanoidiP09174.
KOiK13759.
OMAiTRVMGGP.
OrthoDBiEOG7SN8FW.
PhylomeDBiP09174.
TreeFamiTF333297.

Family and domain databases

Gene3Di4.10.1120.10. 1 hit.
InterProiIPR006952. PDE6_gamma.
[Graphical view]
PANTHERiPTHR12122. PTHR12122. 1 hit.
PfamiPF04868. PDE6_gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF000969. 35-cGMP_Pdiase_g. 1 hit.

Sequencei

Sequence statusi: Complete.

P09174-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNLEPPKGEI RSATRVIGGP VTPRKGPPKF KQRQTRQFKS KPPKKGVQGF
60 70 80
GDDIPGMEGL GTDITVICPW EAFNHLELHE LAQYGII
Length:87
Mass (Da):9,637
Last modified:July 1, 1989 - v1
Checksum:i415CE37E2CF14B99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00746 mRNA. Translation: CAA68714.1.
BC082288 mRNA. Translation: AAH82288.1.
CCDSiCCDS36389.1.
PIRiS00612. ESMSGM.
RefSeqiNP_036197.1. NM_012065.3.
XP_006532517.1. XM_006532454.1.
XP_006532518.1. XM_006532455.1.
XP_006532519.1. XM_006532456.1.
UniGeneiMm.39200.

Genome annotation databases

EnsembliENSMUST00000026452; ENSMUSP00000026452; ENSMUSG00000025386.
GeneIDi18588.
KEGGimmu:18588.
UCSCiuc007mss.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00746 mRNA. Translation: CAA68714.1 .
BC082288 mRNA. Translation: AAH82288.1 .
CCDSi CCDS36389.1.
PIRi S00612. ESMSGM.
RefSeqi NP_036197.1. NM_012065.3.
XP_006532517.1. XM_006532454.1.
XP_006532518.1. XM_006532455.1.
XP_006532519.1. XM_006532456.1.
UniGenei Mm.39200.

3D structure databases

ProteinModelPortali P09174.
SMRi P09174. Positions 1-87.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 202085. 1 interaction.

PTM databases

PhosphoSitei P09174.

Proteomic databases

PRIDEi P09174.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000026452 ; ENSMUSP00000026452 ; ENSMUSG00000025386 .
GeneIDi 18588.
KEGGi mmu:18588.
UCSCi uc007mss.1. mouse.

Organism-specific databases

CTDi 5148.
MGIi MGI:97526. Pde6g.

Phylogenomic databases

eggNOGi NOG44345.
HOGENOMi HOG000261673.
HOVERGENi HBG000447.
InParanoidi P09174.
KOi K13759.
OMAi TRVMGGP.
OrthoDBi EOG7SN8FW.
PhylomeDBi P09174.
TreeFami TF333297.

Enzyme and pathway databases

Reactomei REACT_188252. Activation of the phototransduction cascade.
REACT_188266. Inactivation, recovery and regulation of the phototransduction cascade.
REACT_221970. Ca2+ pathway.

Miscellaneous databases

NextBioi 294468.
PROi P09174.
SOURCEi Search...

Gene expression databases

Bgeei P09174.
CleanExi MM_PDE6G.
ExpressionAtlasi P09174. differential.
Genevestigatori P09174.

Family and domain databases

Gene3Di 4.10.1120.10. 1 hit.
InterProi IPR006952. PDE6_gamma.
[Graphical view ]
PANTHERi PTHR12122. PTHR12122. 1 hit.
Pfami PF04868. PDE6_gamma. 1 hit.
[Graphical view ]
PIRSFi PIRSF000969. 35-cGMP_Pdiase_g. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Gamma-subunit of mouse retinal cyclic-GMP phosphodiesterase: cDNA and corresponding amino acid sequence."
    Tuteja N., Farber D.B.
    FEBS Lett. 232:182-186(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Retina.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiCNRG_MOUSE
AccessioniPrimary (citable) accession number: P09174
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 26, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3