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P09174

- CNRG_MOUSE

UniProt

P09174 - CNRG_MOUSE

Protein

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

Gene

Pde6g

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

    Catalytic activityi

    Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.

    GO - Molecular functioni

    1. 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB-EC
    2. cGMP binding Source: InterPro
    3. protein binding Source: MGI
    4. spectrin binding Source: MGI

    GO - Biological processi

    1. activation of MAPK activity Source: MGI
    2. positive regulation of epidermal growth factor receptor signaling pathway Source: MGI
    3. positive regulation of G-protein coupled receptor protein signaling pathway Source: MGI
    4. response to stimulus Source: UniProtKB-KW
    5. visual perception Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Sensory transduction, Vision

    Keywords - Ligandi

    cGMP

    Enzyme and pathway databases

    ReactomeiREACT_188252. Activation of the phototransduction cascade.
    REACT_188266. Inactivation, recovery and regulation of the phototransduction cascade.
    REACT_221970. Ca2+ pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC:3.1.4.35)
    Short name:
    GMP-PDE gamma
    Gene namesi
    Name:Pde6g
    Synonyms:Pdeg
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:97526. Pde6g.

    Subcellular locationi

    GO - Cellular componenti

    1. plasma membrane Source: Reactome

    Pathology & Biotechi

    Involvement in diseasei

    Deficiency in GMP-PDE activity cause accumulation of cGMP in visual cells. The elevated cGMP levels are associated with degeneration of the photoreceptors and blindness.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 8787Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammaPRO_0000166118Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiP09174.

    PTM databases

    PhosphoSiteiP09174.

    Expressioni

    Gene expression databases

    BgeeiP09174.
    CleanExiMM_PDE6G.
    GenevestigatoriP09174.

    Interactioni

    Subunit structurei

    Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain.

    Protein-protein interaction databases

    BioGridi202085. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP09174.
    SMRiP09174. Positions 1-87.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi24 – 4522Arg/Lys-rich (basic)Add
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG44345.
    HOGENOMiHOG000261673.
    HOVERGENiHBG000447.
    InParanoidiP09174.
    KOiK13759.
    OMAiTRVMGGP.
    OrthoDBiEOG7SN8FW.
    PhylomeDBiP09174.
    TreeFamiTF333297.

    Family and domain databases

    Gene3Di4.10.1120.10. 1 hit.
    InterProiIPR006952. PDE6_gamma.
    [Graphical view]
    PANTHERiPTHR12122. PTHR12122. 1 hit.
    PfamiPF04868. PDE6_gamma. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000969. 35-cGMP_Pdiase_g. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P09174-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNLEPPKGEI RSATRVIGGP VTPRKGPPKF KQRQTRQFKS KPPKKGVQGF   50
    GDDIPGMEGL GTDITVICPW EAFNHLELHE LAQYGII 87
    Length:87
    Mass (Da):9,637
    Last modified:July 1, 1989 - v1
    Checksum:i415CE37E2CF14B99
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y00746 mRNA. Translation: CAA68714.1.
    BC082288 mRNA. Translation: AAH82288.1.
    CCDSiCCDS36389.1.
    PIRiS00612. ESMSGM.
    RefSeqiNP_036197.1. NM_012065.2.
    XP_006532517.1. XM_006532454.1.
    XP_006532518.1. XM_006532455.1.
    XP_006532519.1. XM_006532456.1.
    UniGeneiMm.39200.

    Genome annotation databases

    EnsembliENSMUST00000026452; ENSMUSP00000026452; ENSMUSG00000025386.
    GeneIDi18588.
    KEGGimmu:18588.
    UCSCiuc007mss.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y00746 mRNA. Translation: CAA68714.1 .
    BC082288 mRNA. Translation: AAH82288.1 .
    CCDSi CCDS36389.1.
    PIRi S00612. ESMSGM.
    RefSeqi NP_036197.1. NM_012065.2.
    XP_006532517.1. XM_006532454.1.
    XP_006532518.1. XM_006532455.1.
    XP_006532519.1. XM_006532456.1.
    UniGenei Mm.39200.

    3D structure databases

    ProteinModelPortali P09174.
    SMRi P09174. Positions 1-87.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 202085. 1 interaction.

    PTM databases

    PhosphoSitei P09174.

    Proteomic databases

    PRIDEi P09174.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000026452 ; ENSMUSP00000026452 ; ENSMUSG00000025386 .
    GeneIDi 18588.
    KEGGi mmu:18588.
    UCSCi uc007mss.1. mouse.

    Organism-specific databases

    CTDi 5148.
    MGIi MGI:97526. Pde6g.

    Phylogenomic databases

    eggNOGi NOG44345.
    HOGENOMi HOG000261673.
    HOVERGENi HBG000447.
    InParanoidi P09174.
    KOi K13759.
    OMAi TRVMGGP.
    OrthoDBi EOG7SN8FW.
    PhylomeDBi P09174.
    TreeFami TF333297.

    Enzyme and pathway databases

    Reactomei REACT_188252. Activation of the phototransduction cascade.
    REACT_188266. Inactivation, recovery and regulation of the phototransduction cascade.
    REACT_221970. Ca2+ pathway.

    Miscellaneous databases

    NextBioi 294468.
    PROi P09174.
    SOURCEi Search...

    Gene expression databases

    Bgeei P09174.
    CleanExi MM_PDE6G.
    Genevestigatori P09174.

    Family and domain databases

    Gene3Di 4.10.1120.10. 1 hit.
    InterProi IPR006952. PDE6_gamma.
    [Graphical view ]
    PANTHERi PTHR12122. PTHR12122. 1 hit.
    Pfami PF04868. PDE6_gamma. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000969. 35-cGMP_Pdiase_g. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Gamma-subunit of mouse retinal cyclic-GMP phosphodiesterase: cDNA and corresponding amino acid sequence."
      Tuteja N., Farber D.B.
      FEBS Lett. 232:182-186(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Retina.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.

    Entry informationi

    Entry nameiCNRG_MOUSE
    AccessioniPrimary (citable) accession number: P09174
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3