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P09131 (P3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
P3 protein
Alternative name(s):
Solute carrier family 10 member 3
Gene names
Name:SLC10A3
Synonyms:DXS253E, P3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length477 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The ubiquitous expression and the conservation of the sequence in distant animal species suggest that the gene codes for a protein with housekeeping functions.

Subcellular location

Membrane; Multi-pass membrane protein Probable.

Sequence similarities

Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. [View classification]

Ontologies

Keywords
   Biological processSymport
Transport
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processresponse to retinoic acid

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionbile acid:sodium symporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P09131-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P09131-2)

The sequence of this isoform differs from the canonical sequence as follows:
     120-148: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 477477P3 protein
PRO_0000052343

Regions

Transmembrane225 – 24521Helical; Potential
Transmembrane253 – 27321Helical; Potential
Transmembrane281 – 30121Helical; Potential
Transmembrane320 – 34021Helical; Potential
Transmembrane361 – 38121Helical; Potential
Transmembrane383 – 40321Helical; Potential
Transmembrane417 – 43721Helical; Potential
Transmembrane450 – 47021Helical; Potential

Natural variations

Alternative sequence120 – 14829Missing in isoform 2.
VSP_043669
Natural variant3541V → I.
Corresponds to variant rs35381503 [ dbSNP | Ensembl ].
VAR_050229

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: 49CB363EB3B66A1D

FASTA47750,333
        10         20         30         40         50         60 
MVLMQDKGSS QQWPGLGGEG GGTGPLSMLR AALLLISLPW GAQGTASTSL STAGGHTVPP 

        70         80         90        100        110        120 
TGGRYLSIGD GSVMEFEFPE DSEGIIVISS QYPGQANRTA PGPMLRVTSL DTEVLTIKNV 

       130        140        150        160        170        180 
SAITWGGGGG FVVSIHSGLA GLAPLHIQLV DAHEAPPTLI EERRDFCIKV SPAEDTPATL 

       190        200        210        220        230        240 
SADLAHFSEN PILYLLLPLI FVNKCSFGCK VELEVLKGLM QSPQPMLLGL LGQFLVMPLY 

       250        260        270        280        290        300 
AFLMAKVFML PKALALGLII TCSSPGGGGS YLFSLLLGGD VTLAISMTFL STVAATGFLP 

       310        320        330        340        350        360 
LSSAIYSRLL SIHETLHVPI SKILGTLLFI AIPIAVGVLI KSKLPKFSQL LLQVVKPFSF 

       370        380        390        400        410        420 
VLLLGGLFLA YRMGVFILAG IRLPIVLVGI TVPLVGLLVG YCLATCLKLP VAQRRTVSIE 

       430        440        450        460        470 
VGVQNSLLAL AMLQLSLRRL QADYASQAPF IVALSGTSEM LALVIGHFIY SSLFPVP 

« Hide

Isoform 2 [UniParc].

Checksum: 47A1263CF8EFFF91
Show »

FASTA44847,549

References

« Hide 'large scale' references
[1]"CpG islands of the X chromosome are gene associated."
Alcalay M., Toniolo D.
Nucleic Acids Res. 16:9527-9543(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci."
Chen E.Y., Zollo M., Mazzarella R.A., Ciccodicola A., Chen C.-N., Zuo L., Heiner C., Burough F.W., Ripetto M., Schlessinger D., D'Urso M.
Hum. Mol. Genet. 5:659-668(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The DNA sequence of the human X chromosome."
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. expand/collapse author list , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X12458 Genomic DNA. Translation: CAA30998.1.
L44140 Genomic DNA. Translation: AAA92651.1.
BX664739 Genomic DNA. Translation: CAI43236.2.
BX664739 Genomic DNA. Translation: CAI43238.1.
CH471172 Genomic DNA. Translation: EAW72697.1.
CH471172 Genomic DNA. Translation: EAW72698.1.
CH471172 Genomic DNA. Translation: EAW72699.1.
BC004966 mRNA. Translation: AAH04966.1.
CCDSCCDS14755.1. [P09131-1]
CCDS48195.1. [P09131-2]
PIRS01696.
RefSeqNP_001135863.1. NM_001142391.2. [P09131-2]
NP_001135864.1. NM_001142392.2. [P09131-1]
NP_062822.1. NM_019848.4. [P09131-1]
UniGeneHs.522826.

3D structure databases

ProteinModelPortalP09131.
SMRP09131. Positions 192-474.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113889. 2 interactions.
IntActP09131. 1 interaction.
MINTMINT-4722452.
STRING9606.ENSP00000263512.

Protein family/group databases

TCDB2.A.28.1.8. the bile acid:na(+) symporter (bass) family.

PTM databases

PhosphoSiteP09131.

Polymorphism databases

DMDM129356.

Proteomic databases

MaxQBP09131.
PaxDbP09131.
PRIDEP09131.

Protocols and materials databases

DNASU8273.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000263512; ENSP00000263512; ENSG00000126903. [P09131-1]
ENST00000369649; ENSP00000358663; ENSG00000126903. [P09131-2]
ENST00000393587; ENSP00000377212; ENSG00000126903. [P09131-1]
ENST00000593627; ENSP00000472609; ENSG00000268604. [P09131-1]
ENST00000594267; ENSP00000472068; ENSG00000268604. [P09131-1]
ENST00000596040; ENSP00000469063; ENSG00000268604. [P09131-2]
GeneID8273.
KEGGhsa:8273.
UCSCuc004flp.3. human. [P09131-1]
uc004flr.3. human. [P09131-2]

Organism-specific databases

CTD8273.
GeneCardsGC0XM153715.
HGNCHGNC:22979. SLC10A3.
HPAHPA021656.
MIM312090. gene.
neXtProtNX_P09131.
PharmGKBPA134886398.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0385.
HOGENOMHOG000037944.
HOVERGENHBG002872.
InParanoidP09131.
KOK14343.
PhylomeDBP09131.
TreeFamTF315811.

Gene expression databases

ArrayExpressP09131.
BgeeP09131.
CleanExHS_SLC10A3.
GenevestigatorP09131.

Family and domain databases

InterProIPR004710. Bil_ac_transpt.
IPR002657. BilAc/Na_symport.
[Graphical view]
PANTHERPTHR10361. PTHR10361. 1 hit.
PfamPF01758. SBF. 1 hit.
[Graphical view]
TIGRFAMsTIGR00841. bass. 1 hit.
ProtoNetSearch...

Other

ChiTaRSSLC10A3. human.
GeneWikiSLC10A3.
GenomeRNAi8273.
NextBio31041.
PROP09131.
SOURCESearch...

Entry information

Entry nameP3_HUMAN
AccessionPrimary (citable) accession number: P09131
Secondary accession number(s): Q5HY79, Q9BSL2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: July 9, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM