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P09117

- ALDOC_RAT

UniProt

P09117 - ALDOC_RAT

Protein

Fructose-bisphosphate aldolase C

Gene

Aldoc

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei56 – 561Substrate
    Binding sitei147 – 1471Substrate
    Active sitei188 – 1881Proton acceptorBy similarity
    Active sitei230 – 2301Schiff-base intermediate with dihydroxyacetone-P
    Sitei363 – 3631Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate

    GO - Molecular functioni

    1. fructose-bisphosphate aldolase activity Source: UniProtKB
    2. protein binding Source: RGD

    GO - Biological processi

    1. aging Source: RGD
    2. apoptotic process Source: RGD
    3. fructose 1,6-bisphosphate metabolic process Source: UniProtKB
    4. glycolytic process Source: UniProtKB-UniPathway
    5. organ regeneration Source: RGD
    6. protein heterotetramerization Source: RGD
    7. protein homotetramerization Source: RGD
    8. response to hypoxia Source: RGD
    9. response to organic cyclic compound Source: RGD
    10. response to organonitrogen compound Source: RGD

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Schiff base

    Enzyme and pathway databases

    ReactomeiREACT_217998. Gluconeogenesis.
    REACT_225694. Glycolysis.
    SABIO-RKP09117.
    UniPathwayiUPA00109; UER00183.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fructose-bisphosphate aldolase C (EC:4.1.2.13)
    Alternative name(s):
    Brain-type aldolase
    Gene namesi
    Name:Aldoc
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 10

    Organism-specific databases

    RGDi2091. Aldoc.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: RGD
    2. cytoplasm Source: RGD
    3. mitochondrion Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 363362Fructose-bisphosphate aldolase CPRO_0000216951Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei111 – 1111N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiP09117.
    PRIDEiP09117.

    2D gel databases

    World-2DPAGE0004:P09117.

    PTM databases

    PhosphoSiteiP09117.

    Expressioni

    Tissue specificityi

    High expression in the adult brain.1 Publication

    Developmental stagei

    Detected at low concentration in practically all the fetal tissues and its expression markedly and rapidly decreased after birth.1 Publication

    Gene expression databases

    ArrayExpressiP09117.
    GenevestigatoriP09117.

    Interactioni

    Subunit structurei

    Homotetramer. Interacts with ATP6V1E1 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi246381. 3 interactions.
    IntActiP09117. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP09117.
    SMRiP09117. Positions 3-344.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG3588.
    GeneTreeiENSGT00390000010235.
    HOGENOMiHOG000220876.
    HOVERGENiHBG002386.
    InParanoidiP09117.
    KOiK01623.
    OMAiRGQQDNA.
    OrthoDBiEOG744T94.
    PhylomeDBiP09117.
    TreeFamiTF314203.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR000741. FBA_I.
    [Graphical view]
    PfamiPF00274. Glycolytic. 1 hit.
    [Graphical view]
    PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P09117-1 [UniParc]FASTAAdd to Basket

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    MPHSYPALSA EQKKELSDIA LRIVAPGKGI LAADESVGSM AKRLSQIGVE    50
    NTEENRRLYR QVLFSADDRV KKCIGGVIFF HETLYQKDDN GVPFVRTIQE 100
    KGILVGIKVD KGVVPLAGTD GETTTQGLDG LLERCAQYKK DGADFAKWRC 150
    VLKISDRTPS ALAILENANV LARYASICQQ NGIVPIVEPE ILPDGDHDLK 200
    RCQFVTEKVL AAVYKALSDH HVYLEGTLLK PNMVTPGHAC PIKYSPEEIA 250
    MATVTALRRT VPPAVPGVTF LSGGQSEEEA SLNLNAINRC SLPRPWALTF 300
    SYGRALQASA LSAWRGQRDN AGAATEEFIK RAEMNGLAAQ GKYEGSGDGG 350
    AAAQSLYVAN HAY 363
    Length:363
    Mass (Da):39,284
    Last modified:January 23, 2007 - v3
    Checksum:i00FDB44B602FA9B3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti337 – 3393LAA → ACS in CAA30044. (PubMed:2831050)Curated
    Sequence conflicti337 – 3393LAA → ACS in CAA28889. (PubMed:3830170)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M63656 Genomic DNA. Translation: AAA40717.1.
    X06984 mRNA. Translation: CAA30044.1.
    AB017483 Genomic DNA. Translation: BAA75659.1.
    BC099749 mRNA. Translation: AAH99749.1.
    X05277 mRNA. Translation: CAA28889.1.
    PIRiS00326. ADRTC.
    RefSeqiNP_036629.1. NM_012497.1.
    UniGeneiRn.11211.

    Genome annotation databases

    EnsembliENSRNOT00000015535; ENSRNOP00000015535; ENSRNOG00000011452.
    GeneIDi24191.
    KEGGirno:24191.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M63656 Genomic DNA. Translation: AAA40717.1 .
    X06984 mRNA. Translation: CAA30044.1 .
    AB017483 Genomic DNA. Translation: BAA75659.1 .
    BC099749 mRNA. Translation: AAH99749.1 .
    X05277 mRNA. Translation: CAA28889.1 .
    PIRi S00326. ADRTC.
    RefSeqi NP_036629.1. NM_012497.1.
    UniGenei Rn.11211.

    3D structure databases

    ProteinModelPortali P09117.
    SMRi P09117. Positions 3-344.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 246381. 3 interactions.
    IntActi P09117. 1 interaction.

    PTM databases

    PhosphoSitei P09117.

    2D gel databases

    World-2DPAGE 0004:P09117.

    Proteomic databases

    PaxDbi P09117.
    PRIDEi P09117.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000015535 ; ENSRNOP00000015535 ; ENSRNOG00000011452 .
    GeneIDi 24191.
    KEGGi rno:24191.

    Organism-specific databases

    CTDi 230.
    RGDi 2091. Aldoc.

    Phylogenomic databases

    eggNOGi COG3588.
    GeneTreei ENSGT00390000010235.
    HOGENOMi HOG000220876.
    HOVERGENi HBG002386.
    InParanoidi P09117.
    KOi K01623.
    OMAi RGQQDNA.
    OrthoDBi EOG744T94.
    PhylomeDBi P09117.
    TreeFami TF314203.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00183 .
    Reactomei REACT_217998. Gluconeogenesis.
    REACT_225694. Glycolysis.
    SABIO-RK P09117.

    Miscellaneous databases

    NextBioi 602567.

    Gene expression databases

    ArrayExpressi P09117.
    Genevestigatori P09117.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR000741. FBA_I.
    [Graphical view ]
    Pfami PF00274. Glycolytic. 1 hit.
    [Graphical view ]
    PROSITEi PS00158. ALDOLASE_CLASS_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The structure of the brain-specific rat aldolase C gene and its regional expression."
      Mukai T., Yatsuki H., Masuko S., Arai Y., Joh K., Hori K.
      Biochem. Biophys. Res. Commun. 174:1035-1042(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Brain.
    2. "The structure of brain-specific rat aldolase C mRNA and the evolution of aldolase isozyme genes."
      Kukita A., Mukai T., Miyata T., Hori K.
      Eur. J. Biochem. 171:471-478(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    3. "The first exon of the rat aldolase C gene is essential for restoring the chromatin structure in transgenic mice."
      Arai Y., Sugama T., Hashido K., Ohishi S., Mukai T.
      J. Biochem. 122:927-938(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.
    5. Lubec G., Afjehi-Sadat L., Kang S.U.
      Submitted (JUL-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-13; 15-22; 61-69; 73-96; 112-134; 158-215; 244-258; 260-289; 305-315; 319-330 AND 343-363, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: Sprague-Dawley.
      Tissue: Brain and Spinal cord.
    6. "Molecular cloning and expression of rat aldolase C messenger RNA during development and hepatocarcinogenesis."
      Skala H., Vibert M., Lamas E., Maire P., Schweighoffer F., Kahn A.
      Eur. J. Biochem. 163:513-518(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 251-363, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Strain: Wistar.
      Tissue: Brain.

    Entry informationi

    Entry nameiALDOC_RAT
    AccessioniPrimary (citable) accession number: P09117
    Secondary accession number(s): Q54AI4, Q63037
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 119 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3