P09131 (P3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
P3 protein

Alternative name(s):
Solute carrier family 10 member 3

Gene names

Name:	SLC10A3
Synonyms:	DXS253E, P3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	477 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	The ubiquitous expression and the conservation of the sequence in distant animal species suggest that the gene codes for a protein with housekeeping functions.
Subcellular location	Membrane; Multi-pass membrane protein Probable.
Sequence similarities	Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. [View classification]

Ontologies

Keywords
Biological process	Symport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	response to retinoic acid Inferred from electronic annotation. Source: Compara
Cellular_component	integral to membrane Non-traceable author statement. Source: UniProtKB
Molecular_function	bile acid:sodium symporter activity Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P09131-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P09131-2)

The sequence of this isoform differs from the canonical sequence as follows:
     120-148: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 477	477	P3 protein		PRO_0000052343
Regions
	Transmembrane	225 – 245	21	Helical; Potential
	Transmembrane	253 – 273	21	Helical; Potential
	Transmembrane	281 – 301	21	Helical; Potential
	Transmembrane	320 – 340	21	Helical; Potential
	Transmembrane	361 – 381	21	Helical; Potential
	Transmembrane	383 – 403	21	Helical; Potential
	Transmembrane	417 – 437	21	Helical; Potential
	Transmembrane	450 – 470	21	Helical; Potential
Natural variations
	Alternative sequence	120 – 148	29	Missing in isoform 2.		VSP_043669
	Natural variant	354	1	V → I. Corresponds to variant rs35381503 [ dbSNP | Ensembl ].		VAR_050229

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 1, 1989. Version 1. Checksum: 49CB363EB3B66A1D	FASTA	477	50,333
	10 20 30 40 50 60 MVLMQDKGSS QQWPGLGGEG GGTGPLSMLR AALLLISLPW GAQGTASTSL STAGGHTVPP 70 80 90 100 110 120 TGGRYLSIGD GSVMEFEFPE DSEGIIVISS QYPGQANRTA PGPMLRVTSL DTEVLTIKNV 130 140 150 160 170 180 SAITWGGGGG FVVSIHSGLA GLAPLHIQLV DAHEAPPTLI EERRDFCIKV SPAEDTPATL 190 200 210 220 230 240 SADLAHFSEN PILYLLLPLI FVNKCSFGCK VELEVLKGLM QSPQPMLLGL LGQFLVMPLY 250 260 270 280 290 300 AFLMAKVFML PKALALGLII TCSSPGGGGS YLFSLLLGGD VTLAISMTFL STVAATGFLP 310 320 330 340 350 360 LSSAIYSRLL SIHETLHVPI SKILGTLLFI AIPIAVGVLI KSKLPKFSQL LLQVVKPFSF 370 380 390 400 410 420 VLLLGGLFLA YRMGVFILAG IRLPIVLVGI TVPLVGLLVG YCLATCLKLP VAQRRTVSIE 430 440 450 460 470 VGVQNSLLAL AMLQLSLRRL QADYASQAPF IVALSGTSEM LALVIGHFIY SSLFPVP
	Isoform 2 [UniParc]. Checksum: 47A1263CF8EFFF91	FASTA	448	47,549
	10 20 30 40 50 60 MVLMQDKGSS QQWPGLGGEG GGTGPLSMLR AALLLISLPW GAQGTASTSL STAGGHTVPP 70 80 90 100 110 120 TGGRYLSIGD GSVMEFEFPE DSEGIIVISS QYPGQANRTA PGPMLRVTSL DTEVLTIKNL 130 140 150 160 170 180 VDAHEAPPTL IEERRDFCIK VSPAEDTPAT LSADLAHFSE NPILYLLLPL IFVNKCSFGC 190 200 210 220 230 240 KVELEVLKGL MQSPQPMLLG LLGQFLVMPL YAFLMAKVFM LPKALALGLI ITCSSPGGGG 250 260 270 280 290 300 SYLFSLLLGG DVTLAISMTF LSTVAATGFL PLSSAIYSRL LSIHETLHVP ISKILGTLLF 310 320 330 340 350 360 IAIPIAVGVL IKSKLPKFSQ LLLQVVKPFS FVLLLGGLFL AYRMGVFILA GIRLPIVLVG 370 380 390 400 410 420 ITVPLVGLLV GYCLATCLKL PVAQRRTVSI EVGVQNSLLA LAMLQLSLRR LQADYASQAP 430 440 FIVALSGTSE MLALVIGHFI YSSLFPVP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"CpG islands of the X chromosome are gene associated." Alcalay M., Toniolo D. Nucleic Acids Res. 16:9527-9543(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci." Chen E.Y., Zollo M., Mazzarella R.A., Ciccodicola A., Chen C.-N., Zuo L., Heiner C., Burough F.W., Ripetto M., Schlessinger D., D'Urso M. Hum. Mol. Genet. 5:659-668(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X12458 Genomic DNA. Translation: CAA30998.1. L44140 Genomic DNA. Translation: AAA92651.1. BX664739 Genomic DNA. Translation: CAI43236.2. BX664739 Genomic DNA. Translation: CAI43238.1. CH471172 Genomic DNA. Translation: EAW72697.1. CH471172 Genomic DNA. Translation: EAW72698.1. CH471172 Genomic DNA. Translation: EAW72699.1. BC004966 mRNA. Translation: AAH04966.1.
IPI	IPI00012852. IPI00844228.
PIR	S01696.
RefSeq	NP_001135863.1. NM_001142391.1. NP_001135864.1. NM_001142392.1. NP_062822.1. NM_019848.3.
UniGene	Hs.522826.
3D structure databases
ProteinModelPortal	P09131.
ModBase	Search...
Protein-protein interaction databases
IntAct	P09131. 1 interaction.
MINT	MINT-4722452.
STRING	9606.ENSP00000263512.
PTM databases
PhosphoSite	P09131.
Polymorphism databases
DMDM	129356.
Proteomic databases
PaxDb	P09131.
PRIDE	P09131.
Protocols and materials databases
DNASU	8273.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000263512; ENSP00000263512; ENSG00000126903. ENST00000369649; ENSP00000358663; ENSG00000126903. ENST00000393587; ENSP00000377212; ENSG00000126903. ENST00000593627; ENSP00000472609; ENSG00000268604. ENST00000594267; ENSP00000472068; ENSG00000268604. ENST00000596040; ENSP00000469063; ENSG00000268604.
GeneID	8273.
KEGG	hsa:8273.
UCSC	uc004flp.3. human. uc004flr.3. human.
Organism-specific databases
CTD	8273.
GeneCards	GC0XM153715.
HGNC	HGNC:22979. SLC10A3.
HPA	HPA021656.
MIM	312090. gene.
neXtProt	NX_P09131.
PharmGKB	PA134886398.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0385.
HOGENOM	HOG000037944.
HOVERGEN	HBG002872.
InParanoid	P09131.
KO	K14343.
PhylomeDB	P09131.
Gene expression databases
ArrayExpress	P09131.
Bgee	P09131.
CleanEx	HS_SLC10A3.
Genevestigator	P09131.
GermOnline	ENSG00000126903. Homo sapiens.
Family and domain databases
InterPro	IPR004710. Bil_ac_transpt. IPR002657. BilAc/Na_symport. [Graphical view]
PANTHER	PTHR10361. PTHR10361. 1 hit.
Pfam	PF01758. SBF. 1 hit. [Graphical view]
TIGRFAMs	TIGR00841. bass. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	SLC10A3. human.
GenomeRNAi	8273.
NextBio	31041.
SOURCE	Search...

Entry information

Entry name

P3_HUMAN

Accession

Primary (citable) accession number: P09131
Secondary accession number(s): Q5HY79, Q9BSL2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	May 29, 2013
This is version 112 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.