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P09131

- P3_HUMAN

UniProt

P09131 - P3_HUMAN

Protein

P3 protein

Gene

SLC10A3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    The ubiquitous expression and the conservation of the sequence in distant animal species suggest that the gene codes for a protein with housekeeping functions.

    GO - Molecular functioni

    1. bile acid:sodium symporter activity Source: InterPro

    GO - Biological processi

    1. response to retinoic acid Source: Ensembl

    Keywords - Biological processi

    Symport, Transport

    Protein family/group databases

    TCDBi2.A.28.1.8. the bile acid:na(+) symporter (bass) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    P3 protein
    Alternative name(s):
    Solute carrier family 10 member 3
    Gene namesi
    Name:SLC10A3
    Synonyms:DXS253E, P3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:22979. SLC10A3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134886398.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 477477P3 proteinPRO_0000052343Add
    BLAST

    Proteomic databases

    MaxQBiP09131.
    PaxDbiP09131.
    PRIDEiP09131.

    PTM databases

    PhosphoSiteiP09131.

    Expressioni

    Gene expression databases

    ArrayExpressiP09131.
    BgeeiP09131.
    CleanExiHS_SLC10A3.
    GenevestigatoriP09131.

    Organism-specific databases

    HPAiHPA021656.

    Interactioni

    Protein-protein interaction databases

    BioGridi113889. 2 interactions.
    IntActiP09131. 1 interaction.
    MINTiMINT-4722452.
    STRINGi9606.ENSP00000263512.

    Structurei

    3D structure databases

    ProteinModelPortaliP09131.
    SMRiP09131. Positions 192-474.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei225 – 24521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei253 – 27321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei281 – 30121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei320 – 34021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei361 – 38121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei383 – 40321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei417 – 43721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei450 – 47021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0385.
    HOGENOMiHOG000037944.
    HOVERGENiHBG002872.
    InParanoidiP09131.
    KOiK14343.
    PhylomeDBiP09131.
    TreeFamiTF315811.

    Family and domain databases

    InterProiIPR004710. Bil_ac_transpt.
    IPR002657. BilAc/Na_symport.
    [Graphical view]
    PANTHERiPTHR10361. PTHR10361. 1 hit.
    PfamiPF01758. SBF. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00841. bass. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P09131-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVLMQDKGSS QQWPGLGGEG GGTGPLSMLR AALLLISLPW GAQGTASTSL    50
    STAGGHTVPP TGGRYLSIGD GSVMEFEFPE DSEGIIVISS QYPGQANRTA 100
    PGPMLRVTSL DTEVLTIKNV SAITWGGGGG FVVSIHSGLA GLAPLHIQLV 150
    DAHEAPPTLI EERRDFCIKV SPAEDTPATL SADLAHFSEN PILYLLLPLI 200
    FVNKCSFGCK VELEVLKGLM QSPQPMLLGL LGQFLVMPLY AFLMAKVFML 250
    PKALALGLII TCSSPGGGGS YLFSLLLGGD VTLAISMTFL STVAATGFLP 300
    LSSAIYSRLL SIHETLHVPI SKILGTLLFI AIPIAVGVLI KSKLPKFSQL 350
    LLQVVKPFSF VLLLGGLFLA YRMGVFILAG IRLPIVLVGI TVPLVGLLVG 400
    YCLATCLKLP VAQRRTVSIE VGVQNSLLAL AMLQLSLRRL QADYASQAPF 450
    IVALSGTSEM LALVIGHFIY SSLFPVP 477
    Length:477
    Mass (Da):50,333
    Last modified:July 1, 1989 - v1
    Checksum:i49CB363EB3B66A1D
    GO
    Isoform 2 (identifier: P09131-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         120-148: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:448
    Mass (Da):47,549
    Checksum:i47A1263CF8EFFF91
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti354 – 3541V → I.
    Corresponds to variant rs35381503 [ dbSNP | Ensembl ].
    VAR_050229

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei120 – 14829Missing in isoform 2. 1 PublicationVSP_043669Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X12458 Genomic DNA. Translation: CAA30998.1.
    L44140 Genomic DNA. Translation: AAA92651.1.
    BX664739 Genomic DNA. Translation: CAI43236.2.
    BX664739 Genomic DNA. Translation: CAI43238.1.
    CH471172 Genomic DNA. Translation: EAW72697.1.
    CH471172 Genomic DNA. Translation: EAW72698.1.
    CH471172 Genomic DNA. Translation: EAW72699.1.
    BC004966 mRNA. Translation: AAH04966.1.
    CCDSiCCDS14755.1. [P09131-1]
    CCDS48195.1. [P09131-2]
    PIRiS01696.
    RefSeqiNP_001135863.1. NM_001142391.2. [P09131-2]
    NP_001135864.1. NM_001142392.2. [P09131-1]
    NP_062822.1. NM_019848.4. [P09131-1]
    UniGeneiHs.522826.

    Genome annotation databases

    EnsembliENST00000263512; ENSP00000263512; ENSG00000126903. [P09131-1]
    ENST00000369649; ENSP00000358663; ENSG00000126903. [P09131-2]
    ENST00000393587; ENSP00000377212; ENSG00000126903. [P09131-1]
    GeneIDi8273.
    KEGGihsa:8273.
    UCSCiuc004flp.3. human. [P09131-1]
    uc004flr.3. human. [P09131-2]

    Polymorphism databases

    DMDMi129356.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X12458 Genomic DNA. Translation: CAA30998.1 .
    L44140 Genomic DNA. Translation: AAA92651.1 .
    BX664739 Genomic DNA. Translation: CAI43236.2 .
    BX664739 Genomic DNA. Translation: CAI43238.1 .
    CH471172 Genomic DNA. Translation: EAW72697.1 .
    CH471172 Genomic DNA. Translation: EAW72698.1 .
    CH471172 Genomic DNA. Translation: EAW72699.1 .
    BC004966 mRNA. Translation: AAH04966.1 .
    CCDSi CCDS14755.1. [P09131-1 ]
    CCDS48195.1. [P09131-2 ]
    PIRi S01696.
    RefSeqi NP_001135863.1. NM_001142391.2. [P09131-2 ]
    NP_001135864.1. NM_001142392.2. [P09131-1 ]
    NP_062822.1. NM_019848.4. [P09131-1 ]
    UniGenei Hs.522826.

    3D structure databases

    ProteinModelPortali P09131.
    SMRi P09131. Positions 192-474.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113889. 2 interactions.
    IntActi P09131. 1 interaction.
    MINTi MINT-4722452.
    STRINGi 9606.ENSP00000263512.

    Protein family/group databases

    TCDBi 2.A.28.1.8. the bile acid:na(+) symporter (bass) family.

    PTM databases

    PhosphoSitei P09131.

    Polymorphism databases

    DMDMi 129356.

    Proteomic databases

    MaxQBi P09131.
    PaxDbi P09131.
    PRIDEi P09131.

    Protocols and materials databases

    DNASUi 8273.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000263512 ; ENSP00000263512 ; ENSG00000126903 . [P09131-1 ]
    ENST00000369649 ; ENSP00000358663 ; ENSG00000126903 . [P09131-2 ]
    ENST00000393587 ; ENSP00000377212 ; ENSG00000126903 . [P09131-1 ]
    GeneIDi 8273.
    KEGGi hsa:8273.
    UCSCi uc004flp.3. human. [P09131-1 ]
    uc004flr.3. human. [P09131-2 ]

    Organism-specific databases

    CTDi 8273.
    GeneCardsi GC0XM153715.
    HGNCi HGNC:22979. SLC10A3.
    HPAi HPA021656.
    MIMi 312090. gene.
    neXtProti NX_P09131.
    PharmGKBi PA134886398.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0385.
    HOGENOMi HOG000037944.
    HOVERGENi HBG002872.
    InParanoidi P09131.
    KOi K14343.
    PhylomeDBi P09131.
    TreeFami TF315811.

    Miscellaneous databases

    ChiTaRSi SLC10A3. human.
    GeneWikii SLC10A3.
    GenomeRNAii 8273.
    NextBioi 31041.
    PROi P09131.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P09131.
    Bgeei P09131.
    CleanExi HS_SLC10A3.
    Genevestigatori P09131.

    Family and domain databases

    InterProi IPR004710. Bil_ac_transpt.
    IPR002657. BilAc/Na_symport.
    [Graphical view ]
    PANTHERi PTHR10361. PTHR10361. 1 hit.
    Pfami PF01758. SBF. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00841. bass. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "CpG islands of the X chromosome are gene associated."
      Alcalay M., Toniolo D.
      Nucleic Acids Res. 16:9527-9543(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci."
      Chen E.Y., Zollo M., Mazzarella R.A., Ciccodicola A., Chen C.-N., Zuo L., Heiner C., Burough F.W., Ripetto M., Schlessinger D., D'Urso M.
      Hum. Mol. Genet. 5:659-668(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.

    Entry informationi

    Entry nameiP3_HUMAN
    AccessioniPrimary (citable) accession number: P09131
    Secondary accession number(s): Q5HY79, Q9BSL2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 125 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3