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P09131

- P3_HUMAN

UniProt

P09131 - P3_HUMAN

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Protein
P3 protein
Gene
SLC10A3, DXS253E, P3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

The ubiquitous expression and the conservation of the sequence in distant animal species suggest that the gene codes for a protein with housekeeping functions.

GO - Molecular functioni

  1. bile acid:sodium symporter activity Source: InterPro

GO - Biological processi

  1. response to retinoic acid Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Protein family/group databases

TCDBi2.A.28.1.8. the bile acid:na(+) symporter (bass) family.

Names & Taxonomyi

Protein namesi
Recommended name:
P3 protein
Alternative name(s):
Solute carrier family 10 member 3
Gene namesi
Name:SLC10A3
Synonyms:DXS253E, P3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:22979. SLC10A3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei225 – 24521Helical; Reviewed prediction
Add
BLAST
Transmembranei253 – 27321Helical; Reviewed prediction
Add
BLAST
Transmembranei281 – 30121Helical; Reviewed prediction
Add
BLAST
Transmembranei320 – 34021Helical; Reviewed prediction
Add
BLAST
Transmembranei361 – 38121Helical; Reviewed prediction
Add
BLAST
Transmembranei383 – 40321Helical; Reviewed prediction
Add
BLAST
Transmembranei417 – 43721Helical; Reviewed prediction
Add
BLAST
Transmembranei450 – 47021Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134886398.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 477477P3 protein
PRO_0000052343Add
BLAST

Proteomic databases

MaxQBiP09131.
PaxDbiP09131.
PRIDEiP09131.

PTM databases

PhosphoSiteiP09131.

Expressioni

Gene expression databases

ArrayExpressiP09131.
BgeeiP09131.
CleanExiHS_SLC10A3.
GenevestigatoriP09131.

Organism-specific databases

HPAiHPA021656.

Interactioni

Protein-protein interaction databases

BioGridi113889. 2 interactions.
IntActiP09131. 1 interaction.
MINTiMINT-4722452.
STRINGi9606.ENSP00000263512.

Structurei

3D structure databases

ProteinModelPortaliP09131.
SMRiP09131. Positions 192-474.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0385.
HOGENOMiHOG000037944.
HOVERGENiHBG002872.
InParanoidiP09131.
KOiK14343.
PhylomeDBiP09131.
TreeFamiTF315811.

Family and domain databases

InterProiIPR004710. Bil_ac_transpt.
IPR002657. BilAc/Na_symport.
[Graphical view]
PANTHERiPTHR10361. PTHR10361. 1 hit.
PfamiPF01758. SBF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00841. bass. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P09131-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVLMQDKGSS QQWPGLGGEG GGTGPLSMLR AALLLISLPW GAQGTASTSL    50
STAGGHTVPP TGGRYLSIGD GSVMEFEFPE DSEGIIVISS QYPGQANRTA 100
PGPMLRVTSL DTEVLTIKNV SAITWGGGGG FVVSIHSGLA GLAPLHIQLV 150
DAHEAPPTLI EERRDFCIKV SPAEDTPATL SADLAHFSEN PILYLLLPLI 200
FVNKCSFGCK VELEVLKGLM QSPQPMLLGL LGQFLVMPLY AFLMAKVFML 250
PKALALGLII TCSSPGGGGS YLFSLLLGGD VTLAISMTFL STVAATGFLP 300
LSSAIYSRLL SIHETLHVPI SKILGTLLFI AIPIAVGVLI KSKLPKFSQL 350
LLQVVKPFSF VLLLGGLFLA YRMGVFILAG IRLPIVLVGI TVPLVGLLVG 400
YCLATCLKLP VAQRRTVSIE VGVQNSLLAL AMLQLSLRRL QADYASQAPF 450
IVALSGTSEM LALVIGHFIY SSLFPVP 477
Length:477
Mass (Da):50,333
Last modified:July 1, 1989 - v1
Checksum:i49CB363EB3B66A1D
GO
Isoform 2 (identifier: P09131-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     120-148: Missing.

Note: No experimental confirmation available.

Show »
Length:448
Mass (Da):47,549
Checksum:i47A1263CF8EFFF91
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti354 – 3541V → I.
Corresponds to variant rs35381503 [ dbSNP | Ensembl ].
VAR_050229

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei120 – 14829Missing in isoform 2.
VSP_043669Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X12458 Genomic DNA. Translation: CAA30998.1.
L44140 Genomic DNA. Translation: AAA92651.1.
BX664739 Genomic DNA. Translation: CAI43236.2.
BX664739 Genomic DNA. Translation: CAI43238.1.
CH471172 Genomic DNA. Translation: EAW72697.1.
CH471172 Genomic DNA. Translation: EAW72698.1.
CH471172 Genomic DNA. Translation: EAW72699.1.
BC004966 mRNA. Translation: AAH04966.1.
CCDSiCCDS14755.1. [P09131-1]
CCDS48195.1. [P09131-2]
PIRiS01696.
RefSeqiNP_001135863.1. NM_001142391.2. [P09131-2]
NP_001135864.1. NM_001142392.2. [P09131-1]
NP_062822.1. NM_019848.4. [P09131-1]
UniGeneiHs.522826.

Genome annotation databases

EnsembliENST00000263512; ENSP00000263512; ENSG00000126903. [P09131-1]
ENST00000369649; ENSP00000358663; ENSG00000126903. [P09131-2]
ENST00000393587; ENSP00000377212; ENSG00000126903. [P09131-1]
ENST00000593627; ENSP00000472609; ENSG00000268604. [P09131-1]
ENST00000594267; ENSP00000472068; ENSG00000268604. [P09131-1]
ENST00000596040; ENSP00000469063; ENSG00000268604. [P09131-2]
GeneIDi8273.
KEGGihsa:8273.
UCSCiuc004flp.3. human. [P09131-1]
uc004flr.3. human. [P09131-2]

Polymorphism databases

DMDMi129356.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X12458 Genomic DNA. Translation: CAA30998.1 .
L44140 Genomic DNA. Translation: AAA92651.1 .
BX664739 Genomic DNA. Translation: CAI43236.2 .
BX664739 Genomic DNA. Translation: CAI43238.1 .
CH471172 Genomic DNA. Translation: EAW72697.1 .
CH471172 Genomic DNA. Translation: EAW72698.1 .
CH471172 Genomic DNA. Translation: EAW72699.1 .
BC004966 mRNA. Translation: AAH04966.1 .
CCDSi CCDS14755.1. [P09131-1 ]
CCDS48195.1. [P09131-2 ]
PIRi S01696.
RefSeqi NP_001135863.1. NM_001142391.2. [P09131-2 ]
NP_001135864.1. NM_001142392.2. [P09131-1 ]
NP_062822.1. NM_019848.4. [P09131-1 ]
UniGenei Hs.522826.

3D structure databases

ProteinModelPortali P09131.
SMRi P09131. Positions 192-474.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113889. 2 interactions.
IntActi P09131. 1 interaction.
MINTi MINT-4722452.
STRINGi 9606.ENSP00000263512.

Protein family/group databases

TCDBi 2.A.28.1.8. the bile acid:na(+) symporter (bass) family.

PTM databases

PhosphoSitei P09131.

Polymorphism databases

DMDMi 129356.

Proteomic databases

MaxQBi P09131.
PaxDbi P09131.
PRIDEi P09131.

Protocols and materials databases

DNASUi 8273.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000263512 ; ENSP00000263512 ; ENSG00000126903 . [P09131-1 ]
ENST00000369649 ; ENSP00000358663 ; ENSG00000126903 . [P09131-2 ]
ENST00000393587 ; ENSP00000377212 ; ENSG00000126903 . [P09131-1 ]
ENST00000593627 ; ENSP00000472609 ; ENSG00000268604 . [P09131-1 ]
ENST00000594267 ; ENSP00000472068 ; ENSG00000268604 . [P09131-1 ]
ENST00000596040 ; ENSP00000469063 ; ENSG00000268604 . [P09131-2 ]
GeneIDi 8273.
KEGGi hsa:8273.
UCSCi uc004flp.3. human. [P09131-1 ]
uc004flr.3. human. [P09131-2 ]

Organism-specific databases

CTDi 8273.
GeneCardsi GC0XM153715.
HGNCi HGNC:22979. SLC10A3.
HPAi HPA021656.
MIMi 312090. gene.
neXtProti NX_P09131.
PharmGKBi PA134886398.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0385.
HOGENOMi HOG000037944.
HOVERGENi HBG002872.
InParanoidi P09131.
KOi K14343.
PhylomeDBi P09131.
TreeFami TF315811.

Miscellaneous databases

ChiTaRSi SLC10A3. human.
GeneWikii SLC10A3.
GenomeRNAii 8273.
NextBioi 31041.
PROi P09131.
SOURCEi Search...

Gene expression databases

ArrayExpressi P09131.
Bgeei P09131.
CleanExi HS_SLC10A3.
Genevestigatori P09131.

Family and domain databases

InterProi IPR004710. Bil_ac_transpt.
IPR002657. BilAc/Na_symport.
[Graphical view ]
PANTHERi PTHR10361. PTHR10361. 1 hit.
Pfami PF01758. SBF. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00841. bass. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "CpG islands of the X chromosome are gene associated."
    Alcalay M., Toniolo D.
    Nucleic Acids Res. 16:9527-9543(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci."
    Chen E.Y., Zollo M., Mazzarella R.A., Ciccodicola A., Chen C.-N., Zuo L., Heiner C., Burough F.W., Ripetto M., Schlessinger D., D'Urso M.
    Hum. Mol. Genet. 5:659-668(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.

Entry informationi

Entry nameiP3_HUMAN
AccessioniPrimary (citable) accession number: P09131
Secondary accession number(s): Q5HY79, Q9BSL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: July 9, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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