Reviewed, UniProtKB/Swiss-Prot P09174 (CNRG_MOUSE)

Names and origin

Protein names

Recommended name:
    Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
      Short name=GMP-PDE gamma
    EC=3.1.4.17

Gene names

Name:	Pde6g
Synonyms:	Pdeg

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	87 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.
Catalytic activity	Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.
Subunit structure	Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain.
Involvement in disease	Deficiency in GMP-PDE activity cause accumulation of cGMP in visual cells. The elevated cGMP levels are associated with degeneration of the photoreceptors and blindness.
Sequence similarities	Belongs to the rod/cone cGMP-PDE gamma subunit family.

Ontologies

Keywords
Biological process	Sensory transduction Vision
Ligand	cGMP
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	activation of MAPK activity Inferred from direct assay. Source: MGI positive regulation of G-protein coupled receptor protein signaling pathway Inferred from direct assay. Source: MGI positive regulation of epidermal growth factor receptor signaling pathway Inferred from direct assay. Source: MGI response to stimulus Inferred from electronic annotation. Source: UniProtKB-KW visual perception Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3',5'-cyclic-nucleotide phosphodiesterase activity Inferred from electronic annotation. Source: EC cGMP binding Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 87	87	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma		PRO_0000166118
Regions
	Compositional bias	24 – 45	22	Arg/Lys-rich (basic)

Sequences

	Sequence		Length	Mass (Da)
	P09174-1 [UniParc]. Last modified July 1, 1989. Version 1. Checksum: 415CE37E2CF14B99	FASTA	87	9,637
	10 20 30 40 50 60 MNLEPPKGEI RSATRVIGGP VTPRKGPPKF KQRQTRQFKS KPPKKGVQGF GDDIPGMEGL 70 80 GTDITVICPW EAFNHLELHE LAQYGII

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Gamma-subunit of mouse retinal cyclic-GMP phosphodiesterase: cDNA and corresponding amino acid sequence." Tuteja N., Farber D.B. FEBS Lett. 232:182-186(1988) [PubMed: 2835267] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Retina.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Y00746 mRNA. Translation: CAA68714.1. BC082288 mRNA. Translation: AAH82288.1.
IPI	IPI00133734.
PIR	ESMSGM. S00612.
RefSeq	NP_036197.1.
UniGene	Mm.39200
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P09174.
PTM databases
PhosphoSite	P09174.
Proteomic databases
PRIDE	P09174.
Genome annotation databases
Ensembl	ENSMUST00000026452; ENSMUSP00000026452; ENSMUSG00000025386; Mus musculus. [Genome view]
GeneID	18588.
KEGG	mmu:18588.
UCSC	uc007mss.1. mouse.
Organism-specific databases
CTD	18588.
MGI	MGI:97526. Pde6g.
Phylogenomic databases
HOGENOM	P09174.
HOVERGEN	P09174.
OMA	EFRSATR.
Enzyme and pathway databases
BRENDA	3.1.4.17. 244.
Gene expression databases
ArrayExpress	P09174.
Bgee	P09174.
CleanEx	MM_PDE6G.
Genevestigator	P09174.
GermOnline	ENSMUSG00000025386. Mus musculus.
Family and domain databases
InterPro	IPR006952. PDE6_gamma. [Graphical view]
PANTHER	PTHR12122. PDE6_gamma. 1 hit.
Pfam	PF04868. PDE6_gamma. 1 hit. [Graphical view]
PIRSF	PIRSF000969. 35-cGMP_Pdiase_g. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	294468.
SOURCE	Search...

Entry information

Entry name

CNRG_MOUSE

Accession

Primary (citable) accession number: P09174

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	November 3, 2009
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)