Reviewed, UniProtKB/Swiss-Prot P09140 (LUXA1_PHOLE)

Names and origin

Protein names

Recommended name:
    Alkanal monooxygenase alpha chain
    EC=1.14.14.3
Alternative name(s):
    Bacterial luciferase alpha chain

Gene names

Name:

luxA

Organism

Photobacterium leiognathi

Taxonomic identifier

658 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Photobacterium

Protein attributes

Sequence length	354 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Light-emitting reaction in luminous bacteria.
Catalytic activity	RCHO + reduced FMN + O(2) = RCOOH + FMN + H(2)O + light.
Subunit structure	Heterodimer of an alpha and a beta chain.
Sequence similarities	Belongs to the bacterial luciferase oxidoreductase family.

Ontologies

Keywords
Biological process	Luminescence
Ligand	FMN Flavoprotein
Molecular function	Monooxygenase Oxidoreductase Photoprotein
Gene Ontology (GO)
Biological process	bioluminescence Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alkanal monooxygenase (FMN-linked) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 354	354	Alkanal monooxygenase alpha chain		PRO_0000220164

Sequences

	Sequence		Length	Mass (Da)
	P09140-1 [UniParc]. Last modified July 1, 1989. Version 1. Checksum: 569F6EEB903C7B90	FASTA	354	40,371
	10 20 30 40 50 60 MKFGNICFSY QPPGESHKEV MDRFVRLGVA SEELNFDTFW TLEHHFTEFG LTGNLYVACA 70 80 90 100 110 120 NILGRTKKLN VGTMGIVLPT AHPARQMEDL LLLDQMSKGR FNFGVVRGLY HKDFRVFGVT 130 140 150 160 170 180 MEDSRSITED FHKMIMDGSK SGVLHTDGKN IEFPDVNVYP EAYLDKIPTC MTAESAATTT 190 200 210 220 230 240 WLAERGLPMV LSWIITTSEK KAQMELYNEI AAEHGHDIHN IDHSMTFICS VNEDPEKAES 250 260 270 280 290 300 VCRDFLSNWY ESYTNATNIF KDSNQTRGYD YHKGQWRDFV LQGHTDTRRR LDYSNNLNPV 310 320 330 340 350 GTPEKCIEII QRDIDATGIN NITLGFEANG SEQEIIASME RFMTQVAPYL KDPK

References

[1]	"Nucleotide sequence of part of Photobacterium leiognathi lux region." Illiarinov B.A., Protopopova M.V., Karginov V.A., Mertvetsov N.P., Gitelson J.I. Nucleic Acids Res. 16:9855-9855(1988) [PubMed: 3186447] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 554.
[2]	"Nucleotide sequence of genes for alpha- and beta-subunits of luciferase from Photobacterium leiognathi." Illarionov B.A., Protopopova M.V., Karginov V.A., Mertvetsov N.P., Gitelson J.I. Bioorg. Khim. 14:412-415(1988) [PubMed: 3382442] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 554.
[3]	"Isolation of bioluminescent functions from Photobacterium leiognathi: analysis of luxA, luxB, luxG and neighboring genes." Illarionov B.A., Blinov V.M., Donchenko A.P., Protopopova M.V., Karginov V.A., Mertvetsov N.P., Gitelson J.I. Gene 86:89-94(1990) [PubMed: 2311938] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 554.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X08036 Genomic DNA. Translation: CAA30831.1.
PIR	JQ0413.
3D structure databases
HSSP	HSSP built from PDB template 1BRL based on UniProtKB P07740.
ModBase	Search...
Family and domain databases
InterPro	IPR011251. Luciferase-like_bac. IPR002103. Luciferase_bac. IPR016048. Luciferase_mOase. [Graphical view]
Gene3D	G3DSA:3.20.20.30. Luciferase_like. 1 hit.
Pfam	PF00296. Bac_luciferase. 1 hit. [Graphical view]
PRINTS	PR00089. LUCIFERASE.
PROSITE	PS00494. BACTERIAL_LUCIFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LUXA1_PHOLE

Accession

Primary (citable) accession number: P09140

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	November 25, 2008
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)