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P09126

- HEM4_ECOLI

UniProt

P09126 - HEM4_ECOLI

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Protein

Uroporphyrinogen-III synthase

Gene

hemD

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.By similarity

Catalytic activityi

Hydroxymethylbilane = uroporphyrinogen III + H2O.

Pathwayi

GO - Molecular functioni

  1. uroporphyrinogen-III synthase activity Source: EcoCyc

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Porphyrin biosynthesis

Enzyme and pathway databases

BioCyciEcoCyc:UROGENIIISYN-MONOMER.
ECOL316407:JW3776-MONOMER.
MetaCyc:UROGENIIISYN-MONOMER.
UniPathwayiUPA00251; UER00320.

Names & Taxonomyi

Protein namesi
Recommended name:
Uroporphyrinogen-III synthase (EC:4.2.1.75)
Short name:
UROS
Alternative name(s):
Hydroxymethylbilane hydrolyase [cyclizing]
Uroporphyrinogen-III cosynthase
Gene namesi
Name:hemD
Ordered Locus Names:b3804, JW3776
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG10430. hemD.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 246246Uroporphyrinogen-III synthasePRO_0000135243Add
BLAST

Proteomic databases

PRIDEiP09126.

Expressioni

Gene expression databases

GenevestigatoriP09126.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

IntActiP09126. 3 interactions.
STRINGi511145.b3804.

Structurei

3D structure databases

ProteinModelPortaliP09126.
SMRiP09126. Positions 1-245.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1587.
HOGENOMiHOG000247993.
InParanoidiP09126.
KOiK01719.
OMAiVRYWEVY.
OrthoDBiEOG6RZB2F.
PhylomeDBiP09126.

Family and domain databases

InterProiIPR003754. 4pyrrol_synth_uPrphyn_synth.
[Graphical view]
PfamiPF02602. HEM4. 1 hit.
[Graphical view]
SUPFAMiSSF69618. SSF69618. 1 hit.

Sequencei

Sequence statusi: Complete.

P09126-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSILVTRPSP AGEELVSRLR TLGQVAWHFP LIEFSPGQQL PQLADQLAAL
60 70 80 90 100
GESDLLFALS QHAVAFAQSQ LHQQDRKWPR LPDYFAIGRT TALALHTVSG
110 120 130 140 150
QKILYPQDRE ISEVLLQLPE LQNIAGKRAL ILRGNGGREL IGDTLTARGA
160 170 180 190 200
EVTFCECYQR CAIHYDGAEE AMRWQAREVT MVVVTSGEML QQLWSLIPQW
210 220 230 240
YREHWLLHCR LLVVSERLAK LARELGWQDI KVADNADNDA LLRALQ
Length:246
Mass (Da):27,798
Last modified:July 1, 1989 - v1
Checksum:i0BF7453C72395A0C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti146 – 1461T → A in AAA23956. (PubMed:3040684)Curated
Sequence conflicti236 – 2361A → R(PubMed:3320969)Curated
Sequence conflicti236 – 2361A → R(PubMed:3277628)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X12614 Genomic DNA. Translation: CAA31133.1.
Y00883 Genomic DNA. Translation: CAA68776.1.
M17360 Genomic DNA. Translation: AAA23956.1.
M87049 Genomic DNA. Translation: AAA67600.1.
U00096 Genomic DNA. Translation: AAC76807.1.
AP009048 Genomic DNA. Translation: BAE77497.1.
PIRiE65184.
RefSeqiNP_418248.1. NC_000913.3.
YP_491638.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC76807; AAC76807; b3804.
BAE77497; BAE77497; BAE77497.
GeneIDi12933615.
948587.
KEGGiecj:Y75_p3374.
eco:b3804.
PATRICi32123107. VBIEscCol129921_3919.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X12614 Genomic DNA. Translation: CAA31133.1 .
Y00883 Genomic DNA. Translation: CAA68776.1 .
M17360 Genomic DNA. Translation: AAA23956.1 .
M87049 Genomic DNA. Translation: AAA67600.1 .
U00096 Genomic DNA. Translation: AAC76807.1 .
AP009048 Genomic DNA. Translation: BAE77497.1 .
PIRi E65184.
RefSeqi NP_418248.1. NC_000913.3.
YP_491638.1. NC_007779.1.

3D structure databases

ProteinModelPortali P09126.
SMRi P09126. Positions 1-245.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P09126. 3 interactions.
STRINGi 511145.b3804.

Proteomic databases

PRIDEi P09126.

Protocols and materials databases

DNASUi 948587.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC76807 ; AAC76807 ; b3804 .
BAE77497 ; BAE77497 ; BAE77497 .
GeneIDi 12933615.
948587.
KEGGi ecj:Y75_p3374.
eco:b3804.
PATRICi 32123107. VBIEscCol129921_3919.

Organism-specific databases

EchoBASEi EB0425.
EcoGenei EG10430. hemD.

Phylogenomic databases

eggNOGi COG1587.
HOGENOMi HOG000247993.
InParanoidi P09126.
KOi K01719.
OMAi VRYWEVY.
OrthoDBi EOG6RZB2F.
PhylomeDBi P09126.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00320 .
BioCyci EcoCyc:UROGENIIISYN-MONOMER.
ECOL316407:JW3776-MONOMER.
MetaCyc:UROGENIIISYN-MONOMER.

Miscellaneous databases

PROi P09126.

Gene expression databases

Genevestigatori P09126.

Family and domain databases

InterProi IPR003754. 4pyrrol_synth_uPrphyn_synth.
[Graphical view ]
Pfami PF02602. HEM4. 1 hit.
[Graphical view ]
SUPFAMi SSF69618. SSF69618. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The sequence of hemC, hemD and two additional E. coli genes."
    Alefounder P.R., Abell C., Battersby A.R.
    Nucleic Acids Res. 16:9871-9871(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12 / CS520.
  2. "Nucleotide sequence of hemD, the second gene in the hem operon of Escherichia coli K-12."
    Jordan P.M., Mgbeje B.I.A., Alwan A.F., Thomas S.D.
    Nucleic Acids Res. 15:10583-10583(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  3. "Nucleotide sequence for the hemD gene of Escherichia coli encoding uroporphyrinogen III synthase and initial evidence for a hem operon."
    Jordan P.M., Mgbeje B.I.A., Thomas S.D., Alwan A.F.
    Biochem. J. 249:613-616(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  4. "Molecular cloning and sequencing of the hemD gene of Escherichia coli K-12 and preliminary data on the Uro operon."
    Sasarman A., Nepveu A., Echelard Y., Dymetryszyn J., Drolet M., Goyer C.
    J. Bacteriol. 169:4257-4262(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Analysis of the Escherichia coli genome: DNA sequence of the region from 84.5 to 86.5 minutes."
    Daniels D.L., Plunkett G. III, Burland V.D., Blattner F.R.
    Science 257:771-778(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  7. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiHEM4_ECOLI
AccessioniPrimary (citable) accession number: P09126
Secondary accession number(s): Q2M8A9, Q47250
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 29, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3