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Protein

Threonine synthase

Gene

thrC

Organism
Bacillus sp. (strain ULM1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.By similarity

Catalytic activityi

O-phospho-L-homoserine + H2O = L-threonine + phosphate.

Cofactori

Pathwayi: L-threonine biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes L-threonine from L-aspartate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. Threonine synthase (thrC)
This subpathway is part of the pathway L-threonine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-threonine from L-aspartate, the pathway L-threonine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei85Pyridoxal phosphateBy similarity1
Binding sitei314Pyridoxal phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Threonine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00050; UER00065.

Names & Taxonomyi

Protein namesi
Recommended name:
Threonine synthase (EC:4.2.3.1)
Short name:
TS
Gene namesi
Name:thrC
OrganismiBacillus sp. (strain ULM1)
Taxonomic identifieri231717 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001856251 – 352Threonine synthaseAdd BLAST352

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei59N6-(pyridoxal phosphate)lysineBy similarity1

Structurei

3D structure databases

ProteinModelPortaliP09123.
SMRiP09123.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni185 – 189Pyridoxal phosphate bindingBy similarity5

Sequence similaritiesi

Belongs to the threonine synthase family.Curated

Family and domain databases

InterProiView protein in InterPro
IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR004450. Thr_synthase-like.
IPR026260. Thr_Synthase_bac/arc.
IPR001926. TrpB-like_PLP-dep.
PfamiView protein in Pfam
PF00291. PALP. 1 hit.
PIRSFiPIRSF038945. Thr_synthase. 1 hit.
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR00260. thrC. 1 hit.
PROSITEiView protein in PROSITE
PS00165. DEHYDRATASE_SER_THR. 1 hit.

Sequencei

Sequence statusi: Complete.

P09123-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYKGLLKQYA SYLPVNEKTP DVSLMEGNTP LIPLLNISKQ LGVQLYGKYE
60 70 80 90 100
GANPTGSFKD RGMVMAVAKA KEEGSEAIIC ASTGNTSASA AAYAARLGMK
110 120 130 140 150
CIIVIPEGKI AHGKLAQAVA YGAEIISIEG NFDDALKAVR NIAAEEPITL
160 170 180 190 200
VNSVNPYRIE GQKTAAFEIC DQLQNAPDVL AIPVGNAGNI TAYWKGFCEY
210 220 230 240 250
EKEKGYKKPR IHGFEAEGAA AIVKGHVIEE PETIATAIRI GNPASWSYAV
260 270 280 290 300
EAAEQSHGEI DMVSDEEILH AYRLLAKTEG VFAEPGSNAS LAGVIKHVES
310 320 330 340 350
GKIKKGETVV AVLTGNGLKD PDIAISSNQL DIASVSNDIE QIKDHIKGVI

MS
Length:352
Mass (Da):37,458
Last modified:July 1, 1989 - v1
Checksum:i192550176FAD7930
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z29562 Genomic DNA. Translation: CAA82669.1.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTHRC_BACSL
AccessioniPrimary (citable) accession number: P09123
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: February 15, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Was originally thought to originate from B.lactofermentum=C.glutamicum.1 Publication

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families